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MRSPTMKSSRTTIKRRGTSRDEEPDHGVRQDTCVSSSLGDVLASMQLDQAGPAAFVGRQLPAPANHILGG HISAQALLAASLTAPGRTPHSVHTYFLRPGDSRLTVTFEVVNLQEGRTFSARRVTARQGDEILLEAMSSF KSSTPSARPVTYQPRCPEVAPPESLPRVAPHFAESDEVTKGQWASLRWFERRIVDAAADPPARSRIWWRP DGEVPDDPVLTASLVAYLSAVTLTEPAYAARGGVTVSAQRDHSVWFHAAADLSDWLLYEQSSPSSADTLA LASGTMFNRTGELVCTVRQEMYFPASRH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5814 | - | - | 100% (308) | acyl-CoA thioesterase |
| M. vanbaalenii PYR-1 | Mvan_2565 | - | 2e-29 | 32.35% (238) | acyl-CoA thioesterase II |
| M. vanbaalenii PYR-1 | Mvan_2825 | - | 2e-28 | 30.55% (275) | acyl-CoA thioesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1644 | tesB1 | 2e-32 | 31.16% (292) | acyl-CoA thioesterase II TesB1 |
| M. gilvum PYR-GCK | Mflv_1022 | - | 1e-124 | 81.02% (274) | acyl-CoA thioesterase |
| M. tuberculosis H37Rv | Rv1618 | tesB1 | 5e-32 | 31.16% (292) | acyl-CoA thioesterase II TesB1 |
| M. leprae Br4923 | MLBr_01278 | tesB | 1e-29 | 29.21% (291) | acyl CoA thioesterase II |
| M. abscessus ATCC 19977 | MAB_2891c | - | 2e-32 | 31.46% (267) | acyl-CoA thioesterase II TesB2 |
| M. marinum M | MMAR_2421 | tesB1 | 3e-32 | 31.49% (289) | acyl-CoA thioesterase II TesB1 |
| M. avium 104 | MAV_2695 | - | 2e-86 | 67.65% (238) | acyl-CoA thioesterase family protein |
| M. smegmatis MC2 155 | MSMEG_3812 | - | 6e-64 | 45.71% (280) | acyl-CoA thioesterase |
| M. thermoresistible (build 8) | TH_3497 | - | 4e-57 | 42.96% (277) | PUTATIVE acyl-CoA thioesterase |
| M. ulcerans Agy99 | MUL_1599 | tesB1 | 5e-32 | 31.49% (289) | acyl-CoA thioesterase II TesB1 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu LIRNVRPYGEGEPVDVLVADGQIAEIGEKLPIPGDGELGDVIDADGQILL
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu PGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTDPVADSPV
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu VTDHVWRRGQQVGLVDVHPVGAVTVGLEGRQLTEMGLMAAGAARVRMFSD
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3497|M.thermoresistible__bu DGLCVHDPLVMRRALEYARGLGVLIAQHAEEPRLTVGAVAHXXXWPACPA
MMAR_2421|M.marinum_M --------------------------------------------------
MUL_1599|M.ulcerans_Agy99 --------------------------------------------------
Mb1644|M.bovis_AF2122/97 --------------------------------------------------
Rv1618|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01278|M.leprae_Br4923 --------------------------------------------------
MAB_2891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5814|M.vanbaalenii_PYR-1 ------------------------------------MRSPTMKSSRTTIK
Mflv_1022|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2695|M.avium_104 --------------------------------------------------
MSMEG_3812|M.smegmatis_MC2_155 ------------------------------------MPLP----------
TH_3497|M.thermoresistible__bu RCRPGYRSPPTWCASAPPGRPNAVRRNRSSPRRIGPTPPPGTSRPATDVG
MMAR_2421|M.marinum_M ---------------MPAGDEPNVRDEAKSDFEELLAVLDLKRVADDRFI
MUL_1599|M.ulcerans_Agy99 -----------------------MRDEAKSDFEELLAVLDLKRVADDRFI
Mb1644|M.bovis_AF2122/97 ----------------------MPDGKPMSDFDELLAVLDLNAVASDLFT
Rv1618|M.tuberculosis_H37Rv ----------------------MPDGKPMSDFDELLAVLDLNAVASDLFT
MLBr_01278|M.leprae_Br4923 -------------------MKRLWEKKTMSDFEELLAVLDLNRVADDLFI
MAB_2891c|M.abscessus_ATCC_199 -------------------------------MADIEEILTLEQLEKDIFR
Mvan_5814|M.vanbaalenii_PYR-1 RRGTSRDEEPDHG--------VRQDTCVSSSLGDVLASMQLDQAGPAAFV
Mflv_1022|M.gilvum_PYR-GCK ---------------------------MSSSLGDVLASMQLRSVGDGLFA
MAV_2695|M.avium_104 ---------------------------MIRSPASAVRSASSTSS-KADWS
MSMEG_3812|M.smegmatis_MC2_155 ------------------------------QLADVLATLDITDCGHDMFV
TH_3497|M.thermoresistible__bu RLGSADRARRPGPRCRGAWWLGHDAPVTELTLYDVLTTLDVAQVDDDLFE
. :
MMAR_2421|M.marinum_M GAHPSKNPMRTFGGLLMAQSFVASSRTLLRDDLPPSALSVHFINGGDTTK
MUL_1599|M.ulcerans_Agy99 GAHPSKNPMRTFGGLLMAQSFVANSRTLLRDDLPPSALSVHFINGGDTTK
Mb1644|M.bovis_AF2122/97 GSHPSKNPLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAK
Rv1618|M.tuberculosis_H37Rv GSHPSKNPLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAK
MLBr_01278|M.leprae_Br4923 GSHPSKNPLRTFGGQLVAQSFVASSRTLIRDDLPPSAFSVHFINGGDTAK
MAB_2891c|M.abscessus_ATCC_199 GNVTPSNLRRTFGGQVAGQSLVSAVRTVEPEYLVHS-LHGYFLRPGNPNE
Mvan_5814|M.vanbaalenii_PYR-1 GRQLPAPANHILGGHISAQALLAASLTAP--GRTPHSVHTYFLRPGDSRL
Mflv_1022|M.gilvum_PYR-GCK GAQLPAPANHILGGHISAQALLAASLTAP--GRAPHSVHTYFLRPGDSRH
MAV_2695|M.avium_104 RAIAMFLSVVILGRFTTETHAMALLRQGP--TRRHHLHHS----PG--RS
MSMEG_3812|M.smegmatis_MC2_155 ATQIDNEAHHIIGGHISAQALMAASRTAA--GRVPNSLHVYLLRAGDARY
TH_3497|M.thermoresistible__bu ATQLDNPAHHIVGGHIAGQAVVAASRTAP--QRTAHSAHVYFLRAGDARY
.* :: *
MMAR_2421|M.marinum_M DIEFQVVRLRDERRFANRRIDAVQNGTLLSSAMISYMSG---GRGLEHGV
MUL_1599|M.ulcerans_Agy99 DIEFQVVRLRDERRFANRRIDAVQNGTLLSSAMISYMSG---GRGLEHGV
Mb1644|M.bovis_AF2122/97 DIEFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAG---GRGLEHAL
Rv1618|M.tuberculosis_H37Rv DIEFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAG---GRGHEHAL
MLBr_01278|M.leprae_Br4923 EIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSG---GCGLEHAV
MAB_2891c|M.abscessus_ATCC_199 PTVFLVDRVRDGRSFVTRRVTAIQDGQAIFSMSASFQTL---DTGIEHQD
Mvan_5814|M.vanbaalenii_PYR-1 TVTFEVVNLQEGRTFSARRVTARQGDEILLEAMSSFKSSTPSARPVTYQP
Mflv_1022|M.gilvum_PYR-GCK AVTFEVVKLQEGRTFSARRVTARQGDEILLEALSSFKLPTEAPGGVTYQP
MAV_2695|M.avium_104 PVDFEVVDLQEGRTFSARRVTARQDDKILMEAMSSFKVVNSAAAQVVYQP
MSMEG_3812|M.smegmatis_MC2_155 PVEMQVMNMRDGGMLSTRRVIARQGDEVLLEALVSLSDT---ADTVDYHQ
TH_3497|M.thermoresistible__bu PVQMRVDRLRDGGSLSTXRVTATQDGQVLLEALASFTVR---IDSVDTHH
: * ::: : *: * *.. : . *
MMAR_2421|M.marinum_M EPPPVADPETRPPIGELLRGYEETVPHFVNALQPIEWRYTNDPSWVMRDK
MUL_1599|M.ulcerans_Agy99 EPPPVADPETRPPIGELLRGYEETVPHFVNALQPIEWRYTNDPSWVMRDK
Mb1644|M.bovis_AF2122/97 DPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWRYANDPAWIMRDK
Rv1618|M.tuberculosis_H37Rv DPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWRYANDPAWIMRDK
MLBr_01278|M.leprae_Br4923 EPPEAAEPHTRPPIGELLRGYEQIVQHFVNALQPVEWRYVNDPSWVMRNK
MAB_2891c|M.abscessus_ATCC_199 LMPPVPDPEDLPDAQEQDSFNRDLFRQFA------EWDIRIVPDELMDRN
Mvan_5814|M.vanbaalenii_PYR-1 RCPEVAPPESLPRVAPHFAESDEVTKGQWASLRWFERRIVDAAA------
Mflv_1022|M.gilvum_PYR-GCK PCPDVPAPESLPVVAPHSAES-HSAEGTWASLRWFERRVVDAAT------
MAV_2695|M.avium_104 IMPEAPSPESLPWVAPHLAEADEGSRGRWASLRWFERRTIETET------
MSMEG_3812|M.smegmatis_MC2_155 PMPDVPAPEDLPSVGELLSDYADELDGFWVKPQWIERRYVDAPPRLALDQ
TH_3497|M.thermoresistible__bu PMPDVPDPDTLPPVTEQLVAYADEFGGLWVRPQPIERRYIDPPPRVAYDL
* .. *. * . *
MMAR_2421|M.marinum_M GERLHYNRVWVKALGKLPDDPILHTATMLYSSDTTVLDSVITTHGLSWGF
MUL_1599|M.ulcerans_Agy99 GERLHYNRVWVKALGKLPDDPILHTATMLYSSDTTVLDSVITTHGLSWGF
Mb1644|M.bovis_AF2122/97 GDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWGF
Rv1618|M.tuberculosis_H37Rv GDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWGF
MLBr_01278|M.leprae_Br4923 GQRLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWGF
MAB_2891c|M.abscessus_ATCC_199 PRLAAQQRVWFRCRKHLPDDPVLHICALAYMSDLTLLSSSKVPH----RD
Mvan_5814|M.vanbaalenii_PYR-1 -DPPARSRIWWRPDGEVPDDPVLTASLVAYLSAVTLTEPAYAARGG----
Mflv_1022|M.gilvum_PYR-GCK -GPPAPARIWLRPDGEVPDDPVLTASLVAYLSAVTLTEPAYAARSG----
MAV_2695|M.avium_104 -VPPARAPMWWRPDGRVPDDPVLTASLVAYMSAVTLTEPAFAARGG----
MSMEG_3812|M.smegmatis_MC2_155 PEPPERTRMWWRPAESIPNDPVLNCCVLTYASGTSLLETTVTMRRTT--Q
TH_3497|M.thermoresistible__bu PEPPARTRMWWRATEPVPDDPALNSALLTYVTGTSTLEAAMVAHRTT--P
:* : :*:** * . : * : : .. . :
MMAR_2421|M.marinum_M DRIFAASANHSVWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFNRTGQ
MUL_1599|M.ulcerans_Agy99 DRIFAASANHSVWFHRQVDFNDWVLYSTSSPVAADSRGLGTGHFFNRTGQ
Mb1644|M.bovis_AF2122/97 DRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGK
Rv1618|M.tuberculosis_H37Rv DRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGK
MLBr_01278|M.leprae_Br4923 DRIFAVSANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQ
MAB_2891c|M.abscessus_ATCC_199 TVLQTASLDHALWFLRPFRADEWMLYDETSPSAGFGRALTQGRIFNRDGT
Mvan_5814|M.vanbaalenii_PYR-1 -VTVSAQRDHSVWFHAAADLSDWLLYEQSSPSSADTLALASGTMFNRTGE
Mflv_1022|M.gilvum_PYR-GCK -LVMAAQRDHSVWFHAAADLSDWMLYDMASPSSADTLALARGTLFNRSGE
MAV_2695|M.avium_104 -VGASAQRDHSVWFHGRAVLSDWLFYDRSSPSSAGSLALASGTMFNRTGE
MSMEG_3812|M.smegmatis_MC2_155 ATAFSALIDHTVWFQRPADLSDWVLSDQVSLSGIHGRGLASGTMYNRSGE
TH_3497|M.thermoresistible__bu LHSFNALIDHALWFHRPAHLTDWVLADQFSPSSLGGRGLATATMYNRTGE
. :*::** :*:: . * . .* . :::* *
MMAR_2421|M.marinum_M PVATVVQEGVLKYFPAARR---------
MUL_1599|M.ulcerans_Agy99 PVATVVQEGVLKYFPAARR---------
Mb1644|M.bovis_AF2122/97 LIATVVQEGVLKYFPATPDSAAGRS---
Rv1618|M.tuberculosis_H37Rv LIATVVQEGVLKYFPATPDSAAGRS---
MLBr_01278|M.leprae_Br4923 LIATVVQEGVLKYFPASHR---------
MAB_2891c|M.abscessus_ATCC_199 MVAAVVQEGLTRIERNPEQASVARGNMA
Mvan_5814|M.vanbaalenii_PYR-1 LVCTVRQEMYFPASRH------------
Mflv_1022|M.gilvum_PYR-GCK LVCTVRQEMYFPPPRG------------
MAV_2695|M.avium_104 LVCTVKQEMYFPPQTA------------
MSMEG_3812|M.smegmatis_MC2_155 LVCSATQEIYFGR-GRI-----------
TH_3497|M.thermoresistible__bu LVCTATQELYFGRPARSGSRR-------
:.:. **