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MRIAMISEHASPLAHLGGVDAGGQNVHVAELSCALARRGHDVVVYTRRDDPRLPDSVETPHGYSVVHVPA GPARVLPKDELLQYMYGFAQFLRQQWCSDGPDVAHAHFWMSGVATQQAARAHSIPTVQTFHALGLTKRLH QGSDDTSPDCRIDVEARVAREADWVAATSTDEVFELVRMGRARSRTSVVPCGVDLDAFTPDGPVAARGAR PRIVTVGRLVPRKGFDTIVRALPRIPDAELVIVGGPPAAELAGDEQARRLQRLAGELGVADRVRLLGGVT RAQMPALLRSADVVACTPWYEPFGIVPLEAMACGVPVVATAVGGIRDTVVDGATGRLVPPKDPDALGEAV AALLRDGRRGRTLGEAGRERARARYSWDRVAADTERIYERLSPARRGVGTPSTRSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4082 | - | - | 100% (406) | transferase |
| M. avium 104 | MAV_4064 | - | 3e-69 | 41.99% (381) | glycosyl transferase, group 1 family protein |
| M. avium 104 | MAV_4664 | - | 5e-56 | 36.23% (414) | hypothetical protein MAV_4664 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0496 | - | 4e-55 | 36.07% (402) | mannosyltransferase |
| M. gilvum PYR-GCK | Mflv_3449 | - | 3e-61 | 39.21% (403) | glycosyl transferase, group 1 |
| M. tuberculosis H37Rv | Rv0486 | - | 5e-55 | 36.07% (402) | mannosyltransferase |
| M. leprae Br4923 | MLBr_02443 | - | 3e-52 | 35.59% (399) | putative glycosyl transferase |
| M. abscessus ATCC 19977 | MAB_4057c | - | 2e-56 | 37.59% (415) | glycosyl transferase |
| M. marinum M | MMAR_0812 | - | 5e-56 | 35.57% (402) | mannosyltransferase |
| M. smegmatis MC2 155 | MSMEG_0933 | - | 1e-55 | 37.73% (387) | hypothetical protein MSMEG_0933 |
| M. thermoresistible (build 8) | TH_3188 | - | 1e-163 | 71.32% (401) | PUTATIVE glycosyl transferase, group 1 |
| M. ulcerans Agy99 | MUL_4556 | - | 1e-54 | 35.07% (402) | mannosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3205 | - | 5e-58 | 38.21% (369) | glycosyl transferase, group 1 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4082|M.avium_104 --------------------------------------------MRIAMI
TH_3188|M.thermoresistible__bu ------------------------------------------------MV
Mb0496|M.bovis_AF2122/97 MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALL
Rv0486|M.tuberculosis_H37Rv MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALL
MLBr_02443|M.leprae_Br4923 ------------------------------------------------ML
MMAR_0812|M.marinum_M MRPMRAGAG----------AAGESCKDDGVRPDDVSRLTADAVVRRVALL
MUL_4556|M.ulcerans_Agy99 ---MRAGAG----------AAGESCKDDGVRPDDVSRLTADAVVRRVALL
MSMEG_0933|M.smegmatis_MC2_155 ----------------------------------MRLATDLETPRRVAVL
MAB_4057c|M.abscessus_ATCC_199 ---------------------------MLSGDEFARRAVAALKPRRIAVL
Mflv_3449|M.gilvum_PYR-GCK -----------------------------------------------MRL
Mvan_3205|M.vanbaalenii_PYR-1 -----------------------------------------------MKL
:
MAV_4082|M.avium_104 SEHASPLAHLGGVDAGGQNVHVAELSCALARRGHDVVVYTRRDDPRLPDS
TH_3188|M.thermoresistible__bu SEHASPLAALGGVDAGGQNVHVAELSAALTRRGHEVTVYTRRDDRGLPDR
Mb0496|M.bovis_AF2122/97 AVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPV
Rv0486|M.tuberculosis_H37Rv AVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPV
MLBr_02443|M.leprae_Br4923 AVHTSPLAQPGIGDAGGMNVYVLQSALHLARRGIEVEIFTRATASADPPI
MMAR_0812|M.marinum_M AVHTSPLAQPGTGDAGGMNVYVLQSALHLAKRGIEVEIFTRATASADPPV
MUL_4556|M.ulcerans_Agy99 AVHTSPLAQPGTGDAGGMNVYVLQSALHLAKRGIEVEIFTRATASADPPV
MSMEG_0933|M.smegmatis_MC2_155 SVHTSPLAQPGTGDAGGMNVYVLQTALQLARRGVEVEVFTRATSSADAPV
MAB_4057c|M.abscessus_ATCC_199 SVHTSPLAQPGTGDAGGMNVYVLQTALQLARRGVAVDIFTRATSSSDEPV
Mflv_3449|M.gilvum_PYR-GCK AVVGDLSGVGATDRGGGGRYGIADLAQALARRGHEVRVHT----ALPHPA
Mvan_3205|M.vanbaalenii_PYR-1 ALVGELP--------GGHGYDLTRLGDALVGRGHKVQVFT----ATVPAM
: . ** : . *. ** * :.*
MAV_4082|M.avium_104 VETPHGYSVVHVPAGPARVLPKDELLQYMYGFAQFLRQQWCSDGP---DV
TH_3188|M.thermoresistible__bu VDTPLGYTVVHVPAGPAEQLPKDELLPYMGPFAQFLDAEWSAHRP---DV
Mb0496|M.bovis_AF2122/97 VRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDI
Rv0486|M.tuberculosis_H37Rv VRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDI
MLBr_02443|M.leprae_Br4923 VWVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAAHEPGYYDI
MMAR_0812|M.marinum_M VRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAAHEPGHYDI
MUL_4556|M.ulcerans_Agy99 VRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAAHEPGHYDI
MSMEG_0933|M.smegmatis_MC2_155 VPVAPGVLVRNVVAGPFEGLDKNDLPTQLCAFTAGVLRAEATHEPGYYDV
MAB_4057c|M.abscessus_ATCC_199 VSVTDGVTVRNIVAGPFEGLDKYDLPTQLCAFTAGVLRAEAVHEPGYYNL
Mflv_3449|M.gilvum_PYR-GCK GVQPTGVAVDHVPVATVAVETSPELMPAIGEISRHLVDVWRRDTP---DV
Mvan_3205|M.vanbaalenii_PYR-1 RYTPAGAAVQRLPVDTTGVESSEDLMPLIGEMGRHLVDVWEADGP---DV
. * * .: . . . :* : : : . * ::
MAV_4082|M.avium_104 AHAHFWMSGVATQQAARAHSIPTVQTFHALGLTKRLHQGSDDTS-PDCRI
TH_3188|M.thermoresistible__bu VHAHFWMSGIATQLASRHLDLPAVQTFHALGVVKKRHQGAEDTS-PQERL
Mb0496|M.bovis_AF2122/97 VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRT
Rv0486|M.tuberculosis_H37Rv VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRT
MLBr_02443|M.leprae_Br4923 VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDAAEPPLRS
MMAR_0812|M.marinum_M VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALANGDAPEPPLRT
MUL_4556|M.ulcerans_Agy99 VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALANGDAPEPPLRT
MSMEG_0933|M.smegmatis_MC2_155 VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALAAGDAPEPPLRA
MAB_4057c|M.abscessus_ATCC_199 VHSHYWLSGQAGWLARDRWGVPLVHTAHTLAAVKNQTLAEGDRPEPALRG
Mflv_3449|M.gilvum_PYR-GCK VHCHGWVYGMAAQLAAKKTPVPIVQTFHELSTPGRRESAG---GQAATAA
Mvan_3205|M.vanbaalenii_PYR-1 VHCHGWVYGMAAQLAARRCRIPTVQSFPELSVSAGGDRGE---GLADKRI
.*.* *: * . * :* *:: *. . .
MAV_4082|M.avium_104 DVEARVAREADWVAATSTDEVFELVRMGRA-RSRTSVVPCGVDLDAFTPD
TH_3188|M.thermoresistible__bu QLEAMVARGANWVAATCTDEVFELMRMGRS-RSRISVVPCGVDLDLFTPD
Mb0496|M.bovis_AF2122/97 VGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPG
Rv0486|M.tuberculosis_H37Rv VGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPG
MLBr_02443|M.leprae_Br4923 VGEQQVVDEADRMIVNTDDEARQLISIHRADPAKIDVAHPGVDLDMFRPG
MMAR_0812|M.marinum_M VGEQQVVDEADRLIVNTDDEAKQLISIHRADPARIDVVHPGVDLEVFRPG
MUL_4556|M.ulcerans_Agy99 VGEQQVVDEADRLIVNTDDEAKQLISIHHADPARIDVVHPGVDLEVFRPG
MSMEG_0933|M.smegmatis_MC2_155 VGEQQVVDEADRLIVNTEVEAQQLVSLHNADRSRIDVVHPGVDLDVFTPG
MAB_4057c|M.abscessus_ATCC_199 VGEQQVVDEADRLIVNTKDEADQLVSIHNADPARIDIVHPGVDLDVFTPG
Mflv_3449|M.gilvum_PYR-GCK KLEALLARNATALTAGCHDDVQTLIRLGCP-RAKVSVLSAGVEVDD--AV
Mvan_3205|M.vanbaalenii_PYR-1 QLEALLARNATAVTVACNDDMREIIRLGCT-RAKASVLAPGIDVDDVCAE
* :. * : . : :: : . :: .: *:::: .
MAV_4082|M.avium_104 GPVAARGAR------PRIVTVGRLVPRKGFDTIVRALPRIPDAELVIVGG
TH_3188|M.thermoresistible__bu GPQAPRGER------RRIVTVGRFVPRKGFDTLVRALPAIPNAELVVVGG
Mb0496|M.bovis_AF2122/97 DRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGG
Rv0486|M.tuberculosis_H37Rv DRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGG
MLBr_02443|M.leprae_Br4923 DRRAARAALGLPLDGNVVAFVGRIQPLKAPDIVLRAAAKLPQVRIVVAGG
MMAR_0812|M.marinum_M DRQQARTALGLRPEEKVVAFVGRIQPLKAPDIVLRAVAKLPGVRIIVAGG
MUL_4556|M.ulcerans_Agy99 DRQQARTALGLRPEEKVVAFVGRIQPLKAPDIVLRAVAKLPGVRIIVAGG
MSMEG_0933|M.smegmatis_MC2_155 SRDAARAVFGLPTDQKIVAFVGRIQPLKAPDILLRAAAKLPGVRVLIAGG
MAB_4057c|M.abscessus_ATCC_199 DKAAARAEFGLRADEQVVAFVGRIQPLKAPDLLVRAAERLPGVRVLIVGG
Mflv_3449|M.gilvum_PYR-GCK EIESRGGDV----PPRIVAVARDFGAEQGLADVVAALPSLGAADLTLVAT
Mvan_3205|M.vanbaalenii_PYR-1 EIVFRHGES----SGRVVAVARDFSPQQGLGQVLRVFPSSNAAELVLVTR
:. . : . :. :: . . : :.
MAV_4082|M.avium_104 PPAAELAGDEQARRLQRLAGELGVADRVRLLGGVTRAQMPALLRSADVVA
TH_3188|M.thermoresistible__bu PRRSQLRTEPEARRLCTLAEELGVADRVQLYGSVARADMPAVLRSADVVA
Mb0496|M.bovis_AF2122/97 PSGSGLAS---PDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVA
Rv0486|M.tuberculosis_H37Rv PSGSGLAS---PDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVA
MLBr_02443|M.leprae_Br4923 PSGSGLAS---PDGLVRLADELGITARVTFLPPQSRTNLATVFQAADLVA
MMAR_0812|M.marinum_M PSGSGLAS---PDGLAQLADELGIAERVTFLPPQSRTDLARVFHAVDLVA
MUL_4556|M.ulcerans_Agy99 PSGSGLAS---PDGLAQLADELGIAERVTFLPPQSRTDLARVFHAVDLVA
MSMEG_0933|M.smegmatis_MC2_155 PSGSGLAQ---PDTLVRLADELGISDRVTFLPPQSREQLVNVYRAADLVA
MAB_4057c|M.abscessus_ATCC_199 PSGSGLDE---PTALQDLAVDLGIADRVTFLPPQTRERLAQVYRAADIVA
Mflv_3449|M.gilvum_PYR-GCK DP-TGPDA----GHLGDVARRLRVADRVRMMRGDECPELAALLPSADVVV
Mvan_3205|M.vanbaalenii_PYR-1 EPDDGPDY----DDILSLAREKKAAKRVNLVAGAAGDDLTTLFRSADVVV
: :* : ** : : : :.*:*.
MAV_4082|M.avium_104 CTPWYEPFGIVPLEAMACGVPVVATAVGGIRDTVVDGATGRLVPPKDPDA
TH_3188|M.thermoresistible__bu CTPWYEPFGIVPLEAMACGVPVVAAAVGGMLDTVVHDVTGRLVPPRRPAE
Mb0496|M.bovis_AF2122/97 VPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQ
Rv0486|M.tuberculosis_H37Rv VPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQ
MLBr_02443|M.leprae_Br4923 VPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGVTGTLVFGHNVGH
MMAR_0812|M.marinum_M IPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGVSGTLVSGHDVDQ
MUL_4556|M.ulcerans_Agy99 IPSYSESFGLVAVEAQACGTRVVAAAVGGLPVAVRDGVSGTLVSGHDVDQ
MSMEG_0933|M.smegmatis_MC2_155 VPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVADGVSGALVDGHDIGD
MAB_4057c|M.abscessus_ATCC_199 VPSYSESFGLVAIEAQACGTPVVAAAVGGLPVAVADQRTGLLVPTHRTED
Mflv_3449|M.gilvum_PYR-GCK LPARYEPSSEFVLQAMACGAPVVAFAAGGARDAVIEDVTGLLVQPGDVNA
Mvan_3205|M.vanbaalenii_PYR-1 APARYEPSCATVLQAMACGAPIVATSAGGARDAVIGEVTGLLVPPGNADA
.. *. ::* ***. :** :.** :* :* **
MAV_4082|M.avium_104 LGEAVAALLRDGRRGR-TLGEAGRERARARYSWDRVAADTERIYERLSPA
TH_3188|M.thermoresistible__bu LADTINQLLRDSFLRQ-SLGAAGRDRARARYSWDRVATDTQRIYDRLVPA
Mb0496|M.bovis_AF2122/97 WADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGE
Rv0486|M.tuberculosis_H37Rv WADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGE
MLBr_02443|M.leprae_Br4923 WADAVDQLLRLSAGPQARAISRAAVVHAAQFSWDNTTDALLASYRRAIGD
MMAR_0812|M.marinum_M WAAAIDGLLRSNAGAQGALMSRAAAEHAATFSWENTTDALLASYRRAIGD
MUL_4556|M.ulcerans_Agy99 WAAAIDGLLRSNAGAQGALMSRAAAEHAATFSWENTTDALLASYRRAIGD
MSMEG_0933|M.smegmatis_MC2_155 WADTISEVLDREP----AALSRASAEHAAQFSWAHTVDALLASYSRAMSD
MAB_4057c|M.abscessus_ATCC_199 WADAIGELLVRKG----AGFSRAAVEHAAGFSWSSTADSLLSSYGRAIAD
Mflv_3449|M.gilvum_PYR-GCK LGRAVRTALSQPVLRQGMGLAG-RSRARSRYSWDRIATDAEVAYLAAAAR
Mvan_3205|M.vanbaalenii_PYR-1 LGRALRSTLGQMVLREGMGLAG-RSRARSRYSWDRIATDAEVVYASATTR
. :: * : :** . *
MAV_4082|M.avium_104 RRG---------------VGTPSTRSG------
TH_3188|M.thermoresistible__bu DYR---------------SATASQMSSG-----
Mb0496|M.bovis_AF2122/97 YNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
Rv0486|M.tuberculosis_H37Rv YNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
MLBr_02443|M.leprae_Br4923 FTATRQHR----VRDLVATRKPRRWISRRGMGA
MMAR_0812|M.marinum_M FTAGRRRK----VRDPVAARKPRRWTARRGVGA
MUL_4556|M.ulcerans_Agy99 FTAGRRRK----VRDPVAARKPRRWTARRGVGA
MSMEG_0933|M.smegmatis_MC2_155 YRARHPRP--------AARRSGRRFSMRRGVRT
MAB_4057c|M.abscessus_ATCC_199 YRAPQRPS---TQWASRARFRPRRLSGLRR---
Mflv_3449|M.gilvum_PYR-GCK HSGQAPAGDRGPGTRGSLRPQSCSPVTRK----
Mvan_3205|M.vanbaalenii_PYR-1 ESAFAC---------------------------