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NVMSYVAGAAQILAVMAGAPLVIGAMRQVRARLEGRGGGGVLQPWRDLRKQLGKQQISPQGTTVVFAAAP AIVAGTTLLIVAIAPIVATGSPLDAAADLFAVVGLLFLGTVALTLAGIDTGTSFGGMGASREITIAALVE PTILLAVFALSIPAGSANLGALVTNTIDHPGQVVSLTGLLAFVALVIVIVAETGRLPVDNPATHLELTMV HEAMVLEYAGPRLALVEWASGMRLTVLLALLANLFLPWGIAGGHPSAVDVAIGLAAITAKVTVLAVALAG AEVFIAKLRLFRVPELLAGSFLLALLAVTAANFFTARA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5112 | - | - | 100% (319) | hydrogenase-4, C subunit, putative |
| M. avium 104 | MAV_4040 | - | 1e-08 | 27.69% (242) | NADH dehydrogenase subunit H |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0087 | hycD | 1e-148 | 86.39% (316) | formate hydrogenlyase HYCD |
| M. gilvum PYR-GCK | Mflv_4488 | - | 9e-08 | 24.90% (257) | NADH dehydrogenase subunit H |
| M. tuberculosis H37Rv | Rv0084 | hycD | 1e-148 | 86.39% (316) | formate hydrogenlyase HYCD |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1656 | hycD | 1e-141 | 79.87% (318) | formate hydrogenlyase HycD |
| M. smegmatis MC2 155 | MSMEG_2056 | nuoH | 2e-07 | 24.55% (220) | NADH dehydrogenase subunit H |
| M. thermoresistible (build 8) | TH_1086 | nuoH | 1e-07 | 23.36% (244) | PROBABLE NADH DEHYDROGENASE I (CHAIN H) NUOH |
| M. ulcerans Agy99 | MUL_1893 | hycD | 1e-138 | 79.68% (315) | formate hydrogenlyase HycD |
| M. vanbaalenii PYR-1 | Mvan_1878 | - | 1e-08 | 25.88% (255) | NADH dehydrogenase subunit H |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0087|M.bovis_AF2122/97 ---------------MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRA
Rv0084|M.tuberculosis_H37Rv ---------------MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRA
MAV_5112|M.avium_104 ------------MNVMSYVAGAAQILAVMAGAPLVIGAMRQVRARLEGRG
MMAR_1656|M.marinum_M ------------MNLMSAMAGAAQIGAVILGAPLVIGLMRQIRARSEGRC
MUL_1893|M.ulcerans_Agy99 ---------------MSAMAGAAQIGAVILGAPLVIGLMRQIRARSEGRC
Mflv_4488|M.gilvum_PYR-GCK MTYPDPTLFGHDPWWLILAKSLGVFVFLLLTVLAAILIERKILGRMQLRL
Mvan_1878|M.vanbaalenii_PYR-1 MTYPDPTLFGHDPWWLVLAKSLGIFAFLLLTVLAAILIERKVLGRMQLRF
MSMEG_2056|M.smegmatis_MC2_155 MTHPDPTLFGHDPWWLMLAKAVAIFVFLLLTVLSAILIERKLLGRMQMRF
TH_1086|M.thermoresistible__bu VTYPDPGAFGHDPWWLIVAKTVGIFGFLVLTVLSAILIERKILGRMQMRF
: . : :: . .* *:: .* : *
Mb0087|M.bovis_AF2122/97 GA------GLLQPWRDLLKQLGKQQITPAGT-TIVFAAAPVIVAGTTLLI
Rv0084|M.tuberculosis_H37Rv GA------GLLQPWRDLLKQLGKQQITPAGT-TIVFAAAPVIVAGTTLLI
MAV_5112|M.avium_104 GG------GVLQPWRDLRKQLGKQQISPQGT-TVVFAAAPAIVAGTTLLI
MMAR_1656|M.marinum_M GA------GILQPWRDLRKQLRKQQVTPEGT-TAVFAVAPAVVAATTLLI
MUL_1893|M.ulcerans_Agy99 GA------GILQPWRDLHKQLRKQQVTPEGT-TAVFAVAPAVVAATTLLI
Mflv_4488|M.gilvum_PYR-GCK GPNRVGPRGLLQSLADGIKLALKEGLVPAGVDKWIYLAAPVISVIPAFMA
Mvan_1878|M.vanbaalenii_PYR-1 GPNRVGPHGLLQSLADGVKLALKEGLVPAGVDKWIYLAAPIISVIPAFMA
MSMEG_2056|M.smegmatis_MC2_155 GPNRVGPAGLLQSLADGIKLALKEGLVPAGVDKPIYLLAPVISVIPAFVA
TH_1086|M.thermoresistible__bu GPNRVGPRGLLQSVADGVKLALKEGLIPRAADKPLYLLAPVIAVIPAFMA
* *:**. * * *: : * .. . :: ** : . .:::
Mb0087|M.bovis_AF2122/97 AAIAPLVATGSPL---------DPSADLFAVVGLLFLGTVALTLAGIDTG
Rv0084|M.tuberculosis_H37Rv AAIAPLVATGSPL---------DPSADLFAVVGLLFLGTVALTLAGIDTG
MAV_5112|M.avium_104 VAIAPIVATGSPL---------DAAADLFAVVGLLFLGTVALTLAGIDTG
MMAR_1656|M.marinum_M AAIAPLVATGSPL---------DPVGDLFVVVGLLFLGTVALTLAGIDTG
MUL_1893|M.ulcerans_Agy99 AAIAPLVATGSPL---------DPVGDLFVVVGLLFLGTVALTLAGIDTG
Mflv_4488|M.gilvum_PYR-GCK FAVIPLGPEVSVFGHRTALQLTDLPVAVLYILAVTSIGVYGIVLAGWASG
Mvan_1878|M.vanbaalenii_PYR-1 FAVIPMGGEVSVFGHRTALQLTDLPVAVLYILAVTSIGVYGIVLAGWASG
MSMEG_2056|M.smegmatis_MC2_155 FSVIPLGGAVSVFGHRTPLQLTDLPVAVLFILAATSIGVYGIVLAGWASG
TH_1086|M.thermoresistible__bu FAVIPMGPVVSVFGHRTPLQLTDLPVAVLYILAVASVGVYGFILAGWSSG
:: *: * : * :: ::. :*. .: *** :*
Mb0087|M.bovis_AF2122/97 TSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGALVASTIDHPG
Rv0084|M.tuberculosis_H37Rv TSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGALVASTIDHPG
MAV_5112|M.avium_104 TSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGALVTNTIDHPG
MMAR_1656|M.marinum_M TSFGGMGASREITIAALVEPTILLAVFALSIPAKSANLGAIVAFSLENPA
MUL_1893|M.ulcerans_Agy99 TSFGGMGASREITIAALVEPTILLAVFALSIPAKSANLGAIVAFSLENPA
Mflv_4488|M.gilvum_PYR-GCK SVYPLLGGLRSSAQVISYEIAMALSFVAVFIYAGTMSTSGIVAAQNDVWF
Mvan_1878|M.vanbaalenii_PYR-1 SVYPLLGGLRSSAQVISYEIAMALSFAAVFIYAGTMSTSGIVAAQNDTWY
MSMEG_2056|M.smegmatis_MC2_155 STYPLLGGLRSSAQVVSYEIAMGLSFVAVFLYAGTMSTSGIVAAQDRTWF
TH_1086|M.thermoresistible__bu STYPLLGGLRSTAQVISYEVAMALTFVAVFLYAGTMSTSGIVAAQQGTWY
: : :*. *. : . * :: *:. *: : * : . ..:*:
Mb0087|M.bovis_AF2122/97 HVVSLAGVLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAGP
Rv0084|M.tuberculosis_H37Rv HVVSLAGVLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAGP
MAV_5112|M.avium_104 QVVSLTGLLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAGP
MMAR_1656|M.marinum_M EVVSLAGILAFVALVIVVIAETGRLPVDNPATHLELTMVHEAMVLEYAGP
MUL_1893|M.ulcerans_Agy99 EVVSLAGILAFVALVIVVIAETGRLSVDNPATHLELTMVHEAMVLEYAGP
Mflv_4488|M.gilvum_PYR-GCK IFLLLP---SFLVYLTSMVGETNRAPFDLPEAEGELVG---GFHTEYSSL
Mvan_1878|M.vanbaalenii_PYR-1 IVLLLP---SFLVYVTAMVGETNRAPFDLPEAEGELVG---GFHTEYSSL
MSMEG_2056|M.smegmatis_MC2_155 VFLLLP---SFLVYVVSMVGETNRAPFDLPEAEGELVG---GFHTEYSSL
TH_1086|M.thermoresistible__bu LFLLLP---SFLVFLVAMVGETNRAPFDLPEAEGELVG---GFHTEYSSL
.: *. :*:. : ::.**.* ..* * :. **. .: **:.
Mb0087|M.bovis_AF2122/97 RLALVEWAAGMRLTVLLALLANLFLP-WGIAGAAPTALDVLTGVVAVAAK
Rv0084|M.tuberculosis_H37Rv RLALVEWAAGMRLTVLLALLANLFLP-WGIAGAAPTALDVLTGVVAVAAK
MAV_5112|M.avium_104 RLALVEWASGMRLTVLLALLANLFLP-WGIAGGHPSAVDVAIGLAAITAK
MMAR_1656|M.marinum_M RLGVIEWASGMRLTVLLALLANLFVP-WGIAGADPSLIGIAVGIAAISIK
MUL_1893|M.ulcerans_Agy99 RLGVIEWASGMRLTVLLALLANLFVP-WGIAGADPSLIGIAVGIAAISIK
Mflv_4488|M.gilvum_PYR-GCK KFAMFMLAEYVNMTTVSALATTLFLGGWHAPWPISIADGANSDWWPLLWF
Mvan_1878|M.vanbaalenii_PYR-1 KFAMFMLAEYVNMTTVSALATTLFLGGWHAPWPISIADGANSGWWPLLWF
MSMEG_2056|M.smegmatis_MC2_155 KFAMFMLAEYVNMTTVSALATTMFLGGWHAPFPFNLIDGANSGWWPLLWF
TH_1086|M.thermoresistible__bu KFAMFMLAEYINMATVSALATTLFLGGWAAPWPINMWAGANSGWWPLLWF
::.:. * :.::.: ** :.:*: * . . . .:
Mb0087|M.bovis_AF2122/97 VAILAVLLATFEVFLAKLRLFRVPELLAGSFLLALLAVTAANFFTVGA--
Rv0084|M.tuberculosis_H37Rv VAILAVLLATFEVFLAKLRLFRVPELLAGSFLLALLAVTAANFFTVGA--
MAV_5112|M.avium_104 VTVLAVALAGAEVFIAKLRLFRVPELLAGSFLLALLAVTAANFFTARA--
MMAR_1656|M.marinum_M VAIAAGVLATVEVFIAKLRLFRVPELLAGSFLLALLAVTSANFFTAQV--
MUL_1893|M.ulcerans_Agy99 VAIAAGVLATVEVFIAKLRLFRVPELLAGSFLLALLAVTSANFFTAQV--
Mflv_4488|M.gilvum_PYR-GCK TAKVWLFLFFFMWLRATLPRMRYDQFMRLGWKLLIPVSLAWIAIVATTRA
Mvan_1878|M.vanbaalenii_PYR-1 TVKVWLFLFFFMWLRATLPRMRYDQFMALGWKILIPVSLGWIMIVAITHS
MSMEG_2056|M.smegmatis_MC2_155 TAKVWTFMFLYFWLRATLPRLRYDQFMALGWKVLIPVSLLWIMVVAITRS
TH_1086|M.thermoresistible__bu TAKVWVFLFVFFWLRATLPRLRYDQFMALGWKVLIPMSMVWIMVVATARG
.. : : *.* :* ::: .: : : ... .
Mb0087|M.bovis_AF2122/97 --------------------------------------------------
Rv0084|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5112|M.avium_104 --------------------------------------------------
MMAR_1656|M.marinum_M --------------------------------------------------
MUL_1893|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4488|M.gilvum_PYR-GCK MQNQGYQGWVTALIGVAGVAAILASLLAWRALRARRRRTSHSPPAQSSDH
Mvan_1878|M.vanbaalenii_PYR-1 LRDQGYQAPATAAIGLAVAAVILLALLGRSRLRARRIRP---EPIRPAGD
MSMEG_2056|M.smegmatis_MC2_155 LRQHGEGTWAAWLLTAAVVVVVALIWGLATSLRRRTVQP---PPPQST--
TH_1086|M.thermoresistible__bu LQVFGYVGWSTGLTSVAAITALALIAVVWWVFSRRNEAE---PALPQTHS
Mb0087|M.bovis_AF2122/97 ------------------------
Rv0084|M.tuberculosis_H37Rv ------------------------
MAV_5112|M.avium_104 ------------------------
MMAR_1656|M.marinum_M ------------------------
MUL_1893|M.ulcerans_Agy99 ------------------------
Mflv_4488|M.gilvum_PYR-GCK GAFPVPPLPVK----EPADA----
Mvan_1878|M.vanbaalenii_PYR-1 GAFPVPPLPVKTRALEDADA----
MSMEG_2056|M.smegmatis_MC2_155 GAYPVPPLPSVG-TKETADA----
TH_1086|M.thermoresistible__bu GAFPVPSLPAGQQRTENAKETVDV