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THPSWQTIPEMVLSAADRFGDAEAVVDHGDNPAGAAGPLRLTFVELADRVRRAAGAFLAHGIGRGDRVAI WAPNSAEWMIAAFGALTAGGVVVPVNTRFKAEEAADVIRRSGAKVVLRQQGFLGQDFEVPAGVPAIEIKS DFLASGEPAVVGGLRGTDIADIVYTSGTTGRPKGVMMNHLQTLRLYAEWCDLADLREGDRYLIVNPFFHT FGYKAGCIASLIRGATVLPVAVFDVDAIVELIATERVTMLPGPPTLYHSLLGVPDKAKLATLRAGVTGAA DIPVELIRRIHEELPFETVATGYGLTEAGTATLSRPGDSFTDIATTVGTACDGVEVNLADDGEVLVRGYS VMQGYLDDPAATAEAIDADGWLHTGDLGEFTESGRLRIIGRKKDMFIVGGFNAYPAEIEGFLLEHPDVAQ VAVIGVDDDRMGQVGKAFVVLREPLDGTRQCVTAEDLIAWSRERMAGYKVPRYVEFLEELPLNATGKVMK DHLKAREALSKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4772 | - | - | 100% (503) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 7e-78 | 35.85% (491) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 5e-60 | 34.48% (493) | feruloyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3591 | fadD3 | 1e-111 | 46.63% (489) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2525 | - | 0.0 | 76.60% (483) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3561 | fadD3 | 1e-112 | 46.63% (489) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-48 | 30.66% (486) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_0596c | - | 1e-110 | 43.37% (528) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_4688 | fadD3_2 | 0.0 | 71.22% (490) | fatty-acid-CoA ligase FadD3_2 |
| M. avium 104 | MAV_0971 | - | 0.0 | 74.19% (492) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4544 | - | 0.0 | 69.74% (499) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 1e-104 | 44.23% (477) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4133 | - | 0.0 | 76.52% (494) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3591|M.bovis_AF2122/97 --------------------------MINDLR--------------TVPA
Rv3561|M.tuberculosis_H37Rv --------------------------MINDLR--------------TVPA
MUL_4126|M.ulcerans_Agy99 --------------------------MTSDPR--------------TVPT
MAB_0596c|M.abscessus_ATCC_199 --------------------------MESAQQT----------PGLTIPA
MAV_0971|M.avium_104 --------------------------MQSAKRDEEESANLNSPRWQTIPE
TH_4544|M.thermoresistible__bu ----------------------------VSPRD----------TWRTIPE
Mflv_2525|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4133|M.vanbaalenii_PYR-1 ----------------------------MTFQS----------RWQTIPE
MSMEG_4772|M.smegmatis_MC2_155 ----------------------------MTHPS-----------WQTIPE
MMAR_4688|M.marinum_M -------------------------------MN----------EWQTIPE
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Mb3591|M.bovis_AF2122/97 ALDRLVRQLPDHTALIA---------EDRRFTSTELRDAVYGAAAALIAL
Rv3561|M.tuberculosis_H37Rv ALDRLVRQLPDHTALIA---------EDRRFTSTELRDAVYGAAAALIAL
MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVT---------DERSFTVSELNDEVYRAAAALIEL
MAB_0596c|M.abscessus_ATCC_199 ALDQAAARFGERDALYA---------DGSWLSFSELRARARRFAAALIAL
MAV_0971|M.avium_104 MVLSAADRFGDAEAVVD---------GPLRLTFQQVVERIRCAAGAFAEL
TH_4544|M.thermoresistible__bu MVLSAADRFGDAEAVVD---------GPLRLTFTEVVHRIRCAAGAFRDL
Mflv_2525|M.gilvum_PYR-GCK MVASAADRFGDAEAVVD---------GSLRLSFDDVVERIRCAAGAFADL
Mvan_4133|M.vanbaalenii_PYR-1 MVASAADRFGDAEAVVD---------GPLRLSFTELVERISCAAGAFAEL
MSMEG_4772|M.smegmatis_MC2_155 MVLSAADRFGDAEAVVDHGDNPAGAAGPLRLTFVELADRVRRAAGAFLAH
MMAR_4688|M.marinum_M MVLSAGERFGDAEAIVD---------GSLRITFTELTNRVHRAAGAFAAM
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALID---------EEGTLTYKELDRAAHALANGLIAK
: . *: :: :: * .:
Mb3591|M.bovis_AF2122/97 GVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDR
Rv3561|M.tuberculosis_H37Rv GVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDR
MUL_4126|M.ulcerans_Agy99 GVKPAARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILAR
MAB_0596c|M.abscessus_ATCC_199 GVEHGQRLAIWSPNSWHWPIACLGGQYAGAAVVPMNTRYTVDEATDILQR
MAV_0971|M.avium_104 GVEKGDRVAVWAPNSAEWIIAAFGLLTAGGVLVPVNTRFKTEEAADIIVR
TH_4544|M.thermoresistible__bu GIGKGDRAAIWAPNSAEWIIAAFGLLTAGGVLVPVNTRFRPDEAADIIGR
Mflv_2525|M.gilvum_PYR-GCK GIGKGDRAAIWAPNSVEWIVAAFGLLTAGGVLVPVNTRFKADEAADIISR
Mvan_4133|M.vanbaalenii_PYR-1 GIEKGDRAAIWAPNSAEWIIAAFGLLTAGGVLVPVNTRFKTDEAADIIAR
MSMEG_4772|M.smegmatis_MC2_155 GIGRGDRVAIWAPNSAEWMIAAFGALTAGGVVVPVNTRFKAEEAADVIRR
MMAR_4688|M.marinum_M GIDKGDRVAVWAPNSAEWIIAAFGLLTAGAVLVPVNTRFKTDEAADIIRR
MLBr_02546|M.leprae_Br4923 GVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSER
*: . .: : * : :* . .*. :: :*:.: : :: *
Mb3591|M.bovis_AF2122/97 AGAPVLFAAGLFLGADRAAG--LDRAALPALRHVVRVPVEADDGT-WDEF
Rv3561|M.tuberculosis_H37Rv AGAPVLFAAGLFLGADRAAG--LDRAALPALRHVVRVPVEADDGT-WDEF
MUL_4126|M.ulcerans_Agy99 TEAPVLFAMGHFLGSDRVAG--LDRKALPALRHIVRIPIEEPDGT-WDEF
MAB_0596c|M.abscessus_ATCC_199 SHARVLVSVGKFLGTDRIEQ--LDTSSLPDLRHIVRVAVEDGDESGWDAF
MAV_0971|M.avium_104 ARVQAVLVQKGFLGQDYAAP-----AGIPVIDIKS-------------DF
TH_4544|M.thermoresistible__bu SNARAVLVQKDFLSQDYTLSDTDLAGGPPVIDIKS-------------DF
Mflv_2525|M.gilvum_PYR-GCK SGAKAVLVHQGFLGVDYRAP-----QGVPVIDLKS-------------DF
Mvan_4133|M.vanbaalenii_PYR-1 SGAKAVLVQQGFLGVDYTAP-----GGVPVIDLRS-------------DF
MSMEG_4772|M.smegmatis_MC2_155 SGAKVVLRQQGFLGQDFEVP-----AGVPAIEIKS-------------DF
MMAR_4688|M.marinum_M SGARAVLFEKGFLGMDFTVP-----DGIPAIDLRS-------------GF
MLBr_02546|M.leprae_Br4923 EGAKVIIYDDEYTKVVSKAEP--ALGKLRALGVNPDEEEPPGSTDETLAE
. .:. : :
Mb3591|M.bovis_AF2122/97 IATGAG-ALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSA
Rv3561|M.tuberculosis_H37Rv IATGAG-ALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSA
MUL_4126|M.ulcerans_Agy99 IETGT--DTGAVTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSA
MAB_0596c|M.abscessus_ATCC_199 VAHGDGVSDGDIDTRKAAVSSEDISDILFTSGTTGRSKGVLCMHRQPLAA
MAV_0971|M.avium_104 LSSGSP-------FSR-PVNGTDISDIIFTSGTTGRPKGAMMNHRQTLRM
TH_4544|M.thermoresistible__bu LSGGAP-------FERDDIAGTDISDIIFTSGTTGRPKGAMMNHLQSLRM
Mflv_2525|M.gilvum_PYR-GCK LASGTP-------FSR-PVQGTDVSDIIFTSGTTGRPKGVMMNHQQNLRL
Mvan_4133|M.vanbaalenii_PYR-1 LSSGTP-------FSR-PVQGTDVSDIIFTSGTTGRPKGVMMNHRQNLRL
MSMEG_4772|M.smegmatis_MC2_155 LASGEP-------AVVGGLRGTDIADIVYTSGTTGRPKGVMMNHLQTLRL
MMAR_4688|M.marinum_M LECGKP-------FER-AVSGSDIADIVYTSGTTGRPKGVMMDHAQTLRH
MLBr_02546|M.leprae_Br4923 LIARSS-------SAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAP
: : *: ****** .**. *
Mb3591|M.bovis_AF2122/97 SASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHVTFDP
Rv3561|M.tuberculosis_H37Rv SASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHVTFDP
MUL_4126|M.ulcerans_Agy99 SASWAANGKITADDRHLCINPFFHNFGYKAGILACLQTGATLFPHLTFDP
MAB_0596c|M.abscessus_ATCC_199 SLAWATYGEFTENDRYLCVNPFFHNFGYKAGILACLQTGAALMPQLTFDP
MAV_0971|M.avium_104 YDEWATLADLREGDRYLQINPYFHTFGLKAGLITSFLRGATMLPVPVFDV
TH_4544|M.thermoresistible__bu YEEWATLADLREGDRYLMINPYFHTFGLKAGLIASFLRGATMVPVAVFDA
Mflv_2525|M.gilvum_PYR-GCK YEEWCDLADLREGDRYLMVNPYFHTFGYKAGLIASFIRGATMFPVPVFDV
Mvan_4133|M.vanbaalenii_PYR-1 YQEWCDLADLRQGDRYLMVNPYFHTFGYKAGLIASFIRGATMLPVSVFDV
MSMEG_4772|M.smegmatis_MC2_155 YAEWCDLADLREGDRYLIVNPFFHTFGYKAGCIASLIRGATVLPVAVFDV
MMAR_4688|M.marinum_M YAHWCDRADLRTGDRYLIVNPFFHIFGYKAGCIASLIRGATIIPVRVFVL
MLBr_02546|M.leprae_Br4923 LGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLG-STLVLRRRFKP
: : * * ** :* . :: : :::. *
Mb3591|M.bovis_AF2122/97 LHALRAIERHRITVLPGPPTIYQSLLDHPARKD--FDLSSLRFAVTGAAT
Rv3561|M.tuberculosis_H37Rv LHALRAIERHRITVLPGPPTIYQSLLDHPARKD--FDLSSLRFAVTGAAT
MUL_4126|M.ulcerans_Agy99 LRTLQAIERHRITVLPGPPTIYQTLLDHPARDD--YDLSSLRFAVTGAAT
MAB_0596c|M.abscessus_ATCC_199 EKAMAAVQEHKITVLPGAPTIFQMLLDHPARKN--YDLTSLRYSVTGAAV
MAV_0971|M.avium_104 DTVVDLIERERITMLPGPPTLYHSLLTVPDKS----KLATLRAGVTGAAD
TH_4544|M.thermoresistible__bu EQVVDLVERERITMLPGPPTLYHSLLAVRDKD----KLATLRAAVTGAAD
Mflv_2525|M.gilvum_PYR-GCK DRVVELIAAERITMLPGPPTLYHSLLAVKDKS----RLATLRAGVTGAAD
Mvan_4133|M.vanbaalenii_PYR-1 DRVVELIAAERITMLPGPPTLYHSLLNVTDKS----KLATLRAGVTGAAD
MSMEG_4772|M.smegmatis_MC2_155 DAIVELIATERVTMLPGPPTLYHSLLGVPDKA----KLATLRAGVTGAAD
MMAR_4688|M.marinum_M ENVLELIEHERITMLPGPPTLYHSLLSARGQR----DLSSLRAGVTGAAD
MLBr_02546|M.leprae_Br4923 ATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQ
: : .: * : *.: :* . *::** ....:
Mb3591|M.bovis_AF2122/97 VPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRP
Rv3561|M.tuberculosis_H37Rv VPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRP
MUL_4126|M.ulcerans_Agy99 VPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRP
MAB_0596c|M.abscessus_ATCC_199 VPVVLIERMQSELDFDLVLTAYGLTETQGFATICRSDDDAVTVATTCGRP
MAV_0971|M.avium_104 IPVELVRRIHDELPFQTLMTGYGLTEA-GNVTLSRPGDSFEDVATTAGVP
TH_4544|M.thermoresistible__bu IPVELIRRIRDELPFRSLMTGYGLTEA-GNVTLSRPGDTPEQVATTAGLP
Mflv_2525|M.gilvum_PYR-GCK IPVELIRRVHEELPFQTLATGYGLTEA-GTATLSRPGDSFDDIATTAGVA
Mvan_4133|M.vanbaalenii_PYR-1 IPVELVRRVHEELPFQTLATGYGLTEA-GTVTLSRPGDSFTDIATTAGVA
MSMEG_4772|M.smegmatis_MC2_155 IPVELIRRIHEELPFETVATGYGLTEA-GTATLSRPGDSFTDIATTVGTA
MMAR_4688|M.marinum_M IPVELIRRVRTELPFQTIMTGYGLTEA-GTVTLSKPEDSFEDIATTAGLA
MLBr_02546|M.leprae_Br4923 LGAELATRALEELG-PVIYNMYGSTEI-AFATIAGPKD-LQINSATVGPV
: . * * ** : . ** ** . *:. . * ::* *
Mb3591|M.bovis_AF2122/97 FADFELRIADD------GEVLLRGPN--VMVG---YLDDTEATAAAIDAD
Rv3561|M.tuberculosis_H37Rv FADFELRIADD------GEVLLRGPN--VMVG---YLDDTEATAAAIDAD
MUL_4126|M.ulcerans_Agy99 FADFELRIGPDT-----GEVLLRGPN--VMLG---YLDDPRATAAAIDAD
MAB_0596c|M.abscessus_ATCC_199 MLGYELRIDGAEKPGDEGEVLLRSAN--VMKG---YLDDPKATAEAIDDD
MAV_0971|M.avium_104 CEGVEVRIADD------GEVLVRGYG--VMQG---YLDDPAGTAEAIDAD
TH_4544|M.thermoresistible__bu CEDVEVRIAAD------GEVLVRGYG--VMQG---YLDDPAGTAQAIDPD
Mflv_2525|M.gilvum_PYR-GCK CDGVELRIAED------GEVLIRGYT--VMQG---YLDDPDATAEAIDPD
Mvan_4133|M.vanbaalenii_PYR-1 CDGVEMRIADD------GEVLVRGYT--VMQG---YLDDPVATAETIDPD
MSMEG_4772|M.smegmatis_MC2_155 CDGVEVNLADD------GEVLVRGYS--VMQG---YLDDPAATAEAIDAD
MMAR_4688|M.marinum_M CDGIELATADD------GEILVRGYN--VMKG---YLDDPVATAEAIDGE
MLBr_02546|M.leprae_Br4923 VKGVKVKILDDS-----GKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIID
. :: *: : *. :: * ::. . . :
Mb3591|M.bovis_AF2122/97 GWLHTGDIGAVDQAGNLRINDRLKDMYICGGFNVYPAEVEQVLARMDGVA
Rv3561|M.tuberculosis_H37Rv GWLHTGDIGAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVA
MUL_4126|M.ulcerans_Agy99 GWLHTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVA
MAB_0596c|M.abscessus_ATCC_199 GWLHTGDIGKLDARGNLTITDRLKDMYICGGFNVYPAEIEQVLMRLDGVA
MAV_0971|M.avium_104 GWLHTGDLGTFTETGRLRIVGRKKDMFIVGGFNAYPAEIEGFLLNHPAVA
TH_4544|M.thermoresistible__bu GWLHTGDLGSFDDTGRLRIVGRKKDMFIVGGFNAYPAEIEGFLMEHPAVA
Mflv_2525|M.gilvum_PYR-GCK GWLHTGDLGTLDEAGRLRIVGRKKDMFIVGGFNAYPAEIEGFLLEHPGVA
Mvan_4133|M.vanbaalenii_PYR-1 GWLHTGDLGTVDDAGRLRIVGRKKDMFIVGGFNAYPAEIEGFLLEHRAVA
MSMEG_4772|M.smegmatis_MC2_155 GWLHTGDLGEFTESGRLRIIGRKKDMFIVGGFNAYPAEIEGFLLEHPDVA
MMAR_4688|M.marinum_M GWLHTGDLGTIDETGRLRVVGRKKDMFIVGGFNAYPAEIEGFLMEHEAVA
MLBr_02546|M.leprae_Br4923 GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV
* * :**:* . . * : .* .:* : ** *.:***:* .: *.
Mb3591|M.bovis_AF2122/97 DAAVIGVPDQRLGEVGRAFVVARPGTG------LDEASVIAYTREHLANF
Rv3561|M.tuberculosis_H37Rv DAAVIGVPDQRLGEVGRAFVVARPGTG------LDEASVIAYTREHLANF
MUL_4126|M.ulcerans_Agy99 DVAVIGIPDHRLGEVGRAFIVARPGFN------LDEKSVIDYTREHLANF
MAB_0596c|M.abscessus_ATCC_199 DVAVIGVPDARLGEVGKAYIVLKPGAT------LNADSVIEYSAKHVANF
MAV_0971|M.avium_104 QAAVIGVPDERMGQVGKAFVVANA--------EVSESDLLAWCRDRMAGF
TH_4544|M.thermoresistible__bu QAAVIGVPDERLGQVGKAFIVLDASARRADGPTVSAEDIIEWSRQRMAGY
Mflv_2525|M.gilvum_PYR-GCK QAAVVGVPDERMGQVGKAFVVAAAPAD-GSAGSLDAHALIAWCRERMAGF
Mvan_4133|M.vanbaalenii_PYR-1 QAAVIGVPDERLGQVGKAFVVAKTPAD-GSGAALTAEGLIAWCRDRMAGF
MSMEG_4772|M.smegmatis_MC2_155 QVAVIGVDDDRMGQVGKAFVVLREPLD-GTRQCVTAEDLIAWSRERMAGY
MMAR_4688|M.marinum_M QVAVIGVPDERLGQVGKAFVVRQSGKS-----ALSAEDLLGWCRERMAGF
MLBr_02546|M.leprae_Br4923 EATAIGVDDKEWGARLRAFVVKKQDAT------IDEDAIKAYVRDHLARY
:.:.:*: * . * :*::* : : : .::* :
Mb3591|M.bovis_AF2122/97 KTPRSVRFVDVLPRNAAGKVSKPQLRELG-----------
Rv3561|M.tuberculosis_H37Rv KTPRSVRFVDVLPRNAAGKVSKPQLRELG-----------
MUL_4126|M.ulcerans_Agy99 KAPRSVRFVDTLPRNAGGKVVKPQLRELA-----------
MAB_0596c|M.abscessus_ATCC_199 KKPRFVDFLDELPRNLGGKVVKPTLRAMHGEQRRAQKESS
MAV_0971|M.avium_104 KVPRTVEFLDALPLNATGKVMKDQLR--------------
TH_4544|M.thermoresistible__bu KVPRHVEFRDALPLNATGKVVKEQLR--------------
Mflv_2525|M.gilvum_PYR-GCK KVPRYVEFLDELPLNATGKVMKDRLNTVGR----------
Mvan_4133|M.vanbaalenii_PYR-1 KVPRYVEFLDELPLNATGKVMKDRLQNRQS----------
MSMEG_4772|M.smegmatis_MC2_155 KVPRYVEFLEELPLNATGKVMKDHLKAREALSKR------
MMAR_4688|M.marinum_M KVPRSVRFVDALPLNATGKVVKDLLR--------------
MLBr_02546|M.leprae_Br4923 KVPREVIFLEELPRNPTGKVLKRELRDFEVH---------
* ** * * : ** * *** * *.