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MDIADRLRLDVPVGQAGMGGGLAGAPLAAAVAAAGGLGTLGITTPGRLEASIQRVREQAPGRAVAVNLLL PFTRRRHVAVCVEARVDVVVLAFGENRGLVAHLRQAGAFVFAMVGAVAQARAAIAWGADGLIAQGREAGG HLVGTMAALDFLPHALAAAAGRPVFLAGGIATAADSRAALDAGADGVIAGTRFLLTHEADASRGYQQRVL QADNTIETNLFGLSWPLRHRVVPNAATRRWCGAHGKARALPAALNAASRPLSALGYFDAGALLRLQSPRR PLFTPLAPVAGVPDSLLDSAALYAGETASRIGELTSARQAVADLTPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4991 | - | - | 100% (327) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. avium 104 | MAV_0607 | - | 5e-26 | 30.27% (337) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. avium 104 | MAV_2791 | - | 8e-25 | 29.38% (337) | oxidoreductase, 2-nitropropane dioxygenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3583 | - | 2e-29 | 32.06% (340) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1487 | - | 3e-25 | 31.36% (338) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv3553 | - | 3e-29 | 32.06% (340) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0603c | - | 1e-25 | 29.52% (332) | 2-nitropropane dioxygenase |
| M. marinum M | MMAR_5042 | - | 1e-28 | 31.76% (340) | 2-nitropropane dioxygenase |
| M. smegmatis MC2 155 | MSMEG_6004 | - | 2e-26 | 30.93% (333) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. thermoresistible (build 8) | TH_4534 | - | 1e-110 | 62.27% (326) | PUTATIVE oxidoreductase, 2-nitropropane dioxygenase family |
| M. ulcerans Agy99 | MUL_4116 | - | 2e-28 | 31.76% (340) | 2-nitropropane dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_5269 | - | 3e-25 | 31.36% (338) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1487|M.gilvum_PYR-GCK -MSTLKTPLTELVGIEHPVVQTGMG-WVAGARLVAATSNAGGLGILASAT
Mvan_5269|M.vanbaalenii_PYR-1 -MSRLSTPLTELVGIEHPVVQTGMG-WVAGARLVSATSNAGGLGILASAT
MSMEG_6004|M.smegmatis_MC2_155 -MSRLMTPLTELVGIEHPVVQTGMG-WVAGARLVSATSNAGGLGILASAT
MAB_0603c|M.abscessus_ATCC_199 MTQVLKTALTQLVGIEHPVVQTGMG-WVAGPRLVAATSNAGGLGILASAT
Mb3583|M.bovis_AF2122/97 --MRLRTPLTELIGIEHPVVQTGMG-WVAGARLVSATANAGGLGILASAT
Rv3553|M.tuberculosis_H37Rv --MRLRTPLTELIGIEHPVVQTGMG-WVAGARLVSATANAGGLGILASAT
MMAR_5042|M.marinum_M --MRLRTPLTDLVGVEHPVVQTGMG-WVAGARLVSATANAGGLGILASAT
MUL_4116|M.ulcerans_Agy99 --MRLRTPLTDLVGVEHPVVQTGMG-WVAGARLVSATANAGGLGILASAT
MAV_4991|M.avium_104 ------MDIADRLRLDVPVGQAGMGGGLAGAPLAAAVAAAGGLGTLG--I
TH_4534|M.thermoresistible__bu ------VDVLDRLRLDVPVAQAGMGGGLAGPELAVAVADAGGLGTLG--L
: : : :: ** *:*** :**. *. *.: ***** *.
Mflv_1487|M.gilvum_PYR-GCK MTLTELTTAVAKVKAATDKPFGINIRADAGDAGERVDLLIREGVKVASFA
Mvan_5269|M.vanbaalenii_PYR-1 MTLEELTTAVAKVKAATDKPFGINIRADAGDANARVDLLIREGVKVASFA
MSMEG_6004|M.smegmatis_MC2_155 MTLDELKTAVAKVKAATDKPFGINIRADAGDANERVDLLISEGVKVASFA
MAB_0603c|M.abscessus_ATCC_199 MTLDELIAAVAKTKSLTDKPFGVNIRADAGDATERIDLLIREKVKVASFA
Mb3583|M.bovis_AF2122/97 MTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFA
Rv3553|M.tuberculosis_H37Rv MTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFA
MMAR_5042|M.marinum_M MTLDELATAIGKVKATTDKPFGVNIRADAADASDRVELMIREGVKVASFA
MUL_4116|M.ulcerans_Agy99 MTLDELATAIGKVKATTDKPFGVNIRADAADASDRVELMIREGVKVASFA
MAV_4991|M.avium_104 TTPGRLEASIQRVREQAPGRAVAVNLLLPFTRRRHVAVCVEARVDVVVLA
TH_4534|M.thermoresistible__bu TAPDRLRDGIRRVRAEAPGRAVAVNLLMPFVRRPHVRVCVEERIDVAVVA
: .* .: :.: : . :: : : : *. .*
Mflv_1487|M.gilvum_PYR-GCK LAPKPDLIARLKEAGVVVIPSVGLAKHAKKVAGWGADAVIVQGGEGGGHT
Mvan_5269|M.vanbaalenii_PYR-1 LAPKPDLIARLKDAGVVVIPSVGLAKHAKKVAGWGADAVIVQGGEGGGHT
MSMEG_6004|M.smegmatis_MC2_155 LAPKPDLIAKLKEAGVVVIPSVGLAKHAKKVASWGADAVIVQGGEGGGHT
MAB_0603c|M.abscessus_ATCC_199 LAPKQDLIAKLKDNGVVVVPSIGAAKHAKKVAAWGADAVIVQGGEGGGHT
Mb3583|M.bovis_AF2122/97 LAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHT
Rv3553|M.tuberculosis_H37Rv LAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHT
MMAR_5042|M.marinum_M LAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEGGGHT
MUL_4116|M.ulcerans_Agy99 LAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEGGGHT
MAV_4991|M.avium_104 FGENRGLVAHLRQAGAFVFAMVGAVAQARAAIAWGADGLIAQGREAGGHL
TH_4534|M.thermoresistible__bu FGGDRALVRELRDAGVFVFTMVGTADQVRRALHWGVDALIAQGAEAGGHL
:. . *: .*:: *..*.. :* . :.: . **.*.:*.** *.***
Mflv_1487|M.gilvum_PYR-GCK G-PIATTLLLPSVLDAVADTGMPVIAAGGFFDGRGLAAALTYGAAGVAMG
Mvan_5269|M.vanbaalenii_PYR-1 G-PIATTLLLPSVLDAVADTGMPVIAAGGFFDGRGLAAALSYGAAGVAMG
MSMEG_6004|M.smegmatis_MC2_155 G-PIATTLLLPSVLDAVADTGMPVIAAGGFFDGRGLAAALSYGAAGVAMG
MAB_0603c|M.abscessus_ATCC_199 G-PVATTLLLPSVLDAVKDTGMPVVAAGGFFDGRGLAAALSYGAAGVAMG
Mb3583|M.bovis_AF2122/97 G-PVATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMG
Rv3553|M.tuberculosis_H37Rv G-PVATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMG
MMAR_5042|M.marinum_M G-PVATTLLLPSVLDAVKGTGIPVIAAGGFFDGRGLAAALSYGAAGVAMG
MUL_4116|M.ulcerans_Agy99 G-PVATTLLLPSVLDAVKGTGIPVIAAGGFFDGHGLAAALSYGAAGVAMG
MAV_4991|M.avium_104 VGTMAALDFLPHALAAAAGR--PVFLAGGIATAADSRAALDAGADGVIAG
TH_4534|M.thermoresistible__bu VGESPAAAFLPKARDLAGGR--PVFLAGGVATAADTRAALDAGADAVVAG
.: :** . . . **. ***. . . *** ** .* *
Mflv_1487|M.gilvum_PYR-GCK TRFLLTKDSTVPDAVKQRYLDAALDGTVVSTKVDGMPHRVLRTGLVEKLE
Mvan_5269|M.vanbaalenii_PYR-1 TRFLLTSDSTVPDAVKQRYLDAALDGTVVSTKVDGMPHRVLRTGLVEKLE
MSMEG_6004|M.smegmatis_MC2_155 TRFLLTSDSTVPDAVKQRYLQAALDGTVVSTRVDGMPHRVLRTGLVEKLE
MAB_0603c|M.abscessus_ATCC_199 TRFLLTSDSSVPDGVKQRYLASDLAGTVVSTRVDGMPHRVLRTELVEKLE
Mb3583|M.bovis_AF2122/97 TRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVEKLE
Rv3553|M.tuberculosis_H37Rv TRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVEKLE
MMAR_5042|M.marinum_M TRFLLTSDSTVPEAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGLVEKLE
MUL_4116|M.ulcerans_Agy99 TRFLLTSDSTVPDAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGLVEKLE
MAV_4991|M.avium_104 TRFLLTHEADASRGYQQRVLQADNT---IETNLFGLSWPLR-----HRVV
TH_4534|M.thermoresistible__bu TRFLLTHESGAHPEYQRRLLEAETT---YRTMLFGLGWPAP-----HRVV
****** :: . ::* * : * : *: .::
Mflv_1487|M.gilvum_PYR-GCK SGSPVRGLSAAVLNAQKFKKMSGMTWKSMITDGLAMRHGKDLTWSQVVMA
Mvan_5269|M.vanbaalenii_PYR-1 SGSPIRGLSAAVLNAQKFKKMSGMTWKSMITDGLAMRHGKDLTWSQVVMA
MSMEG_6004|M.smegmatis_MC2_155 SGSRVRGFAAAVGNAQKFKKMSGMTWRSMIKDGLAMRHGKELTWSQVVMA
MAB_0603c|M.abscessus_ATCC_199 SGSRVRGFTAAVRNAAKFKKMTGMSWASMVKDGLAMRHGKELTWSQVLMA
Mb3583|M.bovis_AF2122/97 SGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQVLMA
Rv3553|M.tuberculosis_H37Rv SGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQVLMA
MMAR_5042|M.marinum_M GGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWSQVVMA
MUL_4116|M.ulcerans_Agy99 GGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWSQVLMA
MAV_4991|M.avium_104 PNAATRRWCGAHGKARALPAALNAASRPLSALG-YFDAGALLRLQSPRRP
TH_4534|M.thermoresistible__bu GNAATRRWCDASGTAKRLPVWINARSEFMARLG-DVPPAVLVRWQRPALP
.: * * .* : : * . . : . .
Mflv_1487|M.gilvum_PYR-GCK ANTPMLLKAGLVEGNTEAGVLASGQVAGIIDDLPSCAELVPAIVAEAVEH
Mvan_5269|M.vanbaalenii_PYR-1 ANTPMLLKAGLVEGNTDAGVLASGQVAGIIDDLPSCAELVPAIVAEAVEH
MSMEG_6004|M.smegmatis_MC2_155 ANTPMLLKAGLVEGNTDAGVLASGQVTGIIDDLPSCAELVPAIVADAVEH
MAB_0603c|M.abscessus_ATCC_199 ANTPMLLKAGLVEGNTNAGVLASGQVAGILDDLPSCHELIDAIVTDAVAH
Mb3583|M.bovis_AF2122/97 ANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDAITH
Rv3553|M.tuberculosis_H37Rv ANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDAITH
MMAR_5042|M.marinum_M ANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVHDAIEH
MUL_4116|M.ulcerans_Agy99 ANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVHDAIEH
MAV_4991|M.avium_104 LFTPLAPVAGVPDSLLDSAALYAGETASRIGELTSARQAVADLTPR----
TH_4534|M.thermoresistible__bu LFSPAAPTRAMPAAWVDRTALYAGESVLRMAAVIPARDAVAELSPAQGV-
:* .: . : .* :*: . : : .. : : :
Mflv_1487|M.gilvum_PYR-GCK LQKASQYIR--
Mvan_5269|M.vanbaalenii_PYR-1 LQKASQHIR--
MSMEG_6004|M.smegmatis_MC2_155 LNKASSFIQEK
MAB_0603c|M.abscessus_ATCC_199 LKAANATIL--
Mb3583|M.bovis_AF2122/97 LQTASALVE--
Rv3553|M.tuberculosis_H37Rv LQTASALVE--
MMAR_5042|M.marinum_M LRAAAALVE--
MUL_4116|M.ulcerans_Agy99 LRAAAALVE--
MAV_4991|M.avium_104 -----------
TH_4534|M.thermoresistible__bu -----------