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YFEELGYAMLPIPAQAWTLEVMGPAVLKFAPKLAAQYLPGYLDGSEWWGQGFSEPESGSDLASLRTRAAD DGAGGFIVNGQKIWTSQGGTAKRVCVLVRTGSPESRHRGLTMLLIDTDTPGLAVRPIALASGRRELAEMF FDDVRVPRERLVGDVDGGWAVTMFLMQYERGMYGYAVLNKVLTELGRLREYMVTSAATASQRERFARVYV DVIAAQARAATTVRKLAAGEPVGPESSIDKLLCSRAEREVNDLILDVARNHMLAGGPPGINREAELDTAR AEWWYSRAATIMGGTAEVQRGIVADHLLGLPKERRAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1824 | - | - | 100% (318) | acyl-CoA dehydrogenase family protein |
| M. avium 104 | MAV_2563 | - | e-145 | 79.43% (316) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_0901 | - | 8e-51 | 38.56% (319) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3590c | fadE30 | 3e-46 | 35.11% (319) | acyl-CoA dehydrogenase FADE30 |
| M. gilvum PYR-GCK | Mflv_2435 | - | 7e-53 | 39.38% (325) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3560c | fadE30 | 3e-46 | 35.11% (319) | acyl-CoA dehydrogenase FADE30 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-15 | 23.21% (293) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 7e-47 | 33.86% (319) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4748 | - | 2e-52 | 39.75% (317) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4844 | - | 5e-53 | 40.38% (312) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3751 | - | 1e-141 | 78.55% (317) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2892 | fadE17 | 2e-43 | 37.11% (291) | acyl-CoA dehydrogenase FadE17 |
| M. vanbaalenii PYR-1 | Mvan_4217 | - | 2e-52 | 39.68% (315) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3590c|M.bovis_AF2122/97 --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
Rv3560c|M.tuberculosis_H37Rv --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MUL_2892|M.ulcerans_Agy99 ------------------------------MDEHLPCGWSGPGALAVQ--
MAV_1824|M.avium_104 --------------------------------------------------
TH_3751|M.thermoresistible__bu ----------------VSDVAQFRQDLRQYLRR---LDYADVWRSAASTT
Mflv_2435|M.gilvum_PYR-GCK ------------MTNDLYEPANFRTALRDWLDE---NDLS----PGDDHS
Mvan_4217|M.vanbaalenii_PYR-1 ----------MTVAVDTSNASEFRSQLKAWLDE---NDLT----PPADHS
MSMEG_4844|M.smegmatis_MC2_155 -------------MTELHDPTAFRTALQDWLGR---TDLT----PPEDHS
MMAR_4748|M.marinum_M ------------MTVDIG---RFRADLRTWLDD---NDLT----PGPDHS
MLBr_00737|M.leprae_Br4923 ----------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD
Mb3590c|M.bovis_AF2122/97 EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
Rv3560c|M.tuberculosis_H37Rv EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MUL_2892|M.ulcerans_Agy99 DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MAV_1824|M.avium_104 ----------------------------------------MYFEELGYAM
TH_3751|M.thermoresistible__bu AEDGLAHDATVMASLYADGWNRYGWPEEAGGLGGTEIHRAVLYEELGQAM
Mflv_2435|M.gilvum_PYR-GCK LQGHIRQFARVQRALYDAGWSRYGWPEHAGGLGGPAILRAIVGEEVVGRR
Mvan_4217|M.vanbaalenii_PYR-1 LQGHIRQFARVQRALYDAGWSRYGWPEHAGGLGGPAILRAIVGEEVVGRR
MSMEG_4844|M.smegmatis_MC2_155 LEAHMTQFRRVQRALYDADFGRYGWPETAGGLGGPDVLRAIVGEEIVGRR
MMAR_4748|M.marinum_M LRGHMQQLARVHGALYEAGWMRYGWPTEVGGLGGPALLRAIVGEEVVGRR
MLBr_00737|M.leprae_Br4923 VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
**
Mb3590c|M.bovis_AF2122/97 APDKVNH--FGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPG
Rv3560c|M.tuberculosis_H37Rv APDKVNH--FGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPG
MAB_0597|M.abscessus_ATCC_1997 APHKVNH--LGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MUL_2892|M.ulcerans_Agy99 APEREENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MAV_1824|M.avium_104 LPIPAQA--WTLEVMGPAVLKFAP-KLAAQYLPGYLDGSEWWGQGFSEPE
TH_3751|M.thermoresistible__bu LPIPAQA--WTLEVIAPSVLKFAP-HLASRFLPNYLNGSEWWGQGFSEPE
Mflv_2435|M.gilvum_PYR-GCK LAEPGPY--SMLEVLAPTMIDYAKPELAAEMVPKLLSGEEQWCQGFSEPG
Mvan_4217|M.vanbaalenii_PYR-1 LAEPGPY--SMLEVLAPTMIDYAPAELAAEMVPKLLSGEEQWCQGFSEPG
MSMEG_4844|M.smegmatis_MC2_155 LAEPGPW--SMLEVLAPTMIDYAHPELAAEMVPKLLRGDEQWCQGFSEPG
MMAR_4748|M.marinum_M LAEPGPY--SMAEVLAPTLIDYAPKGLAADMVPRLLSGREQWCQGFSEPG
MLBr_00737|M.leprae_Br4923 ASASLIP--AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSERE
. .: :: . :* . **
Mb3590c|M.bovis_AF2122/97 AGSDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLARTEKG
Rv3560c|M.tuberculosis_H37Rv AGSDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLARTEKG
MAB_0597|M.abscessus_ATCC_1997 AGSDLANVSTSAVLD----GGDWVINGQKVWTSLALQSQWCFVVARTEPG
MUL_2892|M.ulcerans_Agy99 AGSDLASVRTRAVLD----GDQWVINGQKIWTSAGSTANWIFVLARTDPV
MAV_1824|M.avium_104 SGSDLASLRTRAADD---GAGGFIVNGQKIWTSQGGTAKRVCVLVRTGSP
TH_3751|M.thermoresistible__bu SGSDLASLRTRATVD---GDG-FVVNGQKIWTSQGATAKRLLVLVRTGTP
Mflv_2435|M.gilvum_PYR-GCK SGSDLASLTTRAVLKPDSGGGTYVINGQKVWTSFAQFSHRCVLLTRTGDA
Mvan_4217|M.vanbaalenii_PYR-1 SGSDLASLTTRAVQD----GDKWIINGQKVWTSFAQYSHRCILLTRTGDA
MSMEG_4844|M.smegmatis_MC2_155 AGSDLASITTRATQK----GDKWIINGQKVWTSFAQFSQRCILLTRTGDA
MMAR_4748|M.marinum_M SGSDLASLSTRATPR----GDDWIINGQKVWTSFAQFCTRCILLTRT---
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVTDPD
:*** *.: * * . :::** * * : . . ::. *
Mb3590c|M.bovis_AF2122/97 -SQRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADL
Rv3560c|M.tuberculosis_H37Rv -SQRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADL
MAB_0597|M.abscessus_ATCC_1997 -SSRHKGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNARTSADL
MUL_2892|M.ulcerans_Agy99 -APKHQGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVAN
MAV_1824|M.avium_104 -ESRHRGLTMLLIDTDTPGLAVRPIALASGR--RELAEMFFDDVRVPRER
TH_3751|M.thermoresistible__bu -ESRHRGLSMLLIDTDTPGLTVRPIALASGR--RELAEVFFDDVRVPTDR
Mflv_2435|M.gilvum_PYR-GCK DTPNHQAITAFFVDLDTPGISVRPLRTMHDV--DEFCEVYFDDVEVDASR
Mvan_4217|M.vanbaalenii_PYR-1 DTPNHKAITAFFVDIDTPGVTVRPLRTMHDV--DEFCEVYFDDVAVDSSR
MSMEG_4844|M.smegmatis_MC2_155 GTPNHQAITAFFVDLDTPGITVRPLRTMHDV--DEFCEVYFDDVEVDAGR
MMAR_4748|M.marinum_M -APGHEGITAFFVDLDTPGITVRPLRTMHGV--DEFCEVYYDDVVIPSGR
MLBr_00737|M.leprae_Br4923 --KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDR
.:: ::: * .. : * . *::: .
Mb3590c|M.bovis_AF2122/97 VVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADD
Rv3560c|M.tuberculosis_H37Rv VVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADD
MAB_0597|M.abscessus_ATCC_1997 VVGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSNGAADD
MUL_2892|M.ulcerans_Agy99 VVGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARARGLDSD
MAV_1824|M.avium_104 LVGDVDGGWAVTMFLMQYERGMYGYAVLNKVLTELGRLREYMVTSAATAS
TH_3751|M.thermoresistible__bu LIGEVGGGWAVTMFLMQYERGMYGYAALNKSLMELSRVREYMVERAVGQS
Mflv_2435|M.gilvum_PYR-GCK MLGKPGDGWQLAMDLLPYERSTCFWQRIAYLYSRFDSLVDEVKRQGQSID
Mvan_4217|M.vanbaalenii_PYR-1 MLGQPGDGWQLAMDLLPYERSTCFWQRIAYLYSRFDALVDEVKRQGQSVD
MSMEG_4844|M.smegmatis_MC2_155 MLGNPGQGWQLAMALLPYERSTCFWQRIAYLYSRFDALIEAVKRQGQVVD
MMAR_4748|M.marinum_M MLGRPGDGWRLAMDLLPYERSTCFWQRIAYLYSRLDELITDTAATNSALD
MLBr_00737|M.leprae_Br4923 IIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGE
::* . *: :: : . * :. .
Mb3590c|M.bovis_AF2122/97 PLIRERLTRAWTGLRAMR--SYALATMEGPAVEQPGQDNVSKLLWANWHR
Rv3560c|M.tuberculosis_H37Rv PLIRERLTRAWTGLRAMR--SYALATMEGPAVEQPGQDNVSKLLWANWHR
MAB_0597|M.abscessus_ATCC_1997 PAIRERLAQAYVGMRTMR--AYALATMD---EERPGQDNVSKLLWANWHR
MUL_2892|M.ulcerans_Agy99 PRIRDRLAWCYSRTQIMRYRGYCSLTWALNGVLPGAEAAISKVIWSEYFQ
MAV_1824|M.avium_104 QRE--RFARVYVDVIAAQARAATTVRKLAAGEPVGPESSIDKLLCSRAER
TH_3751|M.thermoresistible__bu AWE--KFARVYVEVITAQARAASNVRRLAAGEAIGPESSIDKLLFSEAER
Mflv_2435|M.gilvum_PYR-GCK S----DMGEVYLALHTLRCRSRATQHRLAEGHKLGPDTSIDKVLLAGAEQ
Mvan_4217|M.vanbaalenii_PYR-1 Q----DMGEVYLALHTLRCRSRATQHRLADGHKLGPDTSIDKVLLATAEQ
MSMEG_4844|M.smegmatis_MC2_155 S----DLGEVYLALHTVRCRSAATQRRLAEGHKLGPDTSIDKVLLANAEQ
MMAR_4748|M.marinum_M EY---DLGAAYLGLHTLRCRSRDTQHRLAGGSRLGPETSIDKVLLATAEQ
MLBr_00737|M.leprae_Br4923 SISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-FISAASKC
: . : :. .: :
Mb3590c|M.bovis_AF2122/97 NLGELAMDVIGKPGMTMP---------------DGEFDEWQRLYLFTRAD
Rv3560c|M.tuberculosis_H37Rv NLGELAMDVIGKPGMTMP---------------DGEFDEWQRLYLFTRAD
MAB_0597|M.abscessus_ATCC_1997 DLGELAMEIIGTSTLLTN---------------AGEMDEWQRLFLFSRAD
MUL_2892|M.ulcerans_Agy99 RYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMDELLYARAA
MAV_1824|M.avium_104 EVNDLILDVARNHMLAGGPPGINR---------EAELDTARAEWWYSRAA
TH_3751|M.thermoresistible__bu DVNDLIMDIARDHIMVD-PLGAD----------PAELDTVRAEWWYSRAA
Mflv_2435|M.gilvum_PYR-GCK RLYDTVRDLLPGAIELD-------------------DTPWRTEYLYSRAA
Mvan_4217|M.vanbaalenii_PYR-1 RLYDTARDLLPGVVELD-------------------DTEWRTEYLYSRAA
MSMEG_4844|M.smegmatis_MC2_155 LLYDTARNLLPGVIELE-------------------DSEWRTEYLYSRAA
MMAR_4748|M.marinum_M RLYDTVRDLLPATLELD-------------------DTPWRPEYLYSRAA
MLBr_00737|M.leprae_Br4923 FASDIAMEVTTDAVQLFGGAG------------YTSDFPVERFMRDAKIT
: :: ::
Mb3590c|M.bovis_AF2122/97 TIYGGSNEIQRNIIAERVLGLPREAKG----
Rv3560c|M.tuberculosis_H37Rv TIYGGSNEIQRNIIAERVLGLPREAKG----
MAB_0597|M.abscessus_ATCC_1997 TIYGGSNEIQRNIISERVLGLPREAR-----
MUL_2892|M.ulcerans_Agy99 TIYAGSSQIQRNVIGEQLLGLPKEPRREAVH
MAV_1824|M.avium_104 TIMGGTAEVQRGIVADHLLGLPKERRAS---
TH_3751|M.thermoresistible__bu TIMGGTAEVQRGIIADHLLGLPKEKRA----
Mflv_2435|M.gilvum_PYR-GCK TIYGGTAEVQRNIIARRLLDLGKE-------
Mvan_4217|M.vanbaalenii_PYR-1 TIYGGTAEVQRNIIARRLLDLGKE-------
MSMEG_4844|M.smegmatis_MC2_155 TIYGGTAEVQRNIIAHRLLDLPKG-------
MMAR_4748|M.marinum_M TIYGGTAEIQRNIIARRLLGLGSEK------
MLBr_00737|M.leprae_Br4923 QIYEGTNQIQRVVMSRALLR-----------
* *: ::** ::. :*