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AAGIRNITTTGQIGDGREAAAVDYVLAHAGAGNIDDVLATIDKFAYEKSMLINVGDEKGTLLDAAVRRAD PALALELGTYLGYGALRIARAAPEARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL TEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIE HKTHLEYQTLVPDLVLESEYLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1703c | - | - | 100% (196) | Probable catechol-o-methyltransferase |
| M. tuberculosis H37Rv | Rv0187 | - | 1e-08 | 33.09% (136) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1729c | - | 1e-111 | 100.00% (196) | catechol-o-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3499 | - | 2e-78 | 71.28% (195) | catechol O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1318c | - | 5e-74 | 67.86% (196) | catechol-o-methyltransferase |
| M. marinum M | MMAR_2507 | - | 8e-94 | 85.28% (197) | O-methyltransferase |
| M. avium 104 | MAV_3069 | - | 5e-91 | 81.73% (197) | catechol-O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0224 | - | 2e-11 | 35.29% (136) | O-methyltransferase MdmC |
| M. thermoresistible (build 8) | TH_1541 | - | 3e-80 | 72.59% (197) | Probable catechol-o-methyltransferase |
| M. ulcerans Agy99 | MUL_1691 | - | 5e-94 | 85.28% (197) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3280 | - | 5e-85 | 76.02% (196) | catechol O-methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3499|M.gilvum_PYR-GCK ----MNALRRWA-------RLALGMRSFVRTGQMGDGRESACADHVETHA
Mvan_3280|M.vanbaalenii_PYR-1 ----MNAIRRWA-------RLALGMPSFVRTGQIGDGREAACAAYVEANA
Rv1703c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1729c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2507|M.marinum_M ----MRLNARFAPLRWSVLRLALAFRTLLRTGQVGDGREAAAVDYVLEHA
MUL_1691|M.ulcerans_Agy99 --------------------------------------------------
MAV_3069|M.avium_104 ----MDLKRRIPLLRWSVWRMAAGVQNITTTGQIGDGREAAAVEYVLRNA
TH_1541|M.thermoresistible__bu --------------------MTMTQHRLTTTGQIGDGREAAAADYVERHA
MAB_1318c|M.abscessus_ATCC_199 MSLTRTLKQKLPFLRYSFLRAVFGGLNVMRTGQMGDGREEATAEHVVATA
MSMEG_0224|M.smegmatis_MC2_155 ------------------------------------MAEPSDVDVLFNQL
Mflv_3499|M.gilvum_PYR-GCK APGDIDAALSAIDGFAVREAVLVNVGVEKGALLDAAVRRADPALALELGT
Mvan_3280|M.vanbaalenii_PYR-1 PRGDIDAALSAIDTFAYRKAMLVNIGDEKGALLDAAVRRADPALVLELGT
Rv1703c|M.tuberculosis_H37Rv -------MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGT
Mb1729c|M.bovis_AF2122/97 -------MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGT
MMAR_2507|M.marinum_M RTGDIDDVLATIDKFAYEKSILVNVGDEKGLLLDAAVRRADPALALELGT
MUL_1691|M.ulcerans_Agy99 -------MLATIDKFAYEKSILVNVGDEKGLLLDAAVRRADPALALELGT
MAV_3069|M.avium_104 RAGDIDDVLATIDRFAYQKSMLINVGDEKGLILDAAVRRADPDVALELGT
TH_1541|M.thermoresistible__bu RPGDIDDVLDIIDEYAYRKSFLVNIGDEKGLLLDAAVRRADPELALELGT
MAB_1318c|M.abscessus_ATCC_199 PAGDIDAAIEAIDNFAYDQSILMNVGDEKGQLLDAAVKRANPKIALELGA
MSMEG_0224|M.smegmatis_MC2_155 LQTEDQALAAARESTQAAGMPAIEVSAQHGKLLSLLAGISGARRVLEIGT
: :::. ::* :*. . :.. .**:*:
Mflv_3499|M.gilvum_PYR-GCK YCGYSALRIAR-AAPSARVLSVEFSAANAEVARRIWTHAGVADRVTCVVG
Mvan_3280|M.vanbaalenii_PYR-1 YCGYSALRIAR-AAPSARVLSVEFSAANADVARRIWAHAGVGDRVTCVVG
Rv1703c|M.tuberculosis_H37Rv YLGYGALRIAR-AAPEARVYSVELAEANASNARRIWAHAGVDDRVVCVVG
Mb1729c|M.bovis_AF2122/97 YLGYGALRIAR-AAPEARVYSVELAEANASNARRIWAHAGVDDRVVCVVG
MMAR_2507|M.marinum_M YCGYGALRIAR-AAPQAKVYSVELAEANAANARQIWAHAGVADRVTCVVG
MUL_1691|M.ulcerans_Agy99 YCGYGALRIAR-AAPQAKVYSVELAEANAANARQIWAHAGVADRVTCVVG
MAV_3069|M.avium_104 YCGYGALRIAR-AAPGARVFSVELAEANAANARRIWAHAGVADRVTCVVG
TH_1541|M.thermoresistible__bu YCGYGALRIAR-AAPAARVISVELAEANAQVARRIWAHAGVSDRISCVVG
MAB_1318c|M.abscessus_ATCC_199 YCGYSGLRIAR-AAPGAKFFSIEKSGANASVARRVWAHAGLADRATCLTG
MSMEG_0224|M.smegmatis_MC2_155 LAGYSTINLARGVGADGRVVTCEYEPRHAEVARANLERAGVAGRVEILVG
**. :.:** ... .:. : * :* ** :**: .* :.*
Mflv_3499|M.gilvum_PYR-GCK TLGDGGRTLDSLAGEHGVGPGSVDLLFIDHDNSAYLSDLLSIEQRGWLHR
Mvan_3280|M.vanbaalenii_PYR-1 TLGDGGRTLDTLAREHGVTTGSVDLLFIDHDKKAYLSDLRSVEQRGWLHR
Rv1703c|M.tuberculosis_H37Rv TIGDGGRTLDAL-TEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHP
Mb1729c|M.bovis_AF2122/97 TIGDGGRTLDAL-TEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHP
MMAR_2507|M.marinum_M TIGDGGRTLDALATEHGFAPGALDFVFVDHDKKAYLDDLQSILDREWLHR
MUL_1691|M.ulcerans_Agy99 TIGDGGRTLDALATEHGFAPGALDFVFVDHDKKAYLDDLQSILDREWLHR
MAV_3069|M.avium_104 TIGDGGRTLDVLANEHGFAAGTLDFVFLDHDKDAYLADLKSIMDRGWLHP
TH_1541|M.thermoresistible__bu TIDDGGRTLEALNREHKVSAAALGLVFLDHNKERYLPDLRTIMDQGWLRP
MAB_1318c|M.abscessus_ATCC_199 TADDG-VTLDTLAKDYGFTEGCLDFVFIDHWKDIYLDDLQRLLERGWLHP
MSMEG_0224|M.smegmatis_MC2_155 ------TALDTLPKLAERGD-VFDLVFIDADKENNVAYVEWAIKLG--HP
:*: * ..::*:* :. : : . :
Mflv_3499|M.gilvum_PYR-GCK GSLVVADNVRIPG---APEYRRYMREHEGTRWHTVEHKTHVEYQSLLPDL
Mvan_3280|M.vanbaalenii_PYR-1 GSIVVADNVRVPG---APDYRRHMREQQGTRWNTVEHKTHVEYQSLLPDL
Rv1703c|M.tuberculosis_H37Rv GSIVVADNVRVPG---APKYRAYMRRQQGMSWNTIEHKTHLEYQTLVPDL
Mb1729c|M.bovis_AF2122/97 GSIVVADNVRVPG---APKYRAYMRRQQGMSWNTIEHKTHLEYQTLVPDL
MMAR_2507|M.marinum_M GSIVVADNVKVPG---APEYHEYMRHHQGTLWDTTEHKTHLEYQTLVSDL
MUL_1691|M.ulcerans_Agy99 GSIVVADNVKVPG---APEYHEYMRHHQGTLWDTTEHKTHLEYQTLVSDL
MAV_3069|M.avium_104 GSIVVADNIRWPG---SPKYREYMHVQQGKRFDTVEHKTHAEYQTMLSDL
TH_1541|M.thermoresistible__bu GAVVVADNVRLPG---SPRYRAYMREQQGITWRTTEHKTHGEYGIELPDL
MAB_1318c|M.abscessus_ATCC_199 GTIVVADNVRFPG---APKYRAYMKDQQGKLWQTIEHETHVEYQTLVKDL
MSMEG_0224|M.smegmatis_MC2_155 GTVVVVDNVTRFGRVLEPAPDDLQARGVRDMLQMMGEHPRLDAAAIQTVG
*::**.**: * * ...: :
Mflv_3499|M.gilvum_PYR-GCK VLESEYLVGS---
Mvan_3280|M.vanbaalenii_PYR-1 VLESEYLGS----
Rv1703c|M.tuberculosis_H37Rv VLESEYLG-----
Mb1729c|M.bovis_AF2122/97 VLESEYLG-----
MMAR_2507|M.marinum_M VLESDYLG-----
MUL_1691|M.ulcerans_Agy99 VLESDYLG-----
MAV_3069|M.avium_104 MLESEYLG-----
TH_1541|M.thermoresistible__bu VLESVYLGG----
MAB_1318c|M.abscessus_ATCC_199 VLESEYLG-----
MSMEG_0224|M.smegmatis_MC2_155 AKGWDGFAVAVIS
: