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VVVTGASRGIGAAVAVRAAVDGAAVALLAKTQTPNPKIAGTLGETADAVQRAGGRALPLTCDVRDAAAVA AAVEAVADAFGGIDVVVNNAGALDLRPTAQLPPKSLRRLLEVNVEGPFAIVQAALPYLRRSGNAHVVNVA PPLNMDPRWVGAHVGHTVGKYAESLLTLGWAEEFASVPIAVNSLWPATTIASTGMMVAMGEETVRAQARS PQIMAEAVHALVTRPAAACSGHFYTDEEILREEGRADLSEYLLAANEDDLTPNFYLLSAPAPTV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2555 | - | - | 100% (275) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_1815 | - | e-125 | 80.14% (277) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_0855 | - | 8e-64 | 47.81% (251) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 5e-52 | 39.36% (249) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2386 | - | 4e-58 | 43.65% (252) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3224 | - | 5e-52 | 39.36% (249) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 3e-13 | 27.88% (208) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 2e-58 | 41.57% (267) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1333 | - | 4e-50 | 38.55% (249) | iron-regulated short-chain dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_4882 | - | 4e-57 | 43.53% (255) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_2687 | - | 1e-110 | 75.59% (254) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2546 | - | 1e-50 | 38.96% (249) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4262 | - | 4e-58 | 45.06% (253) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2555|M.avium_104 -------------------MVVVTGASRGIGAAVAVRAAVDGAAVALLAK
TH_2687|M.thermoresistible__bu -------------------MNFQGGHT--LAETRSLTDXADGARVGLLAR
MMAR_1333|M.marinum_M -------------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAK
MUL_2546|M.ulcerans_Agy99 -------------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAK
Mb3251|M.bovis_AF2122/97 -------------MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAK
Rv3224|M.tuberculosis_H37Rv -------------MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAK
MAB_3946c|M.abscessus_ATCC_199 ------------MGSLAGKTIIMSGGSRGIGLAIALRAARDGANVAIMAK
Mflv_2386|M.gilvum_PYR-GCK ---MASESGTSSTESLADRTLVVSGGSRGIGLAIALGAARRGANVVLLAK
Mvan_4262|M.vanbaalenii_PYR-1 MSGTSNETGDIGGTRFAGRTMVVSGGSRGIGLAIALGAARQGANVVLLAK
MSMEG_4882|M.smegmatis_MC2_155 ---MSSQQ-----ESFADRTMVVSGGSRGIGLAIALGAAKRGANVVLLAK
MLBr_01094|M.leprae_Br4923 ------------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDV
. * :. : : ** : :
MAV_2555|M.avium_104 TQTPNPKIAGTLGETADAVQRAGGRALPLTCDVRDAAAVAAAVEAVADAF
TH_2687|M.thermoresistible__bu TETPNPKLAGTLAETAEAVRAAGGQAYEAVCDVRDADSVAAAVADIADAF
MMAR_1333|M.marinum_M TAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQF
MUL_2546|M.ulcerans_Agy99 TAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQF
Mb3251|M.bovis_AF2122/97 TAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQF
Rv3224|M.tuberculosis_H37Rv TAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQF
MAB_3946c|M.abscessus_ATCC_199 TAEPHPKLPGTIYTAAEEIEAAGGHALPLLGDVRDDEVVASAVAQTVEKF
Mflv_2386|M.gilvum_PYR-GCK TAEPHPRLPGTVHTAVADVEAAGGKGVAVVGDVRKEEDVARAIDTAVERF
Mvan_4262|M.vanbaalenii_PYR-1 TAEPHPKLPGTVHTAVADVEAAGGKGVAVVGDVRKEEDVARAIDTAVEHF
MSMEG_4882|M.smegmatis_MC2_155 TAQPHPKLPGTVHTAVAEVEAAGGKGVAVVGDVRKEEDVARAVDTAVERF
MLBr_01094|M.leprae_Br4923 DGE-------GLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENF
: : :. *. . *: . . : *
MAV_2555|M.avium_104 GGIDVVVNNAGALDLRPTAQLPPKSLRRLLEVNVEGPFAIVQAALPYLRR
TH_2687|M.thermoresistible__bu GGIDVVVNNAGALDLRPTSALPPKNFRRLLAVNVEGPFAVVQAALPHLRR
MMAR_1333|M.marinum_M GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKG
MUL_2546|M.ulcerans_Agy99 GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKG
Mb3251|M.bovis_AF2122/97 GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKG
Rv3224|M.tuberculosis_H37Rv GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKG
MAB_3946c|M.abscessus_ATCC_199 GGIDIVVNNASALNLAPSESISMKAYDLMQDINARGSFSLSTSAIGALKE
Mflv_2386|M.gilvum_PYR-GCK GGVDIVVNNASAIATEPTDALSAKKFDLMMDINIRGTFLLTKAALPHLRQ
Mvan_4262|M.vanbaalenii_PYR-1 GGVDVVVNNASAIATEPTEALSAKKFDLMMDINVRGTFLLTKAALPHLRK
MSMEG_4882|M.smegmatis_MC2_155 GGVDIVVNNASAIATEPTESLAVKKFDLMMDINVRGTFLLTKAALPHLRT
MLBr_01094|M.leprae_Br4923 GKVNQIYNNAGIAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLIS
* :: ***. * : :: * : : :
MAV_2555|M.avium_104 SGNA----HVVNVAPPLNMDPRWVG-AHVGHTVGKYAESLLTLGWAEEFA
TH_2687|M.thermoresistible__bu SDNA----HIVNVSPPVNLAPAWIG-AHTGHTVGKYAESLLTIGWAAEFA
MMAR_1333|M.marinum_M RENP----HILTLSPPVQLDKKWLK--PTAYMMAKFGMTLCALGIAEEMR
MUL_2546|M.ulcerans_Agy99 RENP----HILTLSPPVQLDKKWLK--PTAYMMAKFGMTLCALGIAEEMR
Mb3251|M.bovis_AF2122/97 RENP----HILTLSPPILLEKKWLR--PTAYMMAKYGMTLCALGIAEEMR
Rv3224|M.tuberculosis_H37Rv RENP----HILTLSPPILLEKKWLR--PTAYMMAKYGMTLCALGIAEEMR
MAB_3946c|M.abscessus_ATCC_199 ADNP----HILTLSPPITLEPKWFERTTTAYTISKFSMSLVAIGLAAELR
Mflv_2386|M.gilvum_PYR-GCK ARAG---AHVVTLAPPLNMNPHWLG-AHPSYTLSKYGMTLLSLGWANEYA
Mvan_4262|M.vanbaalenii_PYR-1 STSG---AHVITLAPPLNMNPHWLG-AHPTYTLSKYGMTLLSLGWASEYA
MSMEG_4882|M.smegmatis_MC2_155 SVEAGRAAHVLTLAPPLNLNPYWLG-AHPSYTLSKYGMTLLSQGWAAEYA
MLBr_01094|M.leprae_Br4923 SGDG----HVINISSVFGLFS-VPG--QAAYNSAKFAVRGFTEALREEMA
*::.::. . : : .*:. : . *
MAV_2555|M.avium_104 SVP--IAVNSLWPATTIASTGMMVAMGEETVRAQARS------PQIMAEA
TH_2687|M.thermoresistible__bu SIP--VAVNSLWPATTVASTGMLVAMGDE-VRAQARD------PRIMADA
MMAR_1333|M.marinum_M DEG--IASNTLWPRTLVATAAVQNLLGGDEAMGRARK------PDVYADA
MUL_2546|M.ulcerans_Agy99 DEG--IASNTLWPRTLVATAAVQNLLGGEEAMGRARK------PDVYADA
Mb3251|M.bovis_AF2122/97 ADG--IASNTLWPRTMVATAAVQNLLGGDEAMARSRK------PEVYADA
Rv3224|M.tuberculosis_H37Rv ADG--IASNTLWPRTMVATAAVQNLLGGDEAMARSRK------PEVYADA
MAB_3946c|M.abscessus_ATCC_199 QYG--IASNALWPRTTIDTAAIRNILG-AELVARCRS------AQIMADA
Mflv_2386|M.gilvum_PYR-GCK DTG--IGFSCLWPETYIATSAVTNLSDGDALVQASRS------PDIMADA
Mvan_4262|M.vanbaalenii_PYR-1 DAG--IGFSCLWPETYIATSAVSNLADGGDLVKSSRS------PEIMGDA
MSMEG_4882|M.smegmatis_MC2_155 DSG--IGFSCLWPETYIATAAVANGAGGADLLKSSRS------PEIMADA
MLBr_01094|M.leprae_Br4923 LAGRPVNVTTVYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSPQH
: . ::* : . . . :
MAV_2555|M.avium_104 VHALVTRPAAACSGHFYTDEEILREEGRADLSEYLLAANEDDLTPNFYLL
TH_2687|M.thermoresistible__bu LHALVTRP-ADCTGNFYTDEQILREEGVADLTGYRLAASEDDLVPNFYLE
MMAR_1333|M.marinum_M AYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAK-LGVDLWVE
MUL_2546|M.ulcerans_Agy99 AYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAK-LGVDLWVE
Mb3251|M.bovis_AF2122/97 AYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGAT-LGVDLWVE
Rv3224|M.tuberculosis_H37Rv AYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGAT-LGVDLWVE
MAB_3946c|M.abscessus_ATCC_199 AYEILTKPSREVSGNCFIDDEVLREAGVTDFSQYRECAEED-LELDFWME
Mflv_2386|M.gilvum_PYR-GCK AVEILSRPAAEVNGQCFIDSEVLIASGVTDLSRYG--GGDE-PILDIFVD
Mvan_4262|M.vanbaalenii_PYR-1 AVQILSRPPAEVNGQCYIDAAVLADSGVTDLSGYG--GGDD-PILDIFVD
MSMEG_4882|M.smegmatis_MC2_155 AVEILSRPAGEVNGQTFVDSEVLTTAGVSDLSRYG--GGDS-PIIDIFID
MLBr_01094|M.leprae_Br4923 AARIILKAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLIL
:: : ... :: . :
MAV_2555|M.avium_104 SAPAPTV---
TH_2687|M.thermoresistible__bu STPLPTI---
MMAR_1333|M.marinum_M EVNPPGYTQP
MUL_2546|M.ulcerans_Agy99 EVNPPGYTQP
Mb3251|M.bovis_AF2122/97 DANPPGYLPA
Rv3224|M.tuberculosis_H37Rv DANPPGYLPA
MAB_3946c|M.abscessus_ATCC_199 RA--------
Mflv_2386|M.gilvum_PYR-GCK GRTS------
Mvan_4262|M.vanbaalenii_PYR-1 GRVS------
MSMEG_4882|M.smegmatis_MC2_155 APGQGA----
MLBr_01094|M.leprae_Br4923 NQR-------