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MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHEAGPHDHTVPPVVEQLKVKAKQQGLWNLFLPAES GLTNLEYAPLAEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQWLEPLLAGEIRSAFSMTEPAV ASSDARNIETSIVRDGADYVINGRKWWTSGAADPRCKILIVMGRTNPDAASHQQQSMVLVPMDTPGVTVV RSTPVFGWQDQHGHCEIVYDNVRVPVTNLLGEEGSGFAIAQARLGPGRIHHCMRALGGAERALALMVDRA QKRVAFGRPLAEQGVVRESIAKSRNEIDQARLLCEKAAWTIDQHGNKAAHLLVSQIKAVAPKVACDVIDR AIQVHGAAGVSDDTVLARLYGWHRAMRIFDGPDEVHMRTIARAELGREKSALAAAVTAHA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5144 | - | - | 100% (410) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_5173 | - | 3e-63 | 38.96% (367) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_3944 | - | 2e-60 | 38.83% (394) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0159c | fadE2 | 0.0 | 85.61% (403) | acyl-CoA dehydrogenase FADE2 |
| M. gilvum PYR-GCK | Mflv_0734 | - | 0.0 | 83.54% (407) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0154c | fadE2 | 0.0 | 85.61% (403) | acyl-CoA dehydrogenase FADE2 |
| M. leprae Br4923 | MLBr_00660 | fadE23 | 5e-21 | 28.77% (285) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0255 | - | 1e-101 | 49.51% (408) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_0374 | fadE2 | 0.0 | 87.53% (409) | acyl-CoA dehydrogenase FadE2 |
| M. smegmatis MC2 155 | MSMEG_0102 | - | 0.0 | 85.50% (407) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3078 | - | 0.0 | 83.67% (392) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4790 | fadE1 | 2e-64 | 39.12% (363) | acyl-CoA dehydrogenase FadE1 |
| M. vanbaalenii PYR-1 | Mvan_0116 | - | 0.0 | 82.89% (409) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0159c|M.bovis_AF2122/97 -----------------MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRA
Rv0154c|M.tuberculosis_H37Rv -----------------MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRA
MMAR_0374|M.marinum_M -------MSYRGGMDFAMSAKAIDYHQRLSDFMTEYVFPAEADYDKYRED
MAV_5144|M.avium_104 -------------MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHE
MSMEG_0102|M.smegmatis_MC2_155 ----------MAGMDFAMSAKAADYHKRLTDFMVEFVFPAEAEYHAYREE
TH_3078|M.thermoresistible__bu ----------------------------LTEFMTEFVFPAEPEYDRYREE
Mflv_0734|M.gilvum_PYR-GCK -------------MDFAMSAKAQDYHDRLTDFMTEHVFPAEESYHSYRAE
Mvan_0116|M.vanbaalenii_PYR-1 MDLTVYTCHIVAVMDFSMSAKAQDYHDRLTDFMTESVFPAEESYHAYRAE
MAB_0255|M.abscessus_ATCC_1997 -------------MDFAPSARAAELIAAVREFIDAEVMPVERAVLAHHDE
MUL_4790|M.ulcerans_Agy99 ------------MWDFETDPEYQAKLDWVQEFMVNELEPLDLVALDPYDK
MLBr_00660|M.leprae_Br4923 -----------MAINLELSRKLQAVIVKTHQGAAELMRPIARKYDLKEHT
: :
Mb0159c|M.bovis_AF2122/97 A-GPAD------HTAPPIIEELKTKAKDRGLWNLFLSAE---SGLTNLEY
Rv0154c|M.tuberculosis_H37Rv A-GPAD------HTAPPIIEELKTKAKDRGLWNLFLSAE---SGLTNLEY
MMAR_0374|M.marinum_M A-GPND------HTVPPVVEELKANAKARGLWNLFLPAE---SGLTNLEY
MAV_5144|M.avium_104 A-GPHD------HTVPPVVEQLKVKAKQQGLWNLFLPAE---SGLTNLEY
MSMEG_0102|M.smegmatis_MC2_155 K-GPKD------HTVPPVVEELKVKAKDRGLWNLFLPAE---SGLTNLEY
TH_3078|M.thermoresistible__bu K-GPND------FTVPPIVEELKVKARERGLWNLFLPPV---SGLTNLEY
Mflv_0734|M.gilvum_PYR-GCK A-GPKD------HTVPPVVEELKKQAKERGLWNLFLPSV---SGLSNLEY
Mvan_0116|M.vanbaalenii_PYR-1 A-GPDD------HTVPPVVEELKKLAKARGLWNLFLPSE---SGLSNLEY
MAB_0255|M.abscessus_ATCC_1997 LLGARAGTTAELWHVPPELDSLKAKARAAGLWNLFLPDPELGGGLSNSEY
MUL_4790|M.ulcerans_Agy99 K-----------NPEMMAVLRPLQQVKNQGLWAAHLRPEVGGQGFGQVKL
MLBr_00660|M.leprae_Br4923 YPVELDT----LFNLFAGAAESFAFAGADALGDEDNKDE----NHNGANM
. .* . :
Mb0159c|M.bovis_AF2122/97 APLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLLDG
Rv0154c|M.tuberculosis_H37Rv APLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLLDG
MMAR_0374|M.marinum_M APLAELTGWSLEIAPEALNCAAPDTGNMEILHMFGTDEQRRQWLDPLLHG
MAV_5144|M.avium_104 APLAEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQWLEPLLAG
MSMEG_0102|M.smegmatis_MC2_155 APLAEITGWSMEIAPEALNCQAPDTGNMETLHLFANEAQRKQWLEPLLAG
TH_3078|M.thermoresistible__bu AALAEISGWSTVIAPEAINCAAPDTGNMETLHLFANEQQRKQWLEPLLNG
Mflv_0734|M.gilvum_PYR-GCK APLAELTGWSMEIAPEATNCAAPDTGNMETLHLFATEEQRTQWLEPLLAG
Mvan_0116|M.vanbaalenii_PYR-1 APLAELTGWSMEIAPEATNCAAPDTGNMETLHLFATEEQRKQWLEPLLAG
MAB_0255|M.abscessus_ATCC_1997 APLAEQMGRSL-FAPTVFNCNAPDSGNMEVLHRYGSQEQKEVWLEPLLEG
MUL_4790|M.ulcerans_Agy99 ALLNEILGRSR-WAPSVFGCQAPDSGNAEILALFGTEDQKARYLQPLLDG
MLBr_00660|M.leprae_Br4923 AALLQTLEACWGDVAMLLSIPYQGLGNAAISAVATNKQLER-------LG
* * : . .. . . ** .. . *
Mb0159c|M.bovis_AF2122/97 KIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPRCK
Rv0154c|M.tuberculosis_H37Rv KIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPRCK
MMAR_0374|M.marinum_M EIRSAFSMTEPAVASSDARNIETTISRDGADYIINGRKWWTSGAADPRCK
MAV_5144|M.avium_104 EIRSAFSMTEPAVASSDARNIETSIVRDGADYVINGRKWWTSGAADPRCK
MSMEG_0102|M.smegmatis_MC2_155 EIRSAFAMTEPAVASSDARNIETTMLRDGDHYVINGRKWWITGAADPRCK
TH_3078|M.thermoresistible__bu EIRSAFAMTEPAVASSDARNIETTMLRDGDHYVINGRKWWITGAADPRCK
Mflv_0734|M.gilvum_PYR-GCK EIRSAFAMTEPAVASSDARNIETTMLRDGDDYVINGRKWWITGAADPRCK
Mvan_0116|M.vanbaalenii_PYR-1 EIRSAFAMTEPAVASSDARNIETTMLRDGDDYVINGRKWWITGAADPRCK
MAB_0255|M.abscessus_ATCC_1997 DIRSAFCMTEPDVASSDATNMAATAVVEGDEVVINGRKWWSTGVGHPDCK
MUL_4790|M.ulcerans_Agy99 EITSCYSMTEPQGGS-DPGSFVTAATRDGDSWIINGEKWFSTNAKH--AS
MLBr_00660|M.leprae_Br4923 KVWAAMAITEPGFGS-DSAAVSTTATLDGDEYVINGEKIFVTAGSR---A
.: :. .:*** .* *. . :: :* :***.* : :
Mb0159c|M.bovis_AF2122/97 ILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHG-HCE
Rv0154c|M.tuberculosis_H37Rv ILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHG-HCE
MMAR_0374|M.marinum_M ILIVMGRTNPDAAAHQQQSMILVPTDTPGVTIARSTPVFGWQDQHG-HCE
MAV_5144|M.avium_104 ILIVMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHG-HCE
MSMEG_0102|M.smegmatis_MC2_155 ILIVMGRTNPDAAAHQQQSMILVPVDTPGVDIQRSLPVFGWQDQHG-HCE
TH_3078|M.thermoresistible__bu ILIVMGRTNPDAASHQQQSMILVPADTPGVDIRRSLPVFGWQDQHG-HCE
Mflv_0734|M.gilvum_PYR-GCK ILIVMGRTNPDGPSHRQQSMILVPTDTPGVSIERSLPVFGWQDQHG-HCE
Mvan_0116|M.vanbaalenii_PYR-1 ILIVMGRTNPDGPSHRQQSMILVPADTPGVDIQRSLPVFGWQDQHG-HCE
MAB_0255|M.abscessus_ATCC_1997 VIIFMGLTDPNAHRYARHSMVLVPMDTPGITVERMLPTMGFYDEPGGHGV
MUL_4790|M.ulcerans_Agy99 FFIVMAVTNPQARTYEKMSLFIVPAETPGIEIVRNVGVGTESSKHASHGY
MLBr_00660|M.leprae_Br4923 THIVVWATLDKSLGHAAIKSFIVPREHPGVTVERLEYKLGIRGSDT--AA
*.: * .. : . .:** : **: : * .
Mb0159c|M.bovis_AF2122/97 IDYHNVRVPATNLLGEE----GSGFAIAQARLGPGRIHHCMRALGAAERA
Rv0154c|M.tuberculosis_H37Rv IDYHNVRVPATNLLGEE----GSGFAIAQARLGPGRIHHCMRALGAAERA
MMAR_0374|M.marinum_M VVYDNVRVPATNLLGEE----GTGFAIAQARLGPGRIHHCMRALGGAERA
MAV_5144|M.avium_104 IVYDNVRVPVTNLLGEE----GSGFAIAQARLGPGRIHHCMRALGGAERA
MSMEG_0102|M.smegmatis_MC2_155 IVFNDVRVPAENLLDVE----GSGFAIAQARLGPGRIHHCMRAIGAAERA
TH_3078|M.thermoresistible__bu IVFDNVRVPVENLLGEE----GAGFAIAQARLGPGRIHHCMRALGAAERA
Mflv_0734|M.gilvum_PYR-GCK ITFDNVRVPASNLLDEE----GSGFAIAQARLGPGRIHHCMRAIGAAERA
Mvan_0116|M.vanbaalenii_PYR-1 IVFDNVRVPASNLLDEE----GSGFAIAQARLGPGRIHHCMRAIGAAERA
MAB_0255|M.abscessus_ATCC_1997 VSFDNVRLPADAFIAGP----GKGFEIAQGRLGPGRVHHAMRLIGLAEVA
MUL_4790|M.ulcerans_Agy99 VRYHDVRVPADHVLGGE----GQAFMTAQTRLGGGRIHHAMRTIALARRA
MLBr_00660|M.leprae_Br4923 IRFDNVRIPKDNLLGNPEIEVGKGFSGVMETFDNTRPIVAAMAVGVGRAA
: :.:**:* .: * .* . :. * . :. .. *
Mb0159c|M.bovis_AF2122/97 LALMVNRVRNR---VAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAW
Rv0154c|M.tuberculosis_H37Rv LALMVNRVRNR---VAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAW
MMAR_0374|M.marinum_M LALMVDRARNR---VAFGRPLAEQGVVQQAIAKSRNEIDQARLLCEKAAW
MAV_5144|M.avium_104 LALMVDRAQKR---VAFGRPLAEQGVVRESIAKSRNEIDQARLLCEKAAW
MSMEG_0102|M.smegmatis_MC2_155 LTLMVDRVQKR---VAFGKPLAEQGVVREAIAKSRNEIDQARLLCEKAAW
TH_3078|M.thermoresistible__bu LALMVDRVQKR---VAFGKPLAEQGVVREAIAKSRNEIDQARMLCHKAAW
Mflv_0734|M.gilvum_PYR-GCK LALMVDRVQTR---IAFGKPLAEQGVVREAIAKSRNDIEQTRMLCHKAAW
Mvan_0116|M.vanbaalenii_PYR-1 LALMIDRVQTR---IAFGKPLAEQGVVREAIAKSRNEIEQTRLLCHKAAW
MAB_0255|M.abscessus_ATCC_1997 LEHACRRGLDR---TAFGKPLVNLGGNRERIADARIAINQTRLLVLHAAW
MUL_4790|M.ulcerans_Agy99 FDMMCERAVSR---QTRHGRLSDLQMTQEKVADSWIQIEQFRLLVLRTAW
MLBr_00660|M.leprae_Br4923 LEEIRKILTDAGIEICYDKPSHSQNAAAAEFLRMEADWEASYLLSLRAAW
: . . : :* ::**
Mb0159c|M.bovis_AF2122/97 TIDQHGN--KEARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDTPLA
Rv0154c|M.tuberculosis_H37Rv TIDQHGN--KEARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDTPLA
MMAR_0374|M.marinum_M TIDRHGN--KEARHLVAMIKAVAPQVACDVIDRAIQVHGAAGVSNDTPLA
MAV_5144|M.avium_104 TIDQHGN--KAAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGVSDDTVLA
MSMEG_0102|M.smegmatis_MC2_155 TIDLQGN--KAAHVLVSQIKSVAPQVACNVLDRAIQVHGAAGVGDDFPLA
TH_3078|M.thermoresistible__bu TIDQLGNKHKEAQVQVAQIKAVAPTVACNVIDRAIQVHGGAGVSDDFPLA
Mflv_0734|M.gilvum_PYR-GCK TIDQHGNKSKDAQLLVAQIKAVAPQMACDVIDRAIQVHGGAGVSDDFPLA
Mvan_0116|M.vanbaalenii_PYR-1 TIDQQGNKSKDAQLLVAQIKAVAPQMACDVIDRAIQVHGGAGVCDDFPLA
MAB_0255|M.abscessus_ATCC_1997 LLDTVGI--MGALSAVSEIKVAAPNMAQQVIDMAIQIHGGGGLSNDFPLA
MUL_4790|M.ulcerans_Agy99 LIDKHHD-YQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFV
MLBr_00660|M.leprae_Br4923 QADNNIP----NSKEASMSKAKAGRMASDVTLKAVELAGTAGYSEKALLE
* : * : :* *:.: * * :. :
Mb0159c|M.bovis_AF2122/97 RLYGWHRAMRIFDGPDEVHLRSIARAELSREKSTFAAAVT----------
Rv0154c|M.tuberculosis_H37Rv RLYGWHRAMRIFDGPDEVHLRSIARAELSREKSTFAAAVT----------
MMAR_0374|M.marinum_M RLYSWHRAMRIFDGPDEVHMRSIARAELGREKSAFAAAVTSHG-------
MAV_5144|M.avium_104 RLYGWHRAMRIFDGPDEVHMRTIARAELGREKSALAAAVTAHA-------
MSMEG_0102|M.smegmatis_MC2_155 RLYAWHRAMRLFDGPDEVHMRTIARSELGREKSPLALAVTK---------
TH_3078|M.thermoresistible__bu RLYAWHRAMRLFDGPDEVHMRTIARAELGKEKSPLAAAAIKVSSS-----
Mflv_0734|M.gilvum_PYR-GCK RLYSWHRAMRLFDGPDEVHMRTIARAELGREKSALATAACRVSHPGAAG-
Mvan_0116|M.vanbaalenii_PYR-1 RLYSWHRAMRLFDGPDEVHMRTIARAELGREKSAMATAASRQSDTAASRQ
MAB_0255|M.abscessus_ATCC_1997 AAWVNARALRLADGPDEVHRGVVARIELAKYAND----------------
MUL_4790|M.ulcerans_Agy99 KMMVAAESLGIADGATELHKMTVARRTLRQYEPVATPFPSQHIPTRRAAA
MLBr_00660|M.leprae_Br4923 KWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK--------------
. : : :*. ::: :** *
Mb0159c|M.bovis_AF2122/97 ---------------
Rv0154c|M.tuberculosis_H37Rv ---------------
MMAR_0374|M.marinum_M ---------------
MAV_5144|M.avium_104 ---------------
MSMEG_0102|M.smegmatis_MC2_155 ---------------
TH_3078|M.thermoresistible__bu ---------------
Mflv_0734|M.gilvum_PYR-GCK ---------------
Mvan_0116|M.vanbaalenii_PYR-1 SNPAASRQSETAVTG
MAB_0255|M.abscessus_ATCC_1997 ---------------
MUL_4790|M.ulcerans_Agy99 EARLAERLEHSIAEF
MLBr_00660|M.leprae_Br4923 ---------------