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VHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQKVMCSAPTTLPDSSFHDPPWSNIYI GVSEAHKFATGAGVTVAVIDTGVEASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIGGRPAPTDGFI GVAPDVRLLSLRQTSEAFQPVGVQPNANDPNAIPAAGSIRSLARAVVHAANLGASVINISETACYKANKP LDESTLGAAINYAVNVKGVVIIVAAGNTGGDCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGG IAQNGMPSQFSVHGPWVSVAAPTENITTLGYNGEPVNALPGEEGPVALAGTSFATAYVSGLAALLRQRFP DLTPAQIINRIIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASELFNVRSVPPPVITPGPDRNTIM IVAQGILGLSIALGLGVLVRRALQRQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00041 | - | - | 100% (446) | putative secreted protease |
| M. leprae Br4923 | MLBr_02528 | - | 1e-91 | 40.69% (462) | putative protease |
| M. leprae Br4923 | MLBr_01538 | - | 2e-66 | 35.65% (460) | putative protease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3913c | - | 0.0 | 79.15% (446) | secreted protease |
| M. gilvum PYR-GCK | Mflv_0755 | - | 1e-174 | 64.71% (442) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. tuberculosis H37Rv | Rv3883c | mycP1 | 0.0 | 79.37% (446) | membrane-anchored mycosin MYCP1 (serine protease) |
| M. abscessus ATCC 19977 | MAB_2225c | - | 1e-93 | 43.34% (443) | peptidase |
| M. marinum M | MMAR_5459 | mycP3_1 | 0.0 | 79.82% (446) | membrane-anchored serine protease (mycosin), MycP3_1 |
| M. avium 104 | MAV_4862 | - | 1e-96 | 41.43% (461) | subtilase family protein |
| M. smegmatis MC2 155 | MSMEG_0083 | - | 0.0 | 70.65% (443) | membrane-anchored mycosin mycp1 |
| M. thermoresistible (build 8) | TH_3348 | - | 1e-180 | 67.27% (443) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. ulcerans Agy99 | MUL_1213 | mycP3 | 2e-89 | 42.29% (428) | membrane-anchored mycosin MycP3 |
| M. vanbaalenii PYR-1 | Mvan_0092 | - | 0.0 | 67.65% (442) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3913c|M.bovis_AF2122/97 ----------------------MHRIFLITVALALLTASPASAITPPPID
Rv3883c|M.tuberculosis_H37Rv ----------------------MHRIFLITVALALLTASPASAITPPPID
MMAR_5459|M.marinum_M MQAGLTRACQSFTAARERSDSGVHRTLLTMVALALLTAPPALAIDPPSID
MLBr_00041|M.leprae_Br4923 ----------------------MHRILLMMVALALLYAPPALAINPPSID
Mflv_0755|M.gilvum_PYR-GCK --------------------MRRIGALIAALLLVLVTAPPAGAVEQPVID
Mvan_0092|M.vanbaalenii_PYR-1 --------------------MRRIGALIAALFLVLLTAPPASAIEPPIVD
TH_3348|M.thermoresistible__bu -----------------------LGVLITALLLAVVTAPPAGAIEPPVID
MSMEG_0083|M.smegmatis_MC2_155 --------------------MQRVAVMVLAVLLALFSAPPAWAIDPPVID
MAV_4862|M.avium_104 --------------MIRPASACLAAVLALLPATATWASPPALAISPPTVD
MUL_1213|M.ulcerans_Agy99 --------------MKRAGSACLTAILAIFTTGALWAAPPVSAISPPAVD
MAB_2225c|M.abscessus_ATCC_199 -------MTHFIRDAPRARRALGGVVAATLLALSPVAAPVAGAVIQPEAD
:. . *: * *
Mb3913c|M.bovis_AF2122/97 PGALPPD-VAGPDQPTEQRVLCASPTTLPGSGFHDPPWSNTYLGVADAHK
Rv3883c|M.tuberculosis_H37Rv PGALPPD-VTGPDQPTEQRVLCASPTTLPGSGFHDPPWSNTYLGVADAHK
MMAR_5459|M.marinum_M PGAVPPD-VTGPDQPTEQRVLCTSPTTLPDSSFHDPPWSNAYMGVGEAHK
MLBr_00041|M.leprae_Br4923 PGAVPPD-VTGPDQPTEQKVMCSAPTTLPDSSFHDPPWSNIYIGVSEAHK
Mflv_0755|M.gilvum_PYR-GCK PAAIPPD-ETGPDQPMEQRRVCAAPTVFPNANFADRPWASDYLRLADAQQ
Mvan_0092|M.vanbaalenii_PYR-1 PAAIPPD-ETGPDQPMEQRRICAAPTVFPNSNFADRPWASDYLRLTEAQK
TH_3348|M.thermoresistible__bu PAAVPPD-ETGPDNPMEQRRVCAAPTVYPDSNFADRPWASDYLRLTEAHK
MSMEG_0083|M.smegmatis_MC2_155 AGAVPPD-ETGPDQPTEQRKICATPTVMPNSNFADRPWANDYLRIQEAQK
MAV_4862|M.avium_104 PGVPPPSGAPGPGQPMEQRAPCTTSGVIPGSEPAAVTPSQSALNLPAAWR
MUL_1213|M.ulcerans_Agy99 DSVQPPSGTPGPVQTMEQRGACSVSGLIPGTDISVPGASQAMLNLPAAWQ
MAB_2225c|M.abscessus_ATCC_199 PAALPKDSSPSATAGMQS-SACSTTVLLPGTG----TSGKPSPEFEEAWR
.. * . ... :. *: . *.: .. . * :
Mb3913c|M.bovis_AF2122/97 FATGAGVTVAVIDTGVDASPRVP-AEPGGDFVDQAGNGLSDCDAHGTLTA
Rv3883c|M.tuberculosis_H37Rv FATGAGVTVAVIDTGVDASPRVP-AEPGGDFVDQAGNGLSDCDAHGTLTA
MMAR_5459|M.marinum_M FATGAGVTVAVIDTGVDASPRVP-AEPGGDFVDQAGDGLSDCDAHGTLTA
MLBr_00041|M.leprae_Br4923 FATGAGVTVAVIDTGVEASPRVP-AEPGGDFVDQAGNGLSDCDAHGTLTA
Mflv_0755|M.gilvum_PYR-GCK FATGAGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGDGMSDCDAHGTLTA
Mvan_0092|M.vanbaalenii_PYR-1 FATGAGVTVAVIDTGVNGSPRVP-AEPGGDFVDQAGNGMSDCDAHGTLTA
TH_3348|M.thermoresistible__bu FATGAGITVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTLTA
MSMEG_0083|M.smegmatis_MC2_155 FATGAGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTMTA
MAV_4862|M.avium_104 FSRGDGQLVAVLDTGVRPGPRLPNVEPGGDFVETT-DGLTDCDGHGTLLA
MUL_1213|M.ulcerans_Agy99 FSRGEGQLVAILDTGVQPGPRLPNVDAGGDFVDST-DGLTDCDGRGTLVA
MAB_2225c|M.abscessus_ATCC_199 FSRGEGQSVAIIDTGVKPSARLH-VEPGGDYVQST-DGLTDCDGHGTMVA
*: * * **::**** ..*: .:.***:*: : :*::***.:**: *
Mb3913c|M.bovis_AF2122/97 SIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEPVGSQANPNDPNATPAA
Rv3883c|M.tuberculosis_H37Rv SIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEPVGSQANPNDPNATPAA
MMAR_5459|M.marinum_M SIIGGRPAPTDGFVGVAPDVRLLSLRQTSEAFEPVGSQPNPNDPNATPAA
MLBr_00041|M.leprae_Br4923 SIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQPVGVQPNANDPNAIPAA
Mflv_0755|M.gilvum_PYR-GCK AVIAGRPAPTDAFIGVAPDARILSLRQTSDSFSPVGARNDPNDPNATQTA
Mvan_0092|M.vanbaalenii_PYR-1 AVIAGRPAPHDAFIGVAPNARILSLRQTSDSFLPVGARTDPNDPNSTQTA
TH_3348|M.thermoresistible__bu SVIAGRGAPTDGFIGVAPDARILSLRHTSAAFQPVGARTDPNNPNTTQTA
MSMEG_0083|M.smegmatis_MC2_155 AIIGGRPSPTDGFVGMAPDVRLLSLRQTSVAFQPKGARQDPNDPNTTQTA
MAV_4862|M.avium_104 GLVAGQPSPDDGFAGVAPAARVVSIRTTSAKFSPR---TPGGDPLLARAA
MUL_1213|M.ulcerans_Agy99 GIVAGQPG-NDGFSGVAPAARLLSIRVTSDKFSAR---SSGGDPSVERAT
MAB_2225c|M.abscessus_ATCC_199 GIIGAQPG-PDGFSGIAPAAKLISIRQESSKFSPRL--TAGGDPSTNAAT
.::..: . *.* *:** .:::*:* * * . .:* ::
Mb3913c|M.bovis_AF2122/97 GSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGASIDYAVNV
Rv3883c|M.tuberculosis_H37Rv GSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGASIDYAVNV
MMAR_5459|M.marinum_M GSIRSLARAVVHAANLGAGVINISEAACYKVSRPIDEISLGAAIDYAVNA
MLBr_00041|M.leprae_Br4923 GSIRSLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINYAVNV
Mflv_0755|M.gilvum_PYR-GCK GSLRSLARAIVHAANLGAQVINISEAACYKVTRRIDEAVVGAAINYAVNV
Mvan_0092|M.vanbaalenii_PYR-1 GSLRSLARAIVHAANMGAQVINISEAACYKITRPINEAVVGAAINYAVNV
TH_3348|M.thermoresistible__bu GSLRSLARAIVHAANLGAQVINISEAACYKVTRPIDETGVGAAVNYAVHV
MSMEG_0083|M.smegmatis_MC2_155 GSIRSLARSVVHAANLGAQVINISEAACYKVTRRIDETSLGAAINYAVNV
MAV_4862|M.avium_104 AEVGTLARAIVHAADLGARVIDIGSATCLPVDRPVDQAALGAAVRYAAVD
MUL_1213|M.ulcerans_Agy99 IDVAALGRAIVHAADRGARVINISSITCLPADRQVDQAALGAAIRYAAVD
MAB_2225c|M.abscessus_ATCC_199 QYVNTLARSIVHAANLGARVINISSAECVPAAKPIDQAALGAALRYAVAE
: :*.*::****: *. **:*.. * : ::: :**:: **.
Mb3913c|M.bovis_AF2122/97 KGVVVVVAAGNTG--------GDCVQNPAPDPSTPGDPRGWNNVQTVVTP
Rv3883c|M.tuberculosis_H37Rv KGVVVVVAAGNTG--------GDCVQNPAPDPSTPGDPRGWNNVQTVVTP
MMAR_5459|M.marinum_M KNAVVVVAAGNTG--------GDCSQNPMPDASTPNDPRGWNKVQTVVTP
MLBr_00041|M.leprae_Br4923 KGVVIIVAAGNTG--------GDCTQNPMPDVSMPNDPRGWSKVQTIATP
Mflv_0755|M.gilvum_PYR-GCK KGTVIVAAAGNTG--------ENCAQNPPPDPAVPADPRGWQQVQTIVSP
Mvan_0092|M.vanbaalenii_PYR-1 KGAVIVVAAGNTG--------ENCTQNPPPDPAVPADPRGWQEVQTIVSP
TH_3348|M.thermoresistible__bu KNAVVIAAAGNTG--------QDCTQNPPPDPAVPSDPRGWQQVQTIVSP
MSMEG_0083|M.smegmatis_MC2_155 KGAVIVVAAGNTG--------QDCSQNPPPDPSVPSDPRGWREVQTIVSP
MAV_4862|M.avium_104 KDAVIVAAAGDSGPTGSFAGGTSCESNPLTDLSRPSDPRNWAGVTSLSIP
MUL_1213|M.ulcerans_Agy99 KDVVIVAAAGNSGAGGSGSGGT-CESNPLTDLSHPDDPRNWAGVTSVSIP
MAB_2225c|M.abscessus_ATCC_199 KDAVVVAAAGNTS-----GGSANCQQNPLTGSG--ADPRNWSGVESVSVP
*..*::.***::. * .** .. . ***.* * :: *
Mb3913c|M.bovis_AF2122/97 AWYAPLVLSVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDT--GEPV
Rv3883c|M.tuberculosis_H37Rv AWYAPLVLSVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDT--GEPV
MMAR_5459|M.marinum_M AWYAPLVLTVGGIGQNGVPSSFSMHGPWVGVAAPAENIIALGDH--GEPV
MLBr_00041|M.leprae_Br4923 AWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVAAPTENITTLGYN--GEPV
Mflv_0755|M.gilvum_PYR-GCK AWYSPLVLTVGSIAPNGQPSGFSVQGPWVGAAAPGENLVALGYD--GNPV
Mvan_0092|M.vanbaalenii_PYR-1 AWYSPLVLTVGSIAPNGQPSGFSMQGPWVGAAAPGENLIALGYD--GNPV
TH_3348|M.thermoresistible__bu AWYSPLVLTVGGIGPTGQPSNFSMSGPWVGAAAPAENITALGYG--GEPV
MSMEG_0083|M.smegmatis_MC2_155 AWYDPLVLTVGSIGQNGQPSNFSMSGPWVGAAAPGENLTSLGYD--GQPV
MAV_4862|M.avium_104 SWWQPYVLSVASLTPDGQPSKFTVAGPWVGVAAPGERIVSIGNGDGAGLT
MUL_1213|M.ulcerans_Agy99 SLWQPYVLSVASLTAGGQPSKFTMAGPWVGIAAPGENIVSVSNADGGGLA
MAB_2225c|M.abscessus_ATCC_199 SWWQPYVLSVGSVGIDGSPSKFTMAGPWVGIAANGENVTSLSNDAEGGLA
: : * **:*..: * ** *:: ****. ** *.: ::. . .
Mb3913c|M.bovis_AF2122/97 NALQGREG-PVPIAGTSFAAAYVSGLAALLRQRFPDLTPAQIIHRITATA
Rv3883c|M.tuberculosis_H37Rv NALQGREG-PVPIAGTSFAAAYVSGLAALLRQRFPDLTPAQIIHRITATA
MMAR_5459|M.marinum_M NALQGREG-PVPIAGTSFAAAYVSGLAALVRQRFPELTPVQVMNRITATA
MLBr_00041|M.leprae_Br4923 NALPGEEG-PVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINRIIATA
Mflv_0755|M.gilvum_PYR-GCK NALQGEDG-PIPISGTSFSAAFVSGVAALIKQRFPELTPGQIINRITATA
Mvan_0092|M.vanbaalenii_PYR-1 NALQGEDG-PIPISGTSFSAAYVSGLAALLRQRFPELTPAQIINRITATA
TH_3348|M.thermoresistible__bu NALQGQDG-LVPVAGTSFAAAYVSGLAALIRQRYPDLTPAQVINRITATA
MSMEG_0083|M.smegmatis_MC2_155 NATPGEDG-PVPLNGTSFSAAYVSGLAALVKQRFPDLTPAQIINRITATA
MAV_4862|M.avium_104 NGLPDEHQQLAALNGTGYAAGYVAGVAALVRSKYPDLSATAVVHRITATA
MUL_1213|M.ulcerans_Agy99 NGLPNQRQQLTPLSGTSYAAGYVSGVATLVRSNYPELTAAQVMHRLTATA
MAB_2225c|M.abscessus_ATCC_199 NGMIGQNGKPVPLFGTSYATAYVAGVAALVRSRYPELTAPQVISRLQRTA
*. .. .: **.:::.:*:*:*:*::..:*:*:. :: *: **
Mb3913c|M.bovis_AF2122/97 RHPGGGVDDLVGAGVIDAVAALTWDIPPGPASAP--YNVRRLPPPVVEPG
Rv3883c|M.tuberculosis_H37Rv RHPGGGVDDLVGAGVIDAVAALTWDIPPGPASAP--YNVRRLPPPVVEPG
MMAR_5459|M.marinum_M RHPGGGIDNLVGAGVVNAVAALTWDIPPGPASVP--PSVRRLPPPRIEPG
MLBr_00041|M.leprae_Br4923 RHPGGGVDDIVGAGVIDAVAALTWDITPGSASEL--FNVRSVPPPVITPG
Mflv_0755|M.gilvum_PYR-GCK RHPGGGVNNVVGAGVIDPVAALTWDVPAGPADIP--YQIKEIPPPVHIPP
Mvan_0092|M.vanbaalenii_PYR-1 RHPGGGVNNVVGAGVIDPVAALTWDVPPGPADIP--YNIKEIPPPVYVPP
TH_3348|M.thermoresistible__bu RHPGGGVDNYVGAGVIDPVAALTWDVPEGPETAP--YRAKEIPEPEFIPP
MSMEG_0083|M.smegmatis_MC2_155 RHPGGGVDNYVGAGVIDPVAALTWEIPDGPEKAP--FRVKEVPPPVYIPP
MAV_4862|M.avium_104 HNGARDPSNVVGAGSVDPVAALTWQLPAGDQPGP---AAKPIAVPPAPAP
MUL_1213|M.ulcerans_Agy99 HNGARDPSNVVGAGILDPAAALTWELPAADGGAPQVAPAKPVSVPPAPQP
MAB_2225c|M.abscessus_ATCC_199 RDAGRSPSNLVGAGTVDPVAALTWEVPA-DGNASSGPGARAVVPPPPPTP
:. . . .: **** ::..*****::. : : *
Mb3913c|M.bovis_AF2122/97 PDRRPITAVALVAVGLTLALG-LGALARRALSRR----------
Rv3883c|M.tuberculosis_H37Rv PDRRPITAVALVAVGLTLALG-LGALARRALSRR----------
MMAR_5459|M.marinum_M PDHRPITMVAVSVLGLTLVLG-LGTLAARALRRR----------
MLBr_00041|M.leprae_Br4923 PDRNTIMIVAQGILGLSIALG-LGVLVRRALQRQ----------
Mflv_0755|M.gilvum_PYR-GCK PDRSPITGVVVVTIVVAALLG-IGAMARRALRRR----------
Mvan_0092|M.vanbaalenii_PYR-1 PDRSPITGVVLVGVGLAALLG-IAALGRRALRRR----------
TH_3348|M.thermoresistible__bu PDRGPITWVVVSSAAVALALG-IGALTRRALRRR----------
MSMEG_0083|M.smegmatis_MC2_155 PDRGPITAVVIAGATLAFALG-IGALARRALRRKQ---------
MAV_4862|M.avium_104 PDTTPRTVAVAGTAALAVLVAVAGAVTALAARRR--KDPTA---
MUL_1213|M.ulcerans_Agy99 RNTTPRNVAFAGAAALTVLVAGVAATVAIARRRKDAEGRTAREL
MAB_2225c|M.abscessus_ATCC_199 ENPLPRRLAFLGAG---VCLIAVVVVAALSARRR--QESTE---
: . . : . : *: