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SAAFDAIDAALDDLLDCDYAALATREKLALLNRCERLRRRLPAIEHPLINALARDASPAELGGRLSHAIA EATLISRAEAARRVHTAADLGPRVGLTGEPLPPLLAATAARQREGSLGLEQVAVIRKFCHQLPGWIDQAT RERAEADLAREGTRYRPEQLAALAGTLADCLNPDGLYRDEDRARRRSLTLGNQHADGMSELRGWLSPELR ATLEAVLAKLAAPGMCNPLDESPCVEGTPSQTAIEGDARSAAQRNHDGLLAGLRALLASGNLGQHNGLPA SIIVTTTLADLEAAAGRGLTGGGTLLPMSDVIRLSRHARHYLAIFDHGKALALYHTKRLASPGQRIVLYA KDRGCTAPGCTVPGYYSEVHHCTDYATCHTTDINDLTFACGPHHRLLQPGAWTTHKNAKGETEWIPPPHL DRNQPRTNAFHHPEKLLQGEDDDDGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3043 | - | - | 100% (447) | hypothetical protein MAV_3043 |
| M. avium 104 | MAV_2999 | - | 0.0 | 94.65% (449) | hypothetical protein MAV_2999 |
| M. avium 104 | MAV_4180 | - | 0.0 | 93.54% (449) | hypothetical protein MAV_4180 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1728c | - | 1e-170 | 66.14% (443) | hypothetical protein Mb1728c |
| M. gilvum PYR-GCK | Mflv_1835 | - | 1e-114 | 49.32% (440) | hypothetical protein Mflv_1835 |
| M. tuberculosis H37Rv | Rv1702c | - | 1e-170 | 66.14% (443) | hypothetical protein Rv1702c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-123 | 53.20% (438) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-164 | 64.13% (446) | hypothetical protein MMAR_1523 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 6e-98 | 44.49% (445) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 4e-73 | 37.18% (476) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-159 | 62.25% (445) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 1e-111 | 45.70% (488) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1728c|M.bovis_AF2122/97 ---MYS---SSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCE
Rv1702c|M.tuberculosis_H37Rv ---MYS---SSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCE
MAV_3043|M.avium_104 --------------MSAAFDAIDAALDDLLDCDYAALATREKLALLNRCE
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
Mflv_1835|M.gilvum_PYR-GCK ----MYVRVMSGGDLQTRIAVLRAAFDEVAACEIELLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
Mvan_3050|M.vanbaalenii_PYR-1 -------MGCSREDVLGAFDALDAVVESILALDYDALSAAERVRLEARLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
. : . : : : :
Mb1728c|M.bovis_AF2122/97 KIRRRLPAAEHPFINKLADQTDQTELGG-KLPFALAERLHISRGEASRRI
Rv1702c|M.tuberculosis_H37Rv KIRRRLPAAEHPFINKLADQTDQTELGG-KLPFALAERLHISRGEASRRI
MAV_3043|M.avium_104 RLRRRLPAIEHPLINALARDASPAELGG-RLSHAIAEATLISRAEAARRV
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGG-KLAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGG-RLAAVVASRLRITRSEAGRRV
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
Mflv_1835|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQAEGTPQQMGAKNWSEVLRVRWRISGSEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
Mvan_3050|M.vanbaalenii_PYR-1 RNLRRIPTVEHELLASVIAETEPARLGEGSWKKVLTTALRISGAEAGRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVP-AVRDRLWARLRITPGEVKRRL
: : : : :: . **
Mb1728c|M.bovis_AF2122/97 HEAADLGPRRTLTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPH
Rv1702c|M.tuberculosis_H37Rv HEAADLGPRRTLTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPH
MAV_3043|M.avium_104 HTAADLGPRVGLTGEPLPPLLAATAARQREGSLGLEQVAVIRKFCHQLPG
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
Mflv_1835|M.gilvum_PYR-GCK TEAALLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKLPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
Mvan_3050|M.vanbaalenii_PYR-1 KRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFHKRLPA
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
* : ** ::* : * * * : :: : *
Mb1728c|M.bovis_AF2122/97 HVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCLNPDG-NYNDTDRA
Rv1702c|M.tuberculosis_H37Rv HVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCLNPDG-NYNDTDRA
MAV_3043|M.avium_104 WIDQATRERAEADLAREGTRYRPEQLAALAGTLADCLNPDG-LYRDEDRA
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDEDRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDIDRA
Mflv_1835|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGHGPKELNDAADRMLFLLDQDGPEPDDAERG
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
Mvan_3050|M.vanbaalenii_PYR-1 WVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPCDKERA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRA
: : : * . . : .: ** *
Mb1728c|M.bovis_AF2122/97 RRRSIILGNQGPDGMSAISGYLTPEARATVDAVLAKLAAPGMANPADDT-
Rv1702c|M.tuberculosis_H37Rv RRRSIILGNQGPDGMSAISGYLTPEARATVDAVLAKLAAPGMANPADDT-
MAV_3043|M.avium_104 RRRSLTLGNQHADGMSELRGWLSPELRATLEAVLAKLAAPGMCNPLDES-
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAPGMCNPDDES-
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPEDEA-
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRDES-
Mflv_1835|M.gilvum_PYR-GCK RKRGVSIGRQGAEAMSALTGQLTPEARAVWEAIFAKYAAPGMCNPDDEQ-
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTDQT-
Mvan_3050|M.vanbaalenii_PYR-1 RKRGIRISKQHPDGTATISGTLTPEALAIWQAIFAKEAAPGANNPESEHT
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHTTTD
: .: :. * :. : * : .: * :.: ** *
Mb1728c|M.bovis_AF2122/97 -PCLAG------------------------------TPSQAAIE------
Rv1702c|M.tuberculosis_H37Rv -PCLAG------------------------------TPSQAAIE------
MAV_3043|M.avium_104 -PCVEG------------------------------TPSQTAIE------
MMAR_1523|M.marinum_M -PVVQA------------------------------PAGADAVS------
MUL_2371|M.ulcerans_Agy99 -AVVDG------------------------------PVSRDAAD------
MAB_0394c|M.abscessus_ATCC_199 -PMTEG------------------------------EPDSAAAE------
Mflv_1835|M.gilvum_PYR-GCK -PCTSG------------------------------TPSQAQID------
MSMEG_6573|M.smegmatis_MC2_155 -PCISG------------------------------TPSQQQID------
Mvan_3050|M.vanbaalenii_PYR-1 EDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHDPQPERCG------
TH_3287|M.thermoresistible__bu TTGTTG---------------TTETTGTAGTAGTAATAADTAADGVGDID
.
Mb1728c|M.bovis_AF2122/97 ---ADTRSAGQRHHDGLLAALRALLCSGELGQHNGLPAAIIVSTSLTELQ
Rv1702c|M.tuberculosis_H37Rv ---ADTRSAGQRHHDGLLAALRALLCSGELGQHNGLPAAIIVSTSLTELQ
MAV_3043|M.avium_104 ---GDARSAAQRNHDGLLAGLRALLASGNLGQHNGLPASIIVTTTLADLE
MMAR_1523|M.marinum_M ---RDRRSVGQRHHDGLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQ
MUL_2371|M.ulcerans_Agy99 ---RDSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELE
MAB_0394c|M.abscessus_ATCC_199 ---RDTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQ
Mflv_1835|M.gilvum_PYR-GCK ---GDHRSLAQRQHDALLAVGRIALMSGELGQLNGLPVSVIIRTTLQDLE
MSMEG_6573|M.smegmatis_MC2_155 ---SDQRGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELE
Mvan_3050|M.vanbaalenii_PYR-1 ---SDTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELE
TH_3287|M.thermoresistible__bu TGGVDLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELN
* * :*.**.: : : ** .* *.:::: *:* :*:
Mb1728c|M.bovis_AF2122/97 SRA-----------GHALTGGGTLLPMSDVIRLASHANHYLRIF--DHGR
Rv1702c|M.tuberculosis_H37Rv SRA-----------GHALTGGGTLLPMSDVIRLASHANHYLRIF--DHGR
MAV_3043|M.avium_104 AAA-----------GRGLTGGGTLLPMSDVIRLSRHARHYLAIF--DHGK
MMAR_1523|M.marinum_M RAC-----------GRGLTGGGTVLPISDVIRLARHAHHYLAVF--DRGK
MUL_2371|M.ulcerans_Agy99 AAA-----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGE
MAB_0394c|M.abscessus_ATCC_199 SAA-----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGR
Mflv_1835|M.gilvum_PYR-GCK SRA-----------GIGVSGGGTKLPIRDVIRMAGHANHYLAVFDRATGS
MSMEG_6573|M.smegmatis_MC2_155 KAA-----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGI
Mvan_3050|M.vanbaalenii_PYR-1 KGA-----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGK
TH_3287|M.thermoresistible__bu QAAHAVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTER
. * . :.. :.: ::**:: * *** ::
Mb1728c|M.bovis_AF2122/97 ELALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVT-DFAQC
Rv1702c|M.tuberculosis_H37Rv ELALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVT-DFAQC
MAV_3043|M.avium_104 ALALYHTKRLASPGQRIVLYAKDRGCTAPGCTVPGYYSEVHHCT-DYATC
MMAR_1523|M.marinum_M AVGLYHAKRLATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHVA-AWATS
MUL_2371|M.ulcerans_Agy99 AIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAIS
MAB_0394c|M.abscessus_ATCC_199 PLHLGRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDD
Mflv_1835|M.gilvum_PYR-GCK ALDLFRTRRVASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAEADYAHG
MSMEG_6573|M.smegmatis_MC2_155 PLYLGRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKG
Mvan_3050|M.vanbaalenii_PYR-1 SLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDG
TH_3287|M.thermoresistible__bu PLYLGRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQP-AWEDG
: * : :* *.. **: *:* **: * * .* :.** :
Mb1728c|M.bovis_AF2122/97 QETDINELTQGCGPHHQLATTGG--WITRKR-KDGTTEWLPPAHLDHGQP
Rv1702c|M.tuberculosis_H37Rv QETDINELTQGCGPHHQLATTGG--WITRKR-KDGTTEWLPPAHLDHGQP
MAV_3043|M.avium_104 HTTDINDLTFACGPHHRLLQPGA--WTTHKN-AKGETEWIPPPHLDRNQP
MMAR_1523|M.marinum_M GRTDIDQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQP
MUL_2371|M.ulcerans_Agy99 GRTDINQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQP
MAB_0394c|M.abscessus_ATCC_199 GPTDIDNLTFACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQS
Mflv_1835|M.gilvum_PYR-GCK GNTNIDELGLACGPDNRSVTDGG--WTTRMN-DRCEVEWIPPPGLDTGQA
MSMEG_6573|M.smegmatis_MC2_155 GLTDADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPDLLDRGQH
Mvan_3050|M.vanbaalenii_PYR-1 GLTNIDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQH
TH_3287|M.thermoresistible__bu GLTDADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPP
*: : * .* .: * : * *
Mb1728c|M.bovis_AF2122/97 RTNSYFHPEKLLHDSDEDDP------------------------------
Rv1702c|M.tuberculosis_H37Rv RTNSYFHPEKLLHDSDEDDP------------------------------
MAV_3043|M.avium_104 RTNAFHHPEKLLQGEDDDDGP-----------------------------
MMAR_1523|M.marinum_M RTNTYHHPEKLLRDSAADEGEEGG--------------------------
MUL_2371|M.ulcerans_Agy99 RTNSYHHPEKLLRDSADDDDEGHGAA------------------------
MAB_0394c|M.abscessus_ATCC_199 RTNDHHHPERFIRRF-----------------------------------
Mflv_1835|M.gilvum_PYR-GCK RVNTYHRPERLLRPEDPEPLGDNDSQASRPADDPGEPG---------GPA
MSMEG_6573|M.smegmatis_MC2_155 RTNTYHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPA
Mvan_3050|M.vanbaalenii_PYR-1 RVNGHHHPERYLLPEDDLPEDDQGP-------------------------
TH_3287|M.thermoresistible__bu TVNHAHHPEELLRAHTDPPEDPG---------------------------
.* .:** :
Mb1728c|M.bovis_AF2122/97 --------------------------------------------------
Rv1702c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3043|M.avium_104 --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK PP-----EGEAA--------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 IPPELLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSA
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mb1728c|M.bovis_AF2122/97 ------------------
Rv1702c|M.tuberculosis_H37Rv ------------------
MAV_3043|M.avium_104 ------------------
MMAR_1523|M.marinum_M ------------------
MUL_2371|M.ulcerans_Agy99 ------------------
MAB_0394c|M.abscessus_ATCC_199 ------------------
Mflv_1835|M.gilvum_PYR-GCK ------------------
MSMEG_6573|M.smegmatis_MC2_155 ENRNGPSKNAAGDDDEPR
Mvan_3050|M.vanbaalenii_PYR-1 ------------------
TH_3287|M.thermoresistible__bu ------------------