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ADNSLTDRTVVISGGSRGIGLAIGIAAARRGANVVLLAKTDTPHPRLPGTVHTAAADVEAAGGKALAVIG DVRREEDVRRAVEATVQRFGGVDVCVNNASAIAVEPTAELSAKKFDLMQEVNIRGTFLLTKACLPHLRRA ANPHVLTISPPINMNPRWLGAHPAYTLSKYGMTLLSLGWAAEFADDGIGVNCLWPQTYIATAAVANMADG DKLAESSRSPEIMADAAVEIVSRPAREATGDCYIDAEVLHSAGVDDLSVYGGGEQPIPDLFLD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0855 | - | - | 100% (274) | short chain dehydrogenase |
| M. avium 104 | MAV_4172 | - | 1e-75 | 51.10% (272) | short chain dehydrogenase |
| M. avium 104 | MAV_2555 | - | 8e-64 | 47.81% (251) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 2e-75 | 53.31% (257) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2386 | - | 1e-118 | 74.17% (271) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3224 | - | 2e-75 | 53.31% (257) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-10 | 28.95% (190) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 2e-76 | 53.10% (258) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1333 | - | 3e-74 | 50.97% (257) | iron-regulated short-chain dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_4882 | - | 1e-112 | 71.17% (274) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0126 | - | 1e-118 | 74.01% (277) | POSSIBLE IRON-REGULATED SHORT-CHAIN DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_2546 | - | 6e-74 | 50.58% (257) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4262 | - | 1e-113 | 72.28% (267) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2386|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4882|M.smegmatis_MC2_155 --------------------------------------------------
TH_0126|M.thermoresistible__bu --------------------------------------------------
MAV_0855|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2386|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4882|M.smegmatis_MC2_155 --------------------------------------------------
TH_0126|M.thermoresistible__bu --------------------------------------------------
MAV_0855|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2386|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4882|M.smegmatis_MC2_155 --------------------------------------------------
TH_0126|M.thermoresistible__bu --------------------------------------------------
MAV_0855|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2386|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4882|M.smegmatis_MC2_155 --------------------------------------------------
TH_0126|M.thermoresistible__bu --------------------------------------------------
MAV_0855|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2386|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4882|M.smegmatis_MC2_155 --------------------------------------------------
TH_0126|M.thermoresistible__bu --------------------------------------------------
MAV_0855|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2386|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4262|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4882|M.smegmatis_MC2_155 --------------------------------------------------
TH_0126|M.thermoresistible__bu --------------------------------------------------
MAV_0855|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb3251|M.bovis_AF2122/97 -----------------------MSLNGKTMFISGASRGIGLAIAKRAAR
Rv3224|M.tuberculosis_H37Rv -----------------------MSLNGKTMFISGASRGIGLAIAKRAAR
MMAR_1333|M.marinum_M -----------------------MSLNGKTMFISGASRGIGLAIAKRAAQ
MUL_2546|M.ulcerans_Agy99 -----------------------MSLNGKTMFISGASRGIGLAIAKRAAQ
MAB_3946c|M.abscessus_ATCC_199 ----------------------MGSLAGKTIIMSGGSRGIGLAIALRAAR
Mflv_2386|M.gilvum_PYR-GCK -------------MASESGTSSTESLADRTLVVSGGSRGIGLAIALGAAR
Mvan_4262|M.vanbaalenii_PYR-1 ----------MSGTSNETGDIGGTRFAGRTMVVSGGSRGIGLAIALGAAR
MSMEG_4882|M.smegmatis_MC2_155 -------------MSSQQ-----ESFADRTMVVSGGSRGIGLAIALGAAK
TH_0126|M.thermoresistible__bu -------------VSSAD-----ASFTDRTMVISGASRGIGLAIAVGAAR
MAV_0855|M.avium_104 -------------MADNS-------LTDRTVVISGGSRGIGLAIGIAAAR
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
: . : ::*.. *** . *:
Mb3251|M.bovis_AF2122/97 DGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVA
Rv3224|M.tuberculosis_H37Rv DGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVA
MMAR_1333|M.marinum_M DGANIALIAKTAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVS
MUL_2546|M.ulcerans_Agy99 DGANIALIAKTAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVS
MAB_3946c|M.abscessus_ATCC_199 DGANVAIMAKTAEPHPKLPGTIYTAAEEIEAAGGHALPLLGDVRDDEVVA
Mflv_2386|M.gilvum_PYR-GCK RGANVVLLAKTAEPHPRLPGTVHTAVADVEAAGGKGVAVVGDVRKEEDVA
Mvan_4262|M.vanbaalenii_PYR-1 QGANVVLLAKTAEPHPKLPGTVHTAVADVEAAGGKGVAVVGDVRKEEDVA
MSMEG_4882|M.smegmatis_MC2_155 RGANVVLLAKTAQPHPKLPGTVHTAVAEVEAAGGKGVAVVGDVRKEEDVA
TH_0126|M.thermoresistible__bu RGANVVLLAKTAEPHPKLAGTVHTAVAEIEAAGGKAVPVVGDVRREEDVQ
MAV_0855|M.avium_104 RGANVVLLAKTDTPHPRLPGTVHTAAADVEAAGGKALAVIGDVRREEDVR
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEA-------AAKNTAAQIVASGGVAYAYALDVSDAAAVE
**::.: : .:. :: :** . . *: *
Mb3251|M.bovis_AF2122/97 SAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
Rv3224|M.tuberculosis_H37Rv SAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
MMAR_1333|M.marinum_M AAVAKTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
MUL_2546|M.ulcerans_Agy99 AAVAKTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
MAB_3946c|M.abscessus_ATCC_199 SAVAQTVEKFGGIDIVVNNASALNLAPSESISMKAYDLMQDINARGSFSL
Mflv_2386|M.gilvum_PYR-GCK RAIDTAVERFGGVDIVVNNASAIATEPTDALSAKKFDLMMDINIRGTFLL
Mvan_4262|M.vanbaalenii_PYR-1 RAIDTAVEHFGGVDVVVNNASAIATEPTEALSAKKFDLMMDINVRGTFLL
MSMEG_4882|M.smegmatis_MC2_155 RAVDTAVERFGGVDIVVNNASAIATEPTESLAVKKFDLMMDINVRGTFLL
TH_0126|M.thermoresistible__bu RAVDTAVEHFGGVDICVNNASAIATEPTEQLSAKKFDLMQQINIRGTFLL
MAV_0855|M.avium_104 RAVEATVQRFGGVDVCVNNASAIAVEPTAELSAKKFDLMQEVNIRGTFLL
MLBr_00862|M.leprae_Br4923 AFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNC
. :.* *: ****. . : :* : :: *
Mb3251|M.bovis_AF2122/97 SQACIPHMKGRENP----HILTLSPPILLEKKWLR--PTAYMMAKYGMTL
Rv3224|M.tuberculosis_H37Rv SQACIPHMKGRENP----HILTLSPPILLEKKWLR--PTAYMMAKYGMTL
MMAR_1333|M.marinum_M SQACIPHLKGRENP----HILTLSPPVQLDKKWLK--PTAYMMAKFGMTL
MUL_2546|M.ulcerans_Agy99 SQACIPHLKGRENP----HILTLSPPVQLDKKWLK--PTAYMMAKFGMTL
MAB_3946c|M.abscessus_ATCC_199 STSAIGALKEADNP----HILTLSPPITLEPKWFERTTTAYTISKFSMSL
Mflv_2386|M.gilvum_PYR-GCK TKAALPHLRQARAG---AHVVTLAPPLNMNPHWLG-AHPSYTLSKYGMTL
Mvan_4262|M.vanbaalenii_PYR-1 TKAALPHLRKSTSG---AHVITLAPPLNMNPHWLG-AHPTYTLSKYGMTL
MSMEG_4882|M.smegmatis_MC2_155 TKAALPHLRTSVEAGRAAHVLTLAPPLNLNPYWLG-AHPSYTLSKYGMTL
TH_0126|M.thermoresistible__bu TRACLPHLRKSAAG----HVLTISPPLNMNPHWLG-AHPSYTLSKYGMTL
MAV_0855|M.avium_104 TKACLPHLRRAANP----HVLTISPPINMNPRWLG-AHPAYTLSKYGMTL
MLBr_00862|M.leprae_Br4923 CRAFGQRLVERGTG---GHIVNVSSMAAYAPLQSL---SAYCTSKAATYM
: : *::.::. .:* :* . :
Mb3251|M.bovis_AF2122/97 CALGIAEEM-RADG---IASNTLWPRTMVATAAVQNLLGGDEAMA-RSRK
Rv3224|M.tuberculosis_H37Rv CALGIAEEM-RADG---IASNTLWPRTMVATAAVQNLLGGDEAMA-RSRK
MMAR_1333|M.marinum_M CALGIAEEM-RDEG---IASNTLWPRTLVATAAVQNLLGGDEAMG-RARK
MUL_2546|M.ulcerans_Agy99 CALGIAEEM-RDEG---IASNTLWPRTLVATAAVQNLLGGEEAMG-RARK
MAB_3946c|M.abscessus_ATCC_199 VAIGLAAEL-RQYG---IASNALWPRTTIDTAAIRNILG-AELVA-RCRS
Mflv_2386|M.gilvum_PYR-GCK LSLGWANEY-ADTG---IGFSCLWPETYIATSAVTNLSDGDALVQ-ASRS
Mvan_4262|M.vanbaalenii_PYR-1 LSLGWASEY-ADAG---IGFSCLWPETYIATSAVSNLADGGDLVK-SSRS
MSMEG_4882|M.smegmatis_MC2_155 LSQGWAAEY-ADSG---IGFSCLWPETYIATAAVANGAGGADLLK-SSRS
TH_0126|M.thermoresistible__bu LSLGWANEYTAERGGAHIGFSCLWPQTYIATAAVTNLADGQDLVK-RSRS
MAV_0855|M.avium_104 LSLGWAAEF-ADDG---IGVNCLWPQTYIATAAVANMADGDKLAE-SSRS
MLBr_00862|M.leprae_Br4923 FSDCLRAEL-DAVG---VGLTTICPGVIDTNIIQSTRIDTPTAKQERVRD
: * * :. . : * . . . . *.
Mb3251|M.bovis_AF2122/97 PEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLG
Rv3224|M.tuberculosis_H37Rv PEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLG
MMAR_1333|M.marinum_M PDVYADAAYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLG
MUL_2546|M.ulcerans_Agy99 PDVYADAAYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLG
MAB_3946c|M.abscessus_ATCC_199 AQIMADAAYEILTKPSREVSGNCFIDDEVLREAGVTDFSQYRECAEEDLE
Mflv_2386|M.gilvum_PYR-GCK PDIMADAAVEILSRPAAEVNGQCFIDSEVLIASGVTDLSRYG--GGDEPI
Mvan_4262|M.vanbaalenii_PYR-1 PEIMGDAAVQILSRPPAEVNGQCYIDAAVLADSGVTDLSGYG--GGDDPI
MSMEG_4882|M.smegmatis_MC2_155 PEIMADAAVEILSRPAGEVNGQTFVDSEVLTTAGVSDLSRYG--GGDSPI
TH_0126|M.thermoresistible__bu PEIMADAAVEILSRPPAEVNGNCYIDADVLTAAGITDLTRYG--GGDDPI
MAV_0855|M.avium_104 PEIMADAAVEIVSRPAREATGDCYIDAEVLHSAGVDDLSVYG--GGEQPI
MLBr_00862|M.leprae_Br4923 RRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVL
* : . : . *
Mb3251|M.bovis_AF2122/97 VDLWVEDANPPGYLPA
Rv3224|M.tuberculosis_H37Rv VDLWVEDANPPGYLPA
MMAR_1333|M.marinum_M VDLWVEEVNPPGYTQP
MUL_2546|M.ulcerans_Agy99 VDLWVEEVNPPGYTQP
MAB_3946c|M.abscessus_ATCC_199 LDFWMERA--------
Mflv_2386|M.gilvum_PYR-GCK LDIFVDGRTS------
Mvan_4262|M.vanbaalenii_PYR-1 LDIFVDGRVS------
MSMEG_4882|M.smegmatis_MC2_155 IDIFIDAPGQGA----
TH_0126|M.thermoresistible__bu IDIFVDLS--------
MAV_0855|M.avium_104 PDLFLD----------
MLBr_00862|M.leprae_Br4923 PQVLRSTARIRVI---
:. .