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VFPFRYSKASDEQSALRAAAAGGRYIAGGTTLVDLMRETVERPDSLVDINALPYQSIDVQPGVIRVGSLV RMSNLAAHPVVRQQVPMVSQALELSASAQLRNMASIGGNLLQRPRCLYFRDVSAACNRRGPDAGCAAIEG RNRTHAIFGACRHCCATHPSDLAVALVALDAVVLTRQVAGHRRFGLAELYRHPGDSPHWEHNLHPGELLV AIEIPVGPQLHRSGYLKVRDRESYQFALVSAAVALDIAAGTIRTARVAAGGVGTVPWRLPAVEAALRGRP PDADLFRRAAALSAIGAKPLSENRFKVELLKRVVEKQLTVVAAMP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4579 | coxM_1 | - | 100% (325) | carbon monoxyde dehydrogenase (medium chain), CoxM_1 |
| M. ulcerans Agy99 | MUL_0587 | coxM_2 | 1e-11 | 23.43% (286) | aerobic-type carbon monoxide dehydrogenase, CoxM_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0382c | - | 5e-16 | 24.92% (305) | carbon monoxyde dehydrogenase medium subunit |
| M. gilvum PYR-GCK | Mflv_0283 | - | 2e-73 | 46.60% (324) | molybdopterin dehydrogenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0375c | - | 5e-16 | 24.92% (305) | carbon monoxyde dehydrogenase medium subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0835 | coxM_1 | 0.0 | 98.15% (325) | carbon monoxyde dehydrogenase (medium chain), CoxM_1 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0871 | - | 1e-124 | 69.14% (324) | putative aldehyde or xanthine dehydrogenase, molybdopterin |
| M. thermoresistible (build 8) | TH_0174 | - | 2e-18 | 24.84% (322) | PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM CHAIN) |
| M. vanbaalenii PYR-1 | Mvan_2077 | - | 1e-66 | 43.79% (322) | molybdopterin dehydrogenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4579|M.ulcerans_Agy99 ---MFPFRYSKASDEQSALR--AAAAG-GRYIAGGTTLVDLMRETVERPD
MMAR_0835|M.marinum_M ---MFPFRYSKASDEQSALR--AAAAG-GRYIAGGTTLVDLMRETVERPD
MSMEG_0871|M.smegmatis_MC2_155 ---MHPFAFTKAADERSALN--AAASG-GRYVAGGTTLVDLMRETVERPE
Mflv_0283|M.gilvum_PYR-GCK ---MKPFEYHLATSPADAVATLARHPD-AAYLAGGTNLVDHMKLGVAEPR
Mvan_2077|M.vanbaalenii_PYR-1 ---MRTFDHRRAGTVDDAIG-LASVPG-ARYFAGGTNLLDLMKSGVENPT
Mb0382c|M.bovis_AF2122/97 --------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPE
Rv0375c|M.tuberculosis_H37Rv --------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPE
TH_0174|M.thermoresistible__bu MQVPGPFEYERATSVDHAIGLLDRLGDGAMIVAGGHSLLPMMKLRIANPE
*: . .*** .*: *: : .*
MUL_4579|M.ulcerans_Agy99 SLVDINALPYQSIDVQP------GVIRVGSLVRMSNLAAHPVVRQQVPMV
MMAR_0835|M.marinum_M SLVDINALPYQSIDVQP------GVIHVGSLVRMSDLAAHPVVRQQVPMV
MSMEG_0871|M.smegmatis_MC2_155 SLVDINALPYRAIDVTR------NGLRIGALVRMSELAAHPVVRTEYPVI
Mflv_0283|M.gilvum_PYR-GCK LLVDVSRLDLTEVALTDD-----GGLSIGANVRNSDLAAHPVVRSRYPML
Mvan_2077|M.vanbaalenii_PYR-1 VLVDVNRLGLDAVVRTAA-----GGIAIGSGVTNSAVANHPLVRTDYPVL
Mb0382c|M.bovis_AF2122/97 YLVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIF
Rv0375c|M.tuberculosis_H37Rv YLVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIF
TH_0174|M.thermoresistible__bu YLVDINDLAGELGYIVV----NADAVRIGAMTRHREALESAELAQCCPIF
***:. * . : :*: . : *:.
MUL_4579|M.ulcerans_Agy99 SQALELSASAQLRNMASIGGNLLQRPRCLYFRDVSAA-CNRRGPDAGCAA
MMAR_0835|M.marinum_M SQALELSASAQLRNMASIGGNLLQRPRCLYFRDVSAA-CNRRGPDAGCAA
MSMEG_0871|M.smegmatis_MC2_155 AEALNLSASAQLRNMASIGGNLMQRPRCLYFRDVTAA-CNRREPGSGCPA
Mflv_0283|M.gilvum_PYR-GCK ARALLSGASGQLRNAATTGGNLLQRTRCVYFQDVTTP-CNKREPGSGCAA
Mvan_2077|M.vanbaalenii_PYR-1 SQAILSGATTQIRNMATVGGNLMQRTRCPYFMDPRFERCNKRYPGSGCAA
Mb0382c|M.bovis_AF2122/97 RDAERVIADPVVRNRGTLGG------------------------------
Rv0375c|M.tuberculosis_H37Rv RDAERVIADPVVRNRGTLGG------------------------------
TH_0174|M.thermoresistible__bu ADAERVIADPVVRNRGTVGG------------------------------
* * :** .: **
MUL_4579|M.ulcerans_Agy99 IEGRNRTHAIFGACRHCCATHPSDLAVALVALDAVVLTRQVAGHRRFGLA
MMAR_0835|M.marinum_M IEGRNRTHAIFGASQHCCATHPSDLAVALVALDAVVLTRQIAGHRRFGLA
MSMEG_0871|M.smegmatis_MC2_155 IGGRNRTHAILGTSDQCVATHPSDLAVALTALDARVVLRDTDGENIVRLA
Mflv_0283|M.gilvum_PYR-GCK LGGYVRYHAILGASRHCVATHPSDMAVAMSALDAHIVVEGADGSRRIPAT
Mvan_2077|M.vanbaalenii_PYR-1 RDGFNREHAVFGTGGPCVAVHPSDMAVALAALDAVVHIKGPHGPRAATIS
Mb0382c|M.bovis_AF2122/97 --------------SLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAID
Rv0375c|M.tuberculosis_H37Rv --------------SLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAID
TH_0174|M.thermoresistible__bu --------------SLCQADPAEDLSTVCTVLDAVCVVRGPAGRREIGID
* * ..*::.. .*** . * .
MUL_4579|M.ulcerans_Agy99 ELYRHPGDSPHWEHNLHPGELLVAIEIPVGPQLHRSGYLKVRDRESYQFA
MMAR_0835|M.marinum_M ELYRQPGDSPHWEHNLHPGELLVAIEIPVGPQLHRSGYLKVRDRESYQFA
MSMEG_0871|M.smegmatis_MC2_155 DFYRVPGTTPEQEHNMRPGQLITAVEVPATP-ARRSGYLKVRDRTSYEFA
Mflv_0283|M.gilvum_PYR-GCK DFHRLPGDEPQFDTVLDHGELITAVELPAPPPHAVSDYRKVRDRASYAFA
Mvan_2077|M.vanbaalenii_PYR-1 QFFSPPAADPDRDNGMAAADFITSVELPAAADTVHGWYLKVRDRRRYAFA
Mb0382c|M.bovis_AF2122/97 DFLVGP-----YETALAHNEVLIEVRIPLRH-NTSSAYAKVERRVG-DWA
Rv0375c|M.tuberculosis_H37Rv DFLVGP-----YETALAHNEVLIEVRIPLRH-NTSSAYAKVERRVG-DWA
TH_0174|M.thermoresistible__bu DFLVGP-----YETALAHNEILLEVKIPLRP-NSSNAYAKVERRVG-DWA
:: * : : :.: :.:* . * **. * :*
MUL_4579|M.ulcerans_Agy99 LVSAAVALDIAA-GTIRTARVAAGGVGTVPWRLPAVEAALRGRPPDADLF
MMAR_0835|M.marinum_M LVSAAVALDIAA-GTIRTARVAAGGVGTVPWRLPAVEAALRGRPPDADLF
MSMEG_0871|M.smegmatis_MC2_155 ICSAAVALDIQG-STIRSARVAAGGVGTVPWRLPAVERALAGRPATADAI
Mflv_0283|M.gilvum_PYR-GCK LVSVAAELSFVG-ESIATARIALGGVAHKPWRARRAEQMLAGAEATDETF
Mvan_2077|M.vanbaalenii_PYR-1 LVSVAAVLRFDSDGVVASAAVALGGVADRPWRVPAAEAVLTGRRPTPQLF
Mb0382c|M.bovis_AF2122/97 ITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQPATEEVF
Rv0375c|M.tuberculosis_H37Rv ITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQPATEEVF
TH_0174|M.thermoresistible__bu VTAAGAAVTLDG-QTVTAARIGLTAVNPDAAALAEISRRLTGRPATEETF
: :... : : . : :* :. .* . . * * . : :
MUL_4579|M.ulcerans_Agy99 RRAAALSAIGAKPLSENR----FKVELLKRVVEKQLTVVAAMP-------
MMAR_0835|M.marinum_M RRAAALSAIGAKPLSENR----FKVELLKRVVEKQLTVVAAMP-------
MSMEG_0871|M.smegmatis_MC2_155 RAAADLSAEGARPLSENG----FKVELLKRTVARELETIAGVQ-------
Mflv_0283|M.gilvum_PYR-GCK AAAADAEISAAEPLPGNE----FKVELARRTLMAQLRMLTERGTR-----
Mvan_2077|M.vanbaalenii_PYR-1 RSAADTALADAAPLSHNG----FKLPLARNAVMRALVLATGR--------
Mb0382c|M.bovis_AF2122/97 AEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRVLGAPAAP
Rv0375c|M.tuberculosis_H37Rv AEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRVLGAPAAP
TH_0174|M.thermoresistible__bu AEAGRLAAQACEPVTDVRGTADYKRHLAAELTTRTLRTAVQRIQQRHGGA
*. . *:. :* * . * .
MUL_4579|M.ulcerans_Agy99 ----
MMAR_0835|M.marinum_M ----
MSMEG_0871|M.smegmatis_MC2_155 ----
Mflv_0283|M.gilvum_PYR-GCK ----
Mvan_2077|M.vanbaalenii_PYR-1 ----
Mb0382c|M.bovis_AF2122/97 EA--
Rv0375c|M.tuberculosis_H37Rv EA--
TH_0174|M.thermoresistible__bu QPCR