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TNDLYEPANFRTALRDWLDENDLSPGDDHSLQGHIRQFARVQRALYDAGWSRYGWPEHAGGLGGPAILRA IVGEEVVGRRLAEPGPYSMLEVLAPTMIDYAKPELAAEMVPKLLSGEEQWCQGFSEPGSGSDLASLTTRA VLKPDSGGGTYVINGQKVWTSFAQFSHRCVLLTRTGDADTPNHQAITAFFVDLDTPGISVRPLRTMHDVD EFCEVYFDDVEVDASRMLGKPGDGWQLAMDLLPYERSTCFWQRIAYLYSRFDSLVDEVKRQGQSIDSDMG EVYLALHTLRCRSRATQHRLAEGHKLGPDTSIDKVLLAGAEQRLYDTVRDLLPGAIELDDTPWRTEYLYS RAATIYGGTAEVQRNIIARRLLDLGKE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2435 | - | - | 100% (378) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1481 | - | 3e-52 | 35.04% (391) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2394 | - | 5e-51 | 35.00% (380) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3590c | fadE30 | 2e-52 | 35.40% (387) | acyl-CoA dehydrogenase FADE30 |
| M. tuberculosis H37Rv | Rv3560c | fadE30 | 2e-52 | 35.40% (387) | acyl-CoA dehydrogenase FADE30 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-18 | 24.63% (341) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 3e-56 | 35.05% (388) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4748 | - | 1e-164 | 75.34% (369) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0901 | - | 1e-172 | 78.26% (368) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4844 | - | 0.0 | 81.82% (374) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3325 | - | 0.0 | 80.42% (383) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4125 | fadE30 | 2e-50 | 34.63% (387) | acyl-CoA dehydrogenase FadE30 |
| M. vanbaalenii PYR-1 | Mvan_4217 | - | 0.0 | 88.53% (375) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3590c|M.bovis_AF2122/97 --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
Rv3560c|M.tuberculosis_H37Rv --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
MUL_4125|M.ulcerans_Agy99 --------------MQDV--EEFRAEVRGWLAANLVGEFATLKGLGGPGR
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
Mflv_2435|M.gilvum_PYR-GCK ------------MTNDLYEPANFRTALRDWLDEN------DLSPGD-DHS
Mvan_4217|M.vanbaalenii_PYR-1 ----------MTVAVDTSNASEFRSQLKAWLDEN------DLTPPA-DHS
MSMEG_4844|M.smegmatis_MC2_155 -------------MTELHDPTAFRTALQDWLGRT------DLTPPE-DHS
TH_3325|M.thermoresistible__bu ------------MSVDFSSPAEFRTALVAWLDERRE--SGELTPPTGEPT
MMAR_4748|M.marinum_M ---------------MTVDIGRFRADLRTWLDDN------DLTPGP-DHS
MAV_0901|M.avium_104 -----------------MNVEQFRADLRAWLDDN------DLTPGP-DHS
MLBr_00737|M.leprae_Br4923 --------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVD
. :
Mb3590c|M.bovis_AF2122/97 EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
Rv3560c|M.tuberculosis_H37Rv EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
MUL_4125|M.ulcerans_Agy99 EHEAFEERRAWNQHLAAAGLTCLGWPVEHGGRGLSTAHRVAFYEEYARAD
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
Mflv_2435|M.gilvum_PYR-GCK LQGHIRQFARVQRALYDAGWSRYGWPEHAGGLGGPAILRAIVGEEVVGRR
Mvan_4217|M.vanbaalenii_PYR-1 LQGHIRQFARVQRALYDAGWSRYGWPEHAGGLGGPAILRAIVGEEVVGRR
MSMEG_4844|M.smegmatis_MC2_155 LEAHMTQFRRVQRALYDADFGRYGWPETAGGLGGPDVLRAIVGEEIVGRR
TH_3325|M.thermoresistible__bu LEDTMRQFARVLRMLYDAGWSRYGWPERAGGLGGPDILRAIVGEEVVGRR
MMAR_4748|M.marinum_M LRGHMQQLARVHGALYEAGWMRYGWPTEVGGLGGPALLRAIVGEEVVGRR
MAV_0901|M.avium_104 LQGHMKQFARVSRALYDADWMRYGWPAEVGGLGGPAVLRAVVGEEVVGRR
MLBr_00737|M.leprae_Br4923 QRARFP--EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
. : * :. * ** * . ** .
Mb3590c|M.bovis_AF2122/97 APDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAG
Rv3560c|M.tuberculosis_H37Rv APDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAG
MUL_4125|M.ulcerans_Agy99 APDKVNHFGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPGAG
MAB_0597|M.abscessus_ATCC_1997 APHKVNHLGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPGAG
Mflv_2435|M.gilvum_PYR-GCK LAEPGPYSMLEVLAPTMIDYAKPELAAEMVPKLLSGEEQWCQGFSEPGSG
Mvan_4217|M.vanbaalenii_PYR-1 LAEPGPYSMLEVLAPTMIDYAPAELAAEMVPKLLSGEEQWCQGFSEPGSG
MSMEG_4844|M.smegmatis_MC2_155 LAEPGPWSMLEVLAPTMIDYAHPELAAEMVPKLLRGDEQWCQGFSEPGAG
TH_3325|M.thermoresistible__bu LAEPGPYSMLEVLAPTMIDYAPPELAAEMVPKLLSGEEQWCQGFSEPGAG
MMAR_4748|M.marinum_M LAEPGPYSMAEVLAPTLIDYAPKGLAADMVPRLLSGREQWCQGFSEPGSG
MAV_0901|M.avium_104 LAEPGPYSMLEVLAPTMIDYAPAELAAEMVPRLLRGEEHWCQGFSEPGSG
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAG
. :: :* . .:* : . . ** :*
Mb3590c|M.bovis_AF2122/97 SDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLARTE-KGS
Rv3560c|M.tuberculosis_H37Rv SDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLARTE-KGS
MUL_4125|M.ulcerans_Agy99 SDLANVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVVARTE-KGS
MAB_0597|M.abscessus_ATCC_1997 SDLANVSTSAVLD----GGDWVINGQKVWTSLALQSQWCFVVARTE-PGS
Mflv_2435|M.gilvum_PYR-GCK SDLASLTTRAVLKPDSGGGTYVINGQKVWTSFAQFSHRCVLLTRTGDADT
Mvan_4217|M.vanbaalenii_PYR-1 SDLASLTTRAVQD----GDKWIINGQKVWTSFAQYSHRCILLTRTGDADT
MSMEG_4844|M.smegmatis_MC2_155 SDLASITTRATQK----GDKWIINGQKVWTSFAQFSQRCILLTRTGDAGT
TH_3325|M.thermoresistible__bu SDLASLSTRAVRD----GDRWIINGQKVWTSFAQYSHRCILLTRTGDANT
MMAR_4748|M.marinum_M SDLASLSTRATPR----GDDWIINGQKVWTSFAQFCTRCILLTRT----A
MAV_0901|M.avium_104 SDLASLTTRATQD----GDHWIVNGQKVWTSFAQFSTRCVLLTRT----A
MLBr_00737|M.leprae_Br4923 SDAASMRTRAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVTD--PD
** *.: * * *. :::** * * : . . ::: *
Mb3590c|M.bovis_AF2122/97 QRHAGLSYLLVPLDQPGVQIRPIVQITGTA--EFNEVFFDDARTDADLVV
Rv3560c|M.tuberculosis_H37Rv QRHAGLSYLLVPLDQPGVQIRPIVQITGTA--EFNEVFFDDARTDADLVV
MUL_4125|M.ulcerans_Agy99 KRHAGLSYLLVPLDQPSVQIRPIVQITGTA--EFNEVFFDDARTDADLVV
MAB_0597|M.abscessus_ATCC_1997 SRHKGLSYLLVPLDQPGVEIRPIIQLTGTS--EFNEVFFDNARTSADLVV
Mflv_2435|M.gilvum_PYR-GCK PNHQAITAFFVDLDTPGISVRPLRTMHDVD--EFCEVYFDDVEVDASRML
Mvan_4217|M.vanbaalenii_PYR-1 PNHKAITAFFVDIDTPGVTVRPLRTMHDVD--EFCEVYFDDVAVDSSRML
MSMEG_4844|M.smegmatis_MC2_155 PNHQAITAFFVDLDTPGITVRPLRTMHDVD--EFCEVYFDDVEVDAGRML
TH_3325|M.thermoresistible__bu PNHQAISAFFIDLDTPGITVRPLRTMHGVD--EFCEVYFDDVAVDDSRML
MMAR_4748|M.marinum_M PGHEGITAFFVDLDTPGITVRPLRTMHGVD--EFCEVYYDDVVIPSGRML
MAV_0901|M.avium_104 PGYDGITAFFVDLDTPGITIRPLRTMHGVD--EFCEVYYDDVAIPSSRML
MLBr_00737|M.leprae_Br4923 KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRII
.:: ::: * .. : * . *:::*. . ::
Mb3590c|M.bovis_AF2122/97 GAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADDPL
Rv3560c|M.tuberculosis_H37Rv GAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADDPL
MUL_4125|M.ulcerans_Agy99 GAPGDGWRVAMGTLTFERGVSTLGQQIVYARELSDLAALARRTGAADDPF
MAB_0597|M.abscessus_ATCC_1997 GEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSNGAADDPA
Mflv_2435|M.gilvum_PYR-GCK GKPGDGWQLAMDLLPYERSTCFWQRIAYLYSRFDSLVDEVKRQGQSIDS-
Mvan_4217|M.vanbaalenii_PYR-1 GQPGDGWQLAMDLLPYERSTCFWQRIAYLYSRFDALVDEVKRQGQSVDQ-
MSMEG_4844|M.smegmatis_MC2_155 GNPGQGWQLAMALLPYERSTCFWQRIAYLYSRFDALIEAVKRQGQVVDS-
TH_3325|M.thermoresistible__bu GRPGDGWQLAMDLLPYERSTCFWQRIAYLYSRLDALIEEVKRVGQAVDA-
MMAR_4748|M.marinum_M GRPGDGWRLAMDLLPYERSTCFWQRIAYLYSRLDELITDTAATNSALDEY
MAV_0901|M.avium_104 GRPGDGWRLAMDLLPYERSSCFWQRIAYLYSRFDDLIAEVSAAG-EPDES
MLBr_00737|M.leprae_Br4923 GEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESI
* ** *:: *: * . * :. . :
Mb3590c|M.bovis_AF2122/97 --------IRERLTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWA
Rv3560c|M.tuberculosis_H37Rv --------IRERLTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWA
MUL_4125|M.ulcerans_Agy99 --------IREHLTRAWTGLRAMRSYALATMD---VEQPGQDNVSKLLWA
MAB_0597|M.abscessus_ATCC_1997 --------IRERLAQAYVGMRTMRAYALATMD---EERPGQDNVSKLLWA
Mflv_2435|M.gilvum_PYR-GCK --------DMGEVYLALHTLRCRSRATQHRLAEGHKLGP-DTSIDKVLLA
Mvan_4217|M.vanbaalenii_PYR-1 --------DMGEVYLALHTLRCRSRATQHRLADGHKLGP-DTSIDKVLLA
MSMEG_4844|M.smegmatis_MC2_155 --------DLGEVYLALHTVRCRSAATQRRLAEGHKLGP-DTSIDKVLLA
TH_3325|M.thermoresistible__bu --------DLGEAYLALHTLRCRSRETQHRLADGHKLGP-DTSVDKVLLA
MMAR_4748|M.marinum_M --------DLGAAYLGLHTLRCRSRDTQHRLAGGSRLGP-ETSIDKVLLA
MAV_0901|M.avium_104 --------SLGAAYLALHTLRCRSRATQHRMRDGARLGP-DTSIDKVLLA
MLBr_00737|M.leprae_Br4923 STFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFAS
* : .* : :
Mb3590c|M.bovis_AF2122/97 NWHRNLGELAMDVIGKPGMTMPDGEFDEWQRLYLFTRADTIYGGSNEIQR
Rv3560c|M.tuberculosis_H37Rv NWHRNLGELAMDVIGKPGMTMPDGEFDEWQRLYLFTRADTIYGGSNEIQR
MUL_4125|M.ulcerans_Agy99 NWHRSLGELAMDVIGKPGLTLADGEFDEWQRLFLFTRADTIYGGSNEIQR
MAB_0597|M.abscessus_ATCC_1997 NWHRDLGELAMEIIGTSTLLTNAGEMDEWQRLFLFSRADTIYGGSNEIQR
Mflv_2435|M.gilvum_PYR-GCK GAEQRLYDTVRDLLPG----AIELDDTPWRTEYLYSRAATIYGGTAEVQR
Mvan_4217|M.vanbaalenii_PYR-1 TAEQRLYDTARDLLPG----VVELDDTEWRTEYLYSRAATIYGGTAEVQR
MSMEG_4844|M.smegmatis_MC2_155 NAEQLLYDTARNLLPG----VIELEDSEWRTEYLYSRAATIYGGTAEVQR
TH_3325|M.thermoresistible__bu GAEQLFYDTARNLLPG----VIELEGTDWRPEFLYSRAATIYGGTAEVQR
MMAR_4748|M.marinum_M TAEQRLYDTVRDLLPA----TLELDDTPWRPEYLYSRAATIYGGTAEIQR
MAV_0901|M.avium_104 TAEQRLYDTVRDLLPG----TLELENTPWRSEYLYSRAATIYGGTAEIQR
MLBr_00737|M.leprae_Br4923 DIAMEVTTDAVQLFGG----AGYTSDFPVERFMRDAKITQIYEGTNQIQR
. . ::: . . :: ** *: ::**
Mb3590c|M.bovis_AF2122/97 NIIAERVLGLPREAKG
Rv3560c|M.tuberculosis_H37Rv NIIAERVLGLPREAKG
MUL_4125|M.ulcerans_Agy99 NIIAERVLGLPREAKG
MAB_0597|M.abscessus_ATCC_1997 NIISERVLGLPREAR-
Mflv_2435|M.gilvum_PYR-GCK NIIARRLLDLGKE---
Mvan_4217|M.vanbaalenii_PYR-1 NIIARRLLDLGKE---
MSMEG_4844|M.smegmatis_MC2_155 NIIAHRLLDLPKG---
TH_3325|M.thermoresistible__bu NIIARRLLDLGKE---
MMAR_4748|M.marinum_M NIIARRLLGLGSEK--
MAV_0901|M.avium_104 NIIARRLLDLGKE---
MLBr_00737|M.leprae_Br4923 VVMSRALLR-------
:::. :*