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IRSPASAVRSASSTSSKADWSRAIAMFLSVVILGRFTTETHAMALLRQGPTRRHHLHHSPGRSPVDFEVV DLQEGRTFSARRVTARQDDKILMEAMSSFKVVNSAAAQVVYQPIMPEAPSPESLPWVAPHLAEADEGSRG RWASLRWFERRTIETETVPPARAPMWWRPDGRVPDDPVLTASLVAYMSAVTLTEPAFAARGGVGASAQRD HSVWFHGRAVLSDWLFYDRSSPSSAGSLALASGTMFNRTGELVCTVKQEMYFPPQTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2695 | - | - | 100% (268) | acyl-CoA thioesterase family protein |
| M. avium 104 | MAV_2540 | - | 9e-37 | 36.14% (249) | acyl-CoA thioesterase |
| M. avium 104 | MAV_3169 | - | 2e-20 | 28.95% (228) | Acyl-CoA thioesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1644 | tesB1 | 2e-21 | 30.13% (229) | acyl-CoA thioesterase II TesB1 |
| M. gilvum PYR-GCK | Mflv_1022 | - | 4e-80 | 63.60% (239) | acyl-CoA thioesterase |
| M. tuberculosis H37Rv | Rv2605c | tesB2 | 3e-21 | 32.83% (198) | acyl-CoA thioesterase II |
| M. leprae Br4923 | MLBr_01278 | tesB | 8e-20 | 28.44% (225) | acyl CoA thioesterase II |
| M. abscessus ATCC 19977 | MAB_2891c | - | 5e-24 | 33.18% (217) | acyl-CoA thioesterase II TesB2 |
| M. marinum M | MMAR_2095 | tesB2 | 1e-21 | 31.63% (215) | acyl-CoA thioesterase II TesB2 |
| M. smegmatis MC2 155 | MSMEG_3812 | - | 1e-39 | 40.09% (217) | acyl-CoA thioesterase |
| M. thermoresistible (build 8) | TH_3497 | - | 1e-38 | 38.06% (247) | PUTATIVE acyl-CoA thioesterase |
| M. ulcerans Agy99 | MUL_3249 | tesB2 | 7e-22 | 31.63% (215) | acyl-CoA thioesterase II TesB2 |
| M. vanbaalenii PYR-1 | Mvan_5814 | - | 2e-86 | 67.65% (238) | acyl-CoA thioesterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu LIRNVRPYGEGEPVDVLVADGQIAEIGEKLPIPGDGELGDVIDADGQILL
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MMAR_2095|M.marinum_M --------------------------------------------------
MUL_3249|M.ulcerans_Agy99 --------------------------------------------------
Rv2605c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu PGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTDPVADSPV
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MMAR_2095|M.marinum_M --------------------------------------------------
MUL_3249|M.ulcerans_Agy99 --------------------------------------------------
Rv2605c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu VTDHVWRRGQQVGLVDVHPVGAVTVGLEGRQLTEMGLMAAGAARVRMFSD
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MMAR_2095|M.marinum_M --------------------------------------------------
MUL_3249|M.ulcerans_Agy99 --------------------------------------------------
Rv2605c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu DGLCVHDPLVMRRALEYARGLGVLIAQHAEEPRLTVGAVAHXXXWPACPA
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MMAR_2095|M.marinum_M --------------------------------------------------
MUL_3249|M.ulcerans_Agy99 --------------------------------------------------
Rv2605c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 ------------------------------------MRSPTMKSSRTTIK
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 ------------------------------------MPLP----------
TH_3497|M.thermoresistible__bu RCRPGYRSPPTWCASAPPGRPNAVRRNRSSPRRIGPTPPPGTSRPATDVG
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MMAR_2095|M.marinum_M --------------------------------------------------
MUL_3249|M.ulcerans_Agy99 --------------------------------------------------
Rv2605c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK ---------------------------MSSSLGDVLASMQLRSVGDGLFA
Mvan_5814|M.vanbaalenii_PYR-1 RRGTSRDEEPDHG--------VRQDTCVSSSLGDVLASMQLDQAGPAAFV
MAV_2695|M.avium_104 ---------------------------MIRSPASAVRSASSTSS-KADWS
MSMEG_3812|M.smegmatis_MC2_155 ------------------------------QLADVLATLDITDCGHDMFV
TH_3497|M.thermoresistible__bu RLGSADRARRPGPRCRGAWWLGHDAPVTELTLYDVLTTLDVAQVDDDLFE
Mb1644|M.bovis_AF2122/97 ----------------------MPDGKPMSDFDELLAVLDLNAVASDLFT
MLBr_01278|M.leprae_Br4923 -------------------MKRLWEKKTMSDFEELLAVLDLNRVADDLFI
MMAR_2095|M.marinum_M --------------------------------MAIEEILDLEQLEVNIYR
MUL_3249|M.ulcerans_Agy99 --------------------------------MAIEEILDLEQLEVNIYR
Rv2605c|M.tuberculosis_H37Rv --------------------------------MSIEEILDLEQLEVNIYR
MAB_2891c|M.abscessus_ATCC_199 -------------------------------MADIEEILTLEQLEKDIFR
:
Mflv_1022|M.gilvum_PYR-GCK GAQLPAP---ANHILGGHISAQALLAASLTAPGR--APHSVHTYFLRPGD
Mvan_5814|M.vanbaalenii_PYR-1 GRQLPAP---ANHILGGHISAQALLAASLTAPGR--TPHSVHTYFLRPGD
MAV_2695|M.avium_104 RAIAMFL---SVVILGRFTTETHAMALLRQGPTR--RHHLHHS----PG-
MSMEG_3812|M.smegmatis_MC2_155 ATQIDNE---AHHIIGGHISAQALMAASRTAAGR--VPNSLHVYLLRAGD
TH_3497|M.thermoresistible__bu ATQLDNP---AHHIVGGHIAGQAVVAASRTAPQR--TAHSAHVYFLRAGD
Mb1644|M.bovis_AF2122/97 GSHPSKN---PLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGD
MLBr_01278|M.leprae_Br4923 GSHPSKN---PLRTFGGQLVAQSFVASSRTLIRDDLPPSAFSVHFINGGD
MMAR_2095|M.marinum_M GSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYQVHSLHG-YFLRSGD
MUL_3249|M.ulcerans_Agy99 GSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYQVHSLHG-YFLRSGD
Rv2605c|M.tuberculosis_H37Rv GSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHG-YFLRPGD
MAB_2891c|M.abscessus_ATCC_199 GNVTPSN---LRRTFGGQVAGQSLVSAVRTVEPEYLVHSLHG-YFLRPGN
.* :: *
Mflv_1022|M.gilvum_PYR-GCK SRHAVTFEVVKLQEGRTFSARRVTARQGDEILLEALSSFKLPTEAPGGVT
Mvan_5814|M.vanbaalenii_PYR-1 SRLTVTFEVVNLQEGRTFSARRVTARQGDEILLEAMSSFKSSTPSARPVT
MAV_2695|M.avium_104 -RSPVDFEVVDLQEGRTFSARRVTARQDDKILMEAMSSFKVVNSAAAQVV
MSMEG_3812|M.smegmatis_MC2_155 ARYPVEMQVMNMRDGGMLSTRRVIARQGDEVLLEALVSLSDT---ADTVD
TH_3497|M.thermoresistible__bu ARYPVQMRVDRLRDGGSLSTXRVTATQDGQVLLEALASFTVR---IDSVD
Mb1644|M.bovis_AF2122/97 TAKDIEFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAG---GRGLE
MLBr_01278|M.leprae_Br4923 TAKEIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSG---GCGLE
MMAR_2095|M.marinum_M AQEPTVFLVERTRDGGSFVTRRVNAVQHGEVIFSMGASFQTA---QNGIS
MUL_3249|M.ulcerans_Agy99 AQEPTVFLVERTRDGGSFVTRRVNAVQHGEVIFSMGASFQTA---QNGIS
Rv2605c|M.tuberculosis_H37Rv AKERTVFLVERIRDGGSFCTRRVNAVQHGETIFSMAASFQTE---QEGIT
MAB_2891c|M.abscessus_ATCC_199 PNEPTVFLVDRVRDGRSFVTRRVTAIQDGQAIFSMSASFQTL---DTGIE
: * :: : ** * * . : . * :
Mflv_1022|M.gilvum_PYR-GCK YQPPCPDVPAPESLPVVAPHSAES-HSAEGTWASLRWFERRVVDAAT---
Mvan_5814|M.vanbaalenii_PYR-1 YQPRCPEVAPPESLPRVAPHFAESDEVTKGQWASLRWFERRIVDAAA---
MAV_2695|M.avium_104 YQPIMPEAPSPESLPWVAPHLAEADEGSRGRWASLRWFERRTIETET---
MSMEG_3812|M.smegmatis_MC2_155 YHQPMPDVPAPEDLPSVGELLSDYADELDGFWVKPQWIERRYVDAPPRLA
TH_3497|M.thermoresistible__bu THHPMPDVPDPDTLPPVTEQLVAYADEFGGLWVRPQPIERRYIDPPPRVA
Mb1644|M.bovis_AF2122/97 HALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWRYANDPAWIM
MLBr_01278|M.leprae_Br4923 HAVEPPEAAEPHTRPPIGELLRGYEQIVQHFVNALQPVEWRYVNDPSWVM
MMAR_2095|M.marinum_M HQDAMPAAPPPDDLPGLRSVRVFDDAGFRQFE------EWDVRIVPRDLL
MUL_3249|M.ulcerans_Agy99 HQDAMPAAPPPDDLPGLRSVRVFDDAGFRQFE------EWDVRIVPRDLL
Rv2605c|M.tuberculosis_H37Rv HQDVMPAAPPPDGLPGLNSIKVFDDAGFRQFD------EWDVCIVPRERL
MAB_2891c|M.abscessus_ATCC_199 HQDLMPPVPDPEDLPDAQEQDSFNRDLFRQFA------EWDIRIVPDELM
* .. *. * *
Mflv_1022|M.gilvum_PYR-GCK ----GPPAPARIWLRPDGEVPDDPVLTASLVAYLSAVTLTEPAYAARSG-
Mvan_5814|M.vanbaalenii_PYR-1 ----DPPARSRIWWRPDGEVPDDPVLTASLVAYLSAVTLTEPAYAARGG-
MAV_2695|M.avium_104 ----VPPARAPMWWRPDGRVPDDPVLTASLVAYMSAVTLTEPAFAARGG-
MSMEG_3812|M.smegmatis_MC2_155 LDQPEPPERTRMWWRPAESIPNDPVLNCCVLTYASGTSLLETTVTMRRTT
TH_3497|M.thermoresistible__bu YDLPEPPARTRMWWRATEPVPDDPALNSALLTYVTGTSTLEAAMVAHRTT
Mb1644|M.bovis_AF2122/97 RDKGDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLS
MLBr_01278|M.leprae_Br4923 RNKGQRLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLS
MMAR_2095|M.marinum_M APLPGKASQQQVWFRHRDPLPDDPVLHICALAYMSDLTLLGSAQVTHLAE
MUL_3249|M.ulcerans_Agy99 APLPGKASQQQVWFRHRDPLPDDPVLHICALAYMSDLTLLGSAQVTHLAE
Rv2605c|M.tuberculosis_H37Rv RLLPGKASQQQVWLRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDV
MAB_2891c|M.abscessus_ATCC_199 DRNPRLAAQQRVWFRCRKHLPDDPVLHICALAYMSDLTLLSSSKVPHRDT
:* : :*:**.* . : * : : . . :
Mflv_1022|M.gilvum_PYR-GCK ----LVMAAQRDHSVWFHAAADLSDWMLYDMASPSSADTLALARGTLFNR
Mvan_5814|M.vanbaalenii_PYR-1 ----VTVSAQRDHSVWFHAAADLSDWLLYEQSSPSSADTLALASGTMFNR
MAV_2695|M.avium_104 ----VGASAQRDHSVWFHGRAVLSDWLFYDRSSPSSAGSLALASGTMFNR
MSMEG_3812|M.smegmatis_MC2_155 Q--ATAFSALIDHTVWFQRPADLSDWVLSDQVSLSGIHGRGLASGTMYNR
TH_3497|M.thermoresistible__bu P--LHSFNALIDHALWFHRPAHLTDWVLADQFSPSSLGGRGLATATMYNR
Mb1644|M.bovis_AF2122/97 WGFDRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDR
MLBr_01278|M.leprae_Br4923 WGFDRIFAVSANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDR
MMAR_2095|M.marinum_M R--EHLQVASLDHAMWFMRGFRADEWLLYDQSSPSAGGGRALTHGKIFTQ
MUL_3249|M.ulcerans_Agy99 R--EHLQVASLDHAMWFMRGFRADEWLLYDQSSPSAGGGRALTHGKIFTQ
Rv2605c|M.tuberculosis_H37Rv R--DQLQVASLDHAMWFMRPFRADEWLLYDQSSPSASGGRALTRGEIFTR
MAB_2891c|M.abscessus_ATCC_199 ----VLQTASLDHALWFLRPFRADEWMLYDETSPSAGFGRALTQGRIFNR
. :*::** :*:: . * . .* . :: :
Mflv_1022|M.gilvum_PYR-GCK SGELVCTVRQEMYFPPPRG------------
Mvan_5814|M.vanbaalenii_PYR-1 TGELVCTVRQEMYFPASRH------------
MAV_2695|M.avium_104 TGELVCTVKQEMYFPPQTA------------
MSMEG_3812|M.smegmatis_MC2_155 SGELVCSATQEIYFGR-GRI-----------
TH_3497|M.thermoresistible__bu TGELVCTATQELYFGRPARSGSRR-------
Mb1644|M.bovis_AF2122/97 SGKLIATVVQEGVLKYFPATPDSAAGRS---
MLBr_01278|M.leprae_Br4923 SGQLIATVVQEGVLKYFPASHR---------
MMAR_2095|M.marinum_M GGELVAAVMQEGLTRYPSGYQPGEK------
MUL_3249|M.ulcerans_Agy99 GGELVAAVMQEGLTRYPSGYQPGEN------
Rv2605c|M.tuberculosis_H37Rv SGEMVAAVMQEGLTRHRRGHRSVGQ------
MAB_2891c|M.abscessus_ATCC_199 DGTMVAAVVQEGLTRIERNPEQASVARGNMA
* ::.:. **