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SAPVDSALHSGRHLEYLSSIAAYREDFRRYLRDLKTADEWRAAAFTSAEDGLAHDATVMASLNADGWNRY GWPEAAGGLGGNEIHRAVYYEELGHAMLPIPAQHWTLETLGPALLKFAPGLAAAYLPGYLSGVEWWGQSF SEPESGSDLASLRTRAVDDGAGGFVVNGQKIWTSQGPTATRLLALVRTGTPESRHRGLTMIMVDADAPGV TIRPIALASGRRELAEVFFDDVRVDGERVVGDVGGGWAVAMHLMQYERGMYGYAVLNKVLTELGRLREHM VTAGATDAQRQRFARVYVDVAAAQARTATTVRRLAAGEAVGADSSIDKLLFGRAEKEVNDLILEIEREHL IAGTGRGGAELDTARAEWWYSRAATVMGGTAEVQRGIIADHLLGLPKEKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2563 | - | - | 100% (401) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1824 | - | e-145 | 79.43% (316) | acyl-CoA dehydrogenase family protein |
| M. avium 104 | MAV_0901 | - | 4e-62 | 38.64% (383) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3590c | fadE30 | 5e-52 | 34.36% (390) | acyl-CoA dehydrogenase FADE30 |
| M. gilvum PYR-GCK | Mflv_2435 | - | 1e-67 | 40.79% (380) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3560c | fadE30 | 5e-52 | 34.36% (390) | acyl-CoA dehydrogenase FADE30 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-19 | 30.62% (209) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 3e-56 | 37.90% (343) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4748 | - | 2e-63 | 39.48% (385) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4844 | - | 7e-62 | 39.73% (375) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3751 | - | 1e-165 | 73.51% (385) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4125 | fadE30 | 4e-49 | 35.09% (342) | acyl-CoA dehydrogenase FadE30 |
| M. vanbaalenii PYR-1 | Mvan_4217 | - | 3e-67 | 41.11% (377) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3590c|M.bovis_AF2122/97 -------------------MQDV--EEFRAQVRGWLADNLAGEFAALKGL
Rv3560c|M.tuberculosis_H37Rv -------------------MQDV--EEFRAQVRGWLADNLAGEFAALKGL
MUL_4125|M.ulcerans_Agy99 -------------------MQDV--EEFRAEVRGWLAANLVGEFATLKGL
MAB_0597|M.abscessus_ATCC_1997 -----MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGL
MAV_2563|M.avium_104 MSAPVDSALHSGRHLEYLSSIAAYREDFRRYLRDLKTADEWRAAAFTS--
TH_3751|M.thermoresistible__bu -----------------VSDVAQFRQDLRQYLRRLDYADVWRSAASTT--
Mflv_2435|M.gilvum_PYR-GCK -----------------MTNDLYEPANFRTALRDWLDENDLSPGDDHS--
Mvan_4217|M.vanbaalenii_PYR-1 ---------------MTVAVDTSNASEFRSQLKAWLDENDLTPPADHS--
MSMEG_4844|M.smegmatis_MC2_155 ------------------MTELHDPTAFRTALQDWLGRTDLTPPEDHS--
MMAR_4748|M.marinum_M -----------------MTVDIG---RFRADLRTWLDDNDLTPGPDHS--
MLBr_00737|M.leprae_Br4923 ------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVD--
.* ::
Mb3590c|M.bovis_AF2122/97 GGPGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEE
Rv3560c|M.tuberculosis_H37Rv GGPGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEE
MUL_4125|M.ulcerans_Agy99 GGPGREHEAFEERRAWNQHLAAAGLTCLGWPVEHGGRGLSTAHRVAFYEE
MAB_0597|M.abscessus_ATCC_1997 GGPGSEHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEE
MAV_2563|M.avium_104 -----AEDGLAHDATVMASLNADGWNRYGWPEAAGGLGGNEIHRAVYYEE
TH_3751|M.thermoresistible__bu -----AEDGLAHDATVMASLYADGWNRYGWPEEAGGLGGTEIHRAVLYEE
Mflv_2435|M.gilvum_PYR-GCK -----LQGHIRQFARVQRALYDAGWSRYGWPEHAGGLGGPAILRAIVGEE
Mvan_4217|M.vanbaalenii_PYR-1 -----LQGHIRQFARVQRALYDAGWSRYGWPEHAGGLGGPAILRAIVGEE
MSMEG_4844|M.smegmatis_MC2_155 -----LEAHMTQFRRVQRALYDADFGRYGWPETAGGLGGPDVLRAIVGEE
MMAR_4748|M.marinum_M -----LRGHMQQLARVHGALYEAGWMRYGWPTEVGGLGGPALLRAIVGEE
MLBr_00737|M.leprae_Br4923 -------QRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEE
* . * ** * **
Mb3590c|M.bovis_AF2122/97 YARADAPDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYS
Rv3560c|M.tuberculosis_H37Rv YARADAPDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYS
MUL_4125|M.ulcerans_Agy99 YARADAPDKVNHFGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYS
MAB_0597|M.abscessus_ATCC_1997 YARAEAPHKVNHLGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYS
MAV_2563|M.avium_104 LGHAMLPIPAQHWTLETLGPALLKFAP-GLAAAYLPGYLSGVEWWGQSFS
TH_3751|M.thermoresistible__bu LGQAMLPIPAQAWTLEVIAPSVLKFAP-HLASRFLPNYLNGSEWWGQGFS
Mflv_2435|M.gilvum_PYR-GCK VVGRRLAEPGPYSMLEVLAPTMIDYAKPELAAEMVPKLLSGEEQWCQGFS
Mvan_4217|M.vanbaalenii_PYR-1 VVGRRLAEPGPYSMLEVLAPTMIDYAPAELAAEMVPKLLSGEEQWCQGFS
MSMEG_4844|M.smegmatis_MC2_155 IVGRRLAEPGPWSMLEVLAPTMIDYAHPELAAEMVPKLLRGDEQWCQGFS
MMAR_4748|M.marinum_M VVGRRLAEPGPYSMAEVLAPTLIDYAPKGLAADMVPRLLSGREQWCQGFS
MLBr_00737|M.leprae_Br4923 VARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALS
. : :: . :* . *
Mb3590c|M.bovis_AF2122/97 EPGAGSDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLART
Rv3560c|M.tuberculosis_H37Rv EPGAGSDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLART
MUL_4125|M.ulcerans_Agy99 EPGAGSDLANVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVVART
MAB_0597|M.abscessus_ATCC_1997 EPGAGSDLANVSTSAVLD----GGDWVINGQKVWTSLALQSQWCFVVART
MAV_2563|M.avium_104 EPESGSDLASLRTRAVDD---GAGGFVVNGQKIWTSQGPTATRLLALVRT
TH_3751|M.thermoresistible__bu EPESGSDLASLRTRATVD---GDG-FVVNGQKIWTSQGATAKRLLVLVRT
Mflv_2435|M.gilvum_PYR-GCK EPGSGSDLASLTTRAVLKPDSGGGTYVINGQKVWTSFAQFSHRCVLLTRT
Mvan_4217|M.vanbaalenii_PYR-1 EPGSGSDLASLTTRAVQD----GDKWIINGQKVWTSFAQYSHRCILLTRT
MSMEG_4844|M.smegmatis_MC2_155 EPGAGSDLASITTRATQK----GDKWIINGQKVWTSFAQFSQRCILLTRT
MMAR_4748|M.marinum_M EPGSGSDLASLSTRATPR----GDDWIINGQKVWTSFAQFCTRCILLTRT
MLBr_00737|M.leprae_Br4923 EREAGSDAASMRTRAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVT
* :*** *.: * * . :::** * * : . . :. *
Mb3590c|M.bovis_AF2122/97 E-KGSQRHAGLSYLLVPLDQPGVQIRPIVQITGTA--EFNEVFFDDARTD
Rv3560c|M.tuberculosis_H37Rv E-KGSQRHAGLSYLLVPLDQPGVQIRPIVQITGTA--EFNEVFFDDARTD
MUL_4125|M.ulcerans_Agy99 E-KGSKRHAGLSYLLVPLDQPSVQIRPIVQITGTA--EFNEVFFDDARTD
MAB_0597|M.abscessus_ATCC_1997 E-PGSSRHKGLSYLLVPLDQPGVEIRPIIQLTGTS--EFNEVFFDNARTS
MAV_2563|M.avium_104 G-TPESRHRGLTMIMVDADAPGVTIRPIALASGRR--ELAEVFFDDVRVD
TH_3751|M.thermoresistible__bu G-TPESRHRGLSMLLIDTDTPGLTVRPIALASGRR--ELAEVFFDDVRVP
Mflv_2435|M.gilvum_PYR-GCK GDADTPNHQAITAFFVDLDTPGISVRPLRTMHDVD--EFCEVYFDDVEVD
Mvan_4217|M.vanbaalenii_PYR-1 GDADTPNHKAITAFFVDIDTPGVTVRPLRTMHDVD--EFCEVYFDDVAVD
MSMEG_4844|M.smegmatis_MC2_155 GDAGTPNHQAITAFFVDLDTPGITVRPLRTMHDVD--EFCEVYFDDVEVD
MMAR_4748|M.marinum_M ----APGHEGITAFFVDLDTPGITVRPLRTMHGVD--EFCEVYYDDVVIP
MLBr_00737|M.leprae_Br4923 D--PDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIP
.:: ::: * .. : * . *:::*.
Mb3590c|M.bovis_AF2122/97 ADLVVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAA
Rv3560c|M.tuberculosis_H37Rv ADLVVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAA
MUL_4125|M.ulcerans_Agy99 ADLVVGAPGDGWRVAMGTLTFERGVSTLGQQIVYARELSDLAALARRTGA
MAB_0597|M.abscessus_ATCC_1997 ADLVVGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSNGA
MAV_2563|M.avium_104 GERVVGDVGGGWAVAMHLMQYERGMYGYAVLNKVLTELGRLREHMVTAGA
TH_3751|M.thermoresistible__bu TDRLIGEVGGGWAVTMFLMQYERGMYGYAALNKSLMELSRVREYMVERAV
Mflv_2435|M.gilvum_PYR-GCK ASRMLGKPGDGWQLAMDLLPYERSTCFWQRIAYLYSRFDSLVDEVKRQGQ
Mvan_4217|M.vanbaalenii_PYR-1 SSRMLGQPGDGWQLAMDLLPYERSTCFWQRIAYLYSRFDALVDEVKRQGQ
MSMEG_4844|M.smegmatis_MC2_155 AGRMLGNPGQGWQLAMALLPYERSTCFWQRIAYLYSRFDALIEAVKRQGQ
MMAR_4748|M.marinum_M SGRMLGRPGDGWRLAMDLLPYERSTCFWQRIAYLYSRLDELITDTAATNS
MLBr_00737|M.leprae_Br4923 GDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQ
::* * *: :: : . * :.
Mb3590c|M.bovis_AF2122/97 ADDPLIRERLTRAWTGLRAMRSYALATMEGPA--VEQPGQDNVSKLLWAN
Rv3560c|M.tuberculosis_H37Rv ADDPLIRERLTRAWTGLRAMRSYALATMEGPA--VEQPGQDNVSKLLWAN
MUL_4125|M.ulcerans_Agy99 ADDPFIREHLTRAWTGLRAMRSYALATMD-----VEQPGQDNVSKLLWAN
MAB_0597|M.abscessus_ATCC_1997 ADDPAIRERLAQAYVGMRTMRAYALATMD-----EERPGQDNVSKLLWAN
MAV_2563|M.avium_104 TDAQRQ--RFARVYVDVAAAQARTATTVRRLAAGEAVGADSSIDKLLFGR
TH_3751|M.thermoresistible__bu GQSAWE--KFARVYVEVITAQARAASNVRRLAAGEAIGPESSIDKLLFSE
Mflv_2435|M.gilvum_PYR-GCK SIDS----DMGEVYLALHTLRCRSRATQHRLAEGHKLGPDTSIDKVLLAG
Mvan_4217|M.vanbaalenii_PYR-1 SVDQ----DMGEVYLALHTLRCRSRATQHRLADGHKLGPDTSIDKVLLAT
MSMEG_4844|M.smegmatis_MC2_155 VVDS----DLGEVYLALHTVRCRSAATQRRLAEGHKLGPDTSIDKVLLAN
MMAR_4748|M.marinum_M ALDEY---DLGAAYLGLHTLRCRSRDTQHRLAGGSRLGPETSIDKVLLAT
MLBr_00737|M.leprae_Br4923 FGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-FISAA
: : : : .:. .: .
Mb3590c|M.bovis_AF2122/97 WHRNLGELAMDVIGKPGMTMPDG----EFDEWQRLYLFTRADTIYGGSNE
Rv3560c|M.tuberculosis_H37Rv WHRNLGELAMDVIGKPGMTMPDG----EFDEWQRLYLFTRADTIYGGSNE
MUL_4125|M.ulcerans_Agy99 WHRSLGELAMDVIGKPGLTLADG----EFDEWQRLFLFTRADTIYGGSNE
MAB_0597|M.abscessus_ATCC_1997 WHRDLGELAMEIIGTSTLLTNAG----EMDEWQRLFLFSRADTIYGGSNE
MAV_2563|M.avium_104 AEKEVNDLILEIEREHLIAG-TGRGGAELDTARAEWWYSRAATVMGGTAE
TH_3751|M.thermoresistible__bu AERDVNDLIMDIARDHIMVDPLGADPAELDTVRAEWWYSRAATIMGGTAE
Mflv_2435|M.gilvum_PYR-GCK AEQRLYDTVRDLLPGAIELD--------DTPWRTEYLYSRAATIYGGTAE
Mvan_4217|M.vanbaalenii_PYR-1 AEQRLYDTARDLLPGVVELD--------DTEWRTEYLYSRAATIYGGTAE
MSMEG_4844|M.smegmatis_MC2_155 AEQLLYDTARNLLPGVIELE--------DSEWRTEYLYSRAATIYGGTAE
MMAR_4748|M.marinum_M AEQRLYDTVRDLLPATLELD--------DTPWRPEYLYSRAATIYGGTAE
MLBr_00737|M.leprae_Br4923 SKCFASDIAMEVTTDAVQLFGGAG-YTSDFPVERFMRDAKITQIYEGTNQ
. : :: . :: : *: :
Mb3590c|M.bovis_AF2122/97 IQRNIIAERVLGLPREAKG
Rv3560c|M.tuberculosis_H37Rv IQRNIIAERVLGLPREAKG
MUL_4125|M.ulcerans_Agy99 IQRNIIAERVLGLPREAKG
MAB_0597|M.abscessus_ATCC_1997 IQRNIISERVLGLPREAR-
MAV_2563|M.avium_104 VQRGIIADHLLGLPKEKR-
TH_3751|M.thermoresistible__bu VQRGIIADHLLGLPKEKRA
Mflv_2435|M.gilvum_PYR-GCK VQRNIIARRLLDLGKE---
Mvan_4217|M.vanbaalenii_PYR-1 VQRNIIARRLLDLGKE---
MSMEG_4844|M.smegmatis_MC2_155 VQRNIIAHRLLDLPKG---
MMAR_4748|M.marinum_M IQRNIIARRLLGLGSEK--
MLBr_00737|M.leprae_Br4923 IQRVVMSRALLR-------
:** ::: :*