For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. avium 104 MAV_5276 (-)

MKNPVGQAFSFLGLAAHLGRGAGRVSVDAVLGGRFGLPRTVDEIDPAVLSRVMGTTVRTVRVLSRDAGTS
SRARLVLTGKDVPDSVFVKVAAQTAATRLMGELGRLGCTEVRFYRQLAPQVVGVPYCYGAAFDAWTGRYL
LVLEDLPAEACEFPDTLHPLSADQAGLVVELLADLHATFWNRLPRDGRGPLGWLYTPSGDVTSLLTGSLM
HSSIKRLAERTSIPVRDGVFIADNYRAVAALIDTAPHTVMHGDAHPGNMYFHGGKAGLLDWQAVRRGHPS
RELAYTLITSLTPEDRRATQRDLLDDYRRALAAAGGPQLDRDELWLRFRQAALYAYAAPLITAGMGGMQV
EDIAMEGLRRGVAALEDLETVAALKSSL

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_5276	-	-	100% (378)	phosphotransferase enzyme family protein
M. avium 104	MAV_2666	-	2e-30	30.89% (327)	hypothetical protein MAV_2666
M. avium 104	MAV_1965	-	1e-27	29.64% (307)	hypothetical protein MAV_1965

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	-	-	-	-	-
M. gilvum PYR-GCK	Mflv_4117	-	1e-137	65.50% (371)	hypothetical protein Mflv_4117
M. tuberculosis H37Rv	-	-	-	-	-
M. leprae Br4923	-	-	-	-	-
M. abscessus ATCC 19977	-	-	-	-	-
M. marinum M	MMAR_0395	-	1e-117	58.07% (384)	hypothetical protein MMAR_0395
M. smegmatis MC2 155	MSMEG_2554	-	1e-142	68.21% (368)	phosphotransferase enzyme family protein
M. thermoresistible (build 8)	TH_3005	-	3e-33	32.47% (348)	PUTATIVE putative protein of unknown function DUF227
M. ulcerans Agy99	MUL_1045	-	1e-115	58.82% (374)	hypothetical protein MUL_1045
M. vanbaalenii PYR-1	Mvan_2228	-	1e-139	66.30% (368)	aminoglycoside phosphotransferase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0395|M.marinum_M               --MPENRVIALARLATHLGRGLGRVATDAVLRNARAFPRRIHDLDAPALS
MUL_1045|M.ulcerans_Agy99           -------MIALARLATHLGRGLGRVATDAVLRNARAFPRRIHDLDPPALS
Mflv_4117|M.gilvum_PYR-GCK          MSVLSERIAPAVGLASHLGRGVRRIGTDTLIGRLLPLPRTIGDLGPDAMS
Mvan_2228|M.vanbaalenii_PYR-1       MTVITQRIARAAGLAAHLGRALGRIGTDALIGRARALPRTVADLDAAAMS
MSMEG_2554|M.smegmatis_MC2_155      MLSTVRRIPPALALAAHIGHGVQRVAADAALGGLRRFPRRISDLDAGCLS
MAV_5276|M.avium_104                MKNPVGQAFSFLGLAAHLGRGAGRVSVDAVLGGRFGLPRTVDEIDPAVLS
TH_3005|M.thermoresistible__bu      ------------------------MVHPALTIPPRWEDVTPEWMTAAIST
                                                            :   :              : .   :

MMAR_0395|M.marinum_M               EIMGRRVSSVSVLDDSSGTTSRARLALSGND--VPESVFVKMAAATAATR
MUL_1045|M.ulcerans_Agy99           EIMGRRVSSVSVLDDSSGTTSRARLALSGND--VPESVFVKMAAATAATR
Mflv_4117|M.gilvum_PYR-GCK          SLMGRSVTSVAVLDGDAGTSSRARLALTGDG--VPATVFVKMAAETVATR
Mvan_2228|M.vanbaalenii_PYR-1       SVIGRAVTSVSVLDGDAGTSSRARLALTGDG--VPESVFVKMAAETVGTR
MSMEG_2554|M.smegmatis_MC2_155      TIMGRTVRTLSVLGGDAGTSSRARLALSGDG--VPETVFVKLPAETAATR
MAV_5276|M.avium_104                RVMGTTVRTVRVLSRDAGTSSRARLVLTGKD--VPDSVFVKVAAQTAATR
TH_3005|M.thermoresistible__bu      RHPGATVERVTLLLRDDGTNRRARFELAYASGTGPRRVFVKAESGVPGRR
                                       *  *  : :*  . **. ***: *:  .   *  ****  : . . *

MMAR_0395|M.marinum_M               FIGELGRLAETEVSFYRDLSP---ELAPDAPTAYGCAYDPLTGRFVLVLE
MUL_1045|M.ulcerans_Agy99           FIGELGRLAETEVSFYRDLSP---ELAPDAPTAYGCAFDPLTGRFVLVLE
Mflv_4117|M.gilvum_PYR-GCK          LMGELGNLADTETRFYSRLSA---ELT-GVPRCHGSRFDPRTGRFVLILE
Mvan_2228|M.vanbaalenii_PYR-1       LMGELGNLAETETRFYRELSP---ELTTGVPLSYGSAFDPYTGRYILVLE
MSMEG_2554|M.smegmatis_MC2_155      LMGELGRLAHTEVRFYQQLAA---GLP-GVPRAHGSAFDALTGRFVLVLE
MAV_5276|M.avium_104                LMGELGRLGCTEVRFYRQLAP---QVV-GVPYCYGAAFDAWTGRYLLVLE
TH_3005|M.thermoresistible__bu      EIHYENGNLFNESWLYRALLDGRTELPLEHPRAYAVAIDESALDYVIVFE
                                     :   .    .*  :*  *      :    * .:.   *  :  :::::*

MMAR_0395|M.marinum_M               DLAAPAEGTCDFSDTLHPFDNDQAALVVELLARLHATYWVRLN-HGGVRP
MUL_1045|M.ulcerans_Agy99           DLAAPAEGTCDFSDTLHPFDNDQAALVVELLARLHATYWVRLN-HGGVRP
Mflv_4117|M.gilvum_PYR-GCK          DLADASAGPCDFPDTLHPIDADRAALVVELLARLHATFWGRLPERRGTGP
Mvan_2228|M.vanbaalenii_PYR-1       DLAG---GDCEFPDTLHPIDADRAALVVELLATVHATFWGRLPARGHAGP
MSMEG_2554|M.smegmatis_MC2_155      DLAQ---EPCEFPDTLHPLDKDRAALTVELLARVHAAFWGRLPERSGRGP
MAV_5276|M.avium_104                DLPA---EACEFPDTLHPLSADQAGLVVELLADLHATFWNRLP-RDGRGP
TH_3005|M.thermoresistible__bu      DLLER---SADPRDPTRPLTADQVADGLQGLARLHSRHWNRVGDEPELAW
                                    **       .:  *. :*:  *:..  :: ** :*: .* *:  .     

MMAR_0395|M.marinum_M               FGWLYAASRDPSVPLVPTMLRASWRRLGGHAAALLPGRDYVFEHYRAITG
MUL_1045|M.ulcerans_Agy99           FGWRYAASRDPSVPLVPTMLRASWRRLGGHAAALLPGRDFVFEHYRAITG
Mflv_4117|M.gilvum_PYR-GCK          LGWLYSASEDSASLLTAPLLRTSARRLAERTALPVGRGRFIDENYRAAAA
Mvan_2228|M.vanbaalenii_PYR-1       LGWLYSASGDSASLLTAPLLRTSARRLAERTPLPVHRGGFIDDNYRAIAS
MSMEG_2554|M.smegmatis_MC2_155      LGWLYSASGDDTSLLTGTLLKTSTRRLAERADIPVADGRFIDENYRAAAQ
MAV_5276|M.avium_104                LGWLYTPSGDVTSLLTGSLMHSSIKRLAERTSIPVRDGVFIADNYRAVAA
TH_3005|M.thermoresistible__bu      VQPFRPTRGWTAPMTAALPHGITAARDVLSDAVTHLDADGLVDVWTAYIG
                                    .    ..    :   .      :  *              : : : *   

MMAR_0395|M.marinum_M               LIDAPPHTVLHGDAHPGNWYFRSSGGPLAAGLLDWQAVRLGHPARDLAYT
MUL_1045|M.ulcerans_Agy99           LIDAPPHTVLHGDAHPGNWYFRSSGGPLAAGLLDWQAIRLGHPARDLAYT
Mflv_4117|M.gilvum_PYR-GCK          LIDRGPHTVMHGDAHPGNLYFRAG----QAGLLDWQAVRRGHPSRELAYT
Mvan_2228|M.vanbaalenii_PYR-1       LVDRPPHTVMHGDAHPGNLYFRDG----RAGLLDWQAVRRGHPGRELAYT
MSMEG_2554|M.smegmatis_MC2_155      LLDRPPHTVMHGDAHPGNLFFRNG----EAGLLDWQAVRRGHPGRELAYT
MAV_5276|M.avium_104                LIDTAPHTVMHGDAHPGNMYFHGG----KAGLLDWQAVRRGHPSRELAYT
TH_3005|M.thermoresistible__bu      GLGTGPQTFLHGDPHIGNTYLLPDD---TVGFLDWQVVRSGHWSHDVGYF
                                     :.  *:*.:***.* ** ::  .     .*:****.:* ** .:::.* 

MMAR_0395|M.marinum_M               LITGMTTTDRRVTERELLDVYRRALAAAGGPELDREELWLRYRQAAAYAY
MUL_1045|M.ulcerans_Agy99           LITGMTTTDRRVTERELLDVYRRALAAAGGPELDREEPWLRYRQAAACAY
Mflv_4117|M.gilvum_PYR-GCK          LTTSMTVEGRRGSQRDLLEVYRRALAAGGGPELDRDDLWDRYRQAALYPY
Mvan_2228|M.vanbaalenii_PYR-1       LVTSMTTEDRRRSERDLLDVYRRALAASGGPELDGDQLWDRYRQGAMYPY
MSMEG_2554|M.smegmatis_MC2_155      LITSMTTTDRQAAEKDLLDEYRRALAAAGGPRLDADELWERYRLGAVYAY
MAV_5276|M.avium_104                LITSLTPEDRRATQRDLLDDYRRALAAAGGPQLDRDELWLRFRQAALYAY
TH_3005|M.thermoresistible__bu      LQSALTEADRRAHEAALLAHYRNALQLPEIRRPTAEEAWLRYRASAAHGL
                                    * :.:*  .*:  :  **  **.**      .   :: * *:* .*    

MMAR_0395|M.marinum_M               VATTIVAGLGGMQAADIALTGLDLTVAALHDLQTVAALRAADLGGTS---
MUL_1045|M.ulcerans_Agy99           VATTIAAGLGGMQAADIALTGLDLTVAALHDLQTVAALRAADLGGTSWAW
Mflv_4117|M.gilvum_PYR-GCK          VATLITVGMGGMQVEDIAMKGLERALEALDDLETVALLEKNL--------
Mvan_2228|M.vanbaalenii_PYR-1       VATLITAGMGGMQDDGIALKGLERSLHALDDLDTVALLEKSL--------
MSMEG_2554|M.smegmatis_MC2_155      TAPVITAGLGGMQDDGIAVEGARRGVAALADLETVALLKKLL--------
MAV_5276|M.avium_104                AAPLITAGMGGMQVEDIAMEGLRRGVAALEDLETVAALKSSL--------
TH_3005|M.thermoresistible__bu      PVWLITL-LSDAHPTERSRALVQRFAAAFTDLDTPAAVQTLRRT------
                                     .  *.  :.. :    :         *: **:* * :.           

MMAR_0395|M.marinum_M               -----------------------------------------
MUL_1045|M.ulcerans_Agy99           RPGMARSARIRPGASARRCPMVWSTSSHILGVSRHFAMGAW
Mflv_4117|M.gilvum_PYR-GCK          -----------------------------------------
Mvan_2228|M.vanbaalenii_PYR-1       -----------------------------------------
MSMEG_2554|M.smegmatis_MC2_155      -----------------------------------------
MAV_5276|M.avium_104                -----------------------------------------
TH_3005|M.thermoresistible__bu      -----------------------------------------