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FVALALLTSGAFAGLPPAYAISPPKIDPGAVPPDGPPGPATPMKQYSYCTEVGVLPETDFRLLPKYMDML NMFDAWEFGRGGGQKIAVIDTGVTPHPRLPHLIAGGDYVMAGGDGLSDCDAHGTIVASMIGAAPATGAPV PAAPRKPVPIPTTEKSPPPQTVTLSPLPQTVTVIPVPPPPEEGLSPPGVPPPLQSGQHASSGRWDGSTVT ISNYLGGRQVIAIDNPANSSPRAPVPNQPSSPLAPTSRPDAYAGIASDVDILSIRQSSQAFGFKDLYTGD ADPQTSQTIHYIQTMARAIVHAANMGATVINISEVTCMSARNVIDQRALGAAVRYAAVDKNVVIVAAAGD SSKKNCKQNPLFDPLQPNDPRGWNGVNTVVTPSWFSEYVLTVGAVDSHGQPLTQTSIAGPWVSIAAPGTD IIGLSPRDDSLINAIDGPDNTLLVPTGTSFSAAIVSGVAALVRGRYPQLTAYQVINRLIHTARSPARGVD NQVGYGIVDPLAALTWDVPEGPAKPPPQLSSPLNLPKLPAHRDMVPVWVAAGGLTTAVLIGAAAFGTAML VRRTQK*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. leprae Br4923 | MLBr_01538 | - | - | 100% (567) | putative protease |
M. leprae Br4923 | MLBr_02528 | - | 2e-69 | 37.67% (446) | putative protease |
M. leprae Br4923 | MLBr_00041 | - | 3e-66 | 35.65% (460) | putative secreted protease |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1824 | - | 0.0 | 73.03% (571) | Pro-rich protease |
M. gilvum PYR-GCK | Mflv_0755 | - | 1e-74 | 38.46% (468) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
M. tuberculosis H37Rv | Rv1796 | mycP5 | 0.0 | 73.03% (571) | proline rich membrane-anchored mycosin MYCP5 (serine |
M. abscessus ATCC 19977 | MAB_2225c | - | 3e-65 | 38.02% (455) | peptidase |
M. marinum M | MMAR_2678 | mycP5 | 0.0 | 73.33% (570) | proline rich membrane-anchored mycosin MycP5 |
M. avium 104 | MAV_2918 | - | 0.0 | 70.99% (593) | subtilase family protein |
M. smegmatis MC2 155 | MSMEG_0083 | - | 6e-73 | 43.16% (373) | membrane-anchored mycosin mycp1 |
M. thermoresistible (build 8) | TH_3348 | - | 4e-74 | 38.89% (468) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
M. ulcerans Agy99 | MUL_3079 | mycP5 | 0.0 | 73.68% (570) | proline rich membrane-anchored mycosin MycP5 |
M. vanbaalenii PYR-1 | Mvan_0092 | - | 2e-73 | 39.96% (448) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0755|M.gilvum_PYR-GCK MRRIG-------------ALIAALLLV---LVTAPPAGAVEQPVIDPAAI Mvan_0092|M.vanbaalenii_PYR-1 MRRIG-------------ALIAALFLV---LLTAPPASAIEPPIVDPAAI TH_3348|M.thermoresistible__bu ---LG-------------VLITALLLA---VVTAPPAGAIEPPVIDPAAV MSMEG_0083|M.smegmatis_MC2_155 MQRVA-------------VMVLAVLLA---LFSAPPAWAIDPPVIDAGAV Mb1824|M.bovis_AF2122/97 MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTIDPGAL Rv1796|M.tuberculosis_H37Rv MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTIDPGAL MMAR_2678|M.marinum_M MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL MUL_3079|M.ulcerans_Agy99 MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL MAV_2918|M.avium_104 MQRSATAEANVWRGRASAAALAALLLASGALAGLPPAAAISPPTIDPAAV MLBr_01538|M.leprae_Br4923 ------------------MFVALALLTSGAFAGLPPAYAISPPKIDPGAV MAB_2225c|M.abscessus_ATCC_199 MTHFIRDAPRARRALG--GVVAATLLALS-PVAAPVAGAVIQPEADPAAL : :*. * * *: * * .*: Mflv_0755|M.gilvum_PYR-GCK PPD-ETGPDQPMEQRRVCAAPTVFPNANFADRPWASDYLRLADAQQFATG Mvan_0092|M.vanbaalenii_PYR-1 PPD-ETGPDQPMEQRRICAAPTVFPNSNFADRPWASDYLRLTEAQKFATG TH_3348|M.thermoresistible__bu PPD-ETGPDNPMEQRRVCAAPTVYPDSNFADRPWASDYLRLTEAHKFATG MSMEG_0083|M.smegmatis_MC2_155 PPD-ETGPDQPTEQRKICATPTVMPNSNFADRPWANDYLRIQEAQKFATG Mb1824|M.bovis_AF2122/97 PPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRG Rv1796|M.tuberculosis_H37Rv PPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRG MMAR_2678|M.marinum_M PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG MUL_3079|M.ulcerans_Agy99 PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG MAV_2918|M.avium_104 PPDGPPGPGAPMKQNSYCTEVGVLPGTDFRLQPKYMDMLNLQEAWQFGRG MLBr_01538|M.leprae_Br4923 PPDGPPGPATPMKQYSYCTEVGVLPETDFRLLPKYMDMLNMFDAWEFGRG MAB_2225c|M.abscessus_ATCC_199 PKDSSPSATAGMQS-SACSTTVLLPGTGTSGKPSP----EFEEAWRFSRG * * ... :. *: : * :. * .: :* .*. * Mflv_0755|M.gilvum_PYR-GCK AGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGDGMSDCDAHGTLTAAVIA Mvan_0092|M.vanbaalenii_PYR-1 AGVTVAVIDTGVNGSPRVP-AEPGGDFVDQAGNGMSDCDAHGTLTAAVIA TH_3348|M.thermoresistible__bu AGITVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTLTASVIA MSMEG_0083|M.smegmatis_MC2_155 AGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTMTAAIIG Mb1824|M.bovis_AF2122/97 DGVKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIA Rv1796|M.tuberculosis_H37Rv DGVKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIA MMAR_2678|M.marinum_M AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG MUL_3079|M.ulcerans_Agy99 AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG MAV_2918|M.avium_104 AGQKVAVIDTGVTPHPRFPHLIPGGDYIMSG-DGLSDCDAHGTLVASMIG MLBr_01538|M.leprae_Br4923 GGQKIAVIDTGVTPHPRLPHLIAGGDYVMAGGDGLSDCDAHGTIVASMIG MAB_2225c|M.abscessus_ATCC_199 EGQSVAIIDTGVKPSARLH-VEPGGDYVQST-DGLTDCDGHGTMVAGIIG * .:*:*****. .*. .***:: :*: ***.***:.*.:*. Mflv_0755|M.gilvum_PYR-GCK GR----------------------PAP----------------------- Mvan_0092|M.vanbaalenii_PYR-1 GR----------------------PAP----------------------- TH_3348|M.thermoresistible__bu GR----------------------GAP----------------------- MSMEG_0083|M.smegmatis_MC2_155 GR----------------------PSP----------------------- Mb1824|M.bovis_AF2122/97 AVPANGAVPLPSVPRRPVTIPTTETPP---PPQTVTLSPVPPQTVTVIPA Rv1796|M.tuberculosis_H37Rv AVPANGAVPLPSVPRRPVTIPTTETPP---PPQTVTLSPVPPQTVTVIPA MMAR_2678|M.marinum_M AAPANGALPPPAVPRRPVTIPTTEKPP---PPQTVTLSPVPPQTVTVIPG MUL_3079|M.ulcerans_Agy99 AAPANGALPPPAVPRRPVTIPTTEKPP---PPQTVTLSPVPPQTVTVIPG MAV_2918|M.avium_104 AASADGAGVPPAAPRKPVTIPTTEPPPKAPPPQTVTLSPLP-QTVTMVPP MLBr_01538|M.leprae_Br4923 AAPATGA-PVPAAPRKPVPIPTTEKSP---PPQTVTLSPLP-QTVTVIPV MAB_2225c|M.abscessus_ATCC_199 AQ----------------------PGP----------------------- . * Mflv_0755|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0092|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3348|M.thermoresistible__bu -------------------------------------------------- MSMEG_0083|M.smegmatis_MC2_155 -------------------------------------------------- Mb1824|M.bovis_AF2122/97 PPPEE---------GVPPGAPVPGPEPP-PAPGP----QPPAVDRGGGTV Rv1796|M.tuberculosis_H37Rv PPPEE---------GVPPGAPVPGPEPP-PAPGP----QPPAVDRGGGTV MMAR_2678|M.marinum_M PPPEE---------GAPQGEPGPGPVPP-PAPG-----QPPASNHGGGTV MUL_3079|M.ulcerans_Agy99 PPPEE---------GAPQGESGPGPVPP-PAPG-----QPPASNHGGGTV MAV_2918|M.avium_104 PPSQEQQQPPPGPFGAPPPPPAAGPAPAGPPPGPPQGGQAPAGNHGGGTV MLBr_01538|M.leprae_Br4923 PPPPE------------EGLSPPGVPPP-LQSGQ----HASSGRWDGSTV MAB_2225c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0755|M.gilvum_PYR-GCK ---------------------------------------TDAFIGVAPDA Mvan_0092|M.vanbaalenii_PYR-1 ---------------------------------------HDAFIGVAPNA TH_3348|M.thermoresistible__bu ---------------------------------------TDGFIGVAPDA MSMEG_0083|M.smegmatis_MC2_155 ---------------------------------------TDGFVGMAPDV Mb1824|M.bovis_AF2122/97 TVPSYSGGRKIAPIDN-----PRNPHPSAPSPAL--GPPPDAFSGIAPGV Rv1796|M.tuberculosis_H37Rv TVPSYSGGRKIAPIDN-----PRNPHPSAPSPAL--GPPPDAFSGIAPGV MMAR_2678|M.marinum_M TIPSYSGGARVTGVDH-----AGGPRPLDPPPP-----APDAFSGIAPEV MUL_3079|M.ulcerans_Agy99 TIPSYSGGARVTGVDH-----AGGPRPLDPPP------APDAFSGIAPEV MAV_2918|M.avium_104 TIPGHAGAARVTNVDN-----LRGPRPLDPPPPTPPKPGPDAFSGVAPDV MLBr_01538|M.leprae_Br4923 TISNYLGGRQVIAIDNPANSSPRAPVPNQPSSPLAPTSRPDAYAGIASDV MAB_2225c|M.abscessus_ATCC_199 ----------------------------------------DGFSGIAPAA *.: *:*. . Mflv_0755|M.gilvum_PYR-GCK RILSLRQTSDSFSPVGARNDPNDPNATQTAGSLRSLARAIVHAANLGAQV Mvan_0092|M.vanbaalenii_PYR-1 RILSLRQTSDSFLPVGARTDPNDPNSTQTAGSLRSLARAIVHAANMGAQV TH_3348|M.thermoresistible__bu RILSLRHTSAAFQPVGARTDPNNPNTTQTAGSLRSLARAIVHAANLGAQV MSMEG_0083|M.smegmatis_MC2_155 RLLSLRQTSVAFQPKGARQDPNDPNTTQTAGSIRSLARSVVHAANLGAQV Mb1824|M.bovis_AF2122/97 EIISIRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASV Rv1796|M.tuberculosis_H37Rv EIISIRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASV MMAR_2678|M.marinum_M ELISIRQSSQAFGLKDPYTGDEDPQTQQKIDDVETMARAIVHAANMGASV MUL_3079|M.ulcerans_Agy99 ELISIRQSSQAFGLKDPYTGDEDPQTQQKIDDVETMARAIVHAANMGASV MAV_2918|M.avium_104 DIIAIRQSSQAFGLKDAYTGDEDPQTQAKIDNVQTMARAIVHAANMGASV MLBr_01538|M.leprae_Br4923 DILSIRQSSQAFGFKDLYTGDADPQTSQTIHYIQTMARAIVHAANMGATV MAB_2225c|M.abscessus_ATCC_199 KLISIRQESSKFSPR--LTAGGDPSTNAATQYVNTLARSIVHAANLGARV ::::*: * * :*.: :.::**::*****:** * Mflv_0755|M.gilvum_PYR-GCK INISEAACYKVTRRIDEAVVGAAINYAVNVKGTVIVAAAGNTG---ENCA Mvan_0092|M.vanbaalenii_PYR-1 INISEAACYKITRPINEAVVGAAINYAVNVKGAVIVVAAGNTG---ENCT TH_3348|M.thermoresistible__bu INISEAACYKVTRPIDETGVGAAVNYAVHVKNAVVIAAAGNTG---QDCT MSMEG_0083|M.smegmatis_MC2_155 INISEAACYKVTRRIDETSLGAAINYAVNVKGAVIVVAAGNTG---QDCS Mb1824|M.bovis_AF2122/97 INISDVMCMSARNVIDQRALGAAVHYAAVDKDAVIVAAAGDGSK--KDCK Rv1796|M.tuberculosis_H37Rv INISDVMCMSARNVIDQRALGAAVHYAAVDKDAVIVAAAGDGSK--KDCK MMAR_2678|M.marinum_M INISDVTCMSARNVIDQNALGAAVHYAAVDKNVVIVAAAGDGSK--KDCK MUL_3079|M.ulcerans_Agy99 INISDVTCMSARNVIDQNALGAAVHYAAVDKNVVIVAAAGDGSK--KDCK MAV_2918|M.avium_104 INISDVTCMSARNIIDQRALGAAVRYAAVDKNAVIVAAAGDTSK--KDCK MLBr_01538|M.leprae_Br4923 INISEVTCMSARNVIDQRALGAAVRYAAVDKNVVIVAAAGDSSK--KNCK MAB_2225c|M.abscessus_ATCC_199 INISSAECVPAAKPIDQAALGAALRYAVAEKDAVVVAAAGNTSGGSANCQ ****.. * . *:: :***:.**. *..*::.***: . :* Mflv_0755|M.gilvum_PYR-GCK QNPPPDPAVPADPRGWQQVQTIVSPAWYSPLVLTVGSIAPNGQPSGF--- Mvan_0092|M.vanbaalenii_PYR-1 QNPPPDPAVPADPRGWQEVQTIVSPAWYSPLVLTVGSIAPNGQPSGF--- TH_3348|M.thermoresistible__bu QNPPPDPAVPSDPRGWQQVQTIVSPAWYSPLVLTVGGIGPTGQPSNF--- MSMEG_0083|M.smegmatis_MC2_155 QNPPPDPSVPSDPRGWREVQTIVSPAWYDPLVLTVGSIGQNGQPSNF--- Mb1824|M.bovis_AF2122/97 QNPIFDPLQPDDPRAWNAVTTVVTPSWFHDYVLTVGAVDANGQPLSK--- Rv1796|M.tuberculosis_H37Rv QNPIFDPLQPDDPRAWNAVTTVVTPSWFHDYVLTVGAVDANGQPLSK--- MMAR_2678|M.marinum_M QNPIFDPLQPDDPRDWNAVTTVVTPSWFSDYVLTVGAVDTNGQPMTK--- MUL_3079|M.ulcerans_Agy99 QNPIFDPLQPDDPRDWNAVTTVVTPSWFSDYVLTVGAVDTNGQPMTK--- MAV_2918|M.avium_104 QNPPHDPLQPNDPRNWNSVTTVVTPSWFSDYVLTVGAVDTEGHPLSQGNQ MLBr_01538|M.leprae_Br4923 QNPLFDPLQPNDPRGWNGVNTVVTPSWFSEYVLTVGAVDSHGQPLTQ--- MAB_2225c|M.abscessus_ATCC_199 QNPLTGSG--ADPRNWSGVESVSVPSWWQPYVLSVGSVGIDGSPSKF--- *** .. *** * * :: *:*: **:**.: * * Mflv_0755|M.gilvum_PYR-GCK -----SVQGPWVGAAAPGENLVALG--YDGNPVNALQGEDG-PIPISGTS Mvan_0092|M.vanbaalenii_PYR-1 -----SMQGPWVGAAAPGENLIALG--YDGNPVNALQGEDG-PIPISGTS TH_3348|M.thermoresistible__bu -----SMSGPWVGAAAPAENITALG--YGGEPVNALQGQDG-LVPVAGTS MSMEG_0083|M.smegmatis_MC2_155 -----SMSGPWVGAAAPGENLTSLG--YDGQPVNATPGEDG-PVPLNGTS Mb1824|M.bovis_AF2122/97 ----MSIAGPWVSISAPGTDVVGLSP-RDDGLINAIDGPDNSLLVPAGTS Rv1796|M.tuberculosis_H37Rv ----MSIAGPWVSISAPGTDVVGLSP-RDDGLINAIDGPDNSLLVPAGTS MMAR_2678|M.marinum_M ----MSIAGPWVSIAAPGTDVIGLSP-RDDGLINAIDGPDNSLLVPAGTS MUL_3079|M.ulcerans_Agy99 ----MSIAGPWVSIAAPGTDVIGLSP-RDDGLINAIDGPDNSLLVPAGTS MAV_2918|M.avium_104 GQASTSVAGPWVGIAAPGTDVVGLSP-RDDGLINAIDGPDNTLLVPSGTS MLBr_01538|M.leprae_Br4923 ----TSIAGPWVSIAAPGTDIIGLSP-RDDSLINAIDGPDNTLLVPTGTS MAB_2225c|M.abscessus_ATCC_199 -----TMAGPWVGIAANGENVTSLSNDAEGGLANGMIGQNGKPVPLFGTS :: ****. :* . :: .*. . *. * :. : *** Mflv_0755|M.gilvum_PYR-GCK FSAAFVSGVAALIKQRFPELTPGQIINRITATARHPGGGVNNVVGAGVID Mvan_0092|M.vanbaalenii_PYR-1 FSAAYVSGLAALLRQRFPELTPAQIINRITATARHPGGGVNNVVGAGVID TH_3348|M.thermoresistible__bu FAAAYVSGLAALIRQRYPDLTPAQVINRITATARHPGGGVDNYVGAGVID MSMEG_0083|M.smegmatis_MC2_155 FSAAYVSGLAALVKQRFPDLTPAQIINRITATARHPGGGVDNYVGAGVID Mb1824|M.bovis_AF2122/97 FSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDNQVGYGVVD Rv1796|M.tuberculosis_H37Rv FSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDNQVGYGVVD MMAR_2678|M.marinum_M FATAIVSGVVALVRAKYPELSAYQIRNRLIHTARPPARGVDNQVGYGVVD MUL_3079|M.ulcerans_Agy99 FATAIVSGVVALVRAKYPELSAYQIRNRLIHTARPPARGVDNQVGYGVVD MAV_2918|M.avium_104 FSAAIVSGVAALVRAKYPQLSAYQVINRLTRTARAPARGVDNQVGHGIVD MLBr_01538|M.leprae_Br4923 FSAAIVSGVAALVRGRYPQLTAYQVINRLIHTARSPARGVDNQVGYGIVD MAB_2225c|M.abscessus_ATCC_199 YATAYVAGVAALVRSRYPELTAPQVISRLQRTARDAGRSPSNLVGAGTVD :::* *:*:.**:: ::*:*:. *: .*: *** .. . .* ** * :* Mflv_0755|M.gilvum_PYR-GCK PVAALTWDVPAG--PADIPYQIKEIPPPVHIP-PPDRSPITGVVVVTIVV Mvan_0092|M.vanbaalenii_PYR-1 PVAALTWDVPPG--PADIPYNIKEIPPPVYVP-PPDRSPITGVVLVGVGL TH_3348|M.thermoresistible__bu PVAALTWDVPEG--PETAPYRAKEIPEPEFIP-PPDRGPITWVVVSSAAV MSMEG_0083|M.smegmatis_MC2_155 PVAALTWEIPDG--PEKAPFRVKEVPPPVYIP-PPDRGPITAVVIAGATL Mb1824|M.bovis_AF2122/97 PVAALTWDVPKG--PAEPP---KQLSAPLVVPQPPAPRDMVPIWVAAGGL Rv1796|M.tuberculosis_H37Rv PVAALTWDVPKG--PAEPP---KQLSAPLVVPQPPAPRDMVPIWVAAGGL MMAR_2678|M.marinum_M PVAALTWDVPEG--PVKPP---KQLSAPLELPKPPAERNMVPVWVAAGGL MUL_3079|M.ulcerans_Agy99 PVAALTWDVPEG--PVKPP---KQLSAPLELPKPPAERNMVPVWVAAGGL MAV_2918|M.avium_104 PVAALTWDVPDG--PVKPP---QQLSAPLTIPKPVPRRDMVPIWVAAGGL MLBr_01538|M.leprae_Br4923 PLAALTWDVPEG--PAKPP---PQLSSPLNLPKLPAHRDMVPVWVAAGGL MAB_2225c|M.abscessus_ATCC_199 PVAALTWEVPADGNASSGPGARAVVPPPPPTPENPLPRRLAFLGAGVCLI *:*****::* . . * :. * * :. : : Mflv_0755|M.gilvum_PYR-GCK AALLGIG-------AMARRALRRR- Mvan_0092|M.vanbaalenii_PYR-1 AALLGIA-------ALGRRALRRR- TH_3348|M.thermoresistible__bu ALALGIG-------ALTRRALRRR- MSMEG_0083|M.smegmatis_MC2_155 AFALGIG-------ALARRALRRKQ Mb1824|M.bovis_AF2122/97 AGALLIGGAVFGTATLMRRSRKQQ- Rv1796|M.tuberculosis_H37Rv AGALLIGGAVFGTATLMRRSRKQQ- MMAR_2678|M.marinum_M TGALLIGGAVFGTATLMRRSRKRR- MUL_3079|M.ulcerans_Agy99 TGALLIGGAVSGTATLMRRSRKRR- MAV_2918|M.avium_104 FGALLIGGAVFGTAMLMKRSRRQQ- MLBr_01538|M.leprae_Br4923 TTAVLIGAAAFGTAMLVRRTQK--- MAB_2225c|M.abscessus_ATCC_199 AVVVVAA-------LSARRRQESTE : . :* .