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MSWDFSTEPQWARQLEWVEDFVREECEPIDLIVKESHDLDDPVRQALIPPLQKIVKERGLWATHLGPHLG GPGYGQVKLALLNEILGRSECAPIVFGSQAPDSGNSEILAHYGTPELKARYLEPLLDNRIVSCFSMTEPQ GGADPKVFRTTAVPDGDHWVINGEKWFSSFASMASFIIVMAMTDPEAPPYQRYSMFVVPGDTPGITVLRD VGLGYQPLGGGREGYVRYENVRVPADHMLGPRGGAFVVAQTRLGGGRIHHAMRTVGLVRRIFDMICERAV SRYTQGEVLANKQLVQEMVADSWMEIEAFRLLTLQTAWKIDQFNDYRAVRADISAVKAMMQRVLHDVSAR ALQLHGSLGTTHEMPFVQYLVESFVLGLADGPTEVHKVTLARLLLKDRAPAPDLFPSEHLLRLRAAAEAK FADKLAGIPRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3944 | - | - | 100% (431) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_5173 | - | e-147 | 59.34% (423) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_5144 | - | 2e-60 | 38.83% (394) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0136c | fadE1 | 1e-145 | 58.31% (427) | acyl-CoA dehydrogenase FADE1 |
| M. gilvum PYR-GCK | Mflv_2451 | - | 1e-143 | 57.35% (422) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0131c | fadE1 | 1e-145 | 58.31% (427) | acyl-CoA dehydrogenase FADE1 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-26 | 25.59% (340) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4911c | - | 1e-143 | 56.57% (426) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_0331 | fadE1 | 1e-148 | 58.87% (423) | acyl-CoA dehydrogenase FadE1 |
| M. smegmatis MC2 155 | MSMEG_4826 | - | 1e-143 | 57.04% (426) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2939 | - | 1e-144 | 57.44% (430) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4790 | fadE1 | 1e-146 | 58.63% (423) | acyl-CoA dehydrogenase FadE1 |
| M. vanbaalenii PYR-1 | Mvan_4200 | - | 1e-140 | 56.60% (424) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0136c|M.bovis_AF2122/97 MPVRRRAGERLPTVWDFETDPQYQS-KLDWVEKFMAEELEPLDLVALDP-
Rv0131c|M.tuberculosis_H37Rv MPVRRRAGERLPTVWDFETDPQYQS-KLDWVEKFMAEELEPLDLVALDP-
MMAR_0331|M.marinum_M -------------MWDFETDPEYQA-KLDWVQEFMVNELEPLDLVALDP-
MUL_4790|M.ulcerans_Agy99 -------------MWDFETDPEYQA-KLDWVQEFMVNELEPLDLVALDP-
MAB_4911c|M.abscessus_ATCC_199 ---------MTAMAWDFETDPEYQE-LLDWADEFVRTEVEPLDYVFPNP-
Mflv_2451|M.gilvum_PYR-GCK -------------MWSFETDPEYQK-VLDWADEFVREEVEPLDLAFPHQQ
Mvan_4200|M.vanbaalenii_PYR-1 -------------MWSFETDPEYQK-VLDWADEFVREEVEPLDLAFPHQQ
MSMEG_4826|M.smegmatis_MC2_155 ------------MAWDFETDPQYQE-VLDWADEFVREKVEPLDLVWPHLQ
TH_2939|M.thermoresistible__bu ------------MAWDFETDPEYQK-VLDWADEFVRTEVEPLDLAFPHQQ
MAV_3944|M.avium_104 ------------MSWDFSTEPQWAR-QLEWVEDFVREECEPIDLIVKES-
MLBr_00737|M.leprae_Br4923 -------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAP-
.:. :* : * .. : ..:
Mb0136c|M.bovis_AF2122/97 YDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEII
Rv0131c|M.tuberculosis_H37Rv YDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEII
MMAR_0331|M.marinum_M YDKKNPEMMAVLRPLQQQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIL
MUL_4790|M.ulcerans_Agy99 YDKKNPEMMAVLRPLQQ-VKNQGLWAAHLRPEVGGQGFGQVKLALLNEIL
MAB_4911c|M.abscessus_ATCC_199 YDKSDTVAMDYVRPLKEEVKRRGLWACHLGPELGGPGYGQLKLALLNEIL
Mflv_2451|M.gilvum_PYR-GCK FVPLDGKRREAIDPLKEEVRRRGLWATHLGADLGGQGYGQLKLALLNEIL
Mvan_4200|M.vanbaalenii_PYR-1 FVPLDGERRRAIDPLKEEVRRRGLWATHLGADLGGQGYGQLKLALLNEIL
MSMEG_4826|M.smegmatis_MC2_155 FTPLNEARRQVVDPLKEQVRRKGLWATHLGPELGGQGYGQLKLALLNEIL
TH_2939|M.thermoresistible__bu FVPLEGTRREAIEPLKQEVRRRGLWATHLGPELGGQGYGQLKLALLNEIL
MAV_3944|M.avium_104 HDLDDPVRQALIPPLQKIVKERGLWATHLGPHLGGPGYGQVKLALLNEIL
MLBr_00737|M.leprae_Br4923 HAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEV
. :. *: * *: . ** * ..: .:: * :
Mb0136c|M.bovis_AF2122/97 GRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSM
Rv0131c|M.tuberculosis_H37Rv GRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSM
MMAR_0331|M.marinum_M GRSRWAPSVFGCQAPDSGNAEILALFGTEDQKARYLQPLLDGEITSCYSM
MUL_4790|M.ulcerans_Agy99 GRSRWAPSVFGCQAPDSGNAEILALFGTEDQKARYLQPLLDGEITSCYSM
MAB_4911c|M.abscessus_ATCC_199 GRSVWAPSIFGCQAPDTGNAEILAHYGTEAQKAKYLQPLMDGDIGSCYVM
Mflv_2451|M.gilvum_PYR-GCK GRSQWAPIIFGCQAPDTGNAEIIAHYGTEEQKQRYLRPLLDGELFSCYSM
Mvan_4200|M.vanbaalenii_PYR-1 GRSQWAPVIFGCQAPDTGNAEIIAHYGTEEQKQKYLRPLLDGELFSCYSM
MSMEG_4826|M.smegmatis_MC2_155 GRSQWAPIVFGCQAPDTGNAEIIAHYGTDEQKERYLRPLLEGELFSSYSM
TH_2939|M.thermoresistible__bu GRSQWAPVVFGCQAPDTGNAEIIAHYGTEEQQKRYLQPLLDGELFSCYSM
MAV_3944|M.avium_104 GRSECAPIVFGSQAPDSGNSEILAHYGTPELKARYLEPLLDNRIVSCFSM
MLBr_00737|M.leprae_Br4923 ARVDASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYAL
.* :. : . . : *: : : * .* :.: :
Mb0136c|M.bovis_AF2122/97 TEPQGGSDPGLFVTAATRDAAG-NGDWIINGEKWFSTNAKHASFFIVMAV
Rv0131c|M.tuberculosis_H37Rv TEPQGGSDPGLFVTAATRDAAG-NGDWIINGEKWFSTNAKHASFFIVMAV
MMAR_0331|M.marinum_M TEPQGGSDPGSFVTAATRDGD----SWIINGEKWFSTNAKHASFFIVMAV
MUL_4790|M.ulcerans_Agy99 TEPQGGSDPGSFVTAATRDGD----SWIINGEKWFSTNAKHASFFIVMAV
MAB_4911c|M.abscessus_ATCC_199 TEPQGGSDPTLFKTTAVRDGD----EWILNGEKWFNSEARHAAFWIVMAV
Mflv_2451|M.gilvum_PYR-GCK TEPHAGADPTMFTTSAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
Mvan_4200|M.vanbaalenii_PYR-1 TEPHAGADPTMFTTSAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
MSMEG_4826|M.smegmatis_MC2_155 TEPHAGADPTLFTTRAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
TH_2939|M.thermoresistible__bu TEPHAGADPTLFKTTAVRDGAGPDADWVINGWKFFSSNATTASFLIVMAV
MAV_3944|M.avium_104 TEPQGGADPKVFRTTAVPDGD----HWVINGEKWFSSFASMASFIIVMAM
MLBr_00737|M.leprae_Br4923 SEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTVMAV
:* ..*:*. : * * *. *::** * : : . ::: **.:
Mb0136c|M.bovis_AF2122/97 TKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVR
Rv0131c|M.tuberculosis_H37Rv TKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVR
MMAR_0331|M.marinum_M TNPQARTYEKMSLFIVPAETPGIEIVRNVGVGTESSKHASHGYVRYHDVR
MUL_4790|M.ulcerans_Agy99 TNPQARTYEKMSLFIVPAETPGIEIVRNVGVGTESSKHASHGYVRYHDVR
MAB_4911c|M.abscessus_ATCC_199 TNTEVSPYQGMSMFIVDPNAPGVEIVRNITVHGFS---EDEAYTRFTNAR
Mflv_2451|M.gilvum_PYR-GCK TNPDVSAYQGMSMFLVPTDTPGVTIERNVGLYGEREGEGSHALIHYDNVR
Mvan_4200|M.vanbaalenii_PYR-1 TNREVSAYQGMSMFLVPTDTPGVKIERNIGLYGEGAEHGSHALIHYDNVR
MSMEG_4826|M.smegmatis_MC2_155 TNPDVSAYQGMSMFLVPTDTPGVEIVRNVGLYGERDNEGSHALIHYDNVR
TH_2939|M.thermoresistible__bu TNPDVSAYQGMSMFLVPTDTPGVKIERSIGLYGDPPGTGSHALIHYDNVR
MAV_3944|M.avium_104 TDPEAPPYQRYSMFVVPGDTPGITVLRDVGLGYQPLGGGREGYVRYENVR
MLBr_00737|M.leprae_Br4923 TDPDK-GANGISAFIVHKDDEGFSIGPKE--KKLGIKGSPTTELYFDKCR
*. : : * *:* : *. : . : . *
Mb0136c|M.bovis_AF2122/97 VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSR
Rv0131c|M.tuberculosis_H37Rv VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSR
MMAR_0331|M.marinum_M VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERAVSR
MUL_4790|M.ulcerans_Agy99 VPADHVLGGEGQAFMTAQTRLGGGRIHHAMRTIALARRAFDMMCERAVSR
MAB_4911c|M.abscessus_ATCC_199 IPAENMLGAEGGAFAIAQTRLGGGRVHHAMRTVAQVRKAFDMMCERVVSR
Mflv_2451|M.gilvum_PYR-GCK VPSEALLGGEGQAFAIAQTRLGGGRIHHAMRTIGLSRKALDMMCERALSR
Mvan_4200|M.vanbaalenii_PYR-1 VPAEALLGGEGQAFVIAQTRLGGGRIHHAMRTIGLSRKALDMMCERALSR
MSMEG_4826|M.smegmatis_MC2_155 VPAEALLGGEGQAFVIAQTRLGGGRIHHAMRTIGLARKALDMMCERALSR
TH_2939|M.thermoresistible__bu VPADALLGGEGQAFAIAQTRLGGGRIHHAMRTIGLARKALDMMCERALSR
MAV_3944|M.avium_104 VPADHMLGPRGGAFVVAQTRLGGGRIHHAMRTVGLVRRIFDMICERAVSR
MLBr_00737|M.leprae_Br4923 IPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
:*.: ::* * .* * : *. * . :::. : :* . .*
Mb0136c|M.bovis_AF2122/97 QTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
Rv0131c|M.tuberculosis_H37Rv QTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MMAR_0331|M.marinum_M QTRHGRLSDLQMTQEKVADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MUL_4790|M.ulcerans_Agy99 QTRHGRLSDLQMTQEKVADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MAB_4911c|M.abscessus_ATCC_199 EARGGTIAKLQMTQERIADSWIEMESFRLLVLRTAWLIDKHQDYLKVRKD
Mflv_2451|M.gilvum_PYR-GCK ETQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
Mvan_4200|M.vanbaalenii_PYR-1 ETQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
MSMEG_4826|M.smegmatis_MC2_155 KTQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKLVRKD
TH_2939|M.thermoresistible__bu QTQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
MAV_3944|M.avium_104 YTQGEVLANKQLVQEMVADSWMEIEAFRLLTLQTAWKIDQFNDYRAVRAD
MLBr_00737|M.leprae_Br4923 KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFIS-
:: * * :** :: **:. :* :: . .
Mb0136c|M.bovis_AF2122/97 IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGA
Rv0131c|M.tuberculosis_H37Rv IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGA
MMAR_0331|M.marinum_M IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMVAAESLGIADGA
MUL_4790|M.ulcerans_Agy99 IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMVAAESLGIADGA
MAB_4911c|M.abscessus_ATCC_199 ISAIKAAMPKVMHDVAQRALHLHGSLGVSEEMPLAKMFLYSEVMGLVDGP
Mflv_2451|M.gilvum_PYR-GCK IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEVPFLGMVTGAAVMGLADGP
Mvan_4200|M.vanbaalenii_PYR-1 IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEVPFLGMVTGAAVMGLADGP
MSMEG_4826|M.smegmatis_MC2_155 IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEMPFLGMVTGAAVMGLADGP
TH_2939|M.thermoresistible__bu IAAVKATMPTVLHDIAWRAMQVHGALGVTDEMPFMGMITGAAVMGLADGP
MAV_3944|M.avium_104 ISAVKAMMQRVLHDVSARALQLHGSLGTTHEMPFVQYLVESFVLGLADGP
MLBr_00737|M.leprae_Br4923 -AASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGT
:* * : :: *:::.*. * : :.*. . : : :*.
Mb0136c|M.bovis_AF2122/97 TELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
Rv0131c|M.tuberculosis_H37Rv TELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
MMAR_0331|M.marinum_M TELHKMTVARRTLRQYEPVTTPFPSQHIPTRRAAAEARLAERLEHSIAEF
MUL_4790|M.ulcerans_Agy99 TELHKMTVARRTLRQYEPVATPFPSQHIPTRRAAAEARLAERLEHSIAEF
MAB_4911c|M.abscessus_ATCC_199 TEVHKVTIAKEVLKDYTPYEGLFPPSHIPALTEKARAHVAARLEHRVGNL
Mflv_2451|M.gilvum_PYR-GCK TEVHKTTVAKQVLRDHRPAEGMWPSEWIPAKREAAQAKYADFIEHEVGNL
Mvan_4200|M.vanbaalenii_PYR-1 TEVHKTTVAKQVLRDYRPAEGLWPSEWIPAKREAARAKYAEYLENEVGNL
MSMEG_4826|M.smegmatis_MC2_155 TEVHKTTVAKQVLRDYQPTEDTWPTEWIPRKREAARAKLADYLENEVGNL
TH_2939|M.thermoresistible__bu TEVHKATVAKQVLRDYRPSDDVWPSEWIPRKREAALAKYAEYLEHEVGNL
MAV_3944|M.avium_104 TEVHKVTLARLLLKDRAPAPDLFPSEHLLRLRAAAEAKFADKLAGIPRG-
MLBr_00737|M.leprae_Br4923 NQIQRVVMSRALLR------------------------------------
.:::: .::: *: