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RSIIGREDIQDDYDVLRAVVARIQRHSYDALTNPERIRLLEVLEYQTRRLQVPGHQLINQIEQDATPAEI GGKLAHVLADRLLITRAEAARRIDDARDLGVRRTLTGEPLPPRYAATAAAQRDGRIGASHVAVIRRFFDQ LPCWVDAPTRDAAEADLARWAGEHRPESLRKVADRIACYFNPDGVFHDEDRLRHRGLTLGAQQPDGMSQL RGWLTPEARATVEAVLAKLAAPGMCNPDDDAPVVDGPPPEAASQRDSRSAAQRNHDGLNAALRALLAGGK LGQHNGLPASIIVTTTLRDLESAAGKGLTAGGTLLPMSEVIRLARHAHHYLAVFDNGKPLALYHTKRLAS PGQRIVLYAKDRGCSHPGCDVSGYYCEVHHVTGYAKCGRTDIDQLTFACGGHHPLAEQGWITRKNGRGET EWIPPPHLDHGRPRTNAFHHPEKLVADSDNDTGDDTSDAPDDPQPPIP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2806 | - | - | 100% (469) | hypothetical protein MAV_2806 |
| M. avium 104 | MAV_2352 | - | 0.0 | 77.07% (458) | hypothetical protein MAV_2352 |
| M. avium 104 | MAV_2999 | - | e-166 | 64.32% (454) | hypothetical protein MAV_2999 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 1e-169 | 64.35% (446) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_1835 | - | 1e-110 | 47.12% (469) | hypothetical protein Mflv_1835 |
| M. tuberculosis H37Rv | Rv1128c | - | 1e-169 | 64.35% (446) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-131 | 54.48% (435) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-167 | 63.66% (454) | hypothetical protein MMAR_1523 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-96 | 43.54% (457) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 6e-70 | 36.83% (486) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-164 | 63.00% (446) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 1e-106 | 44.29% (499) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1159c|M.bovis_AF2122/97 ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
Rv1128c|M.tuberculosis_H37Rv ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAV_2806|M.avium_104 ---MRS--IIGREDIQDDYDVLRAVVARIQRHSYDALTNPERIRLLEVLE
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
Mflv_1835|M.gilvum_PYR-GCK ----MYVRVMSGGDLQTRIAVLRAAFDEVAACEIELLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
Mvan_3050|M.vanbaalenii_PYR-1 -------MGCSREDVLGAFDALDAVVESILALDYDALSAAERVRLEARLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
: . : . : : :
Mb1159c|M.bovis_AF2122/97 TARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAKRRV
Rv1128c|M.tuberculosis_H37Rv TARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSEAKRRV
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGG-KLAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGG-RLAAVVASRLRITRSEAGRRV
MAV_2806|M.avium_104 YQTRRLQVPGHQLINQIEQDATPAEIGG-KLAHVLADRLLITRAEAARRI
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
Mflv_1835|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQAEGTPQQMGAKNWSEVLRVRWRISGSEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
Mvan_3050|M.vanbaalenii_PYR-1 RNLRRIPTVEHELLASVIAETEPARLGEGSWKKVLTTALRISGAEAGRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVP-AVRDRLWARLRITPGEVKRRL
: : : : :: . **
Mb1159c|M.bovis_AF2122/97 AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
Rv1128c|M.tuberculosis_H37Rv AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAV_2806|M.avium_104 DDARDLGVRRTLTGEPLPPRYAATAAAQRDGRIGASHVAVIRRFFDQLPC
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
Mflv_1835|M.gilvum_PYR-GCK TEAALLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKLPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
Mvan_3050|M.vanbaalenii_PYR-1 KRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFHKRLPA
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
* : * ::* : * * * * : *: : *
Mb1159c|M.bovis_AF2122/97 WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDEDRA
Rv1128c|M.tuberculosis_H37Rv WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDEDRA
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDEDRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MAV_2806|M.avium_104 WVDAPTRDAAEADLARWAGEHRPESLRKVADRIACYFNPDG-VFHDEDRL
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDIDRA
Mflv_1835|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGHGPKELNDAADRMLFLLDQDGPEPDDAERG
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
Mvan_3050|M.vanbaalenii_PYR-1 WVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPCDKERA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRA
* : * . . : .: ** *
Mb1159c|M.bovis_AF2122/97 RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQKA-
Rv1128c|M.tuberculosis_H37Rv RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQKA-
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAPGMCNPDDES-
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPEDEA-
MAV_2806|M.avium_104 RHRGLTLGAQQPDGMSQLRGWLTPEARATVEAVLAKLAAPGMCNPDDDA-
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRDES-
Mflv_1835|M.gilvum_PYR-GCK RKRGVSIGRQGAEAMSALTGQLTPEARAVWEAIFAKYAAPGMCNPDDEQ-
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTDQT-
Mvan_3050|M.vanbaalenii_PYR-1 RKRGIRISKQHPDGTATISGTLTPEALAIWQAIFAKEAAPGANNPESEHT
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHTTTD
: *: :. * :. : * : .: * :.: ** *
Mb1159c|M.bovis_AF2122/97 -PCVNG------------------------------APSKEQAR------
Rv1128c|M.tuberculosis_H37Rv -PCVNG------------------------------APSKEQAR------
MMAR_1523|M.marinum_M -PVVQA------------------------------PAGADAVS------
MUL_2371|M.ulcerans_Agy99 -AVVDG------------------------------PVSRDAAD------
MAV_2806|M.avium_104 -PVVDG------------------------------PPPEAASQ------
MAB_0394c|M.abscessus_ATCC_199 -PMTEG------------------------------EPDSAAAE------
Mflv_1835|M.gilvum_PYR-GCK -PCTSG------------------------------TPSQAQID------
MSMEG_6573|M.smegmatis_MC2_155 -PCISG------------------------------TPSQQQID------
Mvan_3050|M.vanbaalenii_PYR-1 EDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHDPQPERCG------
TH_3287|M.thermoresistible__bu TTGTTG---------------TTETTGTAGTAGTAATAADTAADGVGDID
.
Mb1159c|M.bovis_AF2122/97 ---RDTRSCPQRNHDALNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLE
Rv1128c|M.tuberculosis_H37Rv ---RDTRSCPQRNHDALNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLE
MMAR_1523|M.marinum_M ---RDRRSVGQRHHDGLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQ
MUL_2371|M.ulcerans_Agy99 ---RDSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELE
MAV_2806|M.avium_104 ---RDSRSAAQRNHDGLNAALRALLAGGKLGQHNGLPASIIVTTTLRDLE
MAB_0394c|M.abscessus_ATCC_199 ---RDTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQ
Mflv_1835|M.gilvum_PYR-GCK ---GDHRSLAQRQHDALLAVGRIALMSGELGQLNGLPVSVIIRTTLQDLE
MSMEG_6573|M.smegmatis_MC2_155 ---SDQRGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELE
Mvan_3050|M.vanbaalenii_PYR-1 ---SDTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELE
TH_3287|M.thermoresistible__bu TGGVDLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELN
* * :*.**.: : : ** .* *.:::: *** :*:
Mb1159c|M.bovis_AF2122/97 AAA-----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGK
Rv1128c|M.tuberculosis_H37Rv AAA-----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGK
MMAR_1523|M.marinum_M RAC-----------GRGLTGGGTVLPISDVIRLARHAHHYLAVF--DRGK
MUL_2371|M.ulcerans_Agy99 AAA-----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGE
MAV_2806|M.avium_104 SAA-----------GKGLTAGGTLLPMSEVIRLARHAHHYLAVF--DNGK
MAB_0394c|M.abscessus_ATCC_199 SAA-----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGR
Mflv_1835|M.gilvum_PYR-GCK SRA-----------GIGVSGGGTKLPIRDVIRMAGHANHYLAVFDRATGS
MSMEG_6573|M.smegmatis_MC2_155 KAA-----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGI
Mvan_3050|M.vanbaalenii_PYR-1 KGA-----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGK
TH_3287|M.thermoresistible__bu QAAHAVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTER
. * . :.. :.: ::**:* * *** ::
Mb1159c|M.bovis_AF2122/97 ALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVTP-YAQC
Rv1128c|M.tuberculosis_H37Rv ALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVTP-YAQC
MMAR_1523|M.marinum_M AVGLYHAKRLATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHVAA-WATS
MUL_2371|M.ulcerans_Agy99 AIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAA-WAIS
MAV_2806|M.avium_104 PLALYHTKRLASPGQRIVLYAKDRGCSHPGCDVSGYYCEVHHVTG-YAKC
MAB_0394c|M.abscessus_ATCC_199 PLHLGRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVDD-WRDD
Mflv_1835|M.gilvum_PYR-GCK ALDLFRTRRVASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAEADYAHG
MSMEG_6573|M.smegmatis_MC2_155 PLYLGRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKG
Mvan_3050|M.vanbaalenii_PYR-1 SLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDG
TH_3287|M.thermoresistible__bu PLYLGRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQPA-WEDG
.: * : :* *.. **: *:* **: * * .* .:.** :
Mb1159c|M.bovis_AF2122/97 RNTDVNDLTLGCGGHHP-LAERG--WTTRKN-AHGDTEWLPPPHLDHGQP
Rv1128c|M.tuberculosis_H37Rv RNTDVNDLTLGCGGHHP-LAERG--WTTRKN-AHGDTEWLPPPHLDHGQP
MMAR_1523|M.marinum_M GRTDIDQLTLACGPDHK-LLEQG--WRTRKN-AHGDTEWLPPPHLDHGQP
MUL_2371|M.ulcerans_Agy99 GRTDINQLTLACGPDHK-LLEQG--WRTRKN-AHGDTEWLPPPHLDHGQP
MAV_2806|M.avium_104 GRTDIDQLTFACGGHHP-LAEQG--WITRKN-GRGETEWIPPPHLDHGRP
MAB_0394c|M.abscessus_ATCC_199 GPTDIDNLTFACGPHHR-LLQQG--WTTRKRRSDGITEWIPPPHLDTGQS
Mflv_1835|M.gilvum_PYR-GCK GNTNIDELGLACGPDNRSVTDGG--WTTRMN-DRCEVEWIPPPGLDTGQA
MSMEG_6573|M.smegmatis_MC2_155 GLTDADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPDLLDRGQH
Mvan_3050|M.vanbaalenii_PYR-1 GLTNIDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQH
TH_3287|M.thermoresistible__bu GLTDADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPP
*: : * :.* .: : : * : * *
Mb1159c|M.bovis_AF2122/97 RVNTFHHPEKLLADDEGDP-------------------------------
Rv1128c|M.tuberculosis_H37Rv RVNTFHHPEKLLADDEGDP-------------------------------
MMAR_1523|M.marinum_M RTNTYHHPEKLLRDSAADEGEEGG--------------------------
MUL_2371|M.ulcerans_Agy99 RTNSYHHPEKLLRDSADDDDEGHGAA------------------------
MAV_2806|M.avium_104 RTNAFHHPEKLVADSDNDTGDDTSDAPDDPQPPIP---------------
MAB_0394c|M.abscessus_ATCC_199 RTNDHHHPERFIRRF-----------------------------------
Mflv_1835|M.gilvum_PYR-GCK RVNTYHRPERLLRPEDPEPLGDNDSQASRPADDPGEPG---------GPA
MSMEG_6573|M.smegmatis_MC2_155 RTNTYHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPA
Mvan_3050|M.vanbaalenii_PYR-1 RVNGHHHPERYLLPEDDLPEDDQGP-------------------------
TH_3287|M.thermoresistible__bu TVNHAHHPEELLRAHTDPPEDPG---------------------------
.* *:** :
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAV_2806|M.avium_104 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK PP-----EGEAA--------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 IPPELLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSA
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mb1159c|M.bovis_AF2122/97 ------------------
Rv1128c|M.tuberculosis_H37Rv ------------------
MMAR_1523|M.marinum_M ------------------
MUL_2371|M.ulcerans_Agy99 ------------------
MAV_2806|M.avium_104 ------------------
MAB_0394c|M.abscessus_ATCC_199 ------------------
Mflv_1835|M.gilvum_PYR-GCK ------------------
MSMEG_6573|M.smegmatis_MC2_155 ENRNGPSKNAAGDDDEPR
Mvan_3050|M.vanbaalenii_PYR-1 ------------------
TH_3287|M.thermoresistible__bu ------------------