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KLGIGLPNHIADVPGPAVAQWSRRGEELGFESVATIDRLFSSGVDSLIALATAAGATNELTLVTNVLLAP MYPVIPLAKQLVSLARVSGGRLTVGLGVGNRSDEYAGTGADFHRRGRALDAQVERLRSLWAGEPLADGTA LCGAPVRIPLLFGGRSAATVRRVVTTGDGWAAGAVRLYDEQADVAARIRSGWQDAGRPARPYLQASVNFA LGPAETVAAGRDHLARYYAFAPGYAQVNVADMVCSAADARDTVRRYRDLGFDRLLFHPTSASVEQLDYLA DAILGCL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3379 | - | - | 100% (288) | MmcJ protein |
| M. avium 104 | MAV_1441 | - | 6e-26 | 31.43% (280) | hypothetical protein MAV_1441 |
| M. avium 104 | MAV_2935 | - | 1e-18 | 31.74% (293) | hypothetical protein MAV_2935 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2185c | - | 1e-14 | 33.13% (163) | hypothetical protein Mb2185c |
| M. gilvum PYR-GCK | Mflv_2283 | - | 9e-25 | 30.56% (288) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2161c | - | 1e-14 | 33.13% (163) | hypothetical protein Rv2161c |
| M. leprae Br4923 | MLBr_00348 | - | 2e-06 | 23.92% (255) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3271 | - | 1e-24 | 29.45% (292) | hypothetical protein MAB_3271 |
| M. marinum M | MMAR_4128 | - | 4e-28 | 31.58% (285) | flavin-dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2162 | - | 3e-39 | 34.97% (286) | MmcJ protein |
| M. thermoresistible (build 8) | TH_2001 | - | 1e-29 | 32.99% (288) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3991 | - | 3e-27 | 30.88% (285) | flavin-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4383 | - | 1e-27 | 30.14% (282) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3379|M.avium_104 --MKLGIGLPNHIADVPGPAVAQWSRR-------GEELGFESVATIDRLF
MSMEG_2162|M.smegmatis_MC2_155 MPVRLGIGIPTTIGPPRAPELSRWCRE-------AEERGASSLSCVDRLN
Mflv_2283|M.gilvum_PYR-GCK ------MTMPVMEPDLDREMLKSWAKT-------VDEGPFSSLCWGERIA
Mvan_4383|M.vanbaalenii_PYR-1 --------MPVMEPDLDRATLRSWAQL-------VDGGPFSSLCWGERIA
MMAR_4128|M.marinum_M ------MTMPVMEPDLDANVLKTWARA-------VDEGPFSALCWGERIA
MUL_3991|M.ulcerans_Agy99 -----------MEPDLDANVLKTWARA-------VDEGTFSALCWGERIA
TH_2001|M.thermoresistible__bu ------MTMPVMEPDLDAATLRTWARA-------IDDGPFSALCWGERIA
MAB_3271|M.abscessus_ATCC_1997 --MDIGIALPFMCRDYTRESTITWARL-------ADEGPFSTISSGERIS
Mb2185c|M.bovis_AF2122/97 --MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWP
Rv2161c|M.tuberculosis_H37Rv --MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWP
MLBr_00348|M.leprae_Br4923 -------MVERANAMKLGLQLGYWAAQ-------PPGNAAELVAAAEGAG
*. :.
MAV_3379|M.avium_104 SSGV--------DSLIALA---TAAGATNELTLVTNVLLAPMYP-VIPLA
MSMEG_2162|M.smegmatis_MC2_155 YPNL--------DSFLALA---AAAAVTHTVRLLATVVVAPLRGNGELLR
Mflv_2283|M.gilvum_PYR-GCK FDNP--------ESLTLLGALGALGAWTERVRLVTTVVIPQLHD-PVMLA
Mvan_4383|M.vanbaalenii_PYR-1 FDNP--------ESLTLLG---ALAAWTDRVRLVTTVVIPQLHD-PVMLA
MMAR_4128|M.marinum_M FDNP--------DSLTLLG---ALAAWTDRVRLVTTVIVPQLHD-PVMLA
MUL_3991|M.ulcerans_Agy99 FDNP--------DSSTLLG---ALAAWTDRVRLVTTVIVPQLHD-PVMLA
TH_2001|M.thermoresistible__bu FDNP--------DSLTLLG---ALAAWTDRVRLVTTVVVPQLHD-PVLLA
MAB_3271|M.abscessus_ATCC_1997 YHNQ--------DMWVTLA---AAAAVTERVRILANVSVLPAHP-VPLVA
Mb2185c|M.bovis_AF2122/97 GGELPDWYRRCYDPVVALA---AAAAVTTRLRVGTGACLVAVHD-PILLA
Rv2161c|M.tuberculosis_H37Rv GGELPDWYRRCYDPVVALA---AAAAVTTRLRVGTGACLVAVHD-PILLA
MLBr_00348|M.leprae_Br4923 FDAVFTGEAWGSDAYTPLA---WWGSSTQRVRLGTSVVQLSART-PTACA
: *. .. * : : : .
MAV_3379|M.avium_104 KQLVSLARVSGGRLTVGLGVGNRSDEYAGTGADFHRRGRA-LDAQVERLR
MSMEG_2162|M.smegmatis_MC2_155 KQLANLHHFSGRRFDVGLGVGRRDDDYVASDVDFSTRGKR-FDAQLDRLF
Mflv_2283|M.gilvum_PYR-GCK KQLATGDVLSGGRLTVGIGVGGRHEDYQAVGADPATQTMRQMAERVEIMK
Mvan_4383|M.vanbaalenii_PYR-1 KQLATGDMLCGGRLTVGIGVGGRHEDYRAVGVDPATQTMRQMAERVAVMK
MMAR_4128|M.marinum_M KALATGDMLSGGRLTVGIGVGGRREDYLAVGADPKTQTMGGMATRVAVMK
MUL_3991|M.ulcerans_Agy99 EALATGDMLSGGRLTVGIGVGGRREDYLAVGADPKTQTMGGMATRVAVMK
TH_2001|M.thermoresistible__bu KGLATGDVLSGGRLTVGIGVGGRHEDYRAVGADPATQTMREMAERVAVMK
MAB_3271|M.abscessus_ATCC_1997 KQAATLDVLSEGRFILGVGVGGREHDYRCLDASFGRRHQR-LDDQVAELR
Mb2185c|M.bovis_AF2122/97 KQIASLCAMSGERFVLGVGFGWNVEELADHGVPFAD-RIAVTVDKLAAMR
Rv2161c|M.tuberculosis_H37Rv KQIASLCAMSGERFVLGVGFGWNVEELADHGVPFAD-RIAVTVDKLAAMR
MLBr_00348|M.leprae_Br4923 MAALTLDHLSGGRHILGLGVSGPQVVEGWYGQPFPKPLSR-TREYIDIVR
. .. * :*:*.. . : :
MAV_3379|M.avium_104 SLWAGEPLADG-----TALCG----APVRI-------------PLLFGGR
MSMEG_2162|M.smegmatis_MC2_155 GTGEDK-------------------SPELP-------------CVMFGGQ
Mflv_2283|M.gilvum_PYR-GCK RVWAGEKITDS-----TLPVGPPPVQPGGP-------------PLQVGTL
Mvan_4383|M.vanbaalenii_PYR-1 RVWAGEKVTES-----TLPVGPPPVQPGGP-------------ELHVGTL
MMAR_4128|M.marinum_M RVWAGEQISES-----VRPVGPLPVQPGGP-------------PLLVGTI
MUL_3991|M.ulcerans_Agy99 RVWAGEQISES-----VRPVGPLPVQPGGP-------------PLLVGTI
TH_2001|M.thermoresistible__bu RVWAGEKVTES-----VLPVGPPPVQSGGP-------------PLLVGTI
MAB_3271|M.abscessus_ATCC_1997 RLWRGEPPFEG-----ADPVGPAPVQDGGP-------------PVVAAAI
Mb2185c|M.bovis_AF2122/97 ALWAAEPVHYEGTHASVPPSWAWPKPAVAP-------------PVLFGCR
Rv2161c|M.tuberculosis_H37Rv ALWAAEPVHYEGTHASVPPSWAWPKPAVAP-------------PVLFGCR
MLBr_00348|M.leprae_Br4923 QVWAREAPVVSDGQHYPLPLTGAGATGLGKALKPITHPLRADIPIMLGAE
: : .
MAV_3379|M.avium_104 -SAATVRRVVTTGDGWAAGA-VRLYDEQA--DVAARIRSGWQDAGRPARP
MSMEG_2162|M.smegmatis_MC2_155 -SPATLRRIARWGGGWVSAAGLGGLQSTI--EFSQQVHEAWSSANRPGKP
Mflv_2283|M.gilvum_PYR-GCK -GPKAVRSAASWAEGIAGTTLDLDLDKQN--DLFDVARDAWREAGNEEP-
Mvan_4383|M.vanbaalenii_PYR-1 -GPKTVRSAAAWADGLAGITMDLAVDKQG--ELFDVARDAWQQAGKGKP-
MMAR_4128|M.marinum_M -GPKTLRSAAPWADGLAGTTLDLDAAKQN--ELFDVARAAWAQAGKPKP-
MUL_3991|M.ulcerans_Agy99 -GPKTLRSAAPWADGLAGTTLDLDVAKQN--ELFDVARAAWAQAGKPKP-
TH_2001|M.thermoresistible__bu -GPKTVRSAAAWADGMAGTTLDLDTGKQN--ELFDIARSAWAQAGKPAP-
MAB_3271|M.abscessus_ATCC_1997 -GPKSLARAARWADGITGFSVSGAPAELT--YSADSARAAWQAAGHAEPP
Mb2185c|M.bovis_AF2122/97 PSARAFEVIARHGDGWQPIEGYGELLG-----ALPMLHAAFERAG-RDPA
Rv2161c|M.tuberculosis_H37Rv PSARAFEVIARHGDGWQPIEGYGELLG-----ALPMLHAAFERAG-RDPA
MLBr_00348|M.leprae_Br4923 -GPKNVALAAEICDGWLPIFFSPRMADMYNEWLDEGFARTGARRSREDFE
.. . . * .
MAV_3379|M.avium_104 YLQASVNFALGPAETVA-AGRDHLARYYAFAPGYAQVNVADMVCSA--AD
MSMEG_2162|M.smegmatis_MC2_155 RLVALAYAAVG-KQAAT-HARTHMQEYYGFLGTEGVDRLTRQVIKG--HD
Mflv_2283|M.gilvum_PYR-GCK HLATSFWFAIGDGDAPREQVHRHLLRYMNWIPSEFVDAMAPTTGFAGTAE
Mvan_4383|M.vanbaalenii_PYR-1 HLATSFWFAIGDGDAPRAQVHRHLLRYMNWIPAEFVDALAPTTGFAGTAD
MMAR_4128|M.marinum_M HLATSFWFAFGPQADARAQVHRHLRRYMNWIPAEYVDAMAPTTGWAGSED
MUL_3991|M.ulcerans_Agy99 HLATSFWFAFGPQADARAQVHRHLRRYMNWIPAEYVDAMAPTTGWAGSED
TH_2001|M.thermoresistible__bu HLATSFWFALGAADTARDQVHRHLRRYMNWIPVEFVDAMAPTTGFAGSED
MAB_3271|M.abscessus_ATCC_1997 VLSSGCFYTLG-IPGAESELKQFTSEYLAIFGTQIAEN-VPKTLTNFDAD
Mb2185c|M.bovis_AF2122/97 TAQVCVYSSAGDPATLHEYRRAGVAEVALALPSAGRDQ------------
Rv2161c|M.tuberculosis_H37Rv TAQVCVYSSAGDPATLHEYRRAGVAEVALALPSAGRDQ------------
MLBr_00348|M.leprae_Br4923 ICASAQIVVTEDRAAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMGYAE
:
MAV_3379|M.avium_104 ARDTVR-RYRDLGFDRLLFHPTSASVE------QLDYLADAILGCL----
MSMEG_2162|M.smegmatis_MC2_155 QLTDARGRLADAGFDELIVLPTSDSLD------QLALLDESTA-------
Mflv_2283|M.gilvum_PYR-GCK ELRAVLEGFAGIGTDEVHLIPTSSDIG------QVRRAAEVVADFA----
Mvan_4383|M.vanbaalenii_PYR-1 DLREVLQRFADIGTDEVHLIPTSQDID------QVRRVAEVIDDFS----
MMAR_4128|M.marinum_M ELLAVLRRFEEVGTDEVQLIPTSSDVE------QLRRAIDVVTRFGTA--
MUL_3991|M.ulcerans_Agy99 ELLAVLRRFEEIGTDEVPLIPTSSDVE------QLRRAIDVVTRFGAA--
TH_2001|M.thermoresistible__bu ELHRVLRRFRDIGADEVHLIPTSADVD------QVRRAAEVVREFGEP--
MAB_3271|M.abscessus_ATCC_1997 ALNRTLDGAEEAGLDEFILVPGASDVA------VIEATIELIQRR-----
Mb2185c|M.bovis_AF2122/97 -------VLAALDRSAPLVDAFAGDDR------EVKSHA-----------
Rv2161c|M.tuberculosis_H37Rv -------VLAALDRSAPLVDAFAGDDR------EVKSHA-----------
MLBr_00348|M.leprae_Br4923 VVDEVTALFRSNQKDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAAGV
. :
MAV_3379|M.avium_104 --------------------
MSMEG_2162|M.smegmatis_MC2_155 --------------------
Mflv_2283|M.gilvum_PYR-GCK --------------------
Mvan_4383|M.vanbaalenii_PYR-1 --------------------
MMAR_4128|M.marinum_M --------------------
MUL_3991|M.ulcerans_Agy99 --------------------
TH_2001|M.thermoresistible__bu --------------------
MAB_3271|M.abscessus_ATCC_1997 --------------------
Mb2185c|M.bovis_AF2122/97 --------------------
Rv2161c|M.tuberculosis_H37Rv --------------------
MLBr_00348|M.leprae_Br4923 TMMMVSASSVEQVRDLAGLF