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YKVGVWGPGSMGVIALRGVIDHPQLELVDLVVHSDAKAGRDAGELCGVAPVGVVATQDPAAMLAGDADAV VYAAGANLRPLEAVEDMVSILRAGKNVVSCSVVPLVFPDAVDSAFTEPLRAAALEGQVSFFTTGIDSGFA NDVLPLVLTGVSRVIESVRVTEMFNYATYPDASAVYEILGFGQPPDHPAFAAQPGIFTFGWGPVLHQLAA GLGVEIDHIEESNERIPAPESFDTPTGHIAAGTIAAMRSTLTGYVGAKPTFVLDHVTRMRDDLAPDWPQP RIAIAPKDLGYGLASGRGLYRVEIEGSPSMRCEFEMAEDHDHDLGARIAGSSRMVNAIPAVCAAPPGLLS ALDLPLITGAGLVRPVPGPPPDSRLF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4999 | dapB | - | 100% (377) | dihydrodipicolinate reductase N-terminus domain-containing protein |
| M. avium 104 | MAV_1045 | dapB | 4e-85 | 45.58% (362) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. avium 104 | MAV_5137 | - | 4e-75 | 43.63% (369) | homoserine dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0949c | - | 2e-77 | 44.41% (358) | hypothetical protein Mb0949c |
| M. gilvum PYR-GCK | Mflv_1824 | - | 5e-75 | 42.31% (364) | dihydrodipicolinate reductase |
| M. tuberculosis H37Rv | Rv0926c | - | 2e-77 | 44.41% (358) | hypothetical protein Rv0926c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4633 | - | 8e-79 | 44.35% (363) | hypothetical protein MAB_4633 |
| M. marinum M | MMAR_4582 | - | 1e-79 | 43.84% (365) | hypothetical protein MMAR_4582 |
| M. smegmatis MC2 155 | MSMEG_5586 | - | 9e-81 | 44.51% (364) | hypothetical protein MSMEG_5586 |
| M. thermoresistible (build 8) | TH_4297 | - | 2e-81 | 43.94% (355) | PUTATIVE putative dihydrodipicolinate reductase, N-terminus |
| M. ulcerans Agy99 | MUL_4353 | - | 6e-36 | 31.02% (361) | hypothetical protein MUL_4353 |
| M. vanbaalenii PYR-1 | Mvan_4922 | - | 3e-74 | 42.86% (364) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1824|M.gilvum_PYR-GCK ----MAIKVAAVGTGNVGRHALAQLINDPRFELTAVWVSSEAKAGKDAAE
Mvan_4922|M.vanbaalenii_PYR-1 ----MAIKVAAIGTGNVGRHALTQLITDPRFELTAVWVSSESKAGKDAAE
MSMEG_5586|M.smegmatis_MC2_155 ----MAIRVAAIGTGNVGRHALRQLITNPAYELTAVWVSSPEKAGKDAGD
Mb0949c|M.bovis_AF2122/97 ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
Rv0926c|M.tuberculosis_H37Rv ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
MMAR_4582|M.marinum_M ----MAIPVVQLGTGNVGLHSLRALITNPEFELTGVWVSSDAKAGKDAAE
MAB_4633|M.abscessus_ATCC_1997 ---MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGA
MAV_4999|M.avium_104 -----MYKVGVWGPGSMGVIALRGVIDHPQLELVDLVVHSDAKAGRDAGE
TH_4297|M.thermoresistible__bu --------VILWGPGQVGVGALRAVIAHPGLELVGLVVHSPAKHGKDAGA
MUL_4353|M.ulcerans_Agy99 MSGPAKLRVIQWATGGVGKAAIECILNHPQLELAGCWVHSAAKHGLDVGT
* ..* :* :: :: .* **. * . * * *..
Mflv_1824|M.gilvum_PYR-GCK LAGLQDSTGIRATTDLDEVLATRPECVVYTALADNRLPDALEDYRRILAA
Mvan_4922|M.vanbaalenii_PYR-1 LVGLADSTGIRATTDLDAVLATRPQCAVYTALADNRLPEALEDYRRILAA
MSMEG_5586|M.smegmatis_MC2_155 LAGLEVTTGIKATDSLDEVLATEPECAVYTAMADNRLPDALEDYRRILAA
Mb0949c|M.bovis_AF2122/97 LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
Rv0926c|M.tuberculosis_H37Rv LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
MMAR_4582|M.marinum_M LAGFAESTGVKASTDLDAVLASGPQCAVYNAMADNRLPEALDDYRRVLAA
MAB_4633|M.abscessus_ATCC_1997 LAGLDILTGITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTDLLSA
MAV_4999|M.avium_104 LCGVAP-VGVVATQDPAAMLAGDADAVVYAAGANLRPLEAVEDMVSILRA
TH_4297|M.thermoresistible__bu LCGMPE-TGILATNDIDAALAVDADVVAYFASGDYRYREAAEDIARCLRA
MUL_4353|M.ulcerans_Agy99 IIGAAR-FGVTATNDVDELLALDADCVMYSPQVAD-----EQDVKAILRS
: * *: *: . ** . . * . .* * :
Mflv_1824|M.gilvum_PYR-GCK GVNVVGSSAVFLQHPWQVLPAELISPIEDAAKAGNASLFVNGIDPGFAND
Mvan_4922|M.vanbaalenii_PYR-1 GVNVVGSSAVFLQHPWKVLPDELIAPIEDAAKAGSSTIFVNGIDPGFAND
MSMEG_5586|M.smegmatis_MC2_155 GVNVVGSSAVFLQYPWQVLPEELVKPIEDAAHAGGASLFVNGIDPGFAND
Mb0949c|M.bovis_AF2122/97 GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
Rv0926c|M.tuberculosis_H37Rv GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
MMAR_4582|M.marinum_M GVNIVGSGPVFLQYPWQVLPDELVKPLEDAAREGNSSLYVSGIDPGFAND
MAB_4633|M.abscessus_ATCC_1997 GINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPGFAND
MAV_4999|M.avium_104 GKNVVSCSVVPLVFP-DAVDSAFTEPLRAAALEGQVSFFTTGIDSGFAND
TH_4297|M.thermoresistible__bu GKNVVTTSLVPLCYP-PAADAETVDLIEAACAEGRTTFFNSGVDPGWAND
MUL_4353|M.ulcerans_Agy99 GKNVFTP----VGWVYPDLSKPRVKAVADAAVAGGVTLHGSGIHPGGITE
* *: : : *. * ::. *:..* .:
Mflv_1824|M.gilvum_PYR-GCK LLPMALAGTCQSIQQIRCMEIINYDTYDSAAVMFDVMGFGGSLDETPMLL
Mvan_4922|M.vanbaalenii_PYR-1 LLPMALAGTCQSIQQIRCMEIINYDTYDSAPVMFDVMGFGGSLDETPMLL
MSMEG_5586|M.smegmatis_MC2_155 LLPLALAGTCQQIEQIRCMEIVDYATYDSATVMLDVMGFGKSLDETPMLL
Mb0949c|M.bovis_AF2122/97 LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLL
Rv0926c|M.tuberculosis_H37Rv LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLL
MMAR_4582|M.marinum_M LLPMALAGTCQSIEQIRCMEIVDYATYDSAVVMFDVMGFGKPLDEIPMLL
MAB_4633|M.abscessus_ATCC_1997 LLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFGKPMEETPMLL
MAV_4999|M.avium_104 VLPLVLTGVSRVIESVRVTEMFNYATYPDASAVYEILGFGQPPDHPAFAA
TH_4297|M.thermoresistible__bu LMALTMTGFSSRVDTITMLEILDYAPINQPEIMFDFMGFGHPPEHPAPLF
MUL_4353|M.ulcerans_Agy99 RFPLMVSSLSSAITHVRAEEFSDIRTYNAPDVVRDIMGFGVPHAQAMQGP
:.: : . . : : *: : . . : :.:*** . .
Mflv_1824|M.gilvum_PYR-GCK QPGVLSLAWGSVVRQLAAGLDIELDEVT-ETHERVPAPESFDIAAGRIEE
Mvan_4922|M.vanbaalenii_PYR-1 QPGVLSLAWGSVVRQLAAGLGIELDEVT-ETHLRVPAPEAFDIAAGRIEK
MSMEG_5586|M.smegmatis_MC2_155 QPGVLSLAWGSVVRQLAAGLGIELDAVT-EEHTRVPAPEDFDIAAGHISE
Mb0949c|M.bovis_AF2122/97 QPGVLSLAWGSVVRQLAAGLGISLDGVE-EMYVREPAPEAFNIASGHIPK
Rv0926c|M.tuberculosis_H37Rv QPGVLSLAWGSVVRQLAAGLGISLDGVE-EMYVREPAPEAFNIASGHIPK
MMAR_4582|M.marinum_M QPGVLSLAWGSVVRQLAAGLGLSLDVVE-EMYVREPAPHAFDIASGHIPQ
MAB_4633|M.abscessus_ATCC_1997 QPGVLSLAWGSVVRQLAAGLGVELDEVT-EVYEKLSAPEDFDISSGHIPA
MAV_4999|M.avium_104 QPGIFTFGWGPVLHQLAAGLGVEIDHIE-ESNERIPAPESFDTPTGHIAA
TH_4297|M.thermoresistible__bu DPERLAALWAPTVHLVADGVGLPLDRVE-TTIDKWLATERYRVASGWIEP
MUL_4353|M.ulcerans_Agy99 MAALLESGFKMSVRMIANHMGFHIDPMIRATHEIAVATSDIASDVLPIAA
. : : :: :* :.. :* : *. *
Mflv_1824|M.gilvum_PYR-GCK GTTAAIRFEVRGMKDGNVAVILEHVTRLR-DDLCPDWPQP----------
Mvan_4922|M.vanbaalenii_PYR-1 GTTAAIRFEVRGMKDGEVAVVLEHVTRLR-DDLCPDWPQP----------
MSMEG_5586|M.smegmatis_MC2_155 GTTAAMRFEVRGMVDGKPAVVLEHVTRLR-DDLCPEWPQP----------
Mb0949c|M.bovis_AF2122/97 GSAAALRFEVLGLVDGVPAVVLEHVTRLR-ADLCPEWPQP----------
Rv0926c|M.tuberculosis_H37Rv GSAAALRFEVLGLVDGVPAVVLEHVTRLR-ADLCPEWPQP----------
MMAR_4582|M.marinum_M GSAAALRFEVLGLVDGAPVVVLEHVTRLR-EDLCPDWPQP----------
MAB_4633|M.abscessus_ATCC_1997 GTMAALHFEVRGIKDGRAVTVLEHFTRLR-EDLAPNWPQP----------
MAV_4999|M.avium_104 GTIAAMRSTLTGYVGAKPTFVLDHVTRMR-DDLAPDWPQPRIAIAPKDLG
TH_4297|M.thermoresistible__bu GTMGGMRFKLAGIVDGEPRVVLEHITRMG-EHSAPDWPRH----------
MUL_4353|M.ulcerans_Agy99 DTVAGRKFRWQTLADGKPVITAAVNWLMGQADMHPDWSFG----------
.: .. : .. : . *:*.
Mflv_1824|M.gilvum_PYR-GCK ---AQHGGSYRIEVTGEP----SYAMDLCLSSPNGDHNHAGLVATAARVV
Mvan_4922|M.vanbaalenii_PYR-1 ---AQHGGSYRIEITGEP----SYALDLCLSSPNGDHNHAGLVATAARVV
MSMEG_5586|M.smegmatis_MC2_155 ---AQEGGSYRVEVTGEP----SYALDLCLSSPYGDHNHAGLVATAARVV
Mb0949c|M.bovis_AF2122/97 ---AQPGGSYRIEISGEP----CYAMDICLSSRHGDHNHAGLVATAMRIV
Rv0926c|M.tuberculosis_H37Rv ---AQPGGSYRIEISGEP----CYAMDICLSSRHGDHNHAGLVATAMRIV
MMAR_4582|M.marinum_M ---AQPGGSYRIEITGEP----SYAMDLCLSSRRGDHNHAGLVATAMRVV
MAB_4633|M.abscessus_ATCC_1997 ---AHEGGTYRVEITGEP----SYLLDLGSFSARGDHNYANLIATAMRVV
MAV_4999|M.avium_104 YGLASGRGLYRVEIEGSP----SMRCEFEMAEDH-DHDLGARIAGSSRMV
TH_4297|M.thermoresistible__bu ---PSPHGGYRVVVDGLP----TYTVDIEM-HGRGNNMRGLTYATVMREL
MUL_4353|M.ulcerans_Agy99 ----ERGERFEIEITGNPSVSLVFKGLQPTSITEGLQRNPGVVATANHCA
:.: : * * : * :
Mflv_1824|M.gilvum_PYR-GCK NAIPAVVDSSPGIVTARELPPITG---KGLYANP----------
Mvan_4922|M.vanbaalenii_PYR-1 NAIPAVIDAAPGIVTARELPPITG---EGLYAKP----------
MSMEG_5586|M.smegmatis_MC2_155 NAIPAVFAAPPGIRTTLDMPLITG---KGLYAAR----------
Mb0949c|M.bovis_AF2122/97 NAIPAVVAAEPGIRTTLDLPLITG---EGRYAAA----------
Rv0926c|M.tuberculosis_H37Rv NAIPAVVAAEPGIRTTLDLPLITG---EGRYAAA----------
MMAR_4582|M.marinum_M NAIPAVVAAPPGIRTTLELPLVTG---KGLYLPPAGAA------
MAB_4633|M.abscessus_ATCC_1997 NAVPAVVAAEAGIRTTLDLPLITG---KGRAV------------
MAV_4999|M.avium_104 NAIPAVCAAPPGLLSALDLPLITG---AGLVRPVPGPPPDSRLF
TH_4297|M.thermoresistible__bu NAIPAVVAAPPGLLSTLDLPLVTGPVRGGRWTGTLPPTTRR---
MUL_4353|M.ulcerans_Agy99 NAIPVVCAADPGIATYLDLPLFAG--RPARASRGLER-------
**:*.* : .*: : ::* .:* .