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MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTIDPGALPPDGPPGPLAPMKQNAYCTE VGVLPGTDFQLQPKYMEMLNLNEAWQFGRGDGVKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDA HGTLVASMIAAVPANGAVPLPSVPRRPVTIPTTETPPPPQTVTLSPVPPQTVTVIPAPPPEEGVPPGAPV PGPEPPPAPGPQPPAVDRGGGTVTVPSYSGGRKIAPIDNPRNPHPSAPSPALGPPPDAFSGIAPGVEIIS IRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASVINISDVMCMSARNVIDQRALGAAV HYAAVDKDAVIVAAAGDGSKKDCKQNPIFDPLQPDDPRAWNAVTTVVTPSWFHDYVLTVGAVDANGQPLS KMSIAGPWVSISAPGTDVVGLSPRDDGLINAIDGPDNSLLVPAGTSFSAAIVSGVAALVRAKFPELSAYQ IINRLIHTARPPARGVDNQVGYGVVDPVAALTWDVPKGPAEPPKQLSAPLVVPQPPAPRDMVPIWVAAGG LAGALLIGGAVFGTATLMRRSRKQQ
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1824 | - | - | 100% (585) | Pro-rich protease |
M. bovis AF2122 / 97 | Mb3916c | - | e-129 | 47.08% (582) | secreted alanine and proline rich protease |
M. bovis AF2122 / 97 | Mb0299 | - | 4e-72 | 42.51% (407) | protease precursor |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0755 | - | 3e-75 | 38.58% (464) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
M. tuberculosis H37Rv | Rv1796 | mycP5 | 0.0 | 100.00% (585) | proline rich membrane-anchored mycosin MYCP5 (serine |
M. leprae Br4923 | MLBr_01538 | - | 0.0 | 73.03% (571) | putative protease |
M. abscessus ATCC 19977 | MAB_2225c | - | 4e-69 | 39.87% (454) | peptidase |
M. marinum M | MMAR_2678 | mycP5 | 0.0 | 84.79% (585) | proline rich membrane-anchored mycosin MycP5 |
M. avium 104 | MAV_2918 | - | 0.0 | 74.14% (611) | subtilase family protein |
M. smegmatis MC2 155 | MSMEG_0624 | - | 2e-75 | 40.88% (455) | subtilase family protein |
M. thermoresistible (build 8) | TH_3348 | - | 3e-76 | 39.26% (461) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
M. ulcerans Agy99 | MUL_3079 | mycP5 | 0.0 | 84.44% (585) | proline rich membrane-anchored mycosin MycP5 |
M. vanbaalenii PYR-1 | Mvan_0092 | - | 2e-75 | 40.00% (460) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0755|M.gilvum_PYR-GCK MRRIG-------------ALIAALLLV---LVTAPPAGAVEQPVIDPAAI Mvan_0092|M.vanbaalenii_PYR-1 MRRIG-------------ALIAALFLV---LLTAPPASAIEPPIVDPAAI TH_3348|M.thermoresistible__bu ---LG-------------VLITALLLA---VVTAPPAGAIEPPVIDPAAV Mb1824|M.bovis_AF2122/97 MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTIDPGAL Rv1796|M.tuberculosis_H37Rv MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTIDPGAL MMAR_2678|M.marinum_M MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL MUL_3079|M.ulcerans_Agy99 MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL MAV_2918|M.avium_104 MQRSATAEANVWRGRASAAALAALLLASGALAGLPPAAAISPPTIDPAAV MLBr_01538|M.leprae_Br4923 ------------------MFVALALLTSGAFAGLPPAYAISPPKIDPGAV MAB_2225c|M.abscessus_ATCC_199 ---MTHFIRDAPRARRALGGVVAATLLALSPVAAPVAGAVIQPEADP-AA MSMEG_0624|M.smegmatis_MC2_155 ------------MIHKSLGVVATAGLVLL--IGCPSAGAVSPPQVDPQIA :. * * * *: * * Mflv_0755|M.gilvum_PYR-GCK PPD-ETGPDQPMEQRRVCAAPTVFPNANFADRPWASDYLRLADAQQFATG Mvan_0092|M.vanbaalenii_PYR-1 PPD-ETGPDQPMEQRRICAAPTVFPNSNFADRPWASDYLRLTEAQKFATG TH_3348|M.thermoresistible__bu PPD-ETGPDNPMEQRRVCAAPTVYPDSNFADRPWASDYLRLTEAHKFATG Mb1824|M.bovis_AF2122/97 PPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRG Rv1796|M.tuberculosis_H37Rv PPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRG MMAR_2678|M.marinum_M PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG MUL_3079|M.ulcerans_Agy99 PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG MAV_2918|M.avium_104 PPDGPPGPGAPMKQNSYCTEVGVLPGTDFRLQPKYMDMLNLQEAWQFGRG MLBr_01538|M.leprae_Br4923 PPDGPPGPATPMKQYSYCTEVGVLPETDFRLLPKYMDMLNMFDAWEFGRG MAB_2225c|M.abscessus_ATCC_199 LPKDSSPSATAGMQSSACSTTVLLPGTG----TSGKPSPEFEEAWRFSRG MSMEG_0624|M.smegmatis_MC2_155 PPPGTAGPAQPMMQRSECITTSVLPGTDPGAVSPNQLALNLSGAWQHSRG * . . . * * : * :. . .: * ... * Mflv_0755|M.gilvum_PYR-GCK AGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGDGMSDCDAHGTLTAAVIA Mvan_0092|M.vanbaalenii_PYR-1 AGVTVAVIDTGVNGSPRVP-AEPGGDFVDQAGNGMSDCDAHGTLTAAVIA TH_3348|M.thermoresistible__bu AGITVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTLTASVIA Mb1824|M.bovis_AF2122/97 DGVKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIA Rv1796|M.tuberculosis_H37Rv DGVKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIA MMAR_2678|M.marinum_M AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG MUL_3079|M.ulcerans_Agy99 AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG MAV_2918|M.avium_104 AGQKVAVIDTGVTPHPRFPHLIPGGDYIMSG-DGLSDCDAHGTLVASMIG MLBr_01538|M.leprae_Br4923 GGQKIAVIDTGVTPHPRLPHLIAGGDYVMAGGDGLSDCDAHGTIVASMIG MAB_2225c|M.abscessus_ATCC_199 EGQSVAIIDTGVKPSARLH-VEPGGDYVQST-DGLTDCDGHGTMVAGIIG MSMEG_0624|M.smegmatis_MC2_155 AGQTVAVIDTGVQPGPRLPNVEAGGDYIEST-DGLTDCDGHGTSVAGLIA * .:*:***** .*. .***:: :*: ***.*** .*.:*. Mflv_0755|M.gilvum_PYR-GCK GR----------------------PAP----------------------- Mvan_0092|M.vanbaalenii_PYR-1 GR----------------------PAP----------------------- TH_3348|M.thermoresistible__bu GR----------------------GAP----------------------- Mb1824|M.bovis_AF2122/97 AVPANGAVPLPSVPRRPVTIPTTETPP---PPQTVTLSPVPPQTVTVIPA Rv1796|M.tuberculosis_H37Rv AVPANGAVPLPSVPRRPVTIPTTETPP---PPQTVTLSPVPPQTVTVIPA MMAR_2678|M.marinum_M AAPANGALPPPAVPRRPVTIPTTEKPP---PPQTVTLSPVPPQTVTVIPG MUL_3079|M.ulcerans_Agy99 AAPANGALPPPAVPRRPVTIPTTEKPP---PPQTVTLSPVPPQTVTVIPG MAV_2918|M.avium_104 AASADGAGVPPAAPRKPVTIPTTEPPPKAPPPQTVTLSPLP-QTVTMVPP MLBr_01538|M.leprae_Br4923 AAPATGA-PVPAAPRKPVPIPTTEKSP---PPQTVTLSPLP-QTVTVIPV MAB_2225c|M.abscessus_ATCC_199 AQ----------------------PGP----------------------- MSMEG_0624|M.smegmatis_MC2_155 GQ----------------------PGP----------------------- . * Mflv_0755|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0092|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3348|M.thermoresistible__bu -------------------------------------------------- Mb1824|M.bovis_AF2122/97 PPPEE---------GVPPGAPVPGPEPP-PAPGP----QPPAVDRGGGTV Rv1796|M.tuberculosis_H37Rv PPPEE---------GVPPGAPVPGPEPP-PAPGP----QPPAVDRGGGTV MMAR_2678|M.marinum_M PPPEE---------GAPQGEPGPGPVPP-PAPG-----QPPASNHGGGTV MUL_3079|M.ulcerans_Agy99 PPPEE---------GAPQGESGPGPVPP-PAPG-----QPPASNHGGGTV MAV_2918|M.avium_104 PPSQEQQQPPPGPFGAPPPPPAAGPAPAGPPPGPPQGGQAPAGNHGGGTV MLBr_01538|M.leprae_Br4923 PPPPE------------EGLSPPGVPPP-LQSGQ----HASSGRWDGSTV MAB_2225c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0624|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0755|M.gilvum_PYR-GCK ---------------------------------------TDAFIGVAPDA Mvan_0092|M.vanbaalenii_PYR-1 ---------------------------------------HDAFIGVAPNA TH_3348|M.thermoresistible__bu ---------------------------------------TDGFIGVAPDA Mb1824|M.bovis_AF2122/97 TVPSYSGGRKIAPIDN-----PRNPHPSAPSPAL--GPPPDAFSGIAPGV Rv1796|M.tuberculosis_H37Rv TVPSYSGGRKIAPIDN-----PRNPHPSAPSPAL--GPPPDAFSGIAPGV MMAR_2678|M.marinum_M TIPSYSGGARVTGVDH-----AGGPRPLDPPPP-----APDAFSGIAPEV MUL_3079|M.ulcerans_Agy99 TIPSYSGGARVTGVDH-----AGGPRPLDPPP------APDAFSGIAPEV MAV_2918|M.avium_104 TIPGHAGAARVTNVDN-----LRGPRPLDPPPPTPPKPGPDAFSGVAPDV MLBr_01538|M.leprae_Br4923 TISNYLGGRQVIAIDNPANSSPRAPVPNQPSSPLAPTSRPDAYAGIASDV MAB_2225c|M.abscessus_ATCC_199 ----------------------------------------DGFSGIAPAA MSMEG_0624|M.smegmatis_MC2_155 ----------------------------------------DGFSGVAPEA *.: *:*. . Mflv_0755|M.gilvum_PYR-GCK RILSLRQTSDSFSPVGARNDPNDPNATQTAGSLRSLARAIVHAANLGAQV Mvan_0092|M.vanbaalenii_PYR-1 RILSLRQTSDSFLPVGARTDPNDPNSTQTAGSLRSLARAIVHAANMGAQV TH_3348|M.thermoresistible__bu RILSLRHTSAAFQPVGARTDPNNPNTTQTAGSLRSLARAIVHAANLGAQV Mb1824|M.bovis_AF2122/97 EIISIRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASV Rv1796|M.tuberculosis_H37Rv EIISIRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASV MMAR_2678|M.marinum_M ELISIRQSSQAFGLKDPYTGDEDPQTQQKIDDVETMARAIVHAANMGASV MUL_3079|M.ulcerans_Agy99 ELISIRQSSQAFGLKDPYTGDEDPQTQQKIDDVETMARAIVHAANMGASV MAV_2918|M.avium_104 DIIAIRQSSQAFGLKDAYTGDEDPQTQAKIDNVQTMARAIVHAANMGASV MLBr_01538|M.leprae_Br4923 DILSIRQSSQAFGFKDLYTGDADPQTSQTIHYIQTMARAIVHAANMGATV MAB_2225c|M.abscessus_ATCC_199 KLISIRQESSKFSPRL--TAGGDPSTNAATQYVNTLARSIVHAANLGARV MSMEG_0624|M.smegmatis_MC2_155 RLISIRQNSPRFAPR---TPGADSEATRAASDAETLARAVVRAADMGARV ::::*: * * . :..: .::**::*:**::** * Mflv_0755|M.gilvum_PYR-GCK INISEAACYKVTRRIDEAVVGAAINYAVNVKGTVIVAAAGNTG------E Mvan_0092|M.vanbaalenii_PYR-1 INISEAACYKITRPINEAVVGAAINYAVNVKGAVIVVAAGNTG------E TH_3348|M.thermoresistible__bu INISEAACYKVTRPIDETGVGAAVNYAVHVKNAVVIAAAGNTG------Q Mb1824|M.bovis_AF2122/97 INISDVMCMSARNVIDQRALGAAVHYAAVDKDAVIVAAAGDGSK-----K Rv1796|M.tuberculosis_H37Rv INISDVMCMSARNVIDQRALGAAVHYAAVDKDAVIVAAAGDGSK-----K MMAR_2678|M.marinum_M INISDVTCMSARNVIDQNALGAAVHYAAVDKNVVIVAAAGDGSK-----K MUL_3079|M.ulcerans_Agy99 INISDVTCMSARNVIDQNALGAAVHYAAVDKNVVIVAAAGDGSK-----K MAV_2918|M.avium_104 INISDVTCMSARNIIDQRALGAAVRYAAVDKNAVIVAAAGDTSK-----K MLBr_01538|M.leprae_Br4923 INISEVTCMSARNVIDQRALGAAVRYAAVDKNVVIVAAAGDSSK-----K MAB_2225c|M.abscessus_ATCC_199 INISSAECVPAAKPIDQAALGAALRYAVAEKDAVVVAAAGNTSGGSAN-- MSMEG_0624|M.smegmatis_MC2_155 INISLVTCLPADRTIDQSVLGAALRYAALEKDAVIVAAAGNNRGGVSTGA **** . * . *:: :***:.**. *..*::.***: Mflv_0755|M.gilvum_PYR-GCK NCAQNPPPDPAVPADPRGWQQVQTIVSPAWYSPLVLTVGSIAPNGQPSGF Mvan_0092|M.vanbaalenii_PYR-1 NCTQNPPPDPAVPADPRGWQEVQTIVSPAWYSPLVLTVGSIAPNGQPSGF TH_3348|M.thermoresistible__bu DCTQNPPPDPAVPSDPRGWQQVQTIVSPAWYSPLVLTVGGIGPTGQPSNF Mb1824|M.bovis_AF2122/97 DCKQNPIFDPLQPDDPRAWNAVTTVVTPSWFHDYVLTVGAVDANGQPLSK Rv1796|M.tuberculosis_H37Rv DCKQNPIFDPLQPDDPRAWNAVTTVVTPSWFHDYVLTVGAVDANGQPLSK MMAR_2678|M.marinum_M DCKQNPIFDPLQPDDPRDWNAVTTVVTPSWFSDYVLTVGAVDTNGQPMTK MUL_3079|M.ulcerans_Agy99 DCKQNPIFDPLQPDDPRDWNAVTTVVTPSWFSDYVLTVGAVDTNGQPMTK MAV_2918|M.avium_104 DCKQNPPHDPLQPNDPRNWNSVTTVVTPSWFSDYVLTVGAVDTEGHPLSQ MLBr_01538|M.leprae_Br4923 NCKQNPLFDPLQPNDPRGWNGVNTVVTPSWFSEYVLTVGAVDSHGQPLTQ MAB_2225c|M.abscessus_ATCC_199 -CQQNPLT--GSGADPRNWSGVESVSVPSWWQPYVLSVGSVGIDGSPSKF MSMEG_0624|M.smegmatis_MC2_155 ACESNPLPS-GTPGDPRNWNGVTSVSIPSWWQPYVLSVGAVDSTGQPSSF * .** *** *. * :: *:*: **:**.: * * Mflv_0755|M.gilvum_PYR-GCK --------SVQGPWVGAAAPGENLVALG--YDGNPVNALQGEDG-PIPIS Mvan_0092|M.vanbaalenii_PYR-1 --------SMQGPWVGAAAPGENLIALG--YDGNPVNALQGEDG-PIPIS TH_3348|M.thermoresistible__bu --------SMSGPWVGAAAPAENITALG--YGGEPVNALQGQDG-LVPVA Mb1824|M.bovis_AF2122/97 -------MSIAGPWVSISAPGTDVVGLSP-RDDGLINAIDGPDNSLLVPA Rv1796|M.tuberculosis_H37Rv -------MSIAGPWVSISAPGTDVVGLSP-RDDGLINAIDGPDNSLLVPA MMAR_2678|M.marinum_M -------MSIAGPWVSIAAPGTDVIGLSP-RDDGLINAIDGPDNSLLVPA MUL_3079|M.ulcerans_Agy99 -------MSIAGPWVSIAAPGTDVIGLSP-RDDGLINAIDGPDNSLLVPA MAV_2918|M.avium_104 GNQGQASTSVAGPWVGIAAPGTDVVGLSP-RDDGLINAIDGPDNTLLVPS MLBr_01538|M.leprae_Br4923 -------TSIAGPWVSIAAPGTDIIGLSP-RDDSLINAIDGPDNTLLVPT MAB_2225c|M.abscessus_ATCC_199 --------TMAGPWVGIAANGENVTSLSNDAEGGLANGMIGQNGKPVPLF MSMEG_0624|M.smegmatis_MC2_155 --------TMAGPWVGIAAPGENIVSVSNAPDGGLSNALPSERDRLVPLT :: ****. :* . :: .:. . *.: . . : Mflv_0755|M.gilvum_PYR-GCK GTSFSAAFVSGVAALIKQRFPELTPGQIINRITATARHPGGGVNNVVGAG Mvan_0092|M.vanbaalenii_PYR-1 GTSFSAAYVSGLAALLRQRFPELTPAQIINRITATARHPGGGVNNVVGAG TH_3348|M.thermoresistible__bu GTSFAAAYVSGLAALIRQRYPDLTPAQVINRITATARHPGGGVDNYVGAG Mb1824|M.bovis_AF2122/97 GTSFSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDNQVGYG Rv1796|M.tuberculosis_H37Rv GTSFSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDNQVGYG MMAR_2678|M.marinum_M GTSFATAIVSGVVALVRAKYPELSAYQIRNRLIHTARPPARGVDNQVGYG MUL_3079|M.ulcerans_Agy99 GTSFATAIVSGVVALVRAKYPELSAYQIRNRLIHTARPPARGVDNQVGYG MAV_2918|M.avium_104 GTSFSAAIVSGVAALVRAKYPQLSAYQVINRLTRTARAPARGVDNQVGHG MLBr_01538|M.leprae_Br4923 GTSFSAAIVSGVAALVRGRYPQLTAYQVINRLIHTARSPARGVDNQVGYG MAB_2225c|M.abscessus_ATCC_199 GTSYATAYVAGVAALVRSRYPELTAPQVISRLQRTARDAGRSPSNLVGAG MSMEG_0624|M.smegmatis_MC2_155 GTSYAAAYVSGVAALVRSKFPDLTARQVVHRLTTTAQGAARSPSNLIGAG ***:::* *:*:.**:: ::*:*:. *: *: **: .. . .* :* * Mflv_0755|M.gilvum_PYR-GCK VIDPVAALTWDVPAGPADIPYQIKEIPPPVHIPPPDRSPITGVVVVTIVV Mvan_0092|M.vanbaalenii_PYR-1 VIDPVAALTWDVPPGPADIPYNIKEIPPPVYVPPPDRSPITGVVLVGVGL TH_3348|M.thermoresistible__bu VIDPVAALTWDVPEGPETAPYRAKEIPEPEFIPPPDRGPITWVVVSSAAV Mb1824|M.bovis_AF2122/97 VVDPVAALTWDVPKGPAEPPKQLSAPLVVPQPPAPRDMVPIWVAAGGLAG Rv1796|M.tuberculosis_H37Rv VVDPVAALTWDVPKGPAEPPKQLSAPLVVPQPPAPRDMVPIWVAAGGLAG MMAR_2678|M.marinum_M VVDPVAALTWDVPEGPVKPPKQLSAPLELPKPPAERNMVPVWVAAGGLTG MUL_3079|M.ulcerans_Agy99 VVDPVAALTWDVPEGPVKPPKQLSAPLELPKPPAERNMVPVWVAAGGLTG MAV_2918|M.avium_104 IVDPVAALTWDVPDGPVKPPQQLSAPLTIPKPVPRRDMVPIWVAAGGLFG MLBr_01538|M.leprae_Br4923 IVDPLAALTWDVPEGPAKPPPQLSSPLNLPKLPAHRDMVPVWVAAGGLTT MAB_2225c|M.abscessus_ATCC_199 TVDPVAALTWEVP-ADGNASSGPGARAVVPPPPPTPENPLPRRLAFLGAG MSMEG_0624|M.smegmatis_MC2_155 MVDPVAALTWDVADVPLDGPAAPEGRPIAAPPEPEPRDNTPRIIAFVGTG :**:*****:*. . . Mflv_0755|M.gilvum_PYR-GCK AALLGIGAMARRALRRR----- Mvan_0092|M.vanbaalenii_PYR-1 AALLGIAALGRRALRRR----- TH_3348|M.thermoresistible__bu ALALGIGALTRRALRRR----- Mb1824|M.bovis_AF2122/97 ALLIGGAVFGTATLMRRSRKQQ Rv1796|M.tuberculosis_H37Rv ALLIGGAVFGTATLMRRSRKQQ MMAR_2678|M.marinum_M ALLIGGAVFGTATLMRRSRKRR MUL_3079|M.ulcerans_Agy99 ALLIGGAVSGTATLMRRSRKRR MAV_2918|M.avium_104 ALLIGGAVFGTAMLMKRSRRQQ MLBr_01538|M.leprae_Br4923 AVLIGAAAFGTAMLVRRTQK-- MAB_2225c|M.abscessus_ATCC_199 VCLIAVVVVAALSARRRQESTE MSMEG_0624|M.smegmatis_MC2_155 VLAAAVGAAFYATYRRKDKTT- . . . ::