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MRTFDHRRAGTVDDAIGLASVPGARYFAGGTNLLDLMKSGVENPTVLVDVNRLGLDAVVRTAAGGIAIGS GVTNSAVANHPLVRTDYPVLSQAILSGATTQIRNMATVGGNLMQRTRCPYFMDPRFERCNKRYPGSGCAA RDGFNREHAVFGTGGPCVAVHPSDMAVALAALDAVVHIKGPHGPRAATISQFFSPPAADPDRDNGMAAAD FITSVELPAAADTVHGWYLKVRDRRRYAFALVSVAAVLRFDSDGVVASAAVALGGVADRPWRVPAAEAVL TGRRPTPQLFRSAADTALADAAPLSHNGFKLPLARNAVMRALVLATGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2077 | - | - | 100% (328) | molybdopterin dehydrogenase, FAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0382c | - | 2e-14 | 26.93% (323) | carbon monoxyde dehydrogenase medium subunit |
| M. gilvum PYR-GCK | Mflv_0283 | - | 3e-80 | 49.54% (329) | molybdopterin dehydrogenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0375c | - | 2e-14 | 26.93% (323) | carbon monoxyde dehydrogenase medium subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0835 | coxM_1 | 6e-67 | 43.79% (322) | carbon monoxyde dehydrogenase (medium chain), CoxM_1 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0685 | - | 9e-84 | 51.06% (329) | oxidoreductase, molybdopterin-binding subunit |
| M. thermoresistible (build 8) | TH_0174 | - | 5e-14 | 25.60% (332) | PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM CHAIN) |
| M. ulcerans Agy99 | MUL_4579 | coxM_1 | 7e-67 | 43.79% (322) | carbon monoxyde dehydrogenase (medium chain), CoxM_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0283|M.gilvum_PYR-GCK ---MKPFEYHLATSPADAVATLARHPD-AAYLAGGTNLVDHMKLGVAEPR
MSMEG_0685|M.smegmatis_MC2_155 ---MKAFGYHVATSPADAVATLAGHPG-AAYLAGGTNLVDHMKLGVAEPD
Mvan_2077|M.vanbaalenii_PYR-1 ---MRTFDHRRAGTVDDAIG-LASVPG-ARYFAGGTNLLDLMKSGVENPT
MMAR_0835|M.marinum_M ---MFPFRYSKASDEQSALR--AAAAG-GRYIAGGTTLVDLMRETVERPD
MUL_4579|M.ulcerans_Agy99 ---MFPFRYSKASDEQSALR--AAAAG-GRYIAGGTTLVDLMRETVERPD
Mb0382c|M.bovis_AF2122/97 --------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPE
Rv0375c|M.tuberculosis_H37Rv --------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPE
TH_0174|M.thermoresistible__bu MQVPGPFEYERATSVDHAIGLLDRLGDGAMIVAGGHSLLPMMKLRIANPE
*: . .*** .*: *: : .*
Mflv_0283|M.gilvum_PYR-GCK LLVDVSRLDLTEVALTDD-----GGLSIGANVRNSDLAAHPVVRSRYPML
MSMEG_0685|M.smegmatis_MC2_155 LLVDVSRLDLDQISVTDD-----GAVRIGANVRNSDLAADPVIRSHYPVL
Mvan_2077|M.vanbaalenii_PYR-1 VLVDVNRLGLDAVVRTAA-----GGIAIGSGVTNSAVANHPLVRTDYPVL
MMAR_0835|M.marinum_M SLVDINALPYQSIDVQP------GVIHVGSLVRMSDLAAHPVVRQQVPMV
MUL_4579|M.ulcerans_Agy99 SLVDINALPYQSIDVQP------GVIRVGSLVRMSNLAAHPVVRQQVPMV
Mb0382c|M.bovis_AF2122/97 YLVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIF
Rv0375c|M.tuberculosis_H37Rv YLVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIF
TH_0174|M.thermoresistible__bu YLVDINDLAGELGYIVV----NADAVRIGAMTRHREALESAELAQCCPIF
***:. * . : :*: . : *:.
Mflv_0283|M.gilvum_PYR-GCK ARALLSGASGQLRNAATTGGNLLQRTRCVYFQDVTTP-CNKREPGSGCAA
MSMEG_0685|M.smegmatis_MC2_155 ARALLSGASGQLRNTATTAGNLLQRTRCVYFQDVTTP-CNKREPGSGCAA
Mvan_2077|M.vanbaalenii_PYR-1 SQAILSGATTQIRNMATVGGNLMQRTRCPYFMDPRFERCNKRYPGSGCAA
MMAR_0835|M.marinum_M SQALELSASAQLRNMASIGGNLLQRPRCLYFRDVSAA-CNRRGPDAGCAA
MUL_4579|M.ulcerans_Agy99 SQALELSASAQLRNMASIGGNLLQRPRCLYFRDVSAA-CNRRGPDAGCAA
Mb0382c|M.bovis_AF2122/97 RDAERVIADPVVRNRGTLGG------------------------------
Rv0375c|M.tuberculosis_H37Rv RDAERVIADPVVRNRGTLGG------------------------------
TH_0174|M.thermoresistible__bu ADAERVIADPVVRNRGTVGG------------------------------
* * :** .: .*
Mflv_0283|M.gilvum_PYR-GCK LGGYVRYHAILGASRHCVATHPSDMAVAMSALDAHIVVEGADGSRRIPAT
MSMEG_0685|M.smegmatis_MC2_155 LGGYARYHAILGASEHCVAVHPSDMAVAMSALDATVVVQGPDGQRRLPID
Mvan_2077|M.vanbaalenii_PYR-1 RDGFNREHAVFGTGGPCVAVHPSDMAVALAALDAVVHIKGPHGPRAATIS
MMAR_0835|M.marinum_M IEGRNRTHAIFGASQHCCATHPSDLAVALVALDAVVLTRQIAGHRRFGLA
MUL_4579|M.ulcerans_Agy99 IEGRNRTHAIFGACRHCCATHPSDLAVALVALDAVVLTRQVAGHRRFGLA
Mb0382c|M.bovis_AF2122/97 --------------SLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAID
Rv0375c|M.tuberculosis_H37Rv --------------SLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAID
TH_0174|M.thermoresistible__bu --------------SLCQADPAEDLSTVCTVLDAVCVVRGPAGRREIGID
* * ..*::.. .*** . * *
Mflv_0283|M.gilvum_PYR-GCK DFHRLPGDEPQFDTVLDHGELITAVELPAPPPHAVSDYRKVRDRASYAFA
MSMEG_0685|M.smegmatis_MC2_155 DFHRLPGDEPQRDTTLQHAELITAVELPPPPVGAVSDYRKVRDRASYAFA
Mvan_2077|M.vanbaalenii_PYR-1 QFFSPPAADPDRDNGMAAADFITSVELPAAADTVHGWYLKVRDRRRYAFA
MMAR_0835|M.marinum_M ELYRQPGDSPHWEHNLHPGELLVAIEIPVGPQLHRSGYLKVRDRESYQFA
MUL_4579|M.ulcerans_Agy99 ELYRHPGDSPHWEHNLHPGELLVAIEIPVGPQLHRSGYLKVRDRESYQFA
Mb0382c|M.bovis_AF2122/97 DFLVGP-----YETALAHNEVLIEVRIPLR-HNTSSAYAKVERRVG-DWA
Rv0375c|M.tuberculosis_H37Rv DFLVGP-----YETALAHNEVLIEVRIPLR-HNTSSAYAKVERRVG-DWA
TH_0174|M.thermoresistible__bu DFLVGP-----YETALAHNEILLEVKIPLR-PNSSNAYAKVERRVG-DWA
:: * : : :.: :.:* . * **. * :*
Mflv_0283|M.gilvum_PYR-GCK LVSVAAELSFVG-ESIATARIALGGVAHKPWRARRAEQMLAGAEATDETF
MSMEG_0685|M.smegmatis_MC2_155 LVSVAAELTFTDTRQISSARIALGGVAHKPWRARRAESVLIGDQPSDETF
Mvan_2077|M.vanbaalenii_PYR-1 LVSVAAVLRFDSDGVVASAAVALGGVADRPWRVPAAEAVLTGRRPTPQLF
MMAR_0835|M.marinum_M LVSAAVALDIAA-GTIRTARVAAGGVGTVPWRLPAVEAALRGRPPDADLF
MUL_4579|M.ulcerans_Agy99 LVSAAVALDIAA-GTIRTARVAAGGVGTVPWRLPAVEAALRGRPPDADLF
Mb0382c|M.bovis_AF2122/97 ITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQPATEEVF
Rv0375c|M.tuberculosis_H37Rv ITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQPATEEVF
TH_0174|M.thermoresistible__bu VTAAGAAVTLDG-QTVTAARIGLTAVNPDAAALAEISRRLTGRPATEETF
:.:... : : : :* :. .* . . * * . : *
Mflv_0283|M.gilvum_PYR-GCK AAAADAEISAAEPLPGNE----FKVELARRTLMAQLRMLTERGTR-----
MSMEG_0685|M.smegmatis_MC2_155 IAAADAELNAAEPLPGNE----FKVELARRTLVAQLRMLTARRQQ-----
Mvan_2077|M.vanbaalenii_PYR-1 RSAADTALADAAPLSHNG----FKLPLARNAVMRALVLATGR--------
MMAR_0835|M.marinum_M RRAAALSAIGAKPLSENR----FKVELLKRVVEKQLTVVAAMP-------
MUL_4579|M.ulcerans_Agy99 RRAAALSAIGAKPLSENR----FKVELLKRVVEKQLTVVAAMP-------
Mb0382c|M.bovis_AF2122/97 AEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRVLGAPAAP
Rv0375c|M.tuberculosis_H37Rv AEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRVLGAPAAP
TH_0174|M.thermoresistible__bu AEAGRLAAQACEPVTDVRGTADYKRHLAAELTTRTLRTAVQRIQQRHGGA
*. . *:. :* * . * .
Mflv_0283|M.gilvum_PYR-GCK ----
MSMEG_0685|M.smegmatis_MC2_155 ----
Mvan_2077|M.vanbaalenii_PYR-1 ----
MMAR_0835|M.marinum_M ----
MUL_4579|M.ulcerans_Agy99 ----
Mb0382c|M.bovis_AF2122/97 EA--
Rv0375c|M.tuberculosis_H37Rv EA--
TH_0174|M.thermoresistible__bu QPCR