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VKTHRIGRLLGLGSSALITAAGLLGAPAAVPVASADDCPDVEVIFARGTNEPPGMGRVGDAFVESLRQQT SGLNIDTYGVNYAASKLQLHGGDGANDTINRIKQAVQKCPNTKIVLGGYSQGASVMDIVAGVPIGGINWG SSITPDLASHVAAVATFGDVADRAGGTLPSQSALLGSKAIDLCNPNDPICHAGPGNEWSGHTEGYVPVYT TQAAAFVASKLMGAGQSVPGYGPSVPGAGPQSPGYGQQSPVYGQTPPGSGPSIHDNAPGPGTAPAPAVPS TPPSQAPLV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4394 | - | - | 100% (289) | serine esterase, cutinase family protein |
| M. avium 104 | MAV_4396 | - | 3e-54 | 51.89% (212) | cutinase |
| M. avium 104 | MAV_1682 | - | 8e-41 | 44.14% (222) | serine esterase, cutinase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3481 | cut3 | 4e-83 | 63.79% (243) | cutinase precursor CUT3 |
| M. gilvum PYR-GCK | Mflv_4965 | - | 2e-44 | 42.72% (206) | cutinase |
| M. tuberculosis H37Rv | Rv3451 | cut3 | 4e-83 | 63.79% (243) | cutinase precursor CUT3 |
| M. leprae Br4923 | MLBr_00099 | - | 2e-05 | 25.94% (212) | hypothetical protein MLBr_00099 |
| M. abscessus ATCC 19977 | MAB_3766 | - | 2e-52 | 45.76% (236) | cutinase cut3 precursor |
| M. marinum M | MMAR_1098 | cut3 | 5e-89 | 61.63% (258) | cutinase precursor, Cut3 |
| M. smegmatis MC2 155 | MSMEG_2095 | - | 7e-90 | 58.60% (285) | serine esterase, cutinase family protein |
| M. thermoresistible (build 8) | TH_4127 | - | 4e-39 | 44.29% (210) | PUTATIVE serine esterase, cutinase family protein |
| M. ulcerans Agy99 | MUL_0856 | cut3 | 6e-88 | 60.85% (258) | cutinase precursor, Cut3 |
| M. vanbaalenii PYR-1 | Mvan_1441 | - | 2e-49 | 45.33% (214) | cutinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4965|M.gilvum_PYR-GCK --MKIDLEVVTRG--VRALVAAAVAAGVLVVAPAVAAPRSLPAAGAQG--
Mvan_1441|M.vanbaalenii_PYR-1 --MMIDLDAPARR--ATGVLAAILVA----AATLVAAPVQIPAAHAQG--
Mb3481|M.bovis_AF2122/97 --MNNRPIRLLTSGRAGLGAGALITAVVLLIALGA-VWT--PVAFADG--
Rv3451|M.tuberculosis_H37Rv --MNNRPIRLLTSGRAGLGAGALITAVVLLIALGA-VWT--PVAFADG--
MMAR_1098|M.marinum_M --MNKHPLAVL--------AGALVTATGLLAAPSI-TGTAIPSASAAD--
MUL_0856|M.ulcerans_Agy99 --MNKHPLAVL--------AGALVTATGLLAAPSI-TGTAIPSASAAD--
MAV_4394|M.avium_104 --MKTHRIGRL----LGLGSSALITAAGLLGAP-----AAVPVASADD--
MSMEG_2095|M.smegmatis_MC2_155 --MLSRRIG----------AWALMAAGIALVVP-----ARLPVASAAE--
MAB_3766|M.abscessus_ATCC_1997 --MTTHQRGTRVG--VVLSSFVVLTVLVLSAASVVGPVSAVPRASADP--
TH_4127|M.thermoresistible__bu ---------------------VLGSAALLAGVP-------APTAAAIP--
MLBr_00099|M.leprae_Br4923 MVEKVPRKRHRVLAWTAALSMAAVVALAIVAVVILLRSAESPRSSLPPGV
. . . * :
Mflv_4965|M.gilvum_PYR-GCK ---------------------CTDIQVVFARGTDEPPGLGR--VGSAFVE
Mvan_1441|M.vanbaalenii_PYR-1 ---------------------CPDIEVVFARGTDEPPGLGR--VGAAFVD
Mb3481|M.bovis_AF2122/97 ---------------------CPDAEVTFARGTGEPPGIGR--VGQAFVD
Rv3451|M.tuberculosis_H37Rv ---------------------CPDAEVTFARGTGEPPGIGR--VGQAFVD
MMAR_1098|M.marinum_M ---------------------CPDAEVVFARGTSEPPGIGR--VGEAFVD
MUL_0856|M.ulcerans_Agy99 ---------------------CPDAEVVFPRGTSEPPGIGR--VGEAFVD
MAV_4394|M.avium_104 ---------------------CPDVEVIFARGTNEPPGMGR--VGDAFVE
MSMEG_2095|M.smegmatis_MC2_155 ---------------------CPDAEVVFARGTDEPAGLGR--VGTAFVD
MAB_3766|M.abscessus_ATCC_1997 ---------------------CSDVDVSFARGRKEPVGLGR--VGDEFVD
TH_4127|M.thermoresistible__bu ---------------------CSDVEVVFARGTSEPPGVGR--VGQALAN
MLBr_00099|M.leprae_Br4923 LPIPSTAPHPRKPRPAFQDVSCPDVQLLVVPGTWESSLQDNPLDPVQFPD
*.* :: . * *. .. : :
Mflv_4965|M.gilvum_PYR-GCK SL--------RGRVGGRSVGSYAVAYPATFDFLAAAG-----------GA
Mvan_1441|M.vanbaalenii_PYR-1 SL--------RGRVGGRSVGTYAVNYPASFDFLAAAA-----------GA
Mb3481|M.bovis_AF2122/97 SL--------RQQT-GMEIGVYPVNYAASRLQLHGGD-----------GA
Rv3451|M.tuberculosis_H37Rv SL--------RQQT-GMEIGVYPVNYAASRLQLHGGD-----------GA
MMAR_1098|M.marinum_M SL--------RQQT-GKNIGVYAVNYPASRLQLHGGD-----------GA
MUL_0856|M.ulcerans_Agy99 SL--------RQQT-GKNIGVYAVNYPASRLQLHGGD-----------GA
MAV_4394|M.avium_104 SL--------RQQTSGLNIDTYGVNYAASKLQLHGGD-----------GA
MSMEG_2095|M.smegmatis_MC2_155 AL--------RKQAAGLEIDAYAVDYKAGKLQLSGGD-----------GA
MAB_3766|M.abscessus_ATCC_1997 SLTP------RVQATGATMNVYPVNYDAG--IFSAGG-----------GA
TH_4127|M.thermoresistible__bu AL--------QARLPGRTVSTYGVSYPATYDFLAATD-----------GA
MLBr_00099|M.leprae_Br4923 ALLRNSTMTIGQQFPTSRVQTYTIPYTAQFHNPLSGDKQMTYNDSRAEGT
:* : : * : * * . *:
Mflv_4965|M.gilvum_PYR-GCK NDASNHIQWMMANCPSTRLVLGGYSQGAAVI----------------DVI
Mvan_1441|M.vanbaalenii_PYR-1 NDASLHIQYMMANCPRTRLVLGGYSQGAAVI----------------DVI
Mb3481|M.bovis_AF2122/97 NDAISHIKSMASSCPNTKLVLGGYSQGATVI----------------DIV
Rv3451|M.tuberculosis_H37Rv NDAISHIKSMASSCPNTKLVLGGYSQGATVI----------------DIV
MMAR_1098|M.marinum_M NDVISHVKSMASSCPNTKIVLGGYSQGADVI----------------DIV
MUL_0856|M.ulcerans_Agy99 NDVISHVKSMASSCPNTKIVQGGYSQGADVI----------------DIV
MAV_4394|M.avium_104 NDTINRIKQAVQKCPNTKIVLGGYSQGASVM----------------DIV
MSMEG_2095|M.smegmatis_MC2_155 KDAIAHIKSTVSSCSNTKIVLGGYSQGASVV----------------NIA
MAB_3766|M.abscessus_ATCC_1997 NDLSNHLQSVAASCPRTKLVIGGYSMGAEVI----------------DTI
TH_4127|M.thermoresistible__bu NDATARITTLAQQCPSTRVVLGGYSQGAAVV----------------DML
MLBr_00099|M.leprae_Br4923 RAMVQEMINVNNKCPLTSYVLVGFSQGAVIAGDITSDIGNGHGPVDDDLV
. .: .*. * * *:* ** : :
Mflv_4965|M.gilvum_PYR-GCK AAVPFPA-------VGFD-RPLPPN--APDFIAAIALFGNPTTKVGLPIT
Mvan_1441|M.vanbaalenii_PYR-1 AAVPIPA-------VGFN-APLPPN--TPDFVAAIAVFGNPSTKLGIPIT
Mb3481|M.bovis_AF2122/97 AGVPLGS-------ISFG-SPLPAA--YADNVAAVAVFGNPSNRAGGSLS
Rv3451|M.tuberculosis_H37Rv AGVPLGS-------ISFG-SPLPAA--YADNVAAVAVFGNPSNRAGGSLS
MMAR_1098|M.marinum_M AGVPLAG-------ISFG-NELPAQ--YADNIAAVAVFGNVANRSGGSLT
MUL_0856|M.ulcerans_Agy99 AGVPLAG-------ISFG-NELPAQ--YADNIAAVAVFGNVANRSGGSLT
MAV_4394|M.avium_104 AGVPIGG-------INWG-SSITPD--LASHVAAVATFGDVADRAGGTLP
MSMEG_2095|M.smegmatis_MC2_155 AGNQLGG-------ITWA-DPLPAQ--YANNVAAIVTFGDIATRTGEALS
MAB_3766|M.abscessus_ATCC_1997 IGVPNVG-------IGFN-RPLPPT--VGDRIVAIATFGNATHRTGGPLS
TH_4127|M.thermoresistible__bu GGLPPLGDR-----VGLVGSALPTG--SVGNVAAVAVFGNPSAKFGRPIN
MLBr_00099|M.leprae_Br4923 LGVTLIADGRRQQGVGNDIGPNPPGEGAEVTLHEVPVLSGLGMTMTGARP
. . : .. : : :.. .
Mflv_4965|M.gilvum_PYR-GCK -ASPVWGTRSIDLCNGADPVCSAG--DDIAAHSNYGPAGFTDQAAAFVAG
Mvan_1441|M.vanbaalenii_PYR-1 -ASPVWGSRSIDLCNGLDPVCSGG--DDIAAHSNYGPGMFTDQAAAFVAG
Mb3481|M.bovis_AF2122/97 SLSPLFGSKAIDLCNPTDPICHVGPGNEFSGHIDGYIPTYTTQAASFVVQ
Rv3451|M.tuberculosis_H37Rv SLSPLFGSKAIDLCNPTDPICHVGPGNEFSGHIDGYIPTYTTQAASFVVQ
MMAR_1098|M.marinum_M TQSSLLGSKSIDLCNPSDPICHSGPGNDWNGHTDGYVPTYTTQAASFVAA
MUL_0856|M.ulcerans_Agy99 TQSSLLGSKSIDLCNPSDPICHSGPGNDWNGHTDGYVPTYTTQAASFVAA
MAV_4394|M.avium_104 SQSALLGSKAIDLCNPNDPICHAGPGNEWSGHTEGYVPVYTTQAAAFVAS
MSMEG_2095|M.smegmatis_MC2_155 TRSNLFGSKAIDLCNPSDPICHAGQGNEWSGHTDGYVPVYTTQAAVFAAA
MAB_3766|M.abscessus_ATCC_1997 GIAGVFGSRAIDLCNQGDPICMAGPNNSWDAHTSYERTGLPAEAAAFVAS
TH_4127|M.thermoresistible__bu -TSPVFGGRGIDLCSDGDPICSNG--RNPFAHTNYETSVHIETAADFAAG
MLBr_00099|M.leprae_Br4923 GGFGVLHSRTNEICAPGDLICAAPAEAFSVANLPATLNTLASGAGQPIHA
: : ::* * :* .: *.
Mflv_4965|M.gilvum_PYR-GCK LV------------------------------------------------
Mvan_1441|M.vanbaalenii_PYR-1 RL------------------------------------------------
Mb3481|M.bovis_AF2122/97 RLRAGSVP----------------------------------HLPGSVP-
Rv3451|M.tuberculosis_H37Rv RLRAGSVP----------------------------------HLPGSVP-
MMAR_1098|M.marinum_M KLAASSMAPV-------------------------------VQLPGPVP-
MUL_0856|M.ulcerans_Agy99 KLAASSMAPV-------------------------------VRLPGPVP-
MAV_4394|M.avium_104 KL-MGAGQSVPGYGPSVPGAGP-QSPGYGQQS-----PVYGQTPPGSGPS
MSMEG_2095|M.smegmatis_MC2_155 KLRAGSGRSVPGYG-TVPEYGPGYGPGYGSGNGQGYGPLYGPATPGYDPE
MAB_3766|M.abscessus_ATCC_1997 KLNRHGESEAE---------------------------------------
TH_4127|M.thermoresistible__bu LI------------------------------------------------
MLBr_00099|M.leprae_Br4923 MYATAQFWDLDG-------------------------------APATVWT
Mflv_4965|M.gilvum_PYR-GCK ---------------------------------------------
Mvan_1441|M.vanbaalenii_PYR-1 ---------------------------------------------
Mb3481|M.bovis_AF2122/97 -----QLPGSVLQMPG--TAAP-----APESLHGR----------
Rv3451|M.tuberculosis_H37Rv -----QLPGSVLQMPG--TAAP-----APESLHGR----------
MMAR_1098|M.marinum_M -----RAPGPAPQAPGPATASPGTPVGATGTLVGAH---------
MUL_0856|M.ulcerans_Agy99 -----RAPGPAPQAPGPATASPGTPVGATGTLVGAH---------
MAV_4394|M.avium_104 IHDNAPGPGTAPAPA--VPSTP------PSQAP------LV----
MSMEG_2095|M.smegmatis_MC2_155 SPTHGPPPGYVPAPPGYVPETPGYELPGPSAAEPSAEVGLVSAVG
MAB_3766|M.abscessus_ATCC_1997 ---------------------------------------------
TH_4127|M.thermoresistible__bu ---------------------------------------------
MLBr_00099|M.leprae_Br4923 LNWVHRLIEGAPHPKHG----------------------------