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PVMEPDLDRATLRSWAQLVDGGPFSSLCWGERIAFDNPESLTLLGALAAWTDRVRLVTTVVIPQLHDPVM LAKQLATGDMLCGGRLTVGIGVGGRHEDYRAVGVDPATQTMRQMAERVAVMKRVWAGEKVTESTLPVGPP PVQPGGPELHVGTLGPKTVRSAAAWADGLAGITMDLAVDKQGELFDVARDAWQQAGKGKPHLATSFWFAI GDGDAPRAQVHRHLLRYMNWIPAEFVDALAPTTGFAGTADDLREVLQRFADIGTDEVHLIPTSQDIDQVR RVAEVIDDFS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4383 | - | - | 100% (291) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_4864 | - | 3e-15 | 35.12% (168) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_3595 | - | 1e-14 | 34.84% (155) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0978c | - | 3e-16 | 35.71% (168) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2283 | - | 1e-144 | 82.65% (294) | luciferase family protein |
| M. tuberculosis H37Rv | Rv0953c | - | 4e-16 | 35.71% (168) | oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 3e-08 | 26.13% (287) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3271 | - | 2e-43 | 35.07% (288) | hypothetical protein MAB_3271 |
| M. marinum M | MMAR_4128 | - | 1e-128 | 75.52% (290) | flavin-dependent oxidoreductase |
| M. avium 104 | MAV_1441 | - | 1e-129 | 75.17% (286) | hypothetical protein MAV_1441 |
| M. smegmatis MC2 155 | MSMEG_4967 | - | 1e-134 | 75.60% (291) | hypothetical protein MSMEG_4967 |
| M. thermoresistible (build 8) | TH_2001 | - | 1e-140 | 81.03% (290) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3991 | - | 1e-125 | 74.91% (287) | flavin-dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4383|M.vanbaalenii_PYR-1 -------------MPVMEPDLDRATLRSWAQLVDGGPFSS----------
Mflv_2283|M.gilvum_PYR-GCK -----------MTMPVMEPDLDREMLKSWAKTVDEGPFSS----------
MMAR_4128|M.marinum_M -----------MTMPVMEPDLDANVLKTWARAVDEGPFSA----------
MUL_3991|M.ulcerans_Agy99 ----------------MEPDLDANVLKTWARAVDEGTFSA----------
MAV_1441|M.avium_104 -----------MTMPVMEPDLDATVLETWARTIDEGPFSS----------
TH_2001|M.thermoresistible__bu -----------MTMPVMEPDLDAATLRTWARAIDDGPFSA----------
MSMEG_4967|M.smegmatis_MC2_155 -----------MTLPVMEPQLDAATLRAWAHVIDGGPFSS----------
MAB_3271|M.abscessus_ATCC_1997 -------MDIGIALPFMCRDYTRESTITWARLADEGPFST----------
Mb0978c|M.bovis_AF2122/97 -------MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKR
Rv0953c|M.tuberculosis_H37Rv -------MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKR
MLBr_00348|M.leprae_Br4923 MVERANAMKLGLQLGYWAAQPPGNAAELVAAAEGAG-FDA----------
* . *
Mvan_4383|M.vanbaalenii_PYR-1 ---------LCWGERIAFDNPESLTLLG---ALAAWTDRVRLVTTVVIPQ
Mflv_2283|M.gilvum_PYR-GCK ---------LCWGERIAFDNPESLTLLGALGALGAWTERVRLVTTVVIPQ
MMAR_4128|M.marinum_M ---------LCWGERIAFDNPDSLTLLG---ALAAWTDRVRLVTTVIVPQ
MUL_3991|M.ulcerans_Agy99 ---------LCWGERIAFDNPDSSTLLG---ALAAWTDRVRLVTTVIVPQ
MAV_1441|M.avium_104 ---------LCWGERIAFDNPDSLTLLG---ALAAWTERVRLLTTVIVPQ
TH_2001|M.thermoresistible__bu ---------LCWGERIAFDNPDSLTLLG---ALAAWTDRVRLVTTVVVPQ
MSMEG_4967|M.smegmatis_MC2_155 ---------LCWGERIAFDNPDSLTLLG---ALAAWTDRVRLVTTVIVPQ
MAB_3271|M.abscessus_ATCC_1997 ---------ISSGERISYHNQDMWVTLA---AAAAVTERVRILANVSVLP
Mb0978c|M.bovis_AF2122/97 QAAHPTTGDASLPDDRYMRTLDPWVSLG---AASAVTSRIRLATAVALPV
Rv0953c|M.tuberculosis_H37Rv QAAHPTTGDASLPDDRYMRTLDPWVSLG---AASAVTSRIRLATAVALPV
MLBr_00348|M.leprae_Br4923 ---------VFTGEAWGSDAYTPLAWWG------SSTQRVRLGTSVVQLS
: . . : *.*:*: : *
Mvan_4383|M.vanbaalenii_PYR-1 LHDPVMLAKQLATGDMLCGGRLTVGIGVGGRHEDYRAVGVDPATQTMRQM
Mflv_2283|M.gilvum_PYR-GCK LHDPVMLAKQLATGDVLSGGRLTVGIGVGGRHEDYQAVGADPATQTMRQM
MMAR_4128|M.marinum_M LHDPVMLAKALATGDMLSGGRLTVGIGVGGRREDYLAVGADPKTQTMGGM
MUL_3991|M.ulcerans_Agy99 LHDPVMLAEALATGDMLSGGRLTVGIGVGGRREDYLAVGADPKTQTMGGM
MAV_1441|M.avium_104 LHDPVLLAKGLATGDLLSGGRLSVGIGVGGRQEDYHAVGADPATQTMRGM
TH_2001|M.thermoresistible__bu LHDPVLLAKGLATGDVLSGGRLTVGIGVGGRHEDYRAVGADPATQTMREM
MSMEG_4967|M.smegmatis_MC2_155 LHDPVALAKALATGDMLSGGRLTVGLGIGGREEDYRAVGADLSAQNRKGL
MAB_3271|M.abscessus_ATCC_1997 AHPVPLVAKQAATLDVLSEGRFILGVGVGGREHDYRCLDASFGRRHQR-L
Mb0978c|M.bovis_AF2122/97 EHDPITLAKSIATLDHLSHGRVSVGVGFGWNTDELVDHGVPPGR-RRTML
Rv0953c|M.tuberculosis_H37Rv EHDPITLAKSIATLDHLSHGRVSVGVGFGWNTDELVDHGVPPGR-RRTML
MLBr_00348|M.leprae_Br4923 ARTPTACAMAALTLDHLSGGRHILGLGVSG-PQVVEGWYGQPFPKPLSRT
: * * * *. ** :*:*.. .
Mvan_4383|M.vanbaalenii_PYR-1 AERVAVMKRVWAGEKVTES-------------TLPVG-----PPPVQPGG
Mflv_2283|M.gilvum_PYR-GCK AERVEIMKRVWAGEKITDS-------------TLPVG-----PPPVQPGG
MMAR_4128|M.marinum_M ATRVAVMKRVWAGEQISES-------------VRPVG-----PLPVQPGG
MUL_3991|M.ulcerans_Agy99 ATRVAVMKRVWAGEQISES-------------VRPVG-----PLPVQPGG
MAV_1441|M.avium_104 AERVAVMKRVWAGEKLTES-------------VRPVG-----PAPVQPGG
TH_2001|M.thermoresistible__bu AERVAVMKRVWAGEKVTES-------------VLPVG-----PPPVQSGG
MSMEG_4967|M.smegmatis_MC2_155 ADAVAVMKRVWAGEKVTES-------------VLPVG-----PPPAQTGG
MAB_3271|M.abscessus_ATCC_1997 DDQVAELRRLWRGEPPFEG-------------ADPVG-----PAPVQDGG
Mb0978c|M.bovis_AF2122/97 REYLEAMRALWTQEEACYDGE-----------FVKFGPSWAWPKPVQPHI
Rv0953c|M.tuberculosis_H37Rv REYLEAMRALWTQEEACYDGE-----------FVKFGPSWAWPKPVQPHI
MLBr_00348|M.leprae_Br4923 REYIDIVRQVWAREAPVVSDGQHYPLPLTGAGATGLGKALKPITHPLRAD
: :: :* * . .*
Mvan_4383|M.vanbaalenii_PYR-1 PELHVGTLGPKTVRSAAAWADGLAGITMDLAVDKQGELFDVARDAWQQA-
Mflv_2283|M.gilvum_PYR-GCK PPLQVGTLGPKAVRSAASWAEGIAGTTLDLDLDKQNDLFDVARDAWREA-
MMAR_4128|M.marinum_M PPLLVGTIGPKTLRSAAPWADGLAGTTLDLDAAKQNELFDVARAAWAQA-
MUL_3991|M.ulcerans_Agy99 PPLLVGTIGPKTLRSAAPWADGLAGTTLDLDVAKQNELFDVARAAWAQA-
MAV_1441|M.avium_104 PPLFVGSIGPKTIRSAAAWADGLAGTTLDLDVAKQRELFDVTRDAWARA-
TH_2001|M.thermoresistible__bu PPLLVGTIGPKTVRSAAAWADGMAGTTLDLDTGKQNELFDIARSAWAQA-
MSMEG_4967|M.smegmatis_MC2_155 PPLHIGTIGPKTVRDAAAWADGVAGTTLDLDLGKQAELFQIARSAWAQE-
MAB_3271|M.abscessus_ATCC_1997 PPVVAAAIGPKSLARAARWADGITGFSVSGAPAELTYSADSARAAWQAA-
Mb0978c|M.bovis_AF2122/97 PVLVGAAGTEKNFKWIARSADGWITTPRDVDIDEP---VKLLQDIWAAA-
Rv0953c|M.tuberculosis_H37Rv PVLVGAAGTEKNFKWIARSADGWITTPRDVDIDEP---VKLLQDIWAAA-
MLBr_00348|M.leprae_Br4923 IPIMLGAEGPKNVALAAEICDGWLPIFFSPRMADMYNEWLDEGFARTGAR
: .: * . * .:* . .
Mvan_4383|M.vanbaalenii_PYR-1 -GKGKPHLATS-FWFAIGDGDAPRAQVHRHLLRYMNWIPAE---FVDALA
Mflv_2283|M.gilvum_PYR-GCK -GNEEPHLATS-FWFAIGDGDAPREQVHRHLLRYMNWIPSE---FVDAMA
MMAR_4128|M.marinum_M -GKPKPHLATS-FWFAFGPQADARAQVHRHLRRYMNWIPAE---YVDAMA
MUL_3991|M.ulcerans_Agy99 -GKPKPHLATS-FWFAFGPQADARAQVHRHLRRYMNWIPAE---YVDAMA
MAV_1441|M.avium_104 -GKPAPHLITS-FWFAFGSARGAREQIHRHLRRYMNWIPAD---YVDAMA
TH_2001|M.thermoresistible__bu -GKPAPHLATS-FWFALGAADTARDQVHRHLRRYMNWIPVE---FVDAMA
MSMEG_4967|M.smegmatis_MC2_155 -GKPKPHLATS-FWFALGEPEVARAQVHRHLLRYMNWIPAE---YVDAMA
MAB_3271|M.abscessus_ATCC_1997 -GHAEPPVLSSGCFYTLGIP-GAESELKQFTSEYLAIFGTQ---IAEN-V
Mb0978c|M.bovis_AF2122/97 -GRD-------------GLPQIVALDVKPVPDKLARWAELG---VTEVLF
Rv0953c|M.tuberculosis_H37Rv -GRD-------------GLPQIVALDVKPVPDKLARWAELG---VTEVLF
MLBr_00348|M.leprae_Br4923 RSREDFEICASAQIVVTEDRAAAFAGIKPFLALYMGGMGAEGTNFHADVY
.. ::
Mvan_4383|M.vanbaalenii_PYR-1 PTTGFAGTADDLREVLQRFADIGTDEVH---LIPTSQDIDQVRRVAEVID
Mflv_2283|M.gilvum_PYR-GCK PTTGFAGTAEELRAVLEGFAGIGTDEVH---LIPTSSDIGQVRRAAEVVA
MMAR_4128|M.marinum_M PTTGWAGSEDELLAVLRRFEEVGTDEVQ---LIPTSSDVEQLRRAIDVVT
MUL_3991|M.ulcerans_Agy99 PTTGWAGSEDELLAVLRRFEEIGTDEVP---LIPTSSDVEQLRRAIDVVT
MAV_1441|M.avium_104 PTTGWAGDEDELAEVLRKFAEIGADEVQ---LIPTSSDVGQLRRAADVAA
TH_2001|M.thermoresistible__bu PTTGFAGSEDELHRVLRRFRDIGADEVH---LIPTSADVDQVRRAAEVVR
MSMEG_4967|M.smegmatis_MC2_155 PTTGWAGTEDDLVELLGKFEDIGTDEIH---LIPTSANIDQLRRVAEAVQ
MAB_3271|M.abscessus_ATCC_1997 PKTLTNFDADALNRTLDGAEEAGLDEFI---LVPGASDVAVIEATIELIQ
Mb0978c|M.bovis_AF2122/97 GMP--DRSADDAAAYVERLAAKLACCV-----------------------
Rv0953c|M.tuberculosis_H37Rv GMP--DRSADDAAAYVERLAAKLACCV-----------------------
MLBr_00348|M.leprae_Br4923 RRMGYAEVVDEVTALFRSNQKDKAAEIIPNELVDSTMIVGDVDYVCKQIA
: . .
Mvan_4383|M.vanbaalenii_PYR-1 DFS------------------------
Mflv_2283|M.gilvum_PYR-GCK DFA------------------------
MMAR_4128|M.marinum_M RFGTA----------------------
MUL_3991|M.ulcerans_Agy99 RFGAA----------------------
MAV_1441|M.avium_104 RL-------------------------
TH_2001|M.thermoresistible__bu EFGEP----------------------
MSMEG_4967|M.smegmatis_MC2_155 NFA------------------------
MAB_3271|M.abscessus_ATCC_1997 RR-------------------------
Mb0978c|M.bovis_AF2122/97 ---------------------------
Rv0953c|M.tuberculosis_H37Rv ---------------------------
MLBr_00348|M.leprae_Br4923 AWSAAGVTMMMVSASSVEQVRDLAGLF