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AGMDFAMSAKAADYHKRLTDFMVEFVFPAEAEYHAYREEKGPKDHTVPPVVEELKVKAKDRGLWNLFLPA ESGLTNLEYAPLAEITGWSMEIAPEALNCQAPDTGNMETLHLFANEAQRKQWLEPLLAGEIRSAFAMTEP AVASSDARNIETTMLRDGDHYVINGRKWWITGAADPRCKILIVMGRTNPDAAAHQQQSMILVPVDTPGVD IQRSLPVFGWQDQHGHCEIVFNDVRVPAENLLDVEGSGFAIAQARLGPGRIHHCMRAIGAAERALTLMVD RVQKRVAFGKPLAEQGVVREAIAKSRNEIDQARLLCEKAAWTIDLQGNKAAHVLVSQIKSVAPQVACNVL DRAIQVHGAAGVGDDFPLARLYAWHRAMRLFDGPDEVHMRTIARSELGREKSPLALAVTK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0102 | - | - | 100% (411) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4826 | - | 2e-66 | 43.06% (353) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2070 | - | 2e-39 | 29.30% (413) | acyl-CoA dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0159c | fadE2 | 0.0 | 79.90% (403) | acyl-CoA dehydrogenase FADE2 |
| M. gilvum PYR-GCK | Mflv_0734 | - | 0.0 | 84.63% (410) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0154c | fadE2 | 0.0 | 79.90% (403) | acyl-CoA dehydrogenase FADE2 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-21 | 27.15% (291) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0255 | - | 1e-105 | 50.25% (408) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_0374 | fadE2 | 0.0 | 81.62% (408) | acyl-CoA dehydrogenase FadE2 |
| M. avium 104 | MAV_5144 | - | 0.0 | 85.50% (407) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3078 | - | 0.0 | 87.09% (395) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4790 | fadE1 | 2e-63 | 37.34% (391) | acyl-CoA dehydrogenase FadE1 |
| M. vanbaalenii PYR-1 | Mvan_0116 | - | 0.0 | 85.71% (413) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0159c|M.bovis_AF2122/97 -----------------MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRA
Rv0154c|M.tuberculosis_H37Rv -----------------MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRA
MMAR_0374|M.marinum_M -------MSYRGGMDFAMSAKAIDYHQRLSDFMTEYVFPAEADYDKYRED
MAV_5144|M.avium_104 -------------MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHE
MSMEG_0102|M.smegmatis_MC2_155 ----------MAGMDFAMSAKAADYHKRLTDFMVEFVFPAEAEYHAYREE
TH_3078|M.thermoresistible__bu ----------------------------LTEFMTEFVFPAEPEYDRYREE
Mflv_0734|M.gilvum_PYR-GCK -------------MDFAMSAKAQDYHDRLTDFMTEHVFPAEESYHSYRAE
Mvan_0116|M.vanbaalenii_PYR-1 MDLTVYTCHIVAVMDFSMSAKAQDYHDRLTDFMTESVFPAEESYHAYRAE
MAB_0255|M.abscessus_ATCC_1997 -------------MDFAPSARAAELIAAVREFIDAEVMPVERAVLAHHDE
MUL_4790|M.ulcerans_Agy99 ------------MWDFETDPEYQAKLDWVQEFMVNELEPLDLVALDPYDK
MLBr_00737|M.leprae_Br4923 ----------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD
:: :
Mb0159c|M.bovis_AF2122/97 A-GPAD------HTAPPIIEELKTKAKDRGLWNLFLSAE---SGLTNLEY
Rv0154c|M.tuberculosis_H37Rv A-GPAD------HTAPPIIEELKTKAKDRGLWNLFLSAE---SGLTNLEY
MMAR_0374|M.marinum_M A-GPND------HTVPPVVEELKANAKARGLWNLFLPAE---SGLTNLEY
MAV_5144|M.avium_104 A-GPHD------HTVPPVVEQLKVKAKQQGLWNLFLPAE---SGLTNLEY
MSMEG_0102|M.smegmatis_MC2_155 K-GPKD------HTVPPVVEELKVKAKDRGLWNLFLPAE---SGLTNLEY
TH_3078|M.thermoresistible__bu K-GPND------FTVPPIVEELKVKARERGLWNLFLPPV---SGLTNLEY
Mflv_0734|M.gilvum_PYR-GCK A-GPKD------HTVPPVVEELKKQAKERGLWNLFLPSV---SGLSNLEY
Mvan_0116|M.vanbaalenii_PYR-1 A-GPDD------HTVPPVVEELKKLAKARGLWNLFLPSE---SGLSNLEY
MAB_0255|M.abscessus_ATCC_1997 LLGARAGTTAELWHVPPELDSLKAKARAAGLWNLFLPDPELGGGLSNSEY
MUL_4790|M.ulcerans_Agy99 K-----------NPEMMAVLRPLQQVKNQGLWAAHLRPEVGGQGFGQVKL
MLBr_00737|M.leprae_Br4923 V-----------DQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAA
. *: .: * .
Mb0159c|M.bovis_AF2122/97 APLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLLDG
Rv0154c|M.tuberculosis_H37Rv APLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLLDG
MMAR_0374|M.marinum_M APLAELTGWSLEIAPEALNCAAPDTGNMEILHMFGTDEQRRQWLDPLLHG
MAV_5144|M.avium_104 APLAEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQWLEPLLAG
MSMEG_0102|M.smegmatis_MC2_155 APLAEITGWSMEIAPEALNCQAPDTGNMETLHLFANEAQRKQWLEPLLAG
TH_3078|M.thermoresistible__bu AALAEISGWSTVIAPEAINCAAPDTGNMETLHLFANEQQRKQWLEPLLNG
Mflv_0734|M.gilvum_PYR-GCK APLAELTGWSMEIAPEATNCAAPDTGNMETLHLFATEEQRTQWLEPLLAG
Mvan_0116|M.vanbaalenii_PYR-1 APLAELTGWSMEIAPEATNCAAPDTGNMETLHLFATEEQRKQWLEPLLAG
MAB_0255|M.abscessus_ATCC_1997 APLAEQMGRSL-FAPTVFNCNAPDSGNMEVLHRYGSQEQKEVWLEPLLEG
MUL_4790|M.ulcerans_Agy99 ALLNEILGRSR-WAPSVFGCQAPDSGNAEILALFGTEDQKARYLQPLLDG
MLBr_00737|M.leprae_Br4923 CIVIEEVARVDASASLIP---AVNKLGTMGLILRGSEELKKQVLPSLAAE
. : * . *. * :. . * ..: : * .*
Mb0159c|M.bovis_AF2122/97 KIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPRCK
Rv0154c|M.tuberculosis_H37Rv KIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPRCK
MMAR_0374|M.marinum_M EIRSAFSMTEPAVASSDARNIETTISRDGADYIINGRKWWTSGAADPRCK
MAV_5144|M.avium_104 EIRSAFSMTEPAVASSDARNIETSIVRDGADYVINGRKWWTSGAADPRCK
MSMEG_0102|M.smegmatis_MC2_155 EIRSAFAMTEPAVASSDARNIETTMLRDGDHYVINGRKWWITGAADPRCK
TH_3078|M.thermoresistible__bu EIRSAFAMTEPAVASSDARNIETTMLRDGDHYVINGRKWWITGAADPRCK
Mflv_0734|M.gilvum_PYR-GCK EIRSAFAMTEPAVASSDARNIETTMLRDGDDYVINGRKWWITGAADPRCK
Mvan_0116|M.vanbaalenii_PYR-1 EIRSAFAMTEPAVASSDARNIETTMLRDGDDYVINGRKWWITGAADPRCK
MAB_0255|M.abscessus_ATCC_1997 DIRSAFCMTEPDVASSDATNMAATAVVEGDEVVINGRKWWSTGVGHPDCK
MUL_4790|M.ulcerans_Agy99 EITSCYSMTEPQGGS-DPGSFVTAATRDGDSWIINGEKWFSTNAKH--AS
MLBr_00737|M.leprae_Br4923 GAMASYALSE-REAGSDAASMRTRAKADGDDWILNGFKCWITNGGK--ST
:.:.::* .. *. .: : :* ::** * : :. . ..
Mb0159c|M.bovis_AF2122/97 ILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHG-HCE
Rv0154c|M.tuberculosis_H37Rv ILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHG-HCE
MMAR_0374|M.marinum_M ILIVMGRTNPDAAAHQQQSMILVPTDTPGVTIARSTPVFGWQDQHG-HCE
MAV_5144|M.avium_104 ILIVMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHG-HCE
MSMEG_0102|M.smegmatis_MC2_155 ILIVMGRTNPDAAAHQQQSMILVPVDTPGVDIQRSLPVFGWQDQHG-HCE
TH_3078|M.thermoresistible__bu ILIVMGRTNPDAASHQQQSMILVPADTPGVDIRRSLPVFGWQDQHG-HCE
Mflv_0734|M.gilvum_PYR-GCK ILIVMGRTNPDGPSHRQQSMILVPTDTPGVSIERSLPVFGWQDQHG-HCE
Mvan_0116|M.vanbaalenii_PYR-1 ILIVMGRTNPDGPSHRQQSMILVPADTPGVDIQRSLPVFGWQDQHG-HCE
MAB_0255|M.abscessus_ATCC_1997 VIIFMGLTDPNAHRYARHSMVLVPMDTPGITVERMLPTMGFYDEPGGHGV
MUL_4790|M.ulcerans_Agy99 FFIVMAVTNPQARTYEKMSLFIVPAETPGIEIVRNVGVGTESSKHASHGY
MLBr_00737|M.leprae_Br4923 WYTVMAVTDPDKGANG-ISAFIVHKDDEGFSIGPKEKKLGIKGSPT--TE
.*. *:*: * .:* : *. : .
Mb0159c|M.bovis_AF2122/97 IDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALM
Rv0154c|M.tuberculosis_H37Rv IDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALM
MMAR_0374|M.marinum_M VVYDNVRVPATNLLGEEGTGFAIAQARLGPGRIHHCMRALGGAERALALM
MAV_5144|M.avium_104 IVYDNVRVPVTNLLGEEGSGFAIAQARLGPGRIHHCMRALGGAERALALM
MSMEG_0102|M.smegmatis_MC2_155 IVFNDVRVPAENLLDVEGSGFAIAQARLGPGRIHHCMRAIGAAERALTLM
TH_3078|M.thermoresistible__bu IVFDNVRVPVENLLGEEGAGFAIAQARLGPGRIHHCMRALGAAERALALM
Mflv_0734|M.gilvum_PYR-GCK ITFDNVRVPASNLLDEEGSGFAIAQARLGPGRIHHCMRAIGAAERALALM
Mvan_0116|M.vanbaalenii_PYR-1 IVFDNVRVPASNLLDEEGSGFAIAQARLGPGRIHHCMRAIGAAERALALM
MAB_0255|M.abscessus_ATCC_1997 VSFDNVRLPADAFIAGPGKGFEIAQGRLGPGRVHHAMRLIGLAEVALEHA
MUL_4790|M.ulcerans_Agy99 VRYHDVRVPADHVLGGEGQAFMTAQTRLGGGRIHHAMRTIALARRAFDMM
MLBr_00737|M.leprae_Br4923 LYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAA
: :.. *:* .: * .* * *. * : :. *. *:
Mb0159c|M.bovis_AF2122/97 VNRVRNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGN
Rv0154c|M.tuberculosis_H37Rv VNRVRNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGN
MMAR_0374|M.marinum_M VDRARNRVAFGRPLAEQGVVQQAIAKSRNEIDQARLLCEKAAWTIDRHGN
MAV_5144|M.avium_104 VDRAQKRVAFGRPLAEQGVVRESIAKSRNEIDQARLLCEKAAWTIDQHGN
MSMEG_0102|M.smegmatis_MC2_155 VDRVQKRVAFGKPLAEQGVVREAIAKSRNEIDQARLLCEKAAWTIDLQGN
TH_3078|M.thermoresistible__bu VDRVQKRVAFGKPLAEQGVVREAIAKSRNEIDQARMLCHKAAWTIDQLGN
Mflv_0734|M.gilvum_PYR-GCK VDRVQTRIAFGKPLAEQGVVREAIAKSRNDIEQTRMLCHKAAWTIDQHGN
Mvan_0116|M.vanbaalenii_PYR-1 IDRVQTRIAFGKPLAEQGVVREAIAKSRNEIEQTRLLCHKAAWTIDQQGN
MAB_0255|M.abscessus_ATCC_1997 CRRGLDRTAFGKPLVNLGGNRERIADARIAINQTRLLVLHAAWLLDTVGI
MUL_4790|M.ulcerans_Agy99 CERAVSRQTRHGRLSDLQMTQEKVADSWIQIEQFRLLVLRTAWLIDKHHD
MLBr_00737|M.leprae_Br4923 IVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEP
* : : :*. :: *:: :* :
Mb0159c|M.bovis_AF2122/97 --KEARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGWHR
Rv0154c|M.tuberculosis_H37Rv --KEARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGWHR
MMAR_0374|M.marinum_M --KEARHLVAMIKAVAPQVACDVIDRAIQVHGAAGVSNDTPLARLYSWHR
MAV_5144|M.avium_104 --KAAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGVSDDTVLARLYGWHR
MSMEG_0102|M.smegmatis_MC2_155 --KAAHVLVSQIKSVAPQVACNVLDRAIQVHGAAGVGDDFPLARLYAWHR
TH_3078|M.thermoresistible__bu KHKEAQVQVAQIKAVAPTVACNVIDRAIQVHGGAGVSDDFPLARLYAWHR
Mflv_0734|M.gilvum_PYR-GCK KSKDAQLLVAQIKAVAPQMACDVIDRAIQVHGGAGVSDDFPLARLYSWHR
Mvan_0116|M.vanbaalenii_PYR-1 KSKDAQLLVAQIKAVAPQMACDVIDRAIQVHGGAGVCDDFPLARLYSWHR
MAB_0255|M.abscessus_ATCC_1997 --MGALSAVSEIKVAAPNMAQQVIDMAIQIHGGGGLSNDFPLAAAWVNAR
MUL_4790|M.ulcerans_Agy99 -YQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMVAAE
MLBr_00737|M.leprae_Br4923 ---DLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAK
: * . : :* *:::.*. * .: . .
Mb0159c|M.bovis_AF2122/97 AMRIFDGPDEVHLRSIARAELSREKSTFAAAVT-----------------
Rv0154c|M.tuberculosis_H37Rv AMRIFDGPDEVHLRSIARAELSREKSTFAAAVT-----------------
MMAR_0374|M.marinum_M AMRIFDGPDEVHMRSIARAELGREKSAFAAAVTSHG--------------
MAV_5144|M.avium_104 AMRIFDGPDEVHMRTIARAELGREKSALAAAVTAHA--------------
MSMEG_0102|M.smegmatis_MC2_155 AMRLFDGPDEVHMRTIARSELGREKSPLALAVTK----------------
TH_3078|M.thermoresistible__bu AMRLFDGPDEVHMRTIARAELGKEKSPLAAAAIKVSSS------------
Mflv_0734|M.gilvum_PYR-GCK AMRLFDGPDEVHMRTIARAELGREKSALATAACRVSHPGAAG--------
Mvan_0116|M.vanbaalenii_PYR-1 AMRLFDGPDEVHMRTIARAELGREKSAMATAASRQSDTAASRQSNPAASR
MAB_0255|M.abscessus_ATCC_1997 ALRLADGPDEVHRGVVARIELAKYAND-----------------------
MUL_4790|M.ulcerans_Agy99 SLGIADGATELHKMTVARRTLRQYEPVATPFPSQHIPTRRAAAEARLAER
MLBr_00737|M.leprae_Br4923 ITQIYEGTNQIQRVVMSRALLR----------------------------
: :*. ::: ::* *
Mb0159c|M.bovis_AF2122/97 --------
Rv0154c|M.tuberculosis_H37Rv --------
MMAR_0374|M.marinum_M --------
MAV_5144|M.avium_104 --------
MSMEG_0102|M.smegmatis_MC2_155 --------
TH_3078|M.thermoresistible__bu --------
Mflv_0734|M.gilvum_PYR-GCK --------
Mvan_0116|M.vanbaalenii_PYR-1 QSETAVTG
MAB_0255|M.abscessus_ATCC_1997 --------
MUL_4790|M.ulcerans_Agy99 LEHSIAEF
MLBr_00737|M.leprae_Br4923 --------