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LSGTSNETGDIGGTRFAGRTMVVSGGSRGIGLAIALGAARQGANVVLLAKTAEPHPKLPGTVHTAVADVE AAGGKGVAVVGDVRKEEDVARAIDTAVEHFGGVDVVVNNASAIATEPTEALSAKKFDLMMDINVRGTFLL TKAALPHLRKSTSGAHVITLAPPLNMNPHWLGAHPTYTLSKYGMTLLSLGWASEYADAGIGFSCLWPETY IATSAVSNLADGGDLVKSSRSPEIMGDAAVQILSRPPAEVNGQCYIDAAVLADSGVTDLSGYGGGDDPIL DIFVDGRVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4262 | - | - | 100% (289) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1776 | - | 3e-68 | 49.26% (272) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4252 | - | 2e-33 | 34.32% (236) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 7e-68 | 50.78% (256) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2386 | - | 1e-139 | 84.56% (285) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3224 | - | 7e-68 | 50.78% (256) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 1e-12 | 28.57% (217) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 1e-73 | 52.53% (257) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1333 | - | 2e-65 | 49.22% (256) | iron-regulated short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_0855 | - | 1e-113 | 72.28% (267) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4882 | - | 1e-129 | 82.42% (273) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0126 | - | 1e-127 | 80.66% (274) | POSSIBLE IRON-REGULATED SHORT-CHAIN DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_2546 | - | 2e-65 | 49.22% (256) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3251|M.bovis_AF2122/97 -------------MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAK
Rv3224|M.tuberculosis_H37Rv -------------MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAK
MMAR_1333|M.marinum_M -------------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAK
MUL_2546|M.ulcerans_Agy99 -------------MSLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAK
MAB_3946c|M.abscessus_ATCC_199 ------------MGSLAGKTIIMSGGSRGIGLAIALRAARDGANVAIMAK
Mvan_4262|M.vanbaalenii_PYR-1 MSGTSNETGDIGGTRFAGRTMVVSGGSRGIGLAIALGAARQGANVVLLAK
Mflv_2386|M.gilvum_PYR-GCK ---MASESGTSSTESLADRTLVVSGGSRGIGLAIALGAARRGANVVLLAK
MSMEG_4882|M.smegmatis_MC2_155 ---MSSQQ-----ESFADRTMVVSGGSRGIGLAIALGAAKRGANVVLLAK
TH_0126|M.thermoresistible__bu ---VSSAD-----ASFTDRTMVISGASRGIGLAIAVGAARRGANVVLLAK
MAV_0855|M.avium_104 ---MADNS-------LTDRTVVISGGSRGIGLAIGIAAARRGANVVLLAK
MLBr_01094|M.leprae_Br4923 ------------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDV
: .:. .::*.. *** *:. *: **::.:
Mb3251|M.bovis_AF2122/97 TAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQF
Rv3224|M.tuberculosis_H37Rv TAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQF
MMAR_1333|M.marinum_M TAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQF
MUL_2546|M.ulcerans_Agy99 TAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQF
MAB_3946c|M.abscessus_ATCC_199 TAEPHPKLPGTIYTAAEEIEAAGGHALPLLGDVRDDEVVASAVAQTVEKF
Mvan_4262|M.vanbaalenii_PYR-1 TAEPHPKLPGTVHTAVADVEAAGGKGVAVVGDVRKEEDVARAIDTAVEHF
Mflv_2386|M.gilvum_PYR-GCK TAEPHPRLPGTVHTAVADVEAAGGKGVAVVGDVRKEEDVARAIDTAVERF
MSMEG_4882|M.smegmatis_MC2_155 TAQPHPKLPGTVHTAVAEVEAAGGKGVAVVGDVRKEEDVARAVDTAVERF
TH_0126|M.thermoresistible__bu TAEPHPKLAGTVHTAVAEIEAAGGKAVPVVGDVRREEDVQRAVDTAVEHF
MAV_0855|M.avium_104 TDTPHPRLPGTVHTAAADVEAAGGKALAVIGDVRREEDVRRAVEATVQRF
MLBr_01094|M.leprae_Br4923 DGEGLAQTEG-------QLKAIGASARTDRLDVTEREAFLTYADVVHENF
.: * ::: *. . . *: : . . :.*
Mb3251|M.bovis_AF2122/97 GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKG
Rv3224|M.tuberculosis_H37Rv GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKG
MMAR_1333|M.marinum_M GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKG
MUL_2546|M.ulcerans_Agy99 GGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKG
MAB_3946c|M.abscessus_ATCC_199 GGIDIVVNNASALNLAPSESISMKAYDLMQDINARGSFSLSTSAIGALKE
Mvan_4262|M.vanbaalenii_PYR-1 GGVDVVVNNASAIATEPTEALSAKKFDLMMDINVRGTFLLTKAALPHLRK
Mflv_2386|M.gilvum_PYR-GCK GGVDIVVNNASAIATEPTDALSAKKFDLMMDINIRGTFLLTKAALPHLRQ
MSMEG_4882|M.smegmatis_MC2_155 GGVDIVVNNASAIATEPTESLAVKKFDLMMDINVRGTFLLTKAALPHLRT
TH_0126|M.thermoresistible__bu GGVDICVNNASAIATEPTEQLSAKKFDLMQQINIRGTFLLTRACLPHLRK
MAV_0855|M.avium_104 GGVDVCVNNASAIAVEPTAELSAKKFDLMQEVNIRGTFLLTKACLPHLRR
MLBr_01094|M.leprae_Br4923 GKVNQIYNNAGIAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLIS
* :: ***. * : : :: * : : : :
Mb3251|M.bovis_AF2122/97 RENP----HILTLSPPILLEKKWLR--PTAYMMAKYGMTLCALGIAEEM-
Rv3224|M.tuberculosis_H37Rv RENP----HILTLSPPILLEKKWLR--PTAYMMAKYGMTLCALGIAEEM-
MMAR_1333|M.marinum_M RENP----HILTLSPPVQLDKKWLK--PTAYMMAKFGMTLCALGIAEEM-
MUL_2546|M.ulcerans_Agy99 RENP----HILTLSPPVQLDKKWLK--PTAYMMAKFGMTLCALGIAEEM-
MAB_3946c|M.abscessus_ATCC_199 ADNP----HILTLSPPITLEPKWFERTTTAYTISKFSMSLVAIGLAAEL-
Mvan_4262|M.vanbaalenii_PYR-1 STSG---AHVITLAPPLNMNPHWLG-AHPTYTLSKYGMTLLSLGWASEY-
Mflv_2386|M.gilvum_PYR-GCK ARAG---AHVVTLAPPLNMNPHWLG-AHPSYTLSKYGMTLLSLGWANEY-
MSMEG_4882|M.smegmatis_MC2_155 SVEAGRAAHVLTLAPPLNLNPYWLG-AHPSYTLSKYGMTLLSQGWAAEY-
TH_0126|M.thermoresistible__bu SAAG----HVLTISPPLNMNPHWLG-AHPSYTLSKYGMTLLSLGWANEYT
MAV_0855|M.avium_104 AANP----HVLTISPPINMNPRWLG-AHPAYTLSKYGMTLLSLGWAAEF-
MLBr_01094|M.leprae_Br4923 SGDG----HVINISSVFGLFS-VPG--QAAYNSAKFAVRGFTEALREEMA
*::.::. . : .:* :*:.: : . *
Mb3251|M.bovis_AF2122/97 RADG---IASNTLWP---RTMVATAAVQNLLGGDEAMAR---SRKPEVYA
Rv3224|M.tuberculosis_H37Rv RADG---IASNTLWP---RTMVATAAVQNLLGGDEAMAR---SRKPEVYA
MMAR_1333|M.marinum_M RDEG---IASNTLWP---RTLVATAAVQNLLGGDEAMGR---ARKPDVYA
MUL_2546|M.ulcerans_Agy99 RDEG---IASNTLWP---RTLVATAAVQNLLGGEEAMGR---ARKPDVYA
MAB_3946c|M.abscessus_ATCC_199 RQYG---IASNALWP---RTTIDTAAIRNILG-AELVAR---CRSAQIMA
Mvan_4262|M.vanbaalenii_PYR-1 ADAG---IGFSCLWP---ETYIATSAVSNLADGGDLVKS---SRSPEIMG
Mflv_2386|M.gilvum_PYR-GCK ADTG---IGFSCLWP---ETYIATSAVTNLSDGDALVQA---SRSPDIMA
MSMEG_4882|M.smegmatis_MC2_155 ADSG---IGFSCLWP---ETYIATAAVANGAGGADLLKS---SRSPEIMA
TH_0126|M.thermoresistible__bu AERGGAHIGFSCLWP---QTYIATAAVTNLADGQDLVKR---SRSPEIMA
MAV_0855|M.avium_104 ADDG---IGVNCLWP---QTYIATAAVANMADGDKLAES---SRSPEIMA
MLBr_01094|M.leprae_Br4923 LAGR--PVNVTTVYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSP
: . ::* .* : * ..
Mb3251|M.bovis_AF2122/97 DAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWV
Rv3224|M.tuberculosis_H37Rv DAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWV
MMAR_1333|M.marinum_M DAAYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWV
MUL_2546|M.ulcerans_Agy99 DAAYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWV
MAB_3946c|M.abscessus_ATCC_199 DAAYEILTKPSREVSGNCFIDDEVLREAGVTDFSQYRECAEEDLELDFWM
Mvan_4262|M.vanbaalenii_PYR-1 DAAVQILSRPPAEVNGQCYIDAAVLADSGVTDLSGYG--GGDDPILDIFV
Mflv_2386|M.gilvum_PYR-GCK DAAVEILSRPAAEVNGQCFIDSEVLIASGVTDLSRYG--GGDEPILDIFV
MSMEG_4882|M.smegmatis_MC2_155 DAAVEILSRPAGEVNGQTFVDSEVLTTAGVSDLSRYG--GGDSPIIDIFI
TH_0126|M.thermoresistible__bu DAAVEILSRPPAEVNGNCYIDADVLTAAGITDLTRYG--GGDDPIIDIFV
MAV_0855|M.avium_104 DAAVEIVSRPAREATGDCYIDAEVLHSAGVDDLSVYG--GGEQPIPDLFL
MLBr_01094|M.leprae_Br4923 QHAARIILKAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRL
: * *: : : .. : . : :: :
Mb3251|M.bovis_AF2122/97 EDANPPGYLPA
Rv3224|M.tuberculosis_H37Rv EDANPPGYLPA
MMAR_1333|M.marinum_M EEVNPPGYTQP
MUL_2546|M.ulcerans_Agy99 EEVNPPGYTQP
MAB_3946c|M.abscessus_ATCC_199 ERA--------
Mvan_4262|M.vanbaalenii_PYR-1 DGRVS------
Mflv_2386|M.gilvum_PYR-GCK DGRTS------
MSMEG_4882|M.smegmatis_MC2_155 DAPGQGA----
TH_0126|M.thermoresistible__bu DLS--------
MAV_0855|M.avium_104 D----------
MLBr_01094|M.leprae_Br4923 ILNQR------