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VHYLITGHTGFKGPWLALLLLSRGHQVSGLALDSEQAGLFKRAGLADQLVSDLRVDIRESEATTAALQAV APDVVIHLAAQSLVRESYRNPRYTYETNAMGTLNVLEAVGATPSVRAHVVITTDKVYRNVNQEAGYVETD PLGGDDPYSASKAMADLLTQSWVRSFPNCPTAIARAGNVIGGGDISRDRLFPDLVDAYARGQAPRLRFPR AVRPWQHVLDCLNGYLTLADALLAGSGLGQWNFGPGRDSFVEVGQVASLAAELWGGGAHWDLDDGDHPHE ANLLALDAAKAQAELGWRNRLGFRDAVAWTIDWERQVHGGADPLAVTRDQIAAFESLE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2336 | galE6 | - | 100% (338) | UDP-glucose 4-epimerase, GalE6 |
| M. marinum M | MMAR_1082 | rmlB | 1e-16 | 31.07% (280) | dTDP-glucose-4,6-dehydratase, RmlB |
| M. marinum M | MMAR_5133 | galE1 | 3e-16 | 29.29% (338) | UDP-glucose 4-epimerase GalE1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3493 | rmlB1 | 2e-17 | 29.94% (334) | dTDP-glucose 4,6-dehydratase RmlB1 |
| M. gilvum PYR-GCK | Mflv_3296 | - | 5e-17 | 27.99% (318) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3464 | rmlB | 2e-17 | 29.94% (334) | dTDP-glucose 4,6-dehydratase RMLB |
| M. leprae Br4923 | MLBr_01964 | rmlB | 1e-14 | 28.46% (267) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_3779 | - | 2e-18 | 29.72% (323) | dTDP-glucose 4,6-dehydratase RmlB |
| M. avium 104 | MAV_4406 | rfbB | 2e-15 | 27.08% (325) | dTDP-glucose 4,6-dehydratase |
| M. smegmatis MC2 155 | MSMEG_1512 | rfbB | 2e-18 | 29.65% (344) | dTDP-glucose 4,6-dehydratase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 2e-16 | 29.62% (314) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_0840 | rmlB | 9e-17 | 31.07% (280) | dTDP-glucose-4,6-dehydratase, RmlB |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 9e-18 | 29.38% (337) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3493|M.bovis_AF2122/97 -------------MRLLVTGGAGFIGTNFVHSAVREHPDDA--VTVLDAL
Rv3464|M.tuberculosis_H37Rv -------------MRLLVTGGAGFIGTNFVHSAVREHPDDA--VTVLDAL
MUL_0840|M.ulcerans_Agy99 -------------MRLLVTGGAGFIGANFVHSSVREYPDDA--VTVLDAL
MAV_4406|M.avium_104 -------------MRLLVTGGAGFIGANFVHSTVREHPEDS--VTVLDAL
MLBr_01964|M.leprae_Br4923 -----------MTMRLLVTGGAGFIGANFVHNAVRDHPDDT--VTVLDAM
MSMEG_1512|M.smegmatis_MC2_155 -------------MRLLVTGGAGFIGANFVHLALREARTSS--ITVLDAL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
Mvan_1365|M.vanbaalenii_PYR-1 -------------MRLLVTGGAGFIGANFVRTTVQQRPDVQ--VTVLDSL
MAB_3779|M.abscessus_ATCC_1997 -------------MRILVTGGAGFIGANFVHATVRERPDVS--VTVLDAL
Mflv_3296|M.gilvum_PYR-GCK ------------MARLLVTGGAGFIGSNFVHH-VLAHTDHH--VTVLDKL
MMAR_2336|M.marinum_M -------------MHYLITGHTGFKGPWLALLLLSRGHQVSG-LALDSEQ
:. .: :. : .
Mb3493|M.bovis_AF2122/97 TYAGRRESLADVED-AIRLVQGDITDAELVSQLVAESDAVVHFAAESHVD
Rv3464|M.tuberculosis_H37Rv TYAGRRESLADVED-AIRLVQGDITDAELVSQLVAESDAVVHFAAESHVD
MUL_0840|M.ulcerans_Agy99 TYAGRRESLADLED-AIRLVEGDITDAELVSQLVAESDAVVHFAAESHVD
MAV_4406|M.avium_104 TYAGRRESLAGVED-SIRLVVGDITDAELVSRLVAESDAVVHFAAESHVD
MLBr_01964|M.leprae_Br4923 TYAGRHESLADVDH-AVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVD
MSMEG_1512|M.smegmatis_MC2_155 TYAGSRESLAPVAD-RIRLVQGDITDAALVGDLVAESDAVVHFAAETHVD
TH_0330|M.thermoresistible__bu TYAGSRESLAPVAD-RIRVVEGDVTDSDLVDKLVAESDAVVHFAAESHVD
Mvan_1365|M.vanbaalenii_PYR-1 TYAGSRESLRGVDS-QIRLVEGDITDAELVGKLVADSDAVVHFAAETHVD
MAB_3779|M.abscessus_ATCC_1997 TYAGSSESLAPVAA-AVQLVQGDICDPDTVERLVADSDVVVHFAAETHND
Mflv_3296|M.gilvum_PYR-GCK TYAGNRASLDGLPERRLDFVHGDVADADLVDELVAGTDAVVHYAAESHND
MMAR_2336|M.marinum_M AGLFKRAGLADQLVSDLRVDIRESEATTAALQAVAP-DVVIHLAAQSLVR
: .* : . : . . ** *.*:* **::
Mb3493|M.bovis_AF2122/97 NALDNPEPFLHTNVIGTFTILEAVRRHG----VRLHHIS-TDEVYGDLEL
Rv3464|M.tuberculosis_H37Rv NALDNPEPFLHTNVIGTFTILEAVRRHG----VRLHHIS-TDEVYGDLEL
MUL_0840|M.ulcerans_Agy99 NALDNPEPFVHTNVLGTFTILEAVRRHG----VRLHHIS-TDEVYGDLEL
MAV_4406|M.avium_104 NALAGPEPFLHTNVVGTFTILEAVRRHG----VRLHHIS-TDEVYGDLEL
MLBr_01964|M.leprae_Br4923 NALDDPEPFLRTNVIGTFTILEAVRHHS----VRLHHIS-TDEVYGDLEL
MSMEG_1512|M.smegmatis_MC2_155 NALADPEPFLHSNVVGTYTILEAVRRHN----VRLHHVS-TDEVYGDLEL
TH_0330|M.thermoresistible__bu NALAEPEPFLRTNVVGTFTVLEAVRRHR----VRLHHIS-TDEVYGDLPL
Mvan_1365|M.vanbaalenii_PYR-1 NALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHIS-TDEVYGDLEL
MAB_3779|M.abscessus_ATCC_1997 NSLADPSPFLRSNIIGTYTLLEAVRRHQ----VRLHHIS-TDEVFGDLEL
Mflv_3296|M.gilvum_PYR-GCK NSLDRPEPFLHSNVIGTFTVLEAVRRHG----RRLHHVS-TDEVYGDLEL
MMAR_2336|M.marinum_M ESYRNPRYTYETNAMGTLNVLEAVGATP---SVRAHVVITTDKVYRNVNQ
:: * .:* :** .:**** * * : **:*: ::
Mb3493|M.bovis_AF2122/97 DDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYG-VRATISNCSNNY
Rv3464|M.tuberculosis_H37Rv DDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYG-VRATISNCSNNY
MUL_0840|M.ulcerans_Agy99 HDPARFTEATPYNPSSPYSATKAGADMLVRAWVRSYG-VAATISNCSNNY
MAV_4406|M.avium_104 DDPNRFTESTPYNPSSPYSATKAAADMLVRAWVRSYG-VRATISNCSNNY
MLBr_01964|M.leprae_Br4923 DEPTRFTESTPYNPSSPYSATKAAGDMLVRAWVRSYG-VRATISNCSNNY
MSMEG_1512|M.smegmatis_MC2_155 DNPARFNETTPYNPSSPYSSTKAAADLLVRAWVRSYG-VRATISNCSNNY
TH_0330|M.thermoresistible__bu HDPRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYG-VAATISNCSNNY
Mvan_1365|M.vanbaalenii_PYR-1 DDPARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYR-VAATISNCSNNY
MAB_3779|M.abscessus_ATCC_1997 DDPNRFTETTPYNPSSPYSATKASADLLVRAWIRSFG-ISATISNCSNNY
Mflv_3296|M.gilvum_PYR-GCK DDPARFTESSPYNPSSPYSSTKAGSDLLVRAWTRSFG-VAATISNCSNNY
MMAR_2336|M.marinum_M EAG--YVETDPLGGDDPYSASKAMADLLTQSWVRSFPNCPTAIARAGNVI
. : :: * . ..***::** .*:*.::* **: ::*:...*
Mb3493|M.bovis_AF2122/97 G-PYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRIL
Rv3464|M.tuberculosis_H37Rv G-PYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRIL
MUL_0840|M.ulcerans_Agy99 G-PYQHIEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRIL
MAV_4406|M.avium_104 G-PYQHVEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRIL
MLBr_01964|M.leprae_Br4923 G-PYQHVEKFIPRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQIL
MSMEG_1512|M.smegmatis_MC2_155 G-PYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVWRIL
TH_0330|M.thermoresistible__bu G-PYQHVEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVEDHNDAVWRIL
Mvan_1365|M.vanbaalenii_PYR-1 G-PYQHVEKFIPRQITNVLTGRRPELYGTGANVRDWIHVDDHNSAVWRIL
MAB_3779|M.abscessus_ATCC_1997 G-PYQHVEKFIPRQITNILTGRRPRLYGAGANVRDWIHVDDHNSAVWRII
Mflv_3296|M.gilvum_PYR-GCK G-PYQHVEKFIPRQITNVLWGIRPRLYGEGRNVRDWIHADDHSSAVLLIL
MMAR_2336|M.marinum_M GGGDISRDRLFPDLVDAYARGQAPRLR-FPRAVRPWQHVLDCLNGYLTLA
* ::::* : * *.* ** * *. * .. :
Mb3493|M.bovis_AF2122/97 DRGRIGR-----TYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVG
Rv3464|M.tuberculosis_H37Rv DRGRIGR-----TYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVG
MUL_0840|M.ulcerans_Agy99 EKGQIGK-----TYLISSEGERDNLSVLRTLLRMMDRDPDDFDHVVDRVG
MAV_4406|M.avium_104 ESGEIGR-----TYLISSEGERDNLTVLRTLLQMMGRDPDDFDHVTDRVG
MLBr_01964|M.leprae_Br4923 EKGQIGR-----TYLIGAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVG
MSMEG_1512|M.smegmatis_MC2_155 TDGTIGR-----TYLIGAECERNNLTVMRTILKLMGRDPDDFDHVTDRAG
TH_0330|M.thermoresistible__bu TAGQIGR-----TYLIGADGERDNRTVLRTILKLMDRDPDDFDHVTDRAG
Mvan_1365|M.vanbaalenii_PYR-1 HDGTVGR-----TYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDRVG
MAB_3779|M.abscessus_ATCC_1997 EAGTIGR-----TYLIGADGERDNLSVLHTILELMGKSSDDFDHVTDRAG
Mflv_3296|M.gilvum_PYR-GCK EKGRIGE-----TYLIGANGEKDNKTVVELILTLMGEDADAYDRVPDRLG
MMAR_2336|M.marinum_M DALLAGSGLGQWNFGPGRDSFVEVGQVASLAAELWGGGAHWDLDDGDHPH
* .: . : : * : . ... *:
Mb3493|M.bovis_AF2122/97 HDLRYAIDPSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDAT
Rv3464|M.tuberculosis_H37Rv HDLRYAIDPSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDAT
MUL_0840|M.ulcerans_Agy99 HDLRYAIDPSLLYNELAWAPKHTDFEEGLRTTIDWYRANESWWRPLKDAA
MAV_4406|M.avium_104 HDLRYAIDPSTLYDELCWAPKHTDFEEGLRETIDWYRANESWWRPLKDAS
MLBr_01964|M.leprae_Br4923 HDLRYAIDPTPLYNELCWAPKHANFDEGLRATIDWYRNNESWWRPLKDAV
MSMEG_1512|M.smegmatis_MC2_155 HDLRYAIDPSTLQDELGWAPKHTDFEAGLTDTIDWYRANESWWRPLKDTV
TH_0330|M.thermoresistible__bu HDLRYAIDPSALIDELGWTPRHTDFEAGLRDTIQWYRDNEDWWRPLKDAT
Mvan_1365|M.vanbaalenii_PYR-1 HDLRYAIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKDAV
MAB_3779|M.abscessus_ATCC_1997 HDLRYAIDPTPLRDELGWKPTHSDFTGGLAATIDWYRRNEEWWRPIKDNV
Mflv_3296|M.gilvum_PYR-GCK HDLRYAIDPTKLREELGWQPGYGDFEHGLAATIEWYRTHEDWWTPAKEAT
MMAR_2336|M.marinum_M EANLLALDAAKAQAELGWR-NRLGFRDAVAWTIDWERQVHGGADPLAVTR
. *:*.: ** * .* .: **:* * . *
Mb3493|M.bovis_AF2122/97 EARYQERGQ-
Rv3464|M.tuberculosis_H37Rv EARYQERGQ-
MUL_0840|M.ulcerans_Agy99 EARYQERGQ-
MAV_4406|M.avium_104 EARYEERGQ-
MLBr_01964|M.leprae_Br4923 EARYEERGR-
MSMEG_1512|M.smegmatis_MC2_155 EAKYQERGQ-
TH_0330|M.thermoresistible__bu EDAYAERGQ-
Mvan_1365|M.vanbaalenii_PYR-1 EATYQRRRR-
MAB_3779|M.abscessus_ATCC_1997 ESQYAARGQ-
Mflv_3296|M.gilvum_PYR-GCK EAFYARIGQ-
MMAR_2336|M.marinum_M DQIAAFESLE
: