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MISTLEDVLSLLDLQQIDDAAFVGTQPDTPNHHIIGSQVAAQALMAAGRTTPGRLAHSMHMYFLRRGDAR QPIQYDVTPLRDGGTISSRRVTASQSGVVLFEALASFTIIADDVDWQQRMPDVAGPSAVHGLEDLLAPYA EEFGDWWPQQRPFTMRYLDAPPRVALDLSDPPPPRLRIWLRANGEVTDDPLVNSCVVAYLSALTLLECVM TTMRTTPVGPRLSALVDHTIWFHRAADFTDWLLFDQFSPSIVGRRGLATGTLYNRSGELVCIATQEGYFA EQRQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2540 | - | - | 100% (284) | acyl-CoA thioesterase |
| M. avium 104 | MAV_3169 | - | 9e-37 | 32.28% (285) | Acyl-CoA thioesterase |
| M. avium 104 | MAV_2695 | - | 9e-37 | 36.14% (249) | acyl-CoA thioesterase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1644 | tesB1 | 1e-35 | 31.91% (282) | acyl-CoA thioesterase II TesB1 |
| M. gilvum PYR-GCK | Mflv_1022 | - | 6e-58 | 42.86% (287) | acyl-CoA thioesterase |
| M. tuberculosis H37Rv | Rv1618 | tesB1 | 3e-35 | 31.91% (282) | acyl-CoA thioesterase II TesB1 |
| M. leprae Br4923 | MLBr_01278 | tesB | 3e-35 | 30.50% (282) | acyl CoA thioesterase II |
| M. abscessus ATCC 19977 | MAB_2891c | - | 2e-36 | 34.53% (278) | acyl-CoA thioesterase II TesB2 |
| M. marinum M | MMAR_2421 | tesB1 | 2e-36 | 31.27% (291) | acyl-CoA thioesterase II TesB1 |
| M. smegmatis MC2 155 | MSMEG_3812 | - | 2e-73 | 50.18% (279) | acyl-CoA thioesterase |
| M. thermoresistible (build 8) | TH_3497 | - | 2e-83 | 54.71% (276) | PUTATIVE acyl-CoA thioesterase |
| M. ulcerans Agy99 | MUL_1599 | tesB1 | 2e-36 | 31.27% (291) | acyl-CoA thioesterase II TesB1 |
| M. vanbaalenii PYR-1 | Mvan_5814 | - | 1e-59 | 44.72% (284) | acyl-CoA thioesterase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu LIRNVRPYGEGEPVDVLVADGQIAEIGEKLPIPGDGELGDVIDADGQILL
MAV_2540|M.avium_104 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu PGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTDPVADSPV
MAV_2540|M.avium_104 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu VTDHVWRRGQQVGLVDVHPVGAVTVGLEGRQLTEMGLMAAGAARVRMFSD
MAV_2540|M.avium_104 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu DGLCVHDPLVMRRALEYARGLGVLIAQHAEEPRLTVGAVAHXXXWPACPA
MAV_2540|M.avium_104 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 ------------------------------------MPLP----------
TH_3497|M.thermoresistible__bu RCRPGYRSPPTWCASAPPGRPNAVRRNRSSPRRIGPTPPPGTSRPATDVG
MAV_2540|M.avium_104 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 ------MRSPTMKSSRTTIKRRGTSRDEEPDHGVR---------------
MMAR_2421|M.marinum_M ---------------MPAGDEPNVRDEAKSDFEELLAVLDLKRVADDRFI
MUL_1599|M.ulcerans_Agy99 -----------------------MRDEAKSDFEELLAVLDLKRVADDRFI
Mb1644|M.bovis_AF2122/97 ----------------------MPDGKPMSDFDELLAVLDLNAVASDLFT
Rv1618|M.tuberculosis_H37Rv ----------------------MPDGKPMSDFDELLAVLDLNAVASDLFT
MLBr_01278|M.leprae_Br4923 -------------------MKRLWEKKTMSDFEELLAVLDLNRVADDLFI
MAB_2891c|M.abscessus_ATCC_199 -------------------------------MADIEEILTLEQLEKDIFR
MSMEG_3812|M.smegmatis_MC2_155 ------------------------------QLADVLATLDITDCGHDMFV
TH_3497|M.thermoresistible__bu RLGSADRARRPGPRCRGAWWLGHDAPVTELTLYDVLTTLDVAQVDDDLFE
MAV_2540|M.avium_104 ---------------------------MISTLEDVLSLLDLQQIDDAAFV
Mflv_1022|M.gilvum_PYR-GCK ---------------------------MSSSLGDVLASMQLRSVGDGLFA
Mvan_5814|M.vanbaalenii_PYR-1 -----------------------QDTCVSSSLGDVLASMQLDQAGPAAFV
: :: : : *
MMAR_2421|M.marinum_M GAHPSKNPMRTFGGLLMAQSFVASSRTLLRDDLPPSALSVHFINGGDTTK
MUL_1599|M.ulcerans_Agy99 GAHPSKNPMRTFGGLLMAQSFVANSRTLLRDDLPPSALSVHFINGGDTTK
Mb1644|M.bovis_AF2122/97 GSHPSKNPLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAK
Rv1618|M.tuberculosis_H37Rv GSHPSKNPLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAK
MLBr_01278|M.leprae_Br4923 GSHPSKNPLRTFGGQLVAQSFVASSRTLIRDDLPPSAFSVHFINGGDTAK
MAB_2891c|M.abscessus_ATCC_199 GNVTPSNLRRTFGGQVAGQSLVSAVRTVEPEYLVHS-LHGYFLRPGNPNE
MSMEG_3812|M.smegmatis_MC2_155 ATQIDNEAHHIIGGHISAQALMAASRTAAGR--VPNSLHVYLLRAGDARY
TH_3497|M.thermoresistible__bu ATQLDNPAHHIVGGHIAGQAVVAASRTAPQR--TAHSAHVYFLRAGDARY
MAV_2540|M.avium_104 GTQPDTPNHHIIGSQVAAQALMAAGRTTPGR--LAHSMHMYFLRRGDARQ
Mflv_1022|M.gilvum_PYR-GCK GAQLPAPANHILGGHISAQALLAASLTAPGR--APHSVHTYFLRPGDSRH
Mvan_5814|M.vanbaalenii_PYR-1 GRQLPAPANHILGGHISAQALLAASLTAPGR--TPHSVHTYFLRPGDSRL
. : .*. : .*:.:: * :::. *:.
MMAR_2421|M.marinum_M DIEFQVVRLRDERRFANRRIDAVQNGTLLSSAMISYMSGGRG---LEHGV
MUL_1599|M.ulcerans_Agy99 DIEFQVVRLRDERRFANRRIDAVQNGTLLSSAMISYMSGGRG---LEHGV
Mb1644|M.bovis_AF2122/97 DIEFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAGGRG---LEHAL
Rv1618|M.tuberculosis_H37Rv DIEFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAGGRG---HEHAL
MLBr_01278|M.leprae_Br4923 EIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSGGCG---LEHAV
MAB_2891c|M.abscessus_ATCC_199 PTVFLVDRVRDGRSFVTRRVTAIQDGQAIFSMSASFQTLDTG---IEHQD
MSMEG_3812|M.smegmatis_MC2_155 PVEMQVMNMRDGGMLSTRRVIARQGDEVLLEALVSLSDTADT---VDYHQ
TH_3497|M.thermoresistible__bu PVQMRVDRLRDGGSLSTXRVTATQDGQVLLEALASFTVRIDS---VDTHH
MAV_2540|M.avium_104 PIQYDVTPLRDGGTISSRRVTASQSGVVLFEALASFTIIADD---VDWQQ
Mflv_1022|M.gilvum_PYR-GCK AVTFEVVKLQEGRTFSARRVTARQGDEILLEALSSFKLPTEAPGGVTYQP
Mvan_5814|M.vanbaalenii_PYR-1 TVTFEVVNLQEGRTFSARRVTARQGDEILLEAMSSFKSSTPSARPVTYQP
* ::: : *: * *.. : . *
MMAR_2421|M.marinum_M EPPPVADPETRPPIGELLRGYEETVPHFVNALQPIEWRYTNDPSWVMRDK
MUL_1599|M.ulcerans_Agy99 EPPPVADPETRPPIGELLRGYEETVPHFVNALQPIEWRYTNDPSWVMRDK
Mb1644|M.bovis_AF2122/97 DPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWRYANDPAWIMRDK
Rv1618|M.tuberculosis_H37Rv DPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWRYANDPAWIMRDK
MLBr_01278|M.leprae_Br4923 EPPEAAEPHTRPPIGELLRGYEQIVQHFVNALQPVEWRYVNDPSWVMRNK
MAB_2891c|M.abscessus_ATCC_199 LMPPVPDPEDLPDAQEQDSFNRDLFRQFA------EWDIRIVPDELMDRN
MSMEG_3812|M.smegmatis_MC2_155 PMPDVPAPEDLPSVGELLSDYADELDGFWVKPQWIERRYVDAPPRLALDQ
TH_3497|M.thermoresistible__bu PMPDVPDPDTLPPVTEQLVAYADEFGGLWVRPQPIERRYIDPPPRVAYDL
MAV_2540|M.avium_104 RMPDVAGPSAVHGLEDLLAPYAEEFGDWWPQQRPFTMRYLDAPPRVALDL
Mflv_1022|M.gilvum_PYR-GCK PCPDVPAPESLPVVAPHSAES-HSAEGTWASLRWFERRVVDAAT------
Mvan_5814|M.vanbaalenii_PYR-1 RCPEVAPPESLPRVAPHFAESDEVTKGQWASLRWFERRIVDAAA------
* .. * . .
MMAR_2421|M.marinum_M GERLH-YNRVWVKALGKLPDDPILHTATMLYSSDTTVLDSVITTHGLSWG
MUL_1599|M.ulcerans_Agy99 GERLH-YNRVWVKALGKLPDDPILHTATMLYSSDTTVLDSVITTHGLSWG
Mb1644|M.bovis_AF2122/97 GDRLA-YNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWG
Rv1618|M.tuberculosis_H37Rv GDRLA-YNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWG
MLBr_01278|M.leprae_Br4923 GQRLA-YNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWG
MAB_2891c|M.abscessus_ATCC_199 PRLAA-QQRVWFRCRKHLPDDPVLHICALAYMSDLTLLSSSKVPH----R
MSMEG_3812|M.smegmatis_MC2_155 PEPPE-RTRMWWRPAESIPNDPVLNCCVLTYASGTSLLETTVTMRRTT-Q
TH_3497|M.thermoresistible__bu PEPPA-RTRMWWRATEPVPDDPALNSALLTYVTGTSTLEAAMVAHRTT-P
MAV_2540|M.avium_104 SDPPPPRLRIWLRANGEVTDDPLVNSCVVAYLSALTLLECVMTTMRTT-P
Mflv_1022|M.gilvum_PYR-GCK -GPPA-PARIWLRPDGEVPDDPVLTASLVAYLSAVTLTEPAYAAR-----
Mvan_5814|M.vanbaalenii_PYR-1 -DPPA-RSRIWWRPDGEVPDDPVLTASLVAYLSAVTLTEPAYAAR-----
*:* : :.:** : . : * : : . .
MMAR_2421|M.marinum_M FDRIFAASANHSVWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFNRTG
MUL_1599|M.ulcerans_Agy99 FDRIFAASANHSVWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFNRTG
Mb1644|M.bovis_AF2122/97 FDRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSG
Rv1618|M.tuberculosis_H37Rv FDRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSG
MLBr_01278|M.leprae_Br4923 FDRIFAVSANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSG
MAB_2891c|M.abscessus_ATCC_199 DTVLQTASLDHALWFLRPFRADEWMLYDETSPSAGFGRALTQGRIFNRDG
MSMEG_3812|M.smegmatis_MC2_155 ATA-FSALIDHTVWFQRPADLSDWVLSDQVSLSGIHGRGLASGTMYNRSG
TH_3497|M.thermoresistible__bu LHS-FNALIDHALWFHRPAHLTDWVLADQFSPSSLGGRGLATATMYNRTG
MAV_2540|M.avium_104 VGPRLSALVDHTIWFHRAADFTDWLLFDQFSPSIVGRRGLATGTLYNRSG
Mflv_1022|M.gilvum_PYR-GCK SGLVMAAQRDHSVWFHAAADLSDWMLYDMASPSSADTLALARGTLFNRSG
Mvan_5814|M.vanbaalenii_PYR-1 GGVTVSAQRDHSVWFHAAADLSDWLLYEQSSPSSADTLALASGTMFNRTG
. :*::** :*:* . * .* . :::* *
MMAR_2421|M.marinum_M QPVATVVQEGVLKYFPAARR---------
MUL_1599|M.ulcerans_Agy99 QPVATVVQEGVLKYFPAARR---------
Mb1644|M.bovis_AF2122/97 KLIATVVQEGVLKYFPATPDSAAGRS---
Rv1618|M.tuberculosis_H37Rv KLIATVVQEGVLKYFPATPDSAAGRS---
MLBr_01278|M.leprae_Br4923 QLIATVVQEGVLKYFPASHR---------
MAB_2891c|M.abscessus_ATCC_199 TMVAAVVQEGLTRIERNPEQASVARGNMA
MSMEG_3812|M.smegmatis_MC2_155 ELVCSATQEIYFGR-GRI-----------
TH_3497|M.thermoresistible__bu ELVCTATQELYFGRPARSGSRR-------
MAV_2540|M.avium_104 ELVCIATQEGYFAEQRQ------------
Mflv_1022|M.gilvum_PYR-GCK ELVCTVRQEMYFPPPRG------------
Mvan_5814|M.vanbaalenii_PYR-1 ELVCTVRQEMYFPASRH------------
:. . **