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VDRVPLSSDVVDTRAMLELAAAVHGDIEAYVEPGARITFAEWIGRARSVATQFADLGVGKGDVVVLWLPS GIDYATCYAAAAMIGAITTGLNPRLGRREIESILQQADPALVVADGLLDALPGTGHRLLSRDALCSDTSR SAPPSVELNRRDVVALIFTSGTTGTPKGAAFDADRLAAGAAASGVMSAPYDRRLTSTPFSHAGYMFKLWD QLVWGSTLVVPPTPWSAQGMFDVLRNERVTVAGAVPTQWAKLLDVDGVTSKALPHLRIGVVATAPAPPEL VRRVAEGIGVPLVVRYAMTECPTISGTEPDDAPEVQFRTVGRPAAGMDVRIGSDGVLEVSGPCVMRGYWR NSELTAEVLRDGWLRTGDVGVLGDDGNITLVGRRGDMYIRGGYNVHPGEVERTLTGHPSVKHAAVIGRSA PVIGEIGVACVVPADATAPPTLAELRAHVASELADYKAPDELLIVDELPLTAMLKPDRLALRELITQRDR DIQRRQPTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2622 | - | - | 100% (499) | acyl-CoA synthase |
| M. avium 104 | MAV_1912 | - | 0.0 | 84.17% (499) | acyl-CoA synthase |
| M. avium 104 | MAV_0971 | - | 2e-57 | 33.62% (473) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 3e-49 | 30.67% (525) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_2525 | - | 5e-57 | 34.30% (481) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 3e-49 | 30.67% (525) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02257 | menE | 3e-33 | 33.82% (340) | O-succinylbenzoic acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-47 | 29.49% (512) | AMP-binding domain protein |
| M. marinum M | MMAR_4688 | fadD3_2 | 2e-53 | 30.60% (464) | fatty-acid-CoA ligase FadD3_2 |
| M. smegmatis MC2 155 | MSMEG_4772 | - | 7e-55 | 33.47% (487) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3626 | - | 1e-57 | 36.09% (460) | PUTATIVE putative fatty-acid-CoA ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-41 | 31.56% (488) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4133 | - | 2e-55 | 34.43% (485) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2525|M.gilvum_PYR-GCK ------------------------------MVASAADRFGDAEAVVD---
Mvan_4133|M.vanbaalenii_PYR-1 ------------------MTFQSRWQTIPEMVASAADRFGDAEAVVD---
MSMEG_4772|M.smegmatis_MC2_155 ------------------MTHPS-WQTIPEMVLSAADRFGDAEAVVDHGD
MMAR_4688|M.marinum_M ---------------------MNEWQTIPEMVLSAGERFGDAEAIVD---
MUL_4126|M.ulcerans_Agy99 --------------------MTSDPRTVPTALDRLVRRLPNHDALVT---
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMV-
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMV-
MAB_4377c|M.abscessus_ATCC_199 ----------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVDVS-
TH_3626|M.thermoresistible__bu --------------------MLSQSVHLVSLPDQRAASAPAAPCLAD---
MAV_2622|M.avium_104 ---------------MDRVPLSSDVVDTRAMLELAAAVHGDIEAYVEPG-
MLBr_02257|M.leprae_Br4923 --------------------------------------------------
Mflv_2525|M.gilvum_PYR-GCK ------GSLRLSFDDVVERIRCAAGAFADLGIGKGDRAAIWAPNSVEWIV
Mvan_4133|M.vanbaalenii_PYR-1 ------GPLRLSFTELVERISCAAGAFAELGIEKGDRAAIWAPNSAEWII
MSMEG_4772|M.smegmatis_MC2_155 NPAGAAGPLRLTFVELADRVRRAAGAFLAHGIGRGDRVAIWAPNSAEWMI
MMAR_4688|M.marinum_M ------GSLRITFTELTNRVHRAAGAFAAMGIDKGDRVAVWAPNSAEWII
MUL_4126|M.ulcerans_Agy99 ------DERSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVV
Mb2533c|M.bovis_AF2122/97 ------ARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVL
Rv2505c|M.tuberculosis_H37Rv ------ARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVL
MAB_4377c|M.abscessus_ATCC_199 ------GDRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVL
TH_3626|M.thermoresistible__bu ------DTVALSNAEFRHAVDSAAAVLRGHGVGAGDVVAVMLPNTVDLVV
MAV_2622|M.avium_104 --------ARITFAEWIGRARSVATQFADLGVGKGDVVVLWLPSGIDYAT
MLBr_02257|M.leprae_Br4923 --------------------------------------------------
Mflv_2525|M.gilvum_PYR-GCK AAFGLLTAGGVLVPVNTRFKADEAADIISRSGAKAVLVHQGFLGVD----
Mvan_4133|M.vanbaalenii_PYR-1 AAFGLLTAGGVLVPVNTRFKTDEAADIIARSGAKAVLVQQGFLGVD----
MSMEG_4772|M.smegmatis_MC2_155 AAFGALTAGGVVVPVNTRFKAEEAADVIRRSGAKVVLRQQGFLGQD----
MMAR_4688|M.marinum_M AAFGLLTAGAVLVPVNTRFKTDEAADIIRRSGARAVLFEKGFLGMD----
MUL_4126|M.ulcerans_Agy99 ACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLGSDRVAG
Mb2533c|M.bovis_AF2122/97 VQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAM
Rv2505c|M.tuberculosis_H37Rv VQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAM
MAB_4377c|M.abscessus_ATCC_199 VQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDYVAM
TH_3626|M.thermoresistible__bu TLFAAWRLGAAVTPLNPALSVDESAYQIADAGAKVLVAGGNLPAPAT---
MAV_2622|M.avium_104 CYAAAAMIGAITTGLNPRLGRREIESILQQADPALVVADGLLDALPG---
MLBr_02257|M.leprae_Br4923 ---------MLLPTLERILDGRAPAMVVVPAQHEPIAALR----------
:: : : :
Mflv_2525|M.gilvum_PYR-GCK -----YRAPQGVPVIDLKS------DFLASGT-----PFSR-PVQGTDVS
Mvan_4133|M.vanbaalenii_PYR-1 -----YTAPGGVPVIDLRS------DFLSSGT-----PFSR-PVQGTDVS
MSMEG_4772|M.smegmatis_MC2_155 -----FEVPAGVPAIEIKS------DFLASGE-----PAVVGGLRGTDIA
MMAR_4688|M.marinum_M -----FTVPDGIPAIDLRS------GFLECGK-----PFER-AVSGSDIA
MUL_4126|M.ulcerans_Agy99 LDRKALPALRHIVRIPIEEPDGTWDEFIETGTDTGAVTARAAAVSPDDVS
Mb2533c|M.bovis_AF2122/97 LAEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPV
Rv2505c|M.tuberculosis_H37Rv LAEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPV
MAB_4377c|M.abscessus_ATCC_199 ASQVMPDAPGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLSNTDPI
TH_3626|M.thermoresistible__bu ------PVVRPADLKTGHG------------------PVEVAPPADDRLA
MAV_2622|M.avium_104 ---TGHRLLSRDALCSDTSR----------------SAPPSVELNRRDVV
MLBr_02257|M.leprae_Br4923 -------------------------------------ALRVGEEIDDDVA
Mflv_2525|M.gilvum_PYR-GCK DIIFTSGTTGRPKGVMMNHQQNLRLYEEWCDLADLREGDRYLMVNPYFHT
Mvan_4133|M.vanbaalenii_PYR-1 DIIFTSGTTGRPKGVMMNHRQNLRLYQEWCDLADLRQGDRYLMVNPYFHT
MSMEG_4772|M.smegmatis_MC2_155 DIVYTSGTTGRPKGVMMNHLQTLRLYAEWCDLADLREGDRYLIVNPFFHT
MMAR_4688|M.marinum_M DIVYTSGTTGRPKGVMMDHAQTLRHYAHWCDRADLRTGDRYLIVNPFFHI
MUL_4126|M.ulcerans_Agy99 DILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITADDRHLCINPFFHN
Mb2533c|M.bovis_AF2122/97 NIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHC
Rv2505c|M.tuberculosis_H37Rv NIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHC
MAB_4377c|M.abscessus_ATCC_199 NIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQLQAGDRLCIPVPFYHC
TH_3626|M.thermoresistible__bu LLIYTSGTTGRPKGVMLDHANIAAMCASIIEANELTSADSSLLILPLFHV
MAV_2622|M.avium_104 ALIFTSGTTGTPKGAAFDADRLAAGAAASGVMSAP--YDRRLTSTPFSHA
MLBr_02257|M.leprae_Br4923 LVATTSGTTGVPKGALLTAAALTAS--ASATHDRLGGPGSWLLALPPYHI
: *****. .**. . * *
Mflv_2525|M.gilvum_PYR-GCK FGYKAGLIASFIRG-ATMFPVPV-FDVDRVVELIAAERI--TMLPGPPTL
Mvan_4133|M.vanbaalenii_PYR-1 FGYKAGLIASFIRG-ATMLPVSV-FDVDRVVELIAAERI--TMLPGPPTL
MSMEG_4772|M.smegmatis_MC2_155 FGYKAGCIASLIRG-ATVLPVAV-FDVDAIVELIATERV--TMLPGPPTL
MMAR_4688|M.marinum_M FGYKAGCIASLIRG-ATIIPVRV-FVLENVLELIEHERI--TMLPGPPTL
MUL_4126|M.ulcerans_Agy99 FGYKAGILACLQTG-ATLFPHLT-FDPLRTLQAIERHRI--TVLPGPPTI
Mb2533c|M.bovis_AF2122/97 FGMVMGNLAATSHGAAMVIPAPG-FDPAATLRAVQDERC--TSLYGVPTM
Rv2505c|M.tuberculosis_H37Rv FGMVMGNLAATSHGAAMVIPAPG-FDPAATLRAVQDERC--TSLYGVPTM
MAB_4377c|M.abscessus_ATCC_199 FGMVMGNLGCTTHGATIVMPAPG-FDPGRTLEAIERERC--VGVYGVPTM
TH_3626|M.thermoresistible__bu NGIVVGTLSPLIAG-GHVTIAGR-FDPRTFFDRVRRSRP--TYFSAVPTI
MAV_2622|M.avium_104 G-YMFKLWDQLVWGSTLVVPPTP-WSAQGMFDVLRNERV--TVAGAVPTQ
MLBr_02257|M.leprae_Br4923 GGLQVLVRSVLAGSVPIELDISAGFDLAKLPDAVGRLGTGRRYTSLVATQ
. : : .*
Mflv_2525|M.gilvum_PYR-GCK YHSLLA--VKDKSRLATLRAGVTGAADIPVELIRRVHEELPFQTLATGYG
Mvan_4133|M.vanbaalenii_PYR-1 YHSLLN--VTDKSKLATLRAGVTGAADIPVELVRRVHEELPFQTLATGYG
MSMEG_4772|M.smegmatis_MC2_155 YHSLLG--VPDKAKLATLRAGVTGAADIPVELIRRIHEELPFETVATGYG
MMAR_4688|M.marinum_M YHSLLS--ARGQRDLSSLRAGVTGAADIPVELIRRVRTELPFQTIMTGYG
MUL_4126|M.ulcerans_Agy99 YQTLLDHPARDDYDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYG
Mb2533c|M.bovis_AF2122/97 FIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYG
Rv2505c|M.tuberculosis_H37Rv FIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYG
MAB_4377c|M.abscessus_ATCC_199 FIAMLADPGFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYG
TH_3626|M.thermoresistible__bu YTKLLELPEDPTVDTSSLRFAACGAAPASAELLQRFEQRYGVP-IIEGYG
MAV_2622|M.avium_104 WAKLLDVDGVTSKALPHLRIGVVATAPAPPELVRRVAEGIGVP-LVVRYA
MLBr_02257|M.leprae_Br4923 LAKALT-DSTATAVLAELDAVLVGGGPAPRPILDAATS--AGIMVVGTYG
* * . . . :: : *.
Mflv_2525|M.gilvum_PYR-GCK LTEA-GTATLSRPGDSFDDIATTAGVACDGVELRIAED-----------G
Mvan_4133|M.vanbaalenii_PYR-1 LTEA-GTVTLSRPGDSFTDIATTAGVACDGVEMRIADD-----------G
MSMEG_4772|M.smegmatis_MC2_155 LTEA-GTATLSRPGDSFTDIATTVGTACDGVEVNLADD-----------G
MMAR_4688|M.marinum_M LTEA-GTVTLSKPEDSFEDIATTAGLACDGIELATADD-----------G
MUL_4126|M.ulcerans_Agy99 LTEANGMGTMCRADDDALTVATTCGRPFADFELRIGPDT----------G
Mb2533c|M.bovis_AF2122/97 MTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVG
Rv2505c|M.tuberculosis_H37Rv MTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVG
MAB_4377c|M.abscessus_ATCC_199 MTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIKIVDPNSGETVQRGQSG
TH_3626|M.thermoresistible__bu LSEGTCVSTANPLRG--PRKPGTVGLPLPGQQVRIVDAEG-RTLGANEIG
MAV_2622|M.avium_104 MTECPTISGTE-PDDAPEVQFRTVGRPAAGMDVRIGSD-----------G
MLBr_02257|M.leprae_Br4923 MSETAGGCVYD-------------GVPLDGVCIRVLVN-----------G
::* * : *
Mflv_2525|M.gilvum_PYR-GCK EVLIRGYTVMQGYLDDPDATAEAIDPDGWLHTGDLGTLDEAGRLRIVGRK
Mvan_4133|M.vanbaalenii_PYR-1 EVLVRGYTVMQGYLDDPVATAETIDPDGWLHTGDLGTVDDAGRLRIVGRK
MSMEG_4772|M.smegmatis_MC2_155 EVLVRGYSVMQGYLDDPAATAEAIDADGWLHTGDLGEFTESGRLRIIGRK
MMAR_4688|M.marinum_M EILVRGYNVMKGYLDDPVATAEAIDGEGWLHTGDLGTIDETGRLRVVGRK
MUL_4126|M.ulcerans_Agy99 EVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLRITDRL
Mb2533c|M.bovis_AF2122/97 EFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRI
Rv2505c|M.tuberculosis_H37Rv EFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRI
MAB_4377c|M.abscessus_ATCC_199 ELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGRL
TH_3626|M.thermoresistible__bu EVLIAGPTVMRGYLNRPEETAKTL-VDGWLRTGDIGYLDDDGYLVLVDRA
MAV_2622|M.avium_104 VLEVSGPCVMRGYWRNSELTAEVL-RDGWLRTGDVGVLGDDGNITLVGRR
MLBr_02257|M.leprae_Br4923 HVAIGGATLAKGYRN--PIVPDPFAESGWFHTDDLGTVDGSGVLTVLGRA
. * : ** . : .**::*.*:. . * : .*
Mflv_2525|M.gilvum_PYR-GCK KDMFIVGGFNAYPAEIEGFLLEHPGVAQAAVVGVPDERMGQVGKAFVVAA
Mvan_4133|M.vanbaalenii_PYR-1 KDMFIVGGFNAYPAEIEGFLLEHRAVAQAAVIGVPDERLGQVGKAFVVAK
MSMEG_4772|M.smegmatis_MC2_155 KDMFIVGGFNAYPAEIEGFLLEHPDVAQVAVIGVDDDRMGQVGKAFVVLR
MMAR_4688|M.marinum_M KDMFIVGGFNAYPAEIEGFLMEHEAVAQVAVIGVPDERLGQVGKAFVVRQ
MUL_4126|M.ulcerans_Agy99 KDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVGRAFIVAR
Mb2533c|M.bovis_AF2122/97 KDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLR
Rv2505c|M.tuberculosis_H37Rv KDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLR
MAB_4377c|M.abscessus_ATCC_199 KDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELCAWVRMR
TH_3626|M.thermoresistible__bu KDMIIRGGENIYPKEIEAVAHRLPEISEVAVVGRPHPLYGEVPVMYVAAA
MAV_2622|M.avium_104 GDMYIRGGYNVHPGEVERTLTGHPSVKHAAVIGRSAPVIGEIGVACVVPA
MLBr_02257|M.leprae_Br4923 DDAISTGGLTVLPGPVEAALCTHPAVSDCAVFGLTDDRLGQRVVAAVVLT
* ** . * :* : . *.* *: :
Mflv_2525|M.gilvum_PYR-GCK APADGSAGSLDAHALIAWCRERMAGFKVPRYVEFLDELPLNATGKVMKDR
Mvan_4133|M.vanbaalenii_PYR-1 TPADGSGAALTAEGLIAWCRDRMAGFKVPRYVEFLDELPLNATGKVMKDR
MSMEG_4772|M.smegmatis_MC2_155 EPLDGTRQCVTAEDLIAWSRERMAGYKVPRYVEFLEELPLNATGKVMKDH
MMAR_4688|M.marinum_M S----GKSALSAEDLLGWCRERMAGFKVPRSVRFVDALPLNATGKVVKDL
MUL_4126|M.ulcerans_Agy99 P-----GFNLDEKSVIDYTREHLANFKAPRSVRFVDTLPRNAGGKVVKPQ
Mb2533c|M.bovis_AF2122/97 N----DAPELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTGKVRKVE
Rv2505c|M.tuberculosis_H37Rv N----DAPELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTGKVRKVE
MAB_4377c|M.abscessus_ATCC_199 P----DRVVIDAVAIRAFASGRLAHYKIPRYVHVVESFPMTVTGKVRKIE
TH_3626|M.thermoresistible__bu P-----GAVVDTDAVRRHLAVSLAKYKQPVAIRVLDVLPKNAVGKIDKPA
MAV_2622|M.avium_104 D----ATAPPTLAELRAHVASELADYKAPDELLIVDELPLTAMLKPDRLA
MLBr_02257|M.leprae_Br4923 DG----YATPTLSMLRAHVTRRLDAMAAPRELHIVDTLPRRGIGKVDRTA
: : * : .:: :* * :
Mflv_2525|M.gilvum_PYR-GCK LNTVGR--------------
Mvan_4133|M.vanbaalenii_PYR-1 LQNRQS--------------
MSMEG_4772|M.smegmatis_MC2_155 LKAREALSKR----------
MMAR_4688|M.marinum_M LR------------------
MUL_4126|M.ulcerans_Agy99 LRELA---------------
Mb2533c|M.bovis_AF2122/97 MRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv MRQQALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 MRQQTIQIFGLPEPGRTDEQ
TH_3626|M.thermoresistible__bu IRTLDATATQTA--------
MAV_2622|M.avium_104 LRELITQRDRDIQRRQPTR-
MLBr_02257|M.leprae_Br4923 LVRRFAKSG-----------
: