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RGLQGKTFIVAGGATGIGAATAERLASEGAAVTVGDINIEGANATVGRITQSGGRAIAVEFDLADDASVR NLVQKTIGEFGALHGLHNVGADLSAENLGRDTTLLDTDFDVWRRTLDVNLLGYVRTSRAVLAHLLQQGSG SIVNTSSGGSLGTDPMHVAYNAAKAAVNQLTRHIANNWGAQGVRCNGVMPGLVMGETQKQQNDIQLQQMF LQAAKVTRLGEPRDIAAITAFLLSDEAEWINGQVWYIGGASHMRQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3097 | - | - | 100% (256) | NAD dependent epimerase/dehydratase family protein |
| M. avium 104 | MAV_4177 | - | 1e-57 | 44.92% (256) | putative short-chain type dehydrogenase/reductase y4lA |
| M. avium 104 | MAV_0714 | - | 2e-36 | 34.66% (251) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 3e-37 | 35.34% (249) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1829 | - | 1e-104 | 73.05% (256) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0769 | - | 1e-37 | 35.74% (249) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-17 | 31.67% (221) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1219 | - | 1e-33 | 34.94% (249) | short chain dehydrogenase |
| M. marinum M | MMAR_4927 | - | 7e-36 | 34.26% (251) | dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_5858 | - | 1e-38 | 35.06% (251) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3037 | - | 2e-39 | 36.95% (249) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0478 | - | 4e-34 | 33.47% (251) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5156 | - | 2e-38 | 35.34% (249) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3097|M.avium_104 --------------------------------------------------
Mflv_1829|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAV_3097|M.avium_104 --------------------------------------------------
Mflv_1829|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAV_3097|M.avium_104 --------------------------------------------------
Mflv_1829|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAV_3097|M.avium_104 --------------------------------------------------
Mflv_1829|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAV_3097|M.avium_104 --------------------------------------------------
Mflv_1829|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAV_3097|M.avium_104 --------------------------------------------------
Mflv_1829|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4927|M.marinum_M --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAV_3097|M.avium_104 ----------------------MRGLQGKTFIVAGGATGIGAATAERLAS
Mflv_1829|M.gilvum_PYR-GCK ----------------------MRGLTGKTFIIAGGATGIGAGTAKRLAD
MSMEG_5858|M.smegmatis_MC2_155 ------------------MGQYGTNFEDKVAIVTGAGGGIGQAYAEALAR
Mvan_5156|M.vanbaalenii_PYR-1 ------------------MGLYGDQFKEKVAIVTGAGGGIGQAYAEALAR
TH_3037|M.thermoresistible__bu ------------------MG----QFDDKVAIVTGAGGGIGQAYAEALAR
Mb0792|M.bovis_AF2122/97 ------------------------MFDSKVAIVTGAAQGIGQAYAQALAR
Rv0769|M.tuberculosis_H37Rv ------------------------MFDSKVAIVTGAAQGIGQAYAQALAR
MMAR_4927|M.marinum_M ------------------MG----QFENKVAIVTGAAQGIGQAYADALAR
MUL_0478|M.ulcerans_Agy99 ------------------MG----QFENKVAIVTGAAQGIGQAYADALAR
MAB_1219|M.abscessus_ATCC_1997 ------------------MG----EFDNKVAIVTGAAQGIGEAYAHALAR
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
: . ::*.. *** * **
MAV_3097|M.avium_104 EGAAVTVGDINIEGANATVGRITQSGGRAIAVEFDLADDASVRNLVQKTI
Mflv_1829|M.gilvum_PYR-GCK EGANVVVGDIAIAAATATAEKLCAVGARAIAVEFDLADEFSVRQLVEHTI
MSMEG_5858|M.smegmatis_MC2_155 EGAAVVVADINLEGAQKVADAILGEGGNALAVRVDVSDIDSAKDMAAQTL
Mvan_5156|M.vanbaalenii_PYR-1 EGAAVVVADINTEGAQKVADGIKGEGGNALAVRVDVSDPESAKGMAAQTL
TH_3037|M.thermoresistible__bu EGAAVVVADINTEGAQKVADGIKGEGGDALAVPVDVSDPESAEEMAAQTV
Mb0792|M.bovis_AF2122/97 EGASVVVADINADGAAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAV
Rv0769|M.tuberculosis_H37Rv EGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAV
MMAR_4927|M.marinum_M EGARVVVADINAEAAEKTAKQIVADGGTAIHVPVDVSDEESARAMADRTV
MUL_0478|M.ulcerans_Agy99 EGARVVVADINAEAAEKTAKQIVADGGTAIHVPVDVSDEESARAMADRTV
MAB_1219|M.abscessus_ATCC_1997 EGAAVVVADINAEMGEGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAV
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
.** *.*.** . .. : *. . .*::* :. :. :.
MAV_3097|M.avium_104 GEFGALHGLHNVGADLSAENLGRDTTLLDTDFDVWRRTLDVNLLGYVRTS
Mflv_1829|M.gilvum_PYR-GCK TEFGSVDGLFNVGADLSPETNGTDLTILDTGLDIWQRTLDINLLGYVRTI
MSMEG_5858|M.smegmatis_MC2_155 SEFGGIDYLVNNAAIFGGMKLD---FLLTVDWDYYKKFMSVNLDGALVCT
Mvan_5156|M.vanbaalenii_PYR-1 SEFGGIDYLVNNAAIFGGMKLD---FLITVDWDYYKKFMSVNMDGALVCT
TH_3037|M.thermoresistible__bu SEFGGIDYLVNNAAIFGGMKLD---FLITVDWDYYKRFMSVNLDGALVCT
Mb0792|M.bovis_AF2122/97 GAFGGIDYLVNNAAIYGGMKLD---LLLTVPLDYYKKFMSVNHDGVLVCT
Rv0769|M.tuberculosis_H37Rv GAFGGIDYLVNNAAIYGGMKLD---LLLTVPLDYYKKFMSVNHDGVLVCT
MMAR_4927|M.marinum_M SEFGGIDYLVNNAAIYGGMKLD---LLLTVPLDYYKKFMSVNHDGVLVCT
MUL_0478|M.ulcerans_Agy99 SEFGGIDYLVNNAAIYGGMKLD---LQLTVPLDYYKKFMSVNHDGVLVCT
MAB_1219|M.abscessus_ATCC_1997 SEFGGIDYLVNNAAIYGGMKLD---LLLSVPWDYYKKFMSVNQDGALVCT
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAG------RFLDTPPEEFDRVLAVNLGGVVNCC
.* . : * .. : . : : : : :* * :
MAV_3097|M.avium_104 RAVLAHLLQQG-SGSIVNTSSGGSLGTDPMHVAYNAAKAAVNQLTRHIAN
Mflv_1829|M.gilvum_PYR-GCK RAVLPHLLEQG-SGSIVNTSSGGSLGTDPMHVAYNASKAAVNQLTRHVAN
MSMEG_5858|M.smegmatis_MC2_155 RAVYRKMAKRG-GGAIVNQSSTAAWLYS---NFYGLAKVGINGLTQQLSR
Mvan_5156|M.vanbaalenii_PYR-1 RAVYRKMAKRG-GGAIVNQSSTAAWLYS---NFYGLAKVGINGLTQQLAT
TH_3037|M.thermoresistible__bu RAVYKKMAKRG-GGAIVNQSSTAAWLYS---NYYGLAKAGLNSLTQQLAT
Mb0792|M.bovis_AF2122/97 RAVYKHMAKRG-GGAIVNQSSTAAWLYS---NFYGLAKVGVNGLTQQLAR
Rv0769|M.tuberculosis_H37Rv RAVYKHMAKRG-GGAIVNQSSTAAWLYS---NFYGLAKVGVNGLTQQLAR
MMAR_4927|M.marinum_M RAVYKHMAKRG-GGAIVNQSSTAAWLYS---NFYGLAKVGVNGLTQQLSR
MUL_0478|M.ulcerans_Agy99 RAVYKHMAKRG-GGAIVNQSSTAAWLYS---NFYGLAKVGVNGLTQQLSR
MAB_1219|M.abscessus_ATCC_1997 RAVYKHIAQRG-GGAIVNQSSTAAWLYS---GFYGLAKVGINGLTQQLSR
MLBr_00862|M.leprae_Br4923 RAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
**. :: ::* .* *** ** .: * :*.. :: :
MAV_3097|M.avium_104 NWGAQGVRCNGVMPGLVMG----------ETQKQQNDIQLQQMFLQAAKV
Mflv_1829|M.gilvum_PYR-GCK NYGAKGIRSNCVMPGLVWG----------ETQEKANLEPLREMFVAAART
MSMEG_5858|M.smegmatis_MC2_155 ELGGQNIRINAIAPGPIDT----------EANRTTTPKEMVDDIVKGIPL
Mvan_5156|M.vanbaalenii_PYR-1 ELGGQNIRVNAIAPGPIDT----------EANRTTTPQEMVADIVKGIPL
TH_3037|M.thermoresistible__bu ELGGQNIRVNAIAPGPIDT----------EANRSTTPKEMVDDIVKRIPL
Mb0792|M.bovis_AF2122/97 ELGGMKIRINAIAPGPIDT----------EATRTVTPAELVKNMVQTIPL
Rv0769|M.tuberculosis_H37Rv ELGGMKIRINAIAPGPIDT----------EATRTVTPAELVKNMVQTIPL
MMAR_4927|M.marinum_M ELGGMKIRINAIAPGPIDT----------EATRTVTPGEFVKDMVKQIPL
MUL_0478|M.ulcerans_Agy99 ELGGMKIRINAIAPGPIDT----------EATRTVTPGEFVKDMVKQIPL
MAB_1219|M.abscessus_ATCC_1997 ELGGQKIRINAIAPGPTDT----------EATRGTVPEQFRSELVKNIPL
MLBr_00862|M.leprae_Br4923 ELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRL
: .. : . : ** : . :
MAV_3097|M.avium_104 TRLGEPRDIAAITAFLLSDEAEWING-QVWYIGGASHMRQ----------
Mflv_1829|M.gilvum_PYR-GCK TRVGRPSDLASITAFLLSDEAEWING-QCWYIGGASHMRQ----------
MSMEG_5858|M.smegmatis_MC2_155 SRMGQPEDLVGMCLFLLSDQARWITG-QIFNVDGGQVIRS----------
Mvan_5156|M.vanbaalenii_PYR-1 SRMGEPEDLVGMLLFLLSDQAKWITG-QIFNVDGGQIIRS----------
TH_3037|M.thermoresistible__bu SRLGEPEDLVGMCLFLLSDQAKWITG-QIFNVDGGQIIR-----------
Mb0792|M.bovis_AF2122/97 SRMGTPEDLVGMCLFLLSDSASWITG-QIFNVDGGQIIRS----------
Rv0769|M.tuberculosis_H37Rv SRMGTPEDLVGMCLFLLSDSASWITG-QIFNVDGGQIIRS----------
MMAR_4927|M.marinum_M SRMGTPEDLVGMCLFLLGDQASWITG-QIFNVDGGQIIRS----------
MUL_0478|M.ulcerans_Agy99 SRMGTPEDLVGMCLFLLGDQASRITG-QIFNVDGGQIIRS----------
MAB_1219|M.abscessus_ATCC_1997 SRMGTVDDMVGMCLFLLSDKASWITG-QVFNVDGGQIIRS----------
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIR
* * : : :.. . : : : * . :
MAV_3097|M.avium_104 --
Mflv_1829|M.gilvum_PYR-GCK --
MSMEG_5858|M.smegmatis_MC2_155 --
Mvan_5156|M.vanbaalenii_PYR-1 --
TH_3037|M.thermoresistible__bu --
Mb0792|M.bovis_AF2122/97 --
Rv0769|M.tuberculosis_H37Rv --
MMAR_4927|M.marinum_M --
MUL_0478|M.ulcerans_Agy99 --
MAB_1219|M.abscessus_ATCC_1997 --
MLBr_00862|M.leprae_Br4923 VI