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MRSELRIGLAGIATTLVVFQATLLRGCPWALAISPPVVDPGVPPPNGAPGPVQIMQQRGSCITSGVIPGT DLGIVTSSQSMLNLPAAWQFSRGEGQLVAIVDTGVRPGPRLPNVEAGGDYVESSDGLTDCDGHGTLVAGI VAGQPAPSGEDGFSGVAPAARLLSIRVTSAKFSLRSLGGDPQLKQASLEVTRLSRAIVHAADLGARVINI SAITCLPADRSIDQSGLGAAIRYAAVDKDALLVAPAGNAGSTGTVGGNMNCESNPLTDLGRPDDPRNWAS VTSVSIPSWWQPYVLSVASLTPSGRPSKFTMAGPWVGIAAPGENIVSVSNRDSGDLANALPNDRDQQIAL NGTSYAAGYVSGVAALVRSKYPELTAKQVMRRITATAHTGARTLSNVVGSGTLDSVAALTWDLPATNDSP PVPVKLVTVPPPPAPKDNTPRNVAFAGTATLVMVVAAVVGTATIAARRREGTTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_02528 | - | - | 100% (475) | putative protease |
| M. leprae Br4923 | MLBr_00041 | - | 1e-91 | 40.69% (462) | putative secreted protease |
| M. leprae Br4923 | MLBr_01538 | - | 2e-69 | 37.67% (446) | putative protease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0299 | - | 0.0 | 69.66% (468) | protease precursor |
| M. gilvum PYR-GCK | Mflv_0320 | - | 1e-136 | 55.34% (459) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. tuberculosis H37Rv | Rv0291 | mycP3 | 0.0 | 69.66% (468) | membrane-anchored mycosin |
| M. abscessus ATCC 19977 | MAB_2225c | - | 1e-128 | 54.23% (461) | peptidase |
| M. marinum M | MMAR_0550 | mycP3 | 0.0 | 70.45% (467) | membrane-anchored mycosin MycP3 |
| M. avium 104 | MAV_4862 | - | 0.0 | 67.38% (469) | subtilase family protein |
| M. smegmatis MC2 155 | MSMEG_0624 | - | 1e-156 | 62.03% (453) | subtilase family protein |
| M. thermoresistible (build 8) | TH_3265 | - | 1e-117 | 61.02% (354) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. ulcerans Agy99 | MUL_1213 | mycP3 | 0.0 | 70.02% (467) | membrane-anchored mycosin MycP3 |
| M. vanbaalenii PYR-1 | Mvan_0421 | - | 1e-152 | 59.33% (450) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0320|M.gilvum_PYR-GCK -----MTPVIRPAAALAVAAAVFTIV----AAPAGAIPPPDVDPAATPPS
Mvan_0421|M.vanbaalenii_PYR-1 --------MRAHPWALAAAVALLAAS----APPAGAITPPEVDPAVPPPG
Mb0299|M.bovis_AF2122/97 -------MIRAAFACLAATVVVAG----WWTPPAWAIGPPVVDAAAQPPS
Rv0291|M.tuberculosis_H37Rv -------MIRAAFACLAATVVVAG----WWTPPAWAIGPPVVDAAAQPPS
MMAR_0550|M.marinum_M -------MKRAGSACLTAILAIFTTGALWAAPPVSAISPPAVDDSVQPPS
MUL_1213|M.ulcerans_Agy99 -------MKRAGSACLTAILAIFTTGALWAAPPVSAISPPAVDDSVQPPS
MLBr_02528|M.leprae_Br4923 ---MMRSELRIGLAGIATTLVVFQATLLRGCPWALAISPPVVDPGVPPPN
MAV_4862|M.avium_104 -------MIRPASACLAAVLALLPATATWASPPALAISPPTVDPGVPPPS
MSMEG_0624|M.smegmatis_MC2_155 -------MIHKSLGVVATAGLVLLIG----CPSAGAVSPPQVDPQIAPPP
TH_3265|M.thermoresistible__bu --------------------------------------------------
MAB_2225c|M.abscessus_ATCC_199 MTHFIRDAPRARRALGGVVAATLLALSPVAAPVAGAVIQPEADPAALPKD
Mflv_0320|M.gilvum_PYR-GCK GAAGPVAPMTQRNPCAVTGVVPGSDPAAPSPNQLSLNMSDAWRHSDGRDQ
Mvan_0421|M.vanbaalenii_PYR-1 GSVGPVGAMAQRNPCVISTALPGTDPGAATPDRTALRLSEAWTHSRGEGQ
Mb0299|M.bovis_AF2122/97 GDPGPVAPMEQRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQ
Rv0291|M.tuberculosis_H37Rv GDPGPVAPMEQRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQ
MMAR_0550|M.marinum_M GTPGPVQTMEQRGACSVSGLIPGTDISVPGASQAMLNLPAAWQFSRGEGQ
MUL_1213|M.ulcerans_Agy99 GTPGPVQTMEQRGACSVSGLIPGTDISVPGASQAMLNLPAAWQFSRGEGQ
MLBr_02528|M.leprae_Br4923 GAPGPVQIMQQRGSCITSGVIPGTDLGIVTSSQSMLNLPAAWQFSRGEGQ
MAV_4862|M.avium_104 GAPGPGQPMEQRAPCTTSGVIPGSEPAAVTPSQSALNLPAAWRFSRGDGQ
MSMEG_0624|M.smegmatis_MC2_155 GTAGPAQPMMQRSECITTSVLPGTDPGAVSPNQLALNLSGAWQHSRGAGQ
TH_3265|M.thermoresistible__bu --------------------------------------------------
MAB_2225c|M.abscessus_ATCC_199 SSPSATAGMQS-SACSTTVLLPGTG----TSGKPSPEFEEAWRFSRGEGQ
Mflv_0320|M.gilvum_PYR-GCK LVAVIGTGVTPGPRLPNVDPGGDFVGSGDGLTDCDGSGTLVAGLIAGAP-
Mvan_0421|M.vanbaalenii_PYR-1 TVAVLDTGVKPGPRLPDVEAGGDYVASGDGLTDCDGQGTLVAGLIAGQP-
Mb0299|M.bovis_AF2122/97 LVAIIDTGVQPGPRLPNVDAGGDFVESTDGLTDCDGHGTLVAGIVAGQP-
Rv0291|M.tuberculosis_H37Rv LVAIIDTGVQPGPRLPNVDAGGDFVESTDGLTDCDGHGTLVAGIVAGQP-
MMAR_0550|M.marinum_M LVAILDTGVQPGPRLPNVDAGGDFVDSTDGLTDCDGRGTLVAGIVAGQP-
MUL_1213|M.ulcerans_Agy99 LVAILDTGVQPGPRLPNVDAGGDFVDSTDGLTDCDGRGTLVAGIVAGQP-
MLBr_02528|M.leprae_Br4923 LVAIVDTGVRPGPRLPNVEAGGDYVESSDGLTDCDGHGTLVAGIVAGQPA
MAV_4862|M.avium_104 LVAVLDTGVRPGPRLPNVEPGGDFVETTDGLTDCDGHGTLLAGLVAGQP-
MSMEG_0624|M.smegmatis_MC2_155 TVAVIDTGVQPGPRLPNVEAGGDYIESTDGLTDCDGHGTSVAGLIAGQP-
TH_3265|M.thermoresistible__bu --------VQNG----------------DGLTDCDGHGTAVAGLIAGQP-
MAB_2225c|M.abscessus_ATCC_199 SVAIIDTGVKPSARL-HVEPGGDYVQSTDGLTDCDGHGTMVAGIIGAQP-
* . ******** ** :**::.. *
Mflv_0320|M.gilvum_PYR-GCK --GPDGFSGVAPAARILAIRQTSPRYAPS-STGEDPALTRASIETRTLAR
Mvan_0421|M.vanbaalenii_PYR-1 --GADGFSGVAPAARILSIRVSSPRYAPR-DAGEDPAVTRAMLETEAMAG
Mb0299|M.bovis_AF2122/97 --GNDGFSGVAPAARLLSIRAMSTKFSPR-TSGGDPQLAQATLDVAVLAG
Rv0291|M.tuberculosis_H37Rv --GNDGFSGVAPAARLLSIRAMSTKFSPR-TSGGDPQLAQATLDVAVLAG
MMAR_0550|M.marinum_M --GNDGFSGVAPAARLLSIRVTSDKFSAR-SSGGDPSVERATIDVAALGR
MUL_1213|M.ulcerans_Agy99 --GNDGFSGVAPAARLLSIRVTSDKFSAR-SSGGDPSVERATIDVAALGR
MLBr_02528|M.leprae_Br4923 PSGEDGFSGVAPAARLLSIRVTSAKFSLR-SLGGDPQLKQASLEVTRLSR
MAV_4862|M.avium_104 -SPDDGFAGVAPAARVVSIRTTSAKFSPR-TPGGDPLLARAAAEVGTLAR
MSMEG_0624|M.smegmatis_MC2_155 --GPDGFSGVAPEARLISIRQNSPRFAPR-TPGADSEATRAASDAETLAR
TH_3265|M.thermoresistible__bu --GPDGFSGVAPAARLLAIRQTSNHFAPT-DAGADPVVTRAGLDVLNMAR
MAB_2225c|M.abscessus_ATCC_199 --GPDGFSGIAPAAKLISIRQESSKFSPRLTAGGDPSTNAATQYVNTLAR
***:*:** *::::** * ::: * *. * . :.
Mflv_0320|M.gilvum_PYR-GCK AVVRAADSGARVIAISSVTCVPAGMSVDQSELGAALRYAAVEKDAVIVAA
Mvan_0421|M.vanbaalenii_PYR-1 AIVRAADLGARVINISAVTCVPVGENFDQSGLGAALRYAAVDRDVVIVAA
Mb0299|M.bovis_AF2122/97 AIVHAADLGAKVINVSTITCLPADRMVDQAALGAAIRYAAVDKDAVIVAA
Rv0291|M.tuberculosis_H37Rv AIVHAADLGAKVINVSTITCLPADRMVDQAALGAAIRYAAVDKDAVIVAA
MMAR_0550|M.marinum_M AIVHAADRGARVINISSITCLPADRQVDQAALGAAIRYAAVDKDVVIVAA
MUL_1213|M.ulcerans_Agy99 AIVHAADRGARVINISSITCLPADRQVDQAALGAAIRYAAVDKDVVIVAA
MLBr_02528|M.leprae_Br4923 AIVHAADLGARVINISAITCLPADRSIDQSGLGAAIRYAAVDKDALLVAP
MAV_4862|M.avium_104 AIVHAADLGARVIDIGSATCLPVDRPVDQAALGAAVRYAAVDKDAVIVAA
MSMEG_0624|M.smegmatis_MC2_155 AVVRAADMGARVINISLVTCLPADRTIDQSVLGAALRYAALEKDAVIVAA
TH_3265|M.thermoresistible__bu AVVRAADLGARVITISTATCLPADNTVAQSQLGAALRYAAVERDAVIVAA
MAB_2225c|M.abscessus_ATCC_199 SIVHAANLGARVINISSAECVPAAKPIDQAALGAALRYAVAEKDAVVVAA
::*:**: **:** :. *:*. . *: ****:***. ::*.::**.
Mflv_0320|M.gilvum_PYR-GCK AGDTEGS------TGCGENPLNDPARPADPRNWAGVSTLAIPAWWEQYVL
Mvan_0421|M.vanbaalenii_PYR-1 AGEGGAA------GGCDSNPLSDPALPSDPRNWSGVTAVAIPAWWQQYVL
Mb0299|M.bovis_AF2122/97 AGNTGASGSVS--ASCDSNPLTDLSRPDDPRNWAGVTSVSIPSWWQPYVL
Rv0291|M.tuberculosis_H37Rv AGNTGASGSVS--ASCDSNPLTDLSRPDDPRNWAGVTSVSIPSWWQPYVL
MMAR_0550|M.marinum_M AGNSGAGGSGSG-GTCESNPLTDLSHPDDPRNWAGVTSVSIPSLWQPYVL
MUL_1213|M.ulcerans_Agy99 AGNSGAGGSGSG-GTCESNPLTDLSHPDDPRNWAGVTSVSIPSLWQPYVL
MLBr_02528|M.leprae_Br4923 AGNAGSTGTVGGNMNCESNPLTDLGRPDDPRNWASVTSVSIPSWWQPYVL
MAV_4862|M.avium_104 AGDSGPTGSFAGGTSCESNPLTDLSRPSDPRNWAGVTSLSIPSWWQPYVL
MSMEG_0624|M.smegmatis_MC2_155 AGNNRGGVSTG--AACESNPLPSGT-PGDPRNWNGVTSVSIPSWWQPYVL
TH_3265|M.thermoresistible__bu AGDVRSGGPTG--TACRSNPLGDLSRPDDPRDWAGVGSVSIPSWWQPYVL
MAB_2225c|M.abscessus_ATCC_199 AGNTSGGS-----ANCQQNPLTGSG--ADPRNWSGVESVSVPSWWQPYVL
**: * .*** . ***:* .* ::::*: *: ***
Mflv_0320|M.gilvum_PYR-GCK SVGSVGPQGRPSAFTMAGPWVGIAAPGEDITSVSNDAAGGLANGTLNGEQ
Mvan_0421|M.vanbaalenii_PYR-1 SVGSLAPDGTPSSFTMAGPWVGIAAPGEDITSVSNDEAGGLANGLPGDRD
Mb0299|M.bovis_AF2122/97 SVASLTSAGQPSKFSMPGPWVGIAAPGENIASVSNSGDGALANGLPDAHQ
Rv0291|M.tuberculosis_H37Rv SVASLTSAGQPSKFSMPGPWVGIAAPGENIASVSNSGDGALANGLPDAHQ
MMAR_0550|M.marinum_M SVASLTAGGQPSKFTMAGPWVGIAAPGENIVSVSNADGGGLANGLPNQRQ
MUL_1213|M.ulcerans_Agy99 SVASLTAGGQPSKFTMAGPWVGIAAPGENIVSVSNADGGGLANGLPNQRQ
MLBr_02528|M.leprae_Br4923 SVASLTPSGRPSKFTMAGPWVGIAAPGENIVSVSNRDSGDLANALPNDRD
MAV_4862|M.avium_104 SVASLTPDGQPSKFTVAGPWVGVAAPGERIVSIGNGDGAGLTNGLPDEHQ
MSMEG_0624|M.smegmatis_MC2_155 SVGAVDSTGQPSSFTMAGPWVGIAAPGENIVSVSNAPDGGLSNALPSERD
TH_3265|M.thermoresistible__bu SVGSLNTAGQPSDFTMSGPWVGVAAPGEDIASVSNAPGGGLANALPRGQD
MAB_2225c|M.abscessus_ATCC_199 SVGSVGIDGSPSKFTMAGPWVGIAANGENVTSLSNDAEGGLANGMIGQNG
**.:: * ** *::.*****:** ** :.*:.* . *:*. .
Mflv_0320|M.gilvum_PYR-GCK Q-YDPLSGTGYATAYVAGVAALVRSRFPALTGPQVRERLTGTANQAARAP
Mvan_0421|M.vanbaalenii_PYR-1 R-IDPVRGTGYATAYVSGVAALVRSRFPDLTARQVIERLTGTAQSAARSP
Mb0299|M.bovis_AF2122/97 K-LVALSGTSYAAGYVSGVAALVRSRYPGLNATEVVRRLTATAHRGARES
Rv0291|M.tuberculosis_H37Rv K-LVALSGTSYAAGYVSGVAALVRSRYPGLNATEVVRRLTATAHRGARES
MMAR_0550|M.marinum_M Q-LTPLSGTSYAAGYVSGVAALVRSKYPELTAAQVMHRLTATAHNGARDP
MUL_1213|M.ulcerans_Agy99 Q-LTPLSGTSYAAGYVSGVATLVRSNYPELTAAQVMHRLTATAHNGARDP
MLBr_02528|M.leprae_Br4923 Q-QIALNGTSYAAGYVSGVAALVRSKYPELTAKQVMRRITATAHTGARTL
MAV_4862|M.avium_104 Q-LAALNGTGYAAGYVAGVAALVRSKYPDLSATAVVHRITATAHNGARDP
MSMEG_0624|M.smegmatis_MC2_155 R-LVPLTGTSYAAAYVSGVAALVRSKFPDLTARQVVHRLTTTAQGAARSP
TH_3265|M.thermoresistible__bu QQLAPLAGTGYAAGYVAGVAALVRSRYPELTAAQVVHRITATAQGAARSP
MAB_2225c|M.abscessus_ATCC_199 K-PVPLFGTSYATAYVAGVAALVRSRYPELTAPQVISRLQRTARDAGRSP
: .: **.**:.**:***:****.:* *.. * *: **. ..*
Mflv_0320|M.gilvum_PYR-GCK SNLVGAGRVDPVAALTWNVPAAG-VD--ASVPKQVAAPPDTPPADPLPRL
Mvan_0421|M.vanbaalenii_PYR-1 SNLVGAGRIDPVAALTWNVPATEEIG--TTAARPVAAPAPPPPKDPVPRA
Mb0299|M.bovis_AF2122/97 SNIVGAGNLDAVAALTWQLPAEPGGG--AAPAKPVADPPVPAPKDTTPRN
Rv0291|M.tuberculosis_H37Rv SNIVGAGNLDAVAALTWQLPAEPGGG--AAPAKPVADPPVPAPKDTTPRN
MMAR_0550|M.marinum_M SNVVGAGILDPAAALTWELPAADGGAPQVAPAKPVSVPPAPQPRNTTPRN
MUL_1213|M.ulcerans_Agy99 SNVVGAGILDPAAALTWELPAADGGAPQVAPAKPVSVPPAPQPRNTTPRN
MLBr_02528|M.leprae_Br4923 SNVVGSGTLDSVAALTWDLPATNDSP--PVPVKLVTVPPPPAPKDNTPRN
MAV_4862|M.avium_104 SNVVGAGSVDPVAALTWQLPAGDQPG---PAAKPIAVPPAPAPPDTTPRT
MSMEG_0624|M.smegmatis_MC2_155 SNLIGAGMVDPVAALTWDVADVPLDGPAAPEGRPIAAPPEPEPRDNTPRI
TH_3265|M.thermoresistible__bu SNLIGAGRVDPVAALTWDVPTEPET--TGPAAKPVAAPPEPEAADNTPKI
MAB_2225c|M.abscessus_ATCC_199 SNLVGAGTVDPVAALTWEVPADGNAS-SGPGARAVVPPPPPTPENPLPRR
**::*:* :*..*****::. : : *. . . : *:
Mflv_0320|M.gilvum_PYR-GCK VAYAGVGVLAAVVIAAAVLRAK---RKDPSA------
Mvan_0421|M.vanbaalenii_PYR-1 VAFAGAGVLALVVLTVSLMSTR---RKETSS------
Mb0299|M.bovis_AF2122/97 VAFAGAAALSVLVGLTAATVAIARRRREPTE------
Rv0291|M.tuberculosis_H37Rv VAFAGAAALSVLVGLTAATVAIARRRREPTE------
MMAR_0550|M.marinum_M VAFAGAAALTVLVAGVAATVAIARRRKDAEGRTAREL
MUL_1213|M.ulcerans_Agy99 VAFAGAAALTVLVAGVAATVAIARRRKDAEGRTAREL
MLBr_02528|M.leprae_Br4923 VAFAGTATLVMVVAAVVGTATIAARRREGTTP-----
MAV_4862|M.avium_104 VAVAGTAALAVLVAVAGAVTALAARRRKDPTA-----
MSMEG_0624|M.smegmatis_MC2_155 IAFVGTGVLAAAVG-AAFYATY--RRKDKTT------
TH_3265|M.thermoresistible__bu VAFAGVGVIALLLVVAAAVAAH--RRKDSQT------
MAB_2225c|M.abscessus_ATCC_199 LAFLGAGVCLIAVVVVAALSAR--RRQESTE------
:* *... : . : *:.