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TGGSAQPPRVALVTGAAGGQGRAIAERLRGNGFAVAACDRRIDELAATVAASGDDRLIAVELDVTSEQQW RSAVERVVDRFGALSALVNCAGVLHRTPLPQETADAFENAWRVNCFGAFLGMRAALERLRGTPGASIVNI CSTGAIRPFPQHCAYGSSKWALRGLTQTAAAELAPAGIRVNAVFPGPIATPMLDEATQTRLAAAASFGRI GQPGEVADAVAFLVSAEASFITGAELVVDGGQCLQIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5120 | - | - | 100% (248) | oxidoreductase |
| M. avium 104 | MAV_5136 | - | 7e-38 | 41.63% (233) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. avium 104 | MAV_2509 | - | 2e-34 | 36.48% (233) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 1e-36 | 39.06% (233) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4104 | - | 2e-88 | 68.91% (238) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 1e-36 | 39.06% (233) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-21 | 31.69% (243) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 2e-36 | 38.20% (233) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0402 | - | 2e-98 | 73.68% (247) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2566 | - | 4e-87 | 68.49% (238) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3912 | - | 4e-85 | 67.95% (234) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1052 | - | 3e-97 | 72.87% (247) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2242 | - | 8e-92 | 71.43% (238) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 -----------MSGR---LIGKVALVSGGARGMGASHVRAMVAEGAKVVF
Rv2002|M.tuberculosis_H37Rv -----------MSGR---LIGKVALVSGGARGMGASHVRAMVAEGAKVVF
MAB_4680c|M.abscessus_ATCC_199 -----------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
MMAR_0402|M.marinum_M -----------MTGG-----GRVALVTGAAGGQGWAIVQRLRAEGHSVAA
MUL_1052|M.ulcerans_Agy99 -----------MTGG-----GRVALVTGAAGGQGWAIVQRLRAEGHSVAA
MAV_5120|M.avium_104 -----------MTGGSA-QPPRVALVTGAAGGQGRAIAERLRGNGFAVAA
Mflv_4104|M.gilvum_PYR-GCK -----------MAAD------RIALVTGAARGQGAAIVTRLLQDGFRVAA
Mvan_2242|M.vanbaalenii_PYR-1 -----------MAGD------RVALITGAARGQGAAIAARLIQDGFCVAA
MSMEG_2566|M.smegmatis_MC2_155 -----------MTVD------RVALVTGAARGQGAAIVAKLVADGFRVAA
TH_3912|M.thermoresistible__bu -------------------------VTGAARGQGSAIVRRLLQDGYRVAA
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
::*. * * : : :* *.
Mb2025|M.bovis_AF2122/97 GDILDEEGKAVAAELA-DAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVL
Rv2002|M.tuberculosis_H37Rv GDILDEEGKAVAAELA-DAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVL
MAB_4680c|M.abscessus_ATCC_199 ADVLDGDGRQLAAELG-DAARFTHLDVTDAEQWRELIDTTLAGFGTITGL
MMAR_0402|M.marinum_M CDLRADRLDALVAESGDDAVISLALDVTDEAQWQEAVERAVTRFGALTAL
MUL_1052|M.ulcerans_Agy99 CDLRADRLDALVAESGDDAVISLALDVTDEAQWQEAVERAVTRFGALTAL
MAV_5120|M.avium_104 CDRRIDELAATVAASGDDRLIAVELDVTSEQQWRSAVERVVDRFGALSAL
Mflv_4104|M.gilvum_PYR-GCK CDLLGDDVTRTVAAHDTDHAVAIELDVTSAEQWTRAVGEVVDRFGGLSTL
Mvan_2242|M.vanbaalenii_PYR-1 CDLLVDDLGQTVERLGPDRALAVELDVTSEEQWASAVAAVVDRFGALTAL
MSMEG_2566|M.smegmatis_MC2_155 TDLMIDDLRMSTADLG-GAVIALELDVTSAEQWQWAVHATVEEFGSLGAL
TH_3912|M.thermoresistible__bu CDVLVDELHGSVADLDGDTVLPLALDVTSAPQWADAVAATVGRFGALSAL
MLBr_01807|M.leprae_Br4923 THR---------ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVL
. . ***. . . * : *
Mb2025|M.bovis_AF2122/97 VNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSI
Rv2002|M.tuberculosis_H37Rv VNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSI
MAB_4680c|M.abscessus_ATCC_199 VNNAGISSAAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHGCGSI
MMAR_0402|M.marinum_M INNAGVLHRAALVDETAAGFESAWRVNCLGAFLGMRAALGALSAAEGPVI
MUL_1052|M.ulcerans_Agy99 INNAGVLHRAALVDETAAGFESAWRVNCLGAFLGMRAALGALSAAEGPVI
MAV_5120|M.avium_104 VNCAGVLHRTPLPQETADAFENAWRVNCFGAFLGMRAALERLRGTPGASI
Mflv_4104|M.gilvum_PYR-GCK VNNAGVLHRASLADETPDGFEGSWRVNSLGPFLGIQAALPHLKAAEGAAI
Mvan_2242|M.vanbaalenii_PYR-1 VNNAGVLHRASLSEETPAGFEGSWRVNCLGPFLGIQASLPHLREAEGAAI
MSMEG_2566|M.smegmatis_MC2_155 VNNAGVLHRASLDDETPDGFEGSWRVNCLGPFLGIRTALPHLRRVDGAAV
TH_3912|M.thermoresistible__bu INNAGVLHRAALPDETAEGFERSWRVNCLGPFLGIRAALDPLRHAHNASV
MLBr_01807|M.leprae_Br4923 VANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRY
: **: : . :. :* * * : :
Mb2025|M.bovis_AF2122/97 INISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGL
Rv2002|M.tuberculosis_H37Rv INISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGL
MAB_4680c|M.abscessus_ATCC_199 VNISSAAGLVGLALTSGYGASKWGVRGLSKVAAIELGRERIRVNSVHPGV
MMAR_0402|M.marinum_M VNICSTGAIRPFPHHCAYGAAKWALRGLTQTAAAELAPAGIRVNAVFPGP
MUL_1052|M.ulcerans_Agy99 VNICSTGAIRPFPHHCAYGAAKWALRGLTQTAAAELAPAGFRVNAVFPGP
MAV_5120|M.avium_104 VNICSTGAIRPFPQHCAYGSSKWALRGLTQTAAAELAPAGIRVNAVFPGP
Mflv_4104|M.gilvum_PYR-GCK VNTCSTGAIRPFPNHAAYGSSKWALRGLTQVAAVELAPSGIRVNAVFPGP
Mvan_2242|M.vanbaalenii_PYR-1 VNTCSTGAIRPFPNHSAYGSSKWALRGLTQVAAVELAPAGIRVNAVFPGP
MSMEG_2566|M.smegmatis_MC2_155 VNTCSTGAIRPFPNHAAYGSSKWALRGLTQVAAAELAPDGIRVNAVFPGP
TH_3912|M.thermoresistible__bu VNTCSTGALRAFPNHAAYGSSKWALRGLTQIAAAELAAAGIRVNAVLPGP
MLBr_01807|M.leprae_Br4923 IFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVAPGF
: * .: * ::* .: *::: * **. : .* : **
Mb2025|M.bovis_AF2122/97 VKTPMTDWV-----PEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGA
Rv2002|M.tuberculosis_H37Rv VKTPMTDWV-----PEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGA
MAB_4680c|M.abscessus_ATCC_199 IYTPMTAKEGFREGEGNMPIAAMGRVGNADEVAGAVAYLLSDAASYVTGA
MMAR_0402|M.marinum_M IATSMLDEP---TQARLAAVSMFGRLGRPAEVADAVAFLVSENSSFITGS
MUL_1052|M.ulcerans_Agy99 IATSMLDEP---TQARLAAVSMFGRLGRHAEVADAVAFLVSENSSFITGS
MAV_5120|M.avium_104 IATPMLDEA---TQTRLAAAASFGRIGQPGEVADAVAFLVSAEASFITGA
Mflv_4104|M.gilvum_PYR-GCK VETPMLDAN---TQTRLAANALMGRIGKPMEIADAVAFLVSEHATFITGS
Mvan_2242|M.vanbaalenii_PYR-1 VETPMLDPT---TQSRLAATALMGRIGTPMEIADAVAFLVSEHATFITGS
MSMEG_2566|M.smegmatis_MC2_155 VATPMLDES---TQERLAARAAAGRLARPAEIADAVAFLLSEHASFITGS
TH_3912|M.thermoresistible__bu VATPMLDDA---TQRRLAATMAAGRLGRPTEVADAVAFLVSEQASFITGS
MLBr_01807|M.leprae_Br4923 IDTEMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISGA
: * * ** . *::. * :* * : : :*:
Mb2025|M.bovis_AF2122/97 EFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
Rv2002|M.tuberculosis_H37Rv EFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
MAB_4680c|M.abscessus_ATCC_199 ELAVDGGWTAGPT-----LTTITGQ-----
MMAR_0402|M.marinum_M ELVVDGGQCLQVP-----------------
MUL_1052|M.ulcerans_Agy99 ELVVDGGQCLQVP-----------------
MAV_5120|M.avium_104 ELVVDGGQCLQIR-----------------
Mflv_4104|M.gilvum_PYR-GCK ELIVDGGQSLQIG-----------------
Mvan_2242|M.vanbaalenii_PYR-1 ELTVDGGQSLQIG-----------------
MSMEG_2566|M.smegmatis_MC2_155 ELVVDGGQCLQIG-----------------
TH_3912|M.thermoresistible__bu ELVVDGGQSLTIG-----------------
MLBr_01807|M.leprae_Br4923 VIPVDGGLGMGH------------------
: ****