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TIETHARVDRPAFDPVNVSSQEFWAQSFDQREKAFKILRDERPVSWHRPMEGSMMEPEIDGVWVVTRHED VCYVSKNPEIFCSGQGVNFEAVPEELLDATLSFLGMDGAKHSSLRRLVSSVFTPRQVNKIKNQIEHQAKS IVDDLLKTKEGDFVEQVSKRLPMWTIYEMLGLPDDQRDEAAHLAEGMVAWADPEVAAGRQPAEVLTDSLV GLLNIGIGLAEARRAHPENDLMTSLVQAEVDGRRLTDDELGPYFVLLSVAGNDTTRTTTTFTAIALQQFP EQKALLENDFDGQIKVAIDEFVRWTTPVMTFRRTATQDTELHGQHIREGDWVTMVYSSANRDERVFTDPY KFDITRAPNPHVAFGGGGPHYCMGAFMAKMQLESIFRELIFRAPSLRLGEPEYLTGNFITAVKSLPYTLD *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5097 | - | - | 100% (421) | NikQ protein |
| M. avium 104 | MAV_1734 | - | e-112 | 47.27% (421) | putative cytochrome P450 124 |
| M. avium 104 | MAV_2174 | - | 4e-76 | 36.59% (410) | P450 heme-thiolate protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 5e-75 | 36.86% (407) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_2640 | - | 1e-116 | 50.23% (426) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 5e-75 | 36.86% (407) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-31 | 27.81% (320) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0611 | - | 3e-73 | 38.67% (406) | putative cytochrome P450 |
| M. marinum M | MMAR_3761 | cyp268A2 | 1e-115 | 50.25% (408) | cytochrome P450 268A2 Cyp268A2 |
| M. smegmatis MC2 155 | MSMEG_4619 | - | 1e-116 | 50.61% (413) | putative cytochrome P450 126 |
| M. thermoresistible (build 8) | TH_2564 | - | 1e-176 | 68.01% (422) | PUTATIVE NikQ protein |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 3e-77 | 36.79% (405) | cytochrome P450 124A1, Cyp124A1 |
| M. vanbaalenii PYR-1 | Mvan_2234 | - | 1e-105 | 46.88% (401) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5097|M.avium_104 --------MTIET-HARVD--RPAFDPVNVSS-QEFWAQSFDQREKAFKI
TH_2564|M.thermoresistible__bu --------MTTETTEPRVD--RPPFDPICIST-LEFWSKTAEEREPYFKI
Mflv_2640|M.gilvum_PYR-GCK --------MTVTAHTPPAASAGRPYDPVDLSS-RAFWAGTADQREASFAQ
MSMEG_4619|M.smegmatis_MC2_155 --------MTVLPIT-------RPYDAVDLSS-RAFWATTAADREVAFAQ
MMAR_3761|M.marinum_M --------MTAISAS------VRPYDTIDLSS-RAFWASSASQRESSFSE
Mvan_2234|M.vanbaalenii_PYR-1 --------MTAPSLH------EREHSAIDITS-HDFWSRPFAQRDESFAR
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGS-LDFWALDDDVRDGAFAT
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGS-LDFWALDDDVRDGAFAT
MUL_1282|M.ulcerans_Agy99 MDLSTNLNTGLLPRVNGTPPPEVPLADIELGS-LEFWGRDDDFRDGAFAT
MAB_0611|M.abscessus_ATCC_1997 --------MVQAQHP-------HLPDGIDFTD-PELFVHGIPERE--LAE
MLBr_02088|M.leprae_Br4923 ------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDP
. :
MAV_5097|M.avium_104 LRDERPVSWHRPMEGSMMEPEID-GVWVVTRHEDVCYVSKNPEIFCSGQG
TH_2564|M.thermoresistible__bu LRDERPVSWHPPIEGTMMPPPVD-GVWAITRHEDIEYVSKNPQLFCSGQG
Mflv_2640|M.gilvum_PYR-GCK LREARPLSWHPPVEDALMPDADDPGFWAVTRHADIVEVSRNSEVFLSGKG
MSMEG_4619|M.smegmatis_MC2_155 LRAERPVSWHPPVEDALMHDPDDKGFWAVTRHADIVAISRDSETFLSGQG
MMAR_3761|M.marinum_M LRAERPVSWHPPVEDALIQDPNDPGFWAVTRRADIVAVSRTNEVFLSGNG
Mvan_2234|M.vanbaalenii_PYR-1 LRAGDGLSWHAPFP-SLFP-MEEPGYWAVTRRADIAYVSQHPELFTSERG
Mb2289|M.bovis_AF2122/97 LRREAPISFWPTIE--LPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPN
Rv2266|M.tuberculosis_H37Rv LRREAPISFWPTIE--LPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPN
MUL_1282|M.ulcerans_Agy99 LRREAPISFWPPIE--LAGLTAGKGHWALTKHDDIHFASRHPEIFHSSPN
MAB_0611|M.abscessus_ATCC_1997 LRHTEPIWWNHTERG--VAGFDDDGFWVVSKHKDVKEVSLRCEVFSSEQN
MLBr_02088|M.leprae_Br4923 GTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLK
. . ..: * .
MAV_5097|M.avium_104 VNFEAVP-----EELLDATLSFLGMDGAKHSSLRRLVSSVFTPRQVNKIK
TH_2564|M.thermoresistible__bu TQVEAIP-----PEMLVLAESFLSMDGEEHSSLRRLISSVFTPRRLSIIR
Mflv_2640|M.gilvum_PYR-GCK VLFENVP-----EELLEASQSFLAMDPPRHTLIRKVVHAAFTPRQVRRIE
MSMEG_4619|M.smegmatis_MC2_155 VLFENVP-----QELLEASQSFLAMDAPRHTLIRKLVHSAFTPRQVARIE
MMAR_3761|M.marinum_M VLFENVP-----AELLEASQSFLAMDPPRHTKLRKLVSAAFTPRQVRRIE
Mvan_2234|M.vanbaalenii_PYR-1 VALDPMP-----AEVQRFASFFLTMDPPQHTTYRRLISSAFTPRNVRQIE
Mb2289|M.bovis_AF2122/97 ITINDQT-----PELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIE
Rv2266|M.tuberculosis_H37Rv ITINDQT-----PELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIE
MUL_1282|M.ulcerans_Agy99 IVIHDQT-----PELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIE
MAB_0611|M.abscessus_ATCC_1997 TAIPRYLPTTPRERIDATRLIMLNMDPPRHSRLRHIISRGFTPRAISRLR
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
. :: :* * * :: *:*: : :.
MAV_5097|M.avium_104 NQIEHQAKSIVDDLLKTKEG---DFVEQVSKRLPMWTIYEMLGLPDDQRD
TH_2564|M.thermoresistible__bu DQVNNQAKQIVDDFVKTKEG---DFVEQVAKKLPMWTIYEMVGLPPEKRD
Mflv_2640|M.gilvum_PYR-GCK DSIRANARDIVTELRAAGSGV--DFVSHCAKELPVRTLADMVGIPDSERH
MSMEG_4619|M.smegmatis_MC2_155 DSIKANAAAIVAELKAAGSGV--DFVDHCAKELPIRTLSDMVGIPEGERE
MMAR_3761|M.marinum_M DSIKINAKGIVDELRMAGGGV--DFVEHCAKELPIRTLSDMVGIPEADRE
Mvan_2234|M.vanbaalenii_PYR-1 EQIQRNAVAIVDDLVGAGDI---DFVADCSARLPMLTIMEMLGVPGADQP
Mb2289|M.bovis_AF2122/97 AAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQ
Rv2266|M.tuberculosis_H37Rv AAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQ
MUL_1282|M.ulcerans_Agy99 ASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHE
MAB_0611|M.abscessus_ATCC_1997 DDLNARAQGIARAAAQLRHG---DFVEQVACELPLQAIAGLMGTPLDERE
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQF---DVIADLAFPLAVAVICRLLGVPYEDAP
: . : *.: . : *.: : ::* * .
MAV_5097|M.avium_104 EAAHLAEGMVAWADPEVAAG---RQPAEVLTDSLVGLLNIGIGLAEARRA
TH_2564|M.thermoresistible__bu ETTRHADGMVSWADPEVAAG---REPMQVILESLTALRETAMELADQRRA
Mflv_2640|M.gilvum_PYR-GCK AVADAADAMVSWGDPEYLDG---RNPLEVLFSSQMYLHQVALGLAAERRD
MSMEG_4619|M.smegmatis_MC2_155 KVAHAADALVSWADPIYLAG---RHPLEVLLENQMYLHQVANTLAAERRE
MMAR_3761|M.marinum_M RVAHAADALVSWADPRYLNG---REPLAVLFENQMYLHQVAASLAAERRD
Mvan_2234|M.vanbaalenii_PYR-1 AVALAAEKLFSMSDDEYSSL---EERAANTLNEIMLLSSTGAELAKFRRA
Mb2289|M.bovis_AF2122/97 RIFHWTNVILGFGDPDLAT------DFDEFMQVSADIGAYATALAEDRRV
Rv2266|M.tuberculosis_H37Rv RIFHWTNVILGFGDPDLAT------DFDEFMQVSADIGAYATALAEDRRV
MUL_1282|M.ulcerans_Agy99 QIFHWTNVILGFGDPDLTT------DFDDFLQVSMAIGGYATALADDRRV
MAB_0611|M.abscessus_ATCC_1997 QLFDWSNRLVGSSDGEDDS-----------AVASAELLMYAMGVAARKTA
MLBr_02088|M.leprae_Br4923 EFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRG
: :. * : :. :
MAV_5097|M.avium_104 HPENDLMTSLVQAEVDGRRLTDDELGPYFVLLSVAGNDTTRTTTTFTAIA
TH_2564|M.thermoresistible__bu EPTDDLMSQLVQAEVDGRRLTNDELGAFFVLLSVAGNDTTRNSTSIATMA
Mflv_2640|M.gilvum_PYR-GCK NPGDDLFSSLVHAEVEGARLTDAEIAAFFVLLAVAGNDTTRQTTSHAIKA
MSMEG_4619|M.smegmatis_MC2_155 NPGNDLISALVHAEVDGDRLTDAEVAAFFVLLAVAGNDTTRQTTSHALKA
MMAR_3761|M.marinum_M RPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLKA
Mvan_2234|M.vanbaalenii_PYR-1 HPGDDLMTGIVNAEVDGQRLTDEEIGAFLILLASAGNDTTKQTTTHAMMA
Mb2289|M.bovis_AF2122/97 NHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLA
Rv2266|M.tuberculosis_H37Rv NHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLA
MUL_1282|M.ulcerans_Agy99 NHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTISHGMLA
MAB_0611|M.abscessus_ATCC_1997 EPGADICTDLVNADIDGQKLSDDEFGFFVMLLAVAGNETTRNSITHGMHA
MLBr_02088|M.leprae_Br4923 TPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLA
*: : ::. : .* :*:. :. ** **::** : *
MAV_5097|M.avium_104 LQQFPEQKALLENDFDGQIKVAIDEFVRWTTPVMTFRRTATQDTELHGQH
TH_2564|M.thermoresistible__bu LQEFPDQKELLLNDFDGHIHTAIEEFVRWATPVMTFRRTVTEDTVLRGQE
Mflv_2640|M.gilvum_PYR-GCK LTDHPEQRAWLTASFDDRIGGAVEEFIRWASPVMTFRRTAATDYVLGGQQ
MSMEG_4619|M.smegmatis_MC2_155 LTDFEDQRAWLMEDFDDRIGVAVEEMVRWASPVMTFRRTAAVDVELGGRQ
MMAR_3761|M.marinum_M LTDFPSQKAWLLADFDTRIGTAVEELVRWATPVMTFRRTAAADFELGGQL
Mvan_2234|M.vanbaalenii_PYR-1 LVENPQQRAWLMADFDGRIGAAVEEFVRWSSPVLQFARFATRDTEINGQP
Mb2289|M.bovis_AF2122/97 LSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTK
Rv2266|M.tuberculosis_H37Rv LSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTK
MUL_1282|M.ulcerans_Agy99 LSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGTK
MAB_0611|M.abscessus_ATCC_1997 FTQFPEQWELYKKTRP---ETAADEIVRWATPVTSFQRTALEDTELGGVR
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
: .: . :* :*: ..: : * * :
MAV_5097|M.avium_104 IREGDWVTMVYSSANRDERVFTDPYKFDITRAPNPHVAFGGGGPHYCMGA
TH_2564|M.thermoresistible__bu LKQGDWVLLMYSSGNRDERAFTDPHKFDIRRKPNPHVAFGGGGPHYCMGA
Mflv_2640|M.gilvum_PYR-GCK IAAGEKVVMFYSSGNRDTAVFDRPDLLDLGRDPNPHLGFGGGGRHFCLGA
MSMEG_4619|M.smegmatis_MC2_155 IAAGEKVVMFYASGNWDTTVFDRPDVLDLGRKPNPHLGFGGGGRHFCLGA
MMAR_3761|M.marinum_M IRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVHFCLGA
Mvan_2234|M.vanbaalenii_PYR-1 VAEGDKVGLFYCSANRDEAVFDNPAGFDLSRSPNPHLGFGGGGPHFCLGN
Mb2289|M.bovis_AF2122/97 MAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGA
Rv2266|M.tuberculosis_H37Rv MAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGA
MUL_1282|M.ulcerans_Agy99 MAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLGA
MAB_0611|M.abscessus_ATCC_1997 IKKGQRVVMMYRSANFDEEVFENPFTFDIMRDPNPHVGFGGNGEHHCVGA
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLGA
: *: : : :.* * : * :* * .. ::.*. . *.*:*
MAV_5097|M.avium_104 FMAKMQLESIFRELIFRAPSLRLGE-PEYLTGNFITAVKSLPYTLD----
TH_2564|M.thermoresistible__bu FLAKMQLEAMFRELLFRAPTLRVGE-PSYLRSNFMRAVKSLPYTLD----
Mflv_2640|M.gilvum_PYR-GCK HVARAQLRAIIGELLTQLPDLAAGE-PSFVAGNFIHAVRRMPVTW-----
MSMEG_4619|M.smegmatis_MC2_155 HVARTQLRAIFGELLHQLPDIRAGE-PEYLQGNFVHAIRAMPCTFS----
MMAR_3761|M.marinum_M HLARAQLRAIFGELLVQLPDIQAGD-PVYVPGNFVHAIRSMPCTF-----
Mvan_2234|M.vanbaalenii_PYR-1 QLAKAELRNLFRELLTRLKTVEFGE-PDLLHSSFVHGVKRLPAHVR----
Mb2289|M.bovis_AF2122/97 NLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS----
Rv2266|M.tuberculosis_H37Rv NLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS----
MUL_1282|M.ulcerans_Agy99 NLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVAWSR---
MAB_0611|M.abscessus_ATCC_1997 NLARMTINLMFNAIADHMPDLASAGEPDRLRSGWLNGVKHWEVDFCPAGY
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-----
:*: : : : : . : .:
MAV_5097|M.avium_104 ----
TH_2564|M.thermoresistible__bu ----
Mflv_2640|M.gilvum_PYR-GCK ----
MSMEG_4619|M.smegmatis_MC2_155 ----
MMAR_3761|M.marinum_M ----
Mvan_2234|M.vanbaalenii_PYR-1 ----
Mb2289|M.bovis_AF2122/97 ----
Rv2266|M.tuberculosis_H37Rv ----
MUL_1282|M.ulcerans_Agy99 ----
MAB_0611|M.abscessus_ATCC_1997 GRAS
MLBr_02088|M.leprae_Br4923 ----