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QRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGALPPDGTPGPPAPMKQNSYCTEV GVLPGTDFKLQPKYMEMLNINEAWQFGRGAGVKVAVIDTGVTPHPRFPHLIPGGDYVMGGDGLQDCDAHG TIVASMIGAAPANGALPPPAVPRRPVTIPTTEKPPPPQTVTLSPVPPQTVTVIPGPPPEEGAPQGESGPG PVPPPAPGQPPASNHGGGTVTIPSYSGGARVTGVDHAGGPRPLDPPPAPDAFSGIAPEVELISIRQSSQA FGLKDPYTGDEDPQTQQKIDDVETMARAIVHAANMGASVINISDVTCMSARNVIDQNALGAAVHYAAVDK NVVIVAAAGDGSKKDCKQNPIFDPLQPDDPRDWNAVTTVVTPSWFSDYVLTVGAVDTNGQPMTKMSIAGP WVSIAAPGTDVIGLSPRDDGLINAIDGPDNSLLVPAGTSFATAIVSGVVALVRAKYPELSAYQIRNRLIH TARPPARGVDNQVGYGVVDPVAALTWDVPEGPVKPPKQLSAPLELPKPPAERNMVPVWVAAGGLTGALLI GGAVSGTATLMRRSRKRR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_3079 | mycP5 | - | 100% (579) | proline rich membrane-anchored mycosin MycP5 |
M. ulcerans Agy99 | MUL_1213 | mycP3 | 3e-71 | 38.78% (459) | membrane-anchored mycosin MycP3 |
M. ulcerans Agy99 | MUL_0858 | mycP4 | 2e-52 | 39.51% (329) | membrane-anchored serine protease (mycosin), MycP4 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1824 | - | 0.0 | 84.44% (585) | Pro-rich protease |
M. gilvum PYR-GCK | Mflv_0755 | - | 8e-72 | 36.99% (465) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
M. tuberculosis H37Rv | Rv1796 | mycP5 | 0.0 | 84.44% (585) | proline rich membrane-anchored mycosin MYCP5 (serine |
M. leprae Br4923 | MLBr_01538 | - | 0.0 | 73.68% (570) | putative protease |
M. abscessus ATCC 19977 | MAB_2225c | - | 2e-68 | 39.07% (453) | peptidase |
M. marinum M | MMAR_2678 | mycP5 | 0.0 | 99.48% (580) | proline rich membrane-anchored mycosin MycP5 |
M. avium 104 | MAV_2918 | - | 0.0 | 75.25% (610) | subtilase family protein |
M. smegmatis MC2 155 | MSMEG_0624 | - | 9e-75 | 40.49% (452) | subtilase family protein |
M. thermoresistible (build 8) | TH_3348 | - | 1e-72 | 37.26% (475) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
M. vanbaalenii PYR-1 | Mvan_0092 | - | 4e-71 | 42.25% (374) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0755|M.gilvum_PYR-GCK MRRIG-------------ALIAALLLV---LVTAPPAGAVEQPVIDPAAI Mvan_0092|M.vanbaalenii_PYR-1 MRRIG-------------ALIAALFLV---LLTAPPASAIEPPIVDPAAI TH_3348|M.thermoresistible__bu ---LG-------------VLITALLLA---VVTAPPAGAIEPPVIDPAAV MUL_3079|M.ulcerans_Agy99 MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL MMAR_2678|M.marinum_M MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL Mb1824|M.bovis_AF2122/97 MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTIDPGAL Rv1796|M.tuberculosis_H37Rv MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPTIDPGAL MAV_2918|M.avium_104 MQRSATAEANVWRGRASAAALAALLLASGALAGLPPAAAISPPTIDPAAV MLBr_01538|M.leprae_Br4923 ------------------MFVALALLTSGAFAGLPPAYAISPPKIDPGAV MAB_2225c|M.abscessus_ATCC_199 ---MTHFIRDAPRARRALGGVVAATLLALSPVAAPVAGAVIQPEADP-AA MSMEG_0624|M.smegmatis_MC2_155 ------------MIHKSLGVVATAGLVLL--IGCPSAGAVSPPQVDPQIA :. * * * *: * * Mflv_0755|M.gilvum_PYR-GCK PPD-ETGPDQPMEQRRVCAAPTVFPNANFADRPWASDYLRLADAQQFATG Mvan_0092|M.vanbaalenii_PYR-1 PPD-ETGPDQPMEQRRICAAPTVFPNSNFADRPWASDYLRLTEAQKFATG TH_3348|M.thermoresistible__bu PPD-ETGPDNPMEQRRVCAAPTVYPDSNFADRPWASDYLRLTEAHKFATG MUL_3079|M.ulcerans_Agy99 PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG MMAR_2678|M.marinum_M PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG Mb1824|M.bovis_AF2122/97 PPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRG Rv1796|M.tuberculosis_H37Rv PPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRG MAV_2918|M.avium_104 PPDGPPGPGAPMKQNSYCTEVGVLPGTDFRLQPKYMDMLNLQEAWQFGRG MLBr_01538|M.leprae_Br4923 PPDGPPGPATPMKQYSYCTEVGVLPETDFRLLPKYMDMLNMFDAWEFGRG MAB_2225c|M.abscessus_ATCC_199 LPKDSSPSATAGMQSSACSTTVLLPGTG----TSGKPSPEFEEAWRFSRG MSMEG_0624|M.smegmatis_MC2_155 PPPGTAGPAQPMMQRSECITTSVLPGTDPGAVSPNQLALNLSGAWQHSRG * . . . * * : * :. . .: * ... * Mflv_0755|M.gilvum_PYR-GCK AGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGDGMSDCDAHGTLTAAVIA Mvan_0092|M.vanbaalenii_PYR-1 AGVTVAVIDTGVNGSPRVP-AEPGGDFVDQAGNGMSDCDAHGTLTAAVIA TH_3348|M.thermoresistible__bu AGITVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTLTASVIA MUL_3079|M.ulcerans_Agy99 AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG MMAR_2678|M.marinum_M AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG Mb1824|M.bovis_AF2122/97 DGVKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIA Rv1796|M.tuberculosis_H37Rv DGVKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIA MAV_2918|M.avium_104 AGQKVAVIDTGVTPHPRFPHLIPGGDYIMSG-DGLSDCDAHGTLVASMIG MLBr_01538|M.leprae_Br4923 GGQKIAVIDTGVTPHPRLPHLIAGGDYVMAGGDGLSDCDAHGTIVASMIG MAB_2225c|M.abscessus_ATCC_199 EGQSVAIIDTGVKPSARLH-VEPGGDYVQST-DGLTDCDGHGTMVAGIIG MSMEG_0624|M.smegmatis_MC2_155 AGQTVAVIDTGVQPGPRLPNVEAGGDYIEST-DGLTDCDGHGTSVAGLIA * .:*:***** .*. .***:: :*: ***.*** .*.:*. Mflv_0755|M.gilvum_PYR-GCK GR----------------------PAP----------------------- Mvan_0092|M.vanbaalenii_PYR-1 GR----------------------PAP----------------------- TH_3348|M.thermoresistible__bu GR----------------------GAP----------------------- MUL_3079|M.ulcerans_Agy99 AAPANGALPPPAVPRRPVTIPTTEKPP---PPQTVTLSPVPPQTVTVIPG MMAR_2678|M.marinum_M AAPANGALPPPAVPRRPVTIPTTEKPP---PPQTVTLSPVPPQTVTVIPG Mb1824|M.bovis_AF2122/97 AVPANGAVPLPSVPRRPVTIPTTETPP---PPQTVTLSPVPPQTVTVIPA Rv1796|M.tuberculosis_H37Rv AVPANGAVPLPSVPRRPVTIPTTETPP---PPQTVTLSPVPPQTVTVIPA MAV_2918|M.avium_104 AASADGAGVPPAAPRKPVTIPTTEPPPKAPPPQTVTLSPLP-QTVTMVPP MLBr_01538|M.leprae_Br4923 AAPATGA-PVPAAPRKPVPIPTTEKSP---PPQTVTLSPLP-QTVTVIPV MAB_2225c|M.abscessus_ATCC_199 AQ----------------------PGP----------------------- MSMEG_0624|M.smegmatis_MC2_155 GQ----------------------PGP----------------------- . * Mflv_0755|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0092|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3348|M.thermoresistible__bu -------------------------------------------------- MUL_3079|M.ulcerans_Agy99 PPPEE---------GAPQGESGPGPVPP-PAPG-----QPPASNHGGGTV MMAR_2678|M.marinum_M PPPEE---------GAPQGEPGPGPVPP-PAPG-----QPPASNHGGGTV Mb1824|M.bovis_AF2122/97 PPPEE---------GVPPGAPVPGPEPP-PAPGP----QPPAVDRGGGTV Rv1796|M.tuberculosis_H37Rv PPPEE---------GVPPGAPVPGPEPP-PAPGP----QPPAVDRGGGTV MAV_2918|M.avium_104 PPSQEQQQPPPGPFGAPPPPPAAGPAPAGPPPGPPQGGQAPAGNHGGGTV MLBr_01538|M.leprae_Br4923 PPPPE------------EGLSPPGVPPP-LQSGQ----HASSGRWDGSTV MAB_2225c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0624|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_0755|M.gilvum_PYR-GCK ---------------------------------------TDAFIGVAPDA Mvan_0092|M.vanbaalenii_PYR-1 ---------------------------------------HDAFIGVAPNA TH_3348|M.thermoresistible__bu ---------------------------------------TDGFIGVAPDA MUL_3079|M.ulcerans_Agy99 TIPSYSGGARVTGVDH-----AGGPRPLDPPP------APDAFSGIAPEV MMAR_2678|M.marinum_M TIPSYSGGARVTGVDH-----AGGPRPLDPPPP-----APDAFSGIAPEV Mb1824|M.bovis_AF2122/97 TVPSYSGGRKIAPIDN-----PRNPHPSAPSPAL--GPPPDAFSGIAPGV Rv1796|M.tuberculosis_H37Rv TVPSYSGGRKIAPIDN-----PRNPHPSAPSPAL--GPPPDAFSGIAPGV MAV_2918|M.avium_104 TIPGHAGAARVTNVDN-----LRGPRPLDPPPPTPPKPGPDAFSGVAPDV MLBr_01538|M.leprae_Br4923 TISNYLGGRQVIAIDNPANSSPRAPVPNQPSSPLAPTSRPDAYAGIASDV MAB_2225c|M.abscessus_ATCC_199 ----------------------------------------DGFSGIAPAA MSMEG_0624|M.smegmatis_MC2_155 ----------------------------------------DGFSGVAPEA *.: *:*. . Mflv_0755|M.gilvum_PYR-GCK RILSLRQTSDSFSPVGARNDPNDPNATQTAGSLRSLARAIVHAANLGAQV Mvan_0092|M.vanbaalenii_PYR-1 RILSLRQTSDSFLPVGARTDPNDPNSTQTAGSLRSLARAIVHAANMGAQV TH_3348|M.thermoresistible__bu RILSLRHTSAAFQPVGARTDPNNPNTTQTAGSLRSLARAIVHAANLGAQV MUL_3079|M.ulcerans_Agy99 ELISIRQSSQAFGLKDPYTGDEDPQTQQKIDDVETMARAIVHAANMGASV MMAR_2678|M.marinum_M ELISIRQSSQAFGLKDPYTGDEDPQTQQKIDDVETMARAIVHAANMGASV Mb1824|M.bovis_AF2122/97 EIISIRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASV Rv1796|M.tuberculosis_H37Rv EIISIRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASV MAV_2918|M.avium_104 DIIAIRQSSQAFGLKDAYTGDEDPQTQAKIDNVQTMARAIVHAANMGASV MLBr_01538|M.leprae_Br4923 DILSIRQSSQAFGFKDLYTGDADPQTSQTIHYIQTMARAIVHAANMGATV MAB_2225c|M.abscessus_ATCC_199 KLISIRQESSKFSPRL--TAGGDPSTNAATQYVNTLARSIVHAANLGARV MSMEG_0624|M.smegmatis_MC2_155 RLISIRQNSPRFAPR---TPGADSEATRAASDAETLARAVVRAADMGARV ::::*: * * . :..: .::**::*:**::** * Mflv_0755|M.gilvum_PYR-GCK INISEAACYKVTRRIDEAVVGAAINYAVNVKGTVIVAAAGNTG------E Mvan_0092|M.vanbaalenii_PYR-1 INISEAACYKITRPINEAVVGAAINYAVNVKGAVIVVAAGNTG------E TH_3348|M.thermoresistible__bu INISEAACYKVTRPIDETGVGAAVNYAVHVKNAVVIAAAGNTG------Q MUL_3079|M.ulcerans_Agy99 INISDVTCMSARNVIDQNALGAAVHYAAVDKNVVIVAAAGDGSK-----K MMAR_2678|M.marinum_M INISDVTCMSARNVIDQNALGAAVHYAAVDKNVVIVAAAGDGSK-----K Mb1824|M.bovis_AF2122/97 INISDVMCMSARNVIDQRALGAAVHYAAVDKDAVIVAAAGDGSK-----K Rv1796|M.tuberculosis_H37Rv INISDVMCMSARNVIDQRALGAAVHYAAVDKDAVIVAAAGDGSK-----K MAV_2918|M.avium_104 INISDVTCMSARNIIDQRALGAAVRYAAVDKNAVIVAAAGDTSK-----K MLBr_01538|M.leprae_Br4923 INISEVTCMSARNVIDQRALGAAVRYAAVDKNVVIVAAAGDSSK-----K MAB_2225c|M.abscessus_ATCC_199 INISSAECVPAAKPIDQAALGAALRYAVAEKDAVVVAAAGNTSGGSAN-- MSMEG_0624|M.smegmatis_MC2_155 INISLVTCLPADRTIDQSVLGAALRYAALEKDAVIVAAAGNNRGGVSTGA **** . * . *:: :***:.**. *..*::.***: Mflv_0755|M.gilvum_PYR-GCK NCAQNPPPDPAVPADPRGWQQVQTIVSPAWYSPLVLTVGSIAPNGQPSGF Mvan_0092|M.vanbaalenii_PYR-1 NCTQNPPPDPAVPADPRGWQEVQTIVSPAWYSPLVLTVGSIAPNGQPSGF TH_3348|M.thermoresistible__bu DCTQNPPPDPAVPSDPRGWQQVQTIVSPAWYSPLVLTVGGIGPTGQPSNF MUL_3079|M.ulcerans_Agy99 DCKQNPIFDPLQPDDPRDWNAVTTVVTPSWFSDYVLTVGAVDTNGQPMTK MMAR_2678|M.marinum_M DCKQNPIFDPLQPDDPRDWNAVTTVVTPSWFSDYVLTVGAVDTNGQPMTK Mb1824|M.bovis_AF2122/97 DCKQNPIFDPLQPDDPRAWNAVTTVVTPSWFHDYVLTVGAVDANGQPLSK Rv1796|M.tuberculosis_H37Rv DCKQNPIFDPLQPDDPRAWNAVTTVVTPSWFHDYVLTVGAVDANGQPLSK MAV_2918|M.avium_104 DCKQNPPHDPLQPNDPRNWNSVTTVVTPSWFSDYVLTVGAVDTEGHPLSQ MLBr_01538|M.leprae_Br4923 NCKQNPLFDPLQPNDPRGWNGVNTVVTPSWFSEYVLTVGAVDSHGQPLTQ MAB_2225c|M.abscessus_ATCC_199 -CQQNPLT--GSGADPRNWSGVESVSVPSWWQPYVLSVGSVGIDGSPSKF MSMEG_0624|M.smegmatis_MC2_155 ACESNPLPS-GTPGDPRNWNGVTSVSIPSWWQPYVLSVGAVDSTGQPSSF * .** *** *. * :: *:*: **:**.: * * Mflv_0755|M.gilvum_PYR-GCK --------SVQGPWVGAAAPGENLVALG--YDGNPVNALQGEDG-PIPIS Mvan_0092|M.vanbaalenii_PYR-1 --------SMQGPWVGAAAPGENLIALG--YDGNPVNALQGEDG-PIPIS TH_3348|M.thermoresistible__bu --------SMSGPWVGAAAPAENITALG--YGGEPVNALQGQDG-LVPVA MUL_3079|M.ulcerans_Agy99 -------MSIAGPWVSIAAPGTDVIGLSP-RDDGLINAIDGPDNSLLVPA MMAR_2678|M.marinum_M -------MSIAGPWVSIAAPGTDVIGLSP-RDDGLINAIDGPDNSLLVPA Mb1824|M.bovis_AF2122/97 -------MSIAGPWVSISAPGTDVVGLSP-RDDGLINAIDGPDNSLLVPA Rv1796|M.tuberculosis_H37Rv -------MSIAGPWVSISAPGTDVVGLSP-RDDGLINAIDGPDNSLLVPA MAV_2918|M.avium_104 GNQGQASTSVAGPWVGIAAPGTDVVGLSP-RDDGLINAIDGPDNTLLVPS MLBr_01538|M.leprae_Br4923 -------TSIAGPWVSIAAPGTDIIGLSP-RDDSLINAIDGPDNTLLVPT MAB_2225c|M.abscessus_ATCC_199 --------TMAGPWVGIAANGENVTSLSNDAEGGLANGMIGQNGKPVPLF MSMEG_0624|M.smegmatis_MC2_155 --------TMAGPWVGIAAPGENIVSVSNAPDGGLSNALPSERDRLVPLT :: ****. :* . :: .:. . *.: . . : Mflv_0755|M.gilvum_PYR-GCK GTSFSAAFVSGVAALIKQRFPELTPGQIINRITATARHPGGGVNNVVGAG Mvan_0092|M.vanbaalenii_PYR-1 GTSFSAAYVSGLAALLRQRFPELTPAQIINRITATARHPGGGVNNVVGAG TH_3348|M.thermoresistible__bu GTSFAAAYVSGLAALIRQRYPDLTPAQVINRITATARHPGGGVDNYVGAG MUL_3079|M.ulcerans_Agy99 GTSFATAIVSGVVALVRAKYPELSAYQIRNRLIHTARPPARGVDNQVGYG MMAR_2678|M.marinum_M GTSFATAIVSGVVALVRAKYPELSAYQIRNRLIHTARPPARGVDNQVGYG Mb1824|M.bovis_AF2122/97 GTSFSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDNQVGYG Rv1796|M.tuberculosis_H37Rv GTSFSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDNQVGYG MAV_2918|M.avium_104 GTSFSAAIVSGVAALVRAKYPQLSAYQVINRLTRTARAPARGVDNQVGHG MLBr_01538|M.leprae_Br4923 GTSFSAAIVSGVAALVRGRYPQLTAYQVINRLIHTARSPARGVDNQVGYG MAB_2225c|M.abscessus_ATCC_199 GTSYATAYVAGVAALVRSRYPELTAPQVISRLQRTARDAGRSPSNLVGAG MSMEG_0624|M.smegmatis_MC2_155 GTSYAAAYVSGVAALVRSKFPDLTARQVVHRLTTTAQGAARSPSNLIGAG ***:::* *:*:.**:: ::*:*:. *: *: **: .. . .* :* * Mflv_0755|M.gilvum_PYR-GCK VIDPVAALTWDVPAGPADIPYQIKEIPPPVHIPPPDRSPITGVVVVTIVV Mvan_0092|M.vanbaalenii_PYR-1 VIDPVAALTWDVPPGPADIPYNIKEIPPPVYVPPPDRSPITGVVLVGVGL TH_3348|M.thermoresistible__bu VIDPVAALTWDVPEGPETAPYRAKEIPEPEFIPPPDRGPITWVVVSSAAV MUL_3079|M.ulcerans_Agy99 VVDPVAALTWDVPEGPVKPPKQLSAPLELPKPPAERNMVPVWVAAGGLTG MMAR_2678|M.marinum_M VVDPVAALTWDVPEGPVKPPKQLSAPLELPKPPAERNMVPVWVAAGGLTG Mb1824|M.bovis_AF2122/97 VVDPVAALTWDVPKGPAEPPKQLSAPLVVPQPPAPRDMVPIWVAAGGLAG Rv1796|M.tuberculosis_H37Rv VVDPVAALTWDVPKGPAEPPKQLSAPLVVPQPPAPRDMVPIWVAAGGLAG MAV_2918|M.avium_104 IVDPVAALTWDVPDGPVKPPQQLSAPLTIPKPVPRRDMVPIWVAAGGLFG MLBr_01538|M.leprae_Br4923 IVDPLAALTWDVPEGPAKPPPQLSSPLNLPKLPAHRDMVPVWVAAGGLTT MAB_2225c|M.abscessus_ATCC_199 TVDPVAALTWEVP-ADGNASSGPGARAVVPPPPPTPENPLPRRLAFLGAG MSMEG_0624|M.smegmatis_MC2_155 MVDPVAALTWDVADVPLDGPAAPEGRPIAAPPEPEPRDNTPRIIAFVGTG :**:*****:*. . . Mflv_0755|M.gilvum_PYR-GCK AALLGIGAMARRALRRR----- Mvan_0092|M.vanbaalenii_PYR-1 AALLGIAALGRRALRRR----- TH_3348|M.thermoresistible__bu ALALGIGALTRRALRRR----- MUL_3079|M.ulcerans_Agy99 ALLIGGAVSGTATLMRRSRKRR MMAR_2678|M.marinum_M ALLIGGAVFGTATLMRRSRKRR Mb1824|M.bovis_AF2122/97 ALLIGGAVFGTATLMRRSRKQQ Rv1796|M.tuberculosis_H37Rv ALLIGGAVFGTATLMRRSRKQQ MAV_2918|M.avium_104 ALLIGGAVFGTAMLMKRSRRQQ MLBr_01538|M.leprae_Br4923 AVLIGAAAFGTAMLVRRTQK-- MAB_2225c|M.abscessus_ATCC_199 VCLIAVVVVAALSARRRQESTE MSMEG_0624|M.smegmatis_MC2_155 VLAAAVGAAFYATYRRKDKTT- . . . ::