For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TANTVLVTGAFGQVGKRCTQLLLQRGRTVVAMDLRNDNTAAVATELAAGGYPGTLIPAYTDLLDAEAVRD LVTAHQPDAVVHLAAVVSPLSYRKPDLARRVNVGGTENLLAACTALPRPPLFLMASSAAVYGSRNPYRQP ERITPDTPVNPIDQYGQDKVLAEAAIRASGLPYALFRLGGIISPDTHASINGDYLLLMRSMPSDNRMHAV DARDVALAFANGVDRAATISGKVLLIGGNESYVLTQRELEDAMMEAVGLGRLGPSASLPGNPADDRGWSF TGWYDTTEAQQLLDFQEHDWSQTVAWLAESQGRSRLALRLLGPLLRPLLRTILIVQRRLEGRGPYADPWT LIEKKYGTAALATAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2497 | - | - | 100% (366) | RmlD substrate binding domain-containing protein |
| M. avium 104 | MAV_0524 | - | 8e-10 | 31.45% (159) | nucleoside-diphosphate-sugar epimerase |
| M. avium 104 | MAV_4084 | - | 1e-08 | 32.39% (176) | UDP-glucuronic acid decarboxylase 1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 4e-08 | 28.93% (159) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_2425 | - | 2e-65 | 40.61% (362) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 4e-08 | 28.93% (159) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 4e-10 | 30.82% (159) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_2971c | - | 2e-08 | 28.83% (274) | putative oxidoreductase |
| M. marinum M | MMAR_2336 | galE6 | 2e-08 | 28.42% (183) | UDP-glucose 4-epimerase, GalE6 |
| M. smegmatis MC2 155 | MSMEG_5233 | - | 4e-70 | 43.02% (358) | RmlD substrate binding domain-containing protein |
| M. thermoresistible (build 8) | TH_1115 | - | 7e-70 | 42.27% (362) | RmlD substrate binding domain superfamily protein |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 2e-08 | 29.45% (163) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_4227 | - | 3e-63 | 39.55% (359) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5233|M.smegmatis_MC2_155 ---MSDAVLVTGAFGLVGSAVVATLAAQGRPVVATDVGTPANRKSATGLP
TH_1115|M.thermoresistible__bu ---MSDAVLVTGAFGLVGSATVRRLAADGHRVVATDVATPDTRKAAAELS
Mflv_2425|M.gilvum_PYR-GCK MPATSGTVLVTGGFGLVGSATVRRLAELGRTVVVADLDTPANRAAAERLP
Mvan_4227|M.vanbaalenii_PYR-1 MSGTSGTVLVTGGFGLVGSATVRRLVELGRSVVVADLDTPANRASAAQLP
MAV_2497|M.avium_104 --MTANTVLVTGAFGQVGKRCTQLLLQRGRTVVAMDLRNDNTAAVATELA
Mb3658c|M.bovis_AF2122/97 -----MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLA
Rv3634c|M.tuberculosis_H37Rv -----MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLA
MUL_4210|M.ulcerans_Agy99 -----MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNLEHLV
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA
MMAR_2336|M.marinum_M -----MHYLITGHTGFKGPWLALLLLSRGHQVSGLALDSEQAGLFKRAGL
MAB_2971c|M.abscessus_ATCC_199 -----MRVLVTGGTGFVGGWTAKAMAEAGHKVRFLVRKEARLHTTVATLG
*:** * * . : *: *
MSMEG_5233|M.smegmatis_MC2_155 P-----TVEVRWADLTDAAAVDTLVADVAPAAIVHLAAIIPP-FCYMRRE
TH_1115|M.thermoresistible__bu ADGPG-EVQVRWADLTDPAAVDELMTTVSPAAVIHLAAVIAP-FCYSRQA
Mflv_2425|M.gilvum_PYR-GCK AG-----VTVRWADLTNAEQTSRLVGEVAPAVIIHLAAIIPP-AIYKNRA
Mvan_4227|M.vanbaalenii_PYR-1 AG-----VTVRWTDLTDAEQTSALVSEVAPAVIIHLAAIIPP-AIYKNRA
MAV_2497|M.avium_104 AGGYPGTLIPAYTDLLDAEAVRDLVTAHQPDAVVHLAAVVSP-LSYRKPD
Mb3658c|M.bovis_AF2122/97 DN----SAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQ
Rv3634c|M.tuberculosis_H37Rv DN----SAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQ
MUL_4210|M.ulcerans_Agy99 DN----LAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQ
MLBr_00204|M.leprae_Br4923 ST----PALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQ
MMAR_2336|M.marinum_M AD---QLVSDLRVDIRESEATTAALQAVAPDVVIHLAAQSLVRESYRNPR
MAB_2971c|M.abscessus_ATCC_199 VD----VSDYAVGDITDRASVEAALDGCD--AVVHSAAMVSTDPAEADR-
. .:.* **
MSMEG_5233|M.smegmatis_MC2_155 LARKVNVDATESLLRAAEARATPPRFVLASSVAVYGTRNPHRITDMLTAD
TH_1115|M.thermoresistible__bu LARKVNVDATANLIRAAEAQSSPPRFIQASSIAVYGPRNPHTCSDVLTAD
Mflv_2425|M.gilvum_PYR-GCK LARRVNVDATATLVKIAEAQPDPPRFVQASSNAVYGARNPHKATGPVTAD
Mvan_4227|M.vanbaalenii_PYR-1 LARRVNVEATATLVRIAEAQPTPPRFVQASSNAVYGARNPYKSAGPVTAD
MAV_2497|M.avium_104 LARRVNVGGTENLLAACTALPRPPLFLMASSAAVYGSRNPYRQPERITPD
Mb3658c|M.bovis_AF2122/97 FDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTP----ET
Rv3634c|M.tuberculosis_H37Rv FDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTP----ET
MUL_4210|M.ulcerans_Agy99 FDASVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTS----ER
MLBr_00204|M.leprae_Br4923 FDASVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTP----ET
MMAR_2336|M.marinum_M YTYETNAMGTLNVLEAVGATPSVRAHVVITTDKVYRNVNQEAGY---VET
MAB_2971c|M.abscessus_ATCC_199 -MMAINLEGTRNVLGAAVDRGLDPIVHVSSITALFRPGLETFAADLPAAG
* .* : : ::
MSMEG_5233|M.smegmatis_MC2_155 TPVNPVDIYGAHKVEAENLVRASR---LDWLILRLGGVMSSTF-SVDMDV
TH_1115|M.thermoresistible__bu TPPNPGDLYGGHKYEAEQLVRASN---LEWAILRLGGVLSAEP-MFDMKP
Mflv_2425|M.gilvum_PYR-GCK MPMKHSDLYSALKAEAESIVRASS---LEWIVLRLGGVLSVDPKAIPFNA
Mvan_4227|M.vanbaalenii_PYR-1 MPMKHSDLYSAHKAEAEAIVRASS---LEWVVLRLGGVLSTDPNAIPFSA
MAV_2497|M.avium_104 TPVNPIDQYGQDKVLAEAAIRASG---LPYALFRLGGIISPDT-HASING
Mb3658c|M.bovis_AF2122/97 APTDPASPYAAG---------------------KVAGEIYLNTFRHLYGL
Rv3634c|M.tuberculosis_H37Rv APTDPASPYAAG---------------------KVAGEIYLNTFRHLYGL
MUL_4210|M.ulcerans_Agy99 VPTDPASPYAAG---------------------KVAGEIYLNTFRHLYGL
MLBr_00204|M.leprae_Br4923 VPTDPTSPYAAG---------------------KVAGEIYLNTFRHLCGL
MMAR_2336|M.marinum_M DPLGGDDPYSAS--------------------KAMADLLTQSWVRSFPNC
MAB_2971c|M.abscessus_ATCC_199 GSDGYGQSKARVELYVRALQDSGAPVTITYPGMVLGPPVGDQFGEAAEGV
. . . :. :
MSMEG_5233|M.smegmatis_MC2_155 ELISLESVLP-ADGRLQTVDVRDVATAFAAATTVPVETANHEVLLIGGDP
TH_1115|M.thermoresistible__bu EFLYFEALLP-TDGRLQTVEVRDVAAAFTAAVTAPVAG---QVLLIGGD-
Mflv_2425|M.gilvum_PYR-GCK DALYFESLLP-TDNRVHSVDVRDVAWAFAAATTADAAR---EILLIAGD-
Mvan_4227|M.vanbaalenii_PYR-1 DALYFESVLP-ADGRIHTVDVRDVAWAFAAATTADVAR---EILLIAGD-
MAV_2497|M.avium_104 DYLLLMRSMP-SDNRMHAVDARDVALAFANGVDRAATISG-KVLLIGGN-
Mb3658c|M.bovis_AF2122/97 DCSHIAPANV-YGPRQDPHGEAGVVAIFAQALLSGKPT----RVFGDGTN
Rv3634c|M.tuberculosis_H37Rv DCSHIAPANV-YGPRQDPHGEAGVVAIFAQALLSGKPT----RVFGDGTN
MUL_4210|M.ulcerans_Agy99 ECSHIAPANV-YGPRQDPHGEAGVVAIFAQALLSGKPT----KVFGDGTN
MLBr_00204|M.leprae_Br4923 DCSHIAPANV-YGPRQDPYGEAGVVAIFVQALLSDRPT----KVFGDGTH
MMAR_2336|M.marinum_M PTAIARAGNV-IGG--GDISRDRLFPDLVDAYARGQAPRLRFPRAVRPWQ
MAB_2971c|M.abscessus_ATCC_199 RWVLLTRSVPGRSAAWLVVDVRDLAALHTALLEPSRGP----RRYTAGG-
. : .
MSMEG_5233|M.smegmatis_MC2_155 QTHRHTQARVGSEAAQAMGI-RGGLPAGRPGNPDDDHAWFHTDWMDTTRA
TH_1115|M.thermoresistible__bu DSHRLTQGEIGPSIAAAMGL-VGALPVGRKGNPHSDTDWFATDWLDPGPA
Mflv_2425|M.gilvum_PYR-GCK ESHMLTYADITPALAATRGI-KGGLVPGRKGNPDDDDAWFVTDWMDTTRA
Mvan_4227|M.vanbaalenii_PYR-1 DSHRVLQGDVGRALAESRGL-KGGLVPGRNGDPNSDENWFVTDWMDTRRA
MAV_2497|M.avium_104 ESYVLTQRELEDAMMEAVGLGRLGPSASLPGNPADDRGWSFTGWYDTTEA
Mb3658c|M.bovis_AF2122/97 TRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHSAVAAAVGG
Rv3634c|M.tuberculosis_H37Rv TRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHSAVAAAVGG
MUL_4210|M.ulcerans_Agy99 TRDYVFVDDVVDAFVKAGSDVGGGQRFNIGTGVETSDRQLHSAVAAAVGG
MLBr_00204|M.leprae_Br4923 TRDYVFVDDVVDAFIKASGDAGGGQRFNIGTGIETSDRQLHTAVSAAVGG
MMAR_2336|M.marinum_M HVLDCLNGYLTLADALLAGSGLGQWNFGPGRDSFVEVGQVASLAAELWGG
MAB_2971c|M.abscessus_ATCC_199 --HRLEVGELVDLLTEAAGSAVLAVPVPDSLLRAAGTVMDQIGRYVPWET
: .
MSMEG_5233|M.smegmatis_MC2_155 QEVLTFQHHSWP-QLLADTRANAGWKRYPLGLAAPLIRAFLRSKSAYKNY
TH_1115|M.thermoresistible__bu QELLKFQHYSWP-DILAETADRVGWKRYPLRLIAPLAGLYLRRQSPYHNH
Mflv_2425|M.gilvum_PYR-GCK QEVLQFQHYSWQ-DMLAEASRNAGPSKYVLPLLSPLIRAALKRRGAYWKQ
Mvan_4227|M.vanbaalenii_PYR-1 QEALQFQHYSWQ-NMLDEAQRRAGASRYVLPVFAPLVRAVLKRRSAYWKQ
MAV_2497|M.avium_104 QQLLDFQEHDWS-QTVAWLAESQGRSRLALRLLGPLLRPLLRTILIVQRR
Mb3658c|M.bovis_AF2122/97 PDDPEFHPPRLG-DLKRSCLDIGLAERVLGWRPQIELADGVRRTVEYFRH
Rv3634c|M.tuberculosis_H37Rv PDDPEFHPPRLG-DLKRSCLDIGLAERVLGWRPQIELADGVRRTVEYFRH
MUL_4210|M.ulcerans_Agy99 PDDPEFHPPRLG-DLKRSCLDISRAEEVLGWRPQVELADGVRRTVDYFRR
MLBr_00204|M.leprae_Br4923 PDDPEFHPPRLG-DLKRSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRA
MMAR_2336|M.marinum_M GAHWDLDDGDHPHEANLLALDAAKAQAELGWRNRLGFRDAVAWTIDWERQ
MAB_2971c|M.abscessus_ATCC_199 P----MTEAGMQYYTQMPASDDTPSERELGITYRDPRETLADTVVSLRAG
:
MSMEG_5233|M.smegmatis_MC2_155 P---GRYADVWNAVEKRWGNPRPDRSEA---
TH_1115|M.thermoresistible__bu P---GQYADPWGAIRRKWGEPGLDTDPEDGR
Mflv_2425|M.gilvum_PYR-GCK P---GQYADPWGAIKRRLGDPAPDA------
Mvan_4227|M.vanbaalenii_PYR-1 P---GQYADPWGAIKRGIGDPSPDS------
MAV_2497|M.avium_104 LEGRGPYADPWTLIEKKYGTAALATAD----
Mb3658c|M.bovis_AF2122/97 K-----HTD----------------------
Rv3634c|M.tuberculosis_H37Rv K-----HTD----------------------
MUL_4210|M.ulcerans_Agy99 T-----HGS----------------------
MLBr_00204|M.leprae_Br4923 A-----QRS----------------------
MMAR_2336|M.marinum_M VHG---GADPLAVTRDQIAAFESLE------
MAB_2971c|M.abscessus_ATCC_199 R-----------TTSKLWGLWPFSE------