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PGEDAVTAPMLYIDPQACVDCGACVEVCPVDAIRHEDELTDEQARFKDINAAYFAAQPLTVRPMSPISVP EPLEQGALRVAVVGAGPAGCYAVADLIRTKGIEVNVFERLPTPFGLVRFGVAPDHQLTKDVTRTFASALS AREVTCFFNVAVGRDVTHDELMAHHHAVIYAVGATGSRDLGIPGEQLDGVFAAGDMVAWYNGHPGHADDE FDLSSPRAVIIGNGNVALDVARVLVMNHDDLAATDIAEHALTRLRDSAIDEVIVLGRRGAAHAAFSVGEL LGLDNLREVDVAIDGDLGDRPQDFDGAIKYDIIAEYAGRAPRPGHRRIVLRFGARPVEVVGADRVEGLEI ADSEGTTIIGTSLVLRSIGYRGSAVDGLPFDDEAGIVPNDGGRVIRDGHPVPGVYVTGWIKRGPHGVIGT NRLCARETVANLLADARGGLLPPAVSTTTELATLLTSRDVTVVDWAGWRSIDAAERRHGEAVSRPRMKIV GLDALLTTARLVDAGLPHHD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5072 | - | - | 100% (511) | NADPH-ferredoxin reductase fpra |
| M. avium 104 | MAV_1015 | - | e-117 | 46.23% (517) | ferredoxin/ferredoxin--NADP reductase |
| M. avium 104 | MAV_4007 | - | 4e-92 | 44.77% (449) | NADPH-ferredoxin reductase fpra |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0910 | fprB | 1e-119 | 47.97% (517) | NADPH:adrenodoxin oxidoreductase FprB |
| M. gilvum PYR-GCK | Mflv_1720 | - | 1e-119 | 47.08% (514) | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein |
| M. tuberculosis H37Rv | Rv0886 | fprB | 1e-119 | 47.97% (517) | NADPH:adrenodoxin oxidoreductase FprB |
| M. leprae Br4923 | MLBr_02134 | fprB | 1e-119 | 46.07% (521) | ferredoxin, ferredoxin-NADP reductase |
| M. abscessus ATCC 19977 | MAB_0930 | - | 1e-118 | 44.49% (508) | putative ferredoxin/ferredoxin--NADP reductase |
| M. marinum M | MMAR_4646 | fprB | 1e-119 | 48.05% (514) | NADPH:adrenodoxin oxidoreductase FprB |
| M. smegmatis MC2 155 | MSMEG_5681 | - | 1e-117 | 46.65% (508) | ferredoxin/ferredoxin--NADP reductase |
| M. thermoresistible (build 8) | TH_1806 | - | 1e-115 | 47.24% (525) | probable ferredoxin/ferredoxin--NADP reductase |
| M. ulcerans Agy99 | MUL_0264 | fprB | 1e-118 | 47.47% (514) | NADPH:adrenodoxin oxidoreductase FprB |
| M. vanbaalenii PYR-1 | Mvan_5031 | - | 1e-115 | 47.79% (498) | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5681|M.smegmatis_MC2_155 MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPDACVDCG
TH_1806|M.thermoresistible__bu ---VITQSCCSDASCVYACPVNCIHPTPDEPGFATTEMLYIDPVACVDCG
Mflv_1720|M.gilvum_PYR-GCK MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPVACVDCG
Mvan_5031|M.vanbaalenii_PYR-1 MPHVITQSCCSDGSCVYACPVNCIHPTPDEPGFATAEMLYIDPVACVDCG
Mb0910|M.bovis_AF2122/97 MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG
Rv0886|M.tuberculosis_H37Rv MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG
MMAR_4646|M.marinum_M MPHVITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG
MUL_0264|M.ulcerans_Agy99 MPHVITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVTCVDCG
MLBr_02134|M.leprae_Br4923 MPYIITQSCCNDGSCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCG
MAB_0930|M.abscessus_ATCC_1997 --------------------MNCIHPTPDEPDFLKAEMLHIDASACVDCG
MAV_5072|M.avium_104 --------------------------MPGE-DAVTAPMLYIDPQACVDCG
*.* . .: **:**. :*****
MSMEG_5681|M.smegmatis_MC2_155 ACVSACPVGAIAPDTRLEPRQLPFVEINAAFYPKRE--GKLPPTSKLAPV
TH_1806|M.thermoresistible__bu ACVTACPVGAIAPDHRLDATQRPFIELNAAFYPPRDPDEKLPPTSKLAPV
Mflv_1720|M.gilvum_PYR-GCK ACVSACPVGAIAPDSKLTPEQLPFVELNAAFYPKRE--GKLPPTSKLAPV
Mvan_5031|M.vanbaalenii_PYR-1 ACVSACPVGAIAPETGLAPDQLPFVELNAAFYPKRD--GKLPPTSKLAPV
Mb0910|M.bovis_AF2122/97 ACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPV
Rv0886|M.tuberculosis_H37Rv ACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPV
MMAR_4646|M.marinum_M ACVSACPVGAIAPDSRLDSKQLPFVEINASYYPQRQGGEKLPPTSKLAPV
MUL_0264|M.ulcerans_Agy99 ACVSACPVGAIAPDSRLDSKQLPFVEINASYYPQRQGGEKLPPTSKLAPV
MLBr_02134|M.leprae_Br4923 ACVSACPVGAIASDTRLAPKQLPFIEINASYYPARPIDLKLPPTSKLAPV
MAB_0930|M.abscessus_ATCC_1997 ACVAACPVDAIKPDSTLKEEQLPFLRINSEFYPREI------PRASLAPV
MAV_5072|M.avium_104 ACVEVCPVDAIRHEDELTDEQARFKDINAAYFAAQP-----LTVRPMSPI
*** .***.** : * * * :*: ::. . . ::*:
MSMEG_5681|M.smegmatis_MC2_155 IEAPKITR--DGPLTVAIVGSGPAAMYAADELLTQRGVRVNVFEKLPTPY
TH_1806|M.thermoresistible__bu IPAPRIERR-GGPLRVAIVGSGPAAMYAADELLTQDDVLVNVFERLPTPY
Mflv_1720|M.gilvum_PYR-GCK LEAPVVHRKSGGPLTVAIVGSGPAAMYAADELLTQPDVRVNVFEKLPTRY
Mvan_5031|M.vanbaalenii_PYR-1 LEAPEVRRRPGGPLTVAIVGSGPAAMYAADELLTQQGVRVNVFEKLPTPY
Mb0910|M.bovis_AF2122/97 TPAAEVRVR-RQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPY
Rv0886|M.tuberculosis_H37Rv TPAAEVRVR-RQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPY
MMAR_4646|M.marinum_M IPAAQVRPR-SQPLTVAIVGSGPAAMYAADELLVQHGVCVNVFEKLPTPY
MUL_0264|M.ulcerans_Agy99 IPAAQVRPR-SQPLTVAIVGSGPAAMYAADELLVQHGVRVNVFEKLPTPY
MLBr_02134|M.leprae_Br4923 IPAAQVHVR-RRPLTVAIVGSGPAAMYAADELLTQPGVWVNVFEKLPTPY
MAB_0930|M.abscessus_ATCC_1997 IQAPPVRGT--SALKVAIVGSGPAAMYAADELLTQPNVKVNMFERLPAPY
MAV_5072|M.avium_104 SVPEPLEQG---ALRVAVVGAGPAGCYAVADLIRTKGIEVNVFERLPTPF
. : .* **:**:***. **. :*: .: **:**:**: :
MSMEG_5681|M.smegmatis_MC2_155 GLVRAGVAPDHQSTKRVTELFDRMAAQRGFTFYLNVEVGKHLTHADLLGH
TH_1806|M.thermoresistible__bu GLVRAGVAPDHQKTKGVTDLFDKIAQQPGFEFYLNVEVGTHLSHAELLAH
Mflv_1720|M.gilvum_PYR-GCK GLVRAGVAPDHQHTKRVTELFDTIADKPGFTFFLNTEVGSDLTHDELLRY
Mvan_5031|M.vanbaalenii_PYR-1 GLVRAGVAPDHQHTKRVTKLFESISGLPGFTLYLNVEVGADLTHDELLAH
Mb0910|M.bovis_AF2122/97 GLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAH
Rv0886|M.tuberculosis_H37Rv GLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAH
MMAR_4646|M.marinum_M GLVRAGVAPDHQNTKRVTRLFDRVARHRRFRFYLNVEIGRKLSHADLLAH
MUL_0264|M.ulcerans_Agy99 GLVRAGVAPDHQNTKRVTRLFDRVARHRRFRFYLNVEIGRQLSHADLLAH
MLBr_02134|M.leprae_Br4923 GLVRAGLAPDHQNTKKVTELFDRVAEHRRFRFFLNVEIGRHLSHDELLAH
MAB_0930|M.abscessus_ATCC_1997 GLVRAGVAPDHQQTKRVTKLFDTMAAQPNFEFFLNVEVGKDITHEELLAH
MAV_5072|M.avium_104 GLVRFGVAPDHQLTKDVTRTFASALSAREVTCFFNVAVGRDVTHDELMAH
**** *:***** ** ** * . ::*. :* .: * :*: :
MSMEG_5681|M.smegmatis_MC2_155 HHAVVYAVGAPNDRRLDIEGMDLPGTATATEVVAWINGHPDHTDLPVRLD
TH_1806|M.thermoresistible__bu HHAVLYAVGAPNDRRLDIDGMGLPGTGTATEVVAWYNGHPDFADLPVDLS
Mflv_1720|M.gilvum_PYR-GCK HHAVLYAVGAPSDRRLDIDGMELPGTATATDLVAWYNGHPEAADLRVDLH
Mvan_5031|M.vanbaalenii_PYR-1 HHAVLYAVGAPDDRRLDIDGIGRPGTATATEVVAWYNGHPEFAHLPVDLS
Mb0910|M.bovis_AF2122/97 HHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLS
Rv0886|M.tuberculosis_H37Rv HHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLS
MMAR_4646|M.marinum_M HHAVVYAVGAPDDRRLHIDGMGLPGTGTATELVAWINGHPDFTDLPVDLS
MUL_0264|M.ulcerans_Agy99 HHAVVYAVGAPDDRRLHIDGMGLPGTGTATELVAWINGHPDFTDLPVDLS
MLBr_02134|M.leprae_Br4923 HHAVLYAVGAPDDRRLNIDGMGIPGTGTATELVAWINAHPDFAYLPVDLS
MAB_0930|M.abscessus_ATCC_1997 HHAVIYSVGASSDRRLDIPGIELPGNATATQVVAWINAHPDYADFRVDLD
MAV_5072|M.avium_104 HHAVIYAVGATGSRDLGIPGEQLDGVFAAGDMVAWYNGHPGHADDEFDLS
****:*:***...* * * * * :* ::*** *.** . *
MSMEG_5681|M.smegmatis_MC2_155 HERVVIVGNGNVALDVARVLTSDPDALARTDISDHALAALRSSAVQEVVI
TH_1806|M.thermoresistible__bu GDRVVIVGNGNVALDVARILTADPDELARTDIADHALAALRSSRVREVVI
Mflv_1720|M.gilvum_PYR-GCK TERVVVIGNGNVALDVARILTTDPDALARTDIADHALARLRDSQVREVVV
Mvan_5031|M.vanbaalenii_PYR-1 GDRVVIIGNGNVALDVARILTAEPDVLARTDIADHALAVLRDSRVREVVI
Mb0910|M.bovis_AF2122/97 HERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVV
Rv0886|M.tuberculosis_H37Rv HERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVV
MMAR_4646|M.marinum_M HERAVIIGNGNVALDVARMLTANPDDLARTDIADPALRALRNSAVREVVI
MUL_0264|M.ulcerans_Agy99 HERAVITGNGNVALDVARMLTANPDDLARTDIADPALRALRNSAVREVVI
MLBr_02134|M.leprae_Br4923 HERVVVIGNGNVALDVARLLTADPDNLARTDISEFALHVLGGSAVREVVV
MAB_0930|M.abscessus_ATCC_1997 HERAVVIGNGNVALDVARVLTGDVERLARTDISDTALTALRSSKLREVVI
MAV_5072|M.avium_104 SPRAVIIGNGNVALDVARVLVMNHDDLAATDIAEHALTRLRDSAIDEVIV
*.*: ***********:*. : . ** ***:: ** * .* : **::
MSMEG_5681|M.smegmatis_MC2_155 AARRGPAASAFTLPELIGLT--STCDVVLDSADHDLVLRDLAQETDPLT-
TH_1806|M.thermoresistible__bu AARRGPADSAFTLPELIGLT--ATADVVLDARDHELVDRDLARTTDSLT-
Mflv_1720|M.gilvum_PYR-GCK AARRGPAAAAFTLPELIGLT--SSCDVVLDPADHDSVLAELAEATDPLT-
Mvan_5031|M.vanbaalenii_PYR-1 AARRGPAASSFTLPELIGLT--STCEVVLDPADHERVLTDLAAATDPLT-
Mb0910|M.bovis_AF2122/97 AARRGPAHSAFTLPELIGLT--AGADVVLDPGDHQRVLDDLAIVADPLT-
Rv0886|M.tuberculosis_H37Rv AARRGPAHSAFTLPELIGLT--AGADVVLDPGDHQRVLDDLAIVADPLT-
MMAR_4646|M.marinum_M AARRGPAHSAFTLPELIGLT--GCAEVVLDAADRQRVLDDLATVSDQLT-
MUL_0264|M.ulcerans_Agy99 AARRGPAHSAFTLPELIGLT--GCAEVVLDAADRQRVLDDLATVSDQLT-
MLBr_02134|M.leprae_Br4923 AARRGPAHSAFTLPELIGLK--ATSEVVLDAGDRKLVEGDFATVSDSLT-
MAB_0930|M.abscessus_ATCC_1997 VGRRGPEHSAFTLPELLGLVGLPDMTVVVDQETADLVDQALQTHLEPLT-
MAV_5072|M.avium_104 LGRRGAAHAAFSVGELLGLDNLREVDVAIDG--------DLGDRPQDFDG
.***. ::*:: **:** *.:* : : :
MSMEG_5681|M.smegmatis_MC2_155 RNKLEILAKLGDASAPITRP---RIRFAYQLTPRRVLGE-----NQVTAV
TH_1806|M.thermoresistible__bu RNKLEILAKLPDAAAPITRP---RIRFAYQLTPRAILRAGAPAADRAAGI
Mflv_1720|M.gilvum_PYR-GCK RNKLEILSTLGDTTAPVTRP---RIRLAYQLTPRRITGD-----ARAAGV
Mvan_5031|M.vanbaalenii_PYR-1 RSKLEIMSKLGDATAPVTRP---RIRLAYRLTPRRVLGE-----ERATGV
Mb0910|M.bovis_AF2122/97 RNKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQ-----RRAGGV
Rv0886|M.tuberculosis_H37Rv RNKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQ-----RRAGGV
MMAR_4646|M.marinum_M KRKLEILATLGEGS-AASGP---RIRLAYQLTPRSVRGE-----QRVSGV
MUL_0264|M.ulcerans_Agy99 KRKLEILATLGEGS-AASGP---RIRLAYQLTPRSVRGE-----QRASGV
MLBr_02134|M.leprae_Br4923 RKKLEVLSSLVDSSKPTSRR---RIRLAYQLTPKRVLGN-----QRATGV
MAB_0930|M.abscessus_ATCC_1997 RQKLEVLSTCPREAREPGGK---TIRFAYNRTPARVLGE-----DRVEAI
MAV_5072|M.avium_104 AIKYDIIAEYAGRAPRPGHR---RIVLRFGARPVEVVGA-----DRVEGL
* :::: : * : : * : :. .:
MSMEG_5681|M.smegmatis_MC2_155 EFGVTGTDEVRTLDAGLLLTSIGYRGKAIADLPFDEDASVVPNDGGRVID
TH_1806|M.thermoresistible__bu EFVRTGTDEVCRLDAGLVLTSIGYRGRPIRDLPFDDTAAVVPNDGGRVVD
Mflv_1720|M.gilvum_PYR-GCK EFTVTGGDEVVEISAGLVLTSIGYRGTPIRGLPFDADAAVVPNDGGRVIA
Mvan_5031|M.vanbaalenii_PYR-1 QFDVTGTGETCELTAGLVLTSIGYRGKPIRGLPFDEAAAVVPNAGGRVVD
Mb0910|M.bovis_AF2122/97 QFSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVID
Rv0886|M.tuberculosis_H37Rv QFSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVID
MMAR_4646|M.marinum_M EFSVTGTDEMRTLDAGLVLTSIGYRGKKIGDLPFDDNAAVVPNDGGRVVD
MUL_0264|M.ulcerans_Agy99 EFSVTGTDEMRTLDAGLVLTSIGYRGTKIGDLPFDDNAAVVRNDGGRVVD
MLBr_02134|M.leprae_Br4923 EFSVTGTEESRRFDAGLVLTSVGYRGKRIRDLPFDEEAAVIPNDGGRVVD
MAB_0930|M.abscessus_ATCC_1997 EFQHGDTTDT--IKAGLFLTSIGYRGVPMPDVPFDSQRGTIPNEQGRVKD
MAV_5072|M.avium_104 EIADS--EGTTIIGTSLVLRSIGYRGSAVDGLPFDDEAGIVPNDGGRVIR
:: : :.*.* *:**** : .:*** . : * ***
MSMEG_5681|M.smegmatis_MC2_155 PATGAPVPGAYVAGWIKRGPTGFIGTNKSCAAQTVHHLVDDYNAGALTDP
TH_1806|M.thermoresistible__bu PATGRPVPGSYVAGWIKRGPTGFIGTNKSCAAETVHKLVDDYNAGLLTEP
Mflv_1720|M.gilvum_PYR-GCK --GADPVRGSYVAGWIKRGPTGFIGTNKSCAAETVHNLVADYNDGLLADP
Mvan_5031|M.vanbaalenii_PYR-1 PETGEPVRGSYVAGWIKRGPTGFIGTNKSCAAETVHHLAADYNAGLLADP
Mb0910|M.bovis_AF2122/97 PGTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDP
Rv0886|M.tuberculosis_H37Rv PGTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDP
MMAR_4646|M.marinum_M PVRGAPVPGVYVAGWIKRGPSGFIGTNKSCSLQTVAALVADFNAGKLGDP
MUL_0264|M.ulcerans_Agy99 PVRGAPVPGVYVAGWIKRGPSGFIGTNKSCSLQTVAALVADFNAGKLGDP
MLBr_02134|M.leprae_Br4923 PSRGRPMPGAYVAGWIKRGPTGFIGTNKLCSVQTVQAVVADFNAGWLTDP
MAB_0930|M.abscessus_ATCC_1997 SSTGQAHPGTYVAGWIKRGPTGFIGTNKSCSQQTVTSLVEDYNNGLLADP
MAV_5072|M.avium_104 --DGHPVPGVYVTGWIKRGPHGVIGTNRLCARETVANLLADARGGLLPPA
. . * **:******* *.****: *: :** : * . * * .
MSMEG_5681|M.smegmatis_MC2_155 PRKPSALDKLVRARQPDVVDAAGWRAIDAAEIARGGDD-RPRDKFTTVPE
TH_1806|M.thermoresistible__bu IHRPSALDKLVRSRRPDLVTAAGWRAIDAAEIDRGGQE-RPRVKFTGTDQ
Mflv_1720|M.gilvum_PYR-GCK VHRGAALEHFVRGRRPAVIGTAGWKAIDEAEIARGAGV-RPREKFTSVAE
Mvan_5031|M.vanbaalenii_PYR-1 SHKASALDRFVRGRQPAVIDACGWRAIDAAEVARGAGL-RPRDKFTTVAE
Mb0910|M.bovis_AF2122/97 VATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAE
Rv0886|M.tuberculosis_H37Rv VATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAE
MMAR_4646|M.marinum_M VCKPAALAKLVHTREPDVIDSAGWFAIDAAEIARGNGEGRPRNKFTDVAD
MUL_0264|M.ulcerans_Agy99 VCKPAALAKLVHTREPDVIDSAGWFAIDAAEIARGNAEGRPRNKFTDVAD
MLBr_02134|M.leprae_Br4923 VAEPAELAKLVHARQPDTVDSVGWRAIDAAEIAQGSTEGRPRRKFTDVAD
MAB_0930|M.abscessus_ATCC_1997 PQRLSGLSKVIQRRQPTIIGHDGWLAIDRAEIARGKGAGRPRDKFVSVPE
MAV_5072|M.avium_104 VSTTTELATLLTSRDVTVVDWAGWRSIDAAERRHGEAVSRPRMKIVGLDA
: * .: * : ** :** ** :* * * *:.
MSMEG_5681|M.smegmatis_MC2_155 MLAVAVTAPKPSVRQR-----LTAGLLG--------
TH_1806|M.thermoresistible__bu MLAVARTAPAPPLRQR-----LLAALRQPLTGVV--
Mflv_1720|M.gilvum_PYR-GCK MVEVAANAPAPPIHRR-----VLAALRR--------
Mvan_5031|M.vanbaalenii_PYR-1 MENVAAAAAAPPMSKR-----LLEALRR--------
Mb0910|M.bovis_AF2122/97 MLAAATSAPKEPLRRRVLA--RLRDLGQPIVLTVPL
Rv0886|M.tuberculosis_H37Rv MLAAATSAPKEPLRRRVLA--RLRDLGQPIVLTVPL
MMAR_4646|M.marinum_M MLGAAASGA--PVRS-------SRGLLAGILGR---
MUL_0264|M.ulcerans_Agy99 MLGAAASGA--PVRP-------SRGLLAAILGR---
MLBr_02134|M.leprae_Br4923 MLAVAAGAP--PLR--------LRALS---------
MAB_0930|M.abscessus_ATCC_1997 MLRVAADAPQPPLWRKAIRGSALEDLLR--------
MAV_5072|M.avium_104 LLTTARLVDAGLPHHD--------------------
: .*