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TDVENLQTIEFQVTDHVATVALNRPEKLNSFTEQMAADLATVWARVRDDDDIHVAVLCANGERAFCTGID VSEGTWWKHKTIFNQEDPGQLLGPKAHKVWKPVIAALHSIVAGGAMYFVNECDFAICGETATFFDPHANA GIVSALEPMGMLALGVPYGEVMRWALLGSEERMTAQTALRIGIVTEVVPDDQLRSRAIELAREIAARRPL GVQGTVRAMWEARDLPPTIAARHGKFYTDLGNAGATPDSLNNKKRPRTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1898 | - | - | 100% (260) | enoyl-CoA hydratase/isomerase family protein |
| M. avium 104 | MAV_2609 | - | e-134 | 88.63% (255) | enoyl-CoA hydratase/isomerase family protein |
| M. avium 104 | MAV_1581 | - | 1e-62 | 48.75% (240) | enoyl-CoA hydratase/isomerase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3545 | echA19 | 4e-19 | 30.73% (218) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4361 | - | 3e-62 | 48.63% (255) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv3516 | echA19 | 4e-19 | 30.40% (227) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 3e-12 | 26.96% (230) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_2058 | - | 1e-22 | 33.94% (218) | enoyl-CoA dehydratase/isomerase |
| M. marinum M | MMAR_4024 | echA16_1 | 9e-60 | 46.58% (234) | enoyl-CoA hydratase EchA16_1 |
| M. smegmatis MC2 155 | MSMEG_2218 | - | 2e-61 | 48.76% (242) | enoyl-CoA hydratase/isomerase family protein |
| M. thermoresistible (build 8) | TH_3648 | - | 2e-61 | 48.33% (240) | PUTATIVE Enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_3889 | echA16_1 | 3e-60 | 46.58% (234) | enoyl-CoA hydratase EchA16_1 |
| M. vanbaalenii PYR-1 | Mvan_1983 | - | 5e-59 | 47.52% (242) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4361|M.gilvum_PYR-GCK -------------MPMTFETIDLDLDHDVRVATITLNRPEALNSFNRAMC
Mvan_1983|M.vanbaalenii_PYR-1 ---------------MTFETILLDLDHEVRVATVTLNRPDALNSFNRAMC
MSMEG_2218|M.smegmatis_MC2_155 --------------MTEYETVLLDLDHEVRVATVTLNRPESLNSFNRTMC
MMAR_4024|M.marinum_M -------MTPQRSEKPDFTTILVDVNTTDHVATITLHRPDQLNAFNRTMC
MUL_3889|M.ulcerans_Agy99 -----MPVTPQRSEKPDFTTILVDVNTTDHVATITLHRPDQLNAFNRTMC
TH_3648|M.thermoresistible__bu ------------MSGPSFETIRLDVEPGDRVATITLNRPERLNAFNRTMC
MAV_1898|M.avium_104 -----------MTDVENLQTIEFQVT--DHVATVALNRPEKLNSFTEQMA
Mb3545|M.bovis_AF2122/97 ----------------MESGPDALVERRGHTLIVTMNRPAARNALSTEMM
Rv3516|M.tuberculosis_H37Rv ----------------MESGPDALVERRGHTLIVTMNRPAARNALSTEMM
MAB_2058|M.abscessus_ATCC_1997 ----------------MAEQP-IRYEVVDSVAWLTINRPEARNALNNAVR
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
. ::::** *:: :
Mflv_4361|M.gilvum_PYR-GCK REMRDAWHLVKSDESINAVVLRAAGDRAFSAGLDVKS-SYGQPDI----V
Mvan_1983|M.vanbaalenii_PYR-1 EEMKDVWRIIKADEGINAVVLRAAGERAFSAGLDVRA-SYGQPEI----V
MSMEG_2218|M.smegmatis_MC2_155 EEMRQIWHVIKGDEQINAVVLRAAGDRAFSAGLDVKS-RYGQPEI----V
MMAR_4024|M.marinum_M EEMAAAWHLIKHDESVHAVVLRAAGSRAFSAGLDIKT-PYGQPKN----I
MUL_3889|M.ulcerans_Agy99 EEMAAAWHLIKHDESVHAVVLRAAGSRAFSAGLDIKT-PYGQPKN----I
TH_3648|M.thermoresistible__bu EEMAQAWRAVKFDDRVHAVVLRAAGDRAFSAGLDIKS-SYGQPDN----V
MAV_1898|M.avium_104 ADLATVWARVRDDDDIHVAVLCANGERAFCTGIDVSEGTWWKHKT----I
Mb3545|M.bovis_AF2122/97 RIMVQAWDRVDNDPDIRCCILTGAGG-YFCAGMDLKAATQKPPGD----S
Rv3516|M.tuberculosis_H37Rv RIMVQAWDRVDNDPDIRCCILTGAGG-YFCAGMDLKAATQKPPGD----S
MAB_2058|M.abscessus_ATCC_1997 TGLIDAVLRFNDDDAAKVLVLTGVGDKAFCAGGDLKEMAQNALKV----P
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGR-GFCSGADQKFTAPVPQVEGLTQP
: . * . :* . * *.:* *
Mflv_4361|M.gilvum_PYR-GCK WNHEDPGE---LLSPKWQKMWKPVVCAVQGMCTAGALYFVNEADVVICSD
Mvan_1983|M.vanbaalenii_PYR-1 WNHEDPGE---LLSPKWQKMWKPVVCAVQGMCTAGALYFVNEADIVICSR
MSMEG_2218|M.smegmatis_MC2_155 WNHEDPGE---LLSPKWQKMWKPVVCAVHGMCTAGALYFVNESDVVICSS
MMAR_4024|M.marinum_M WNHEDPGE---FLSPKWRKMWKPVVCAVQGMCTAGAFYFINESDVVICST
MUL_3889|M.ulcerans_Agy99 WNHEDPGE---FLSPKWQKIWKPVVCAVQGMCTAGAFYFINESDVVICST
TH_3648|M.thermoresistible__bu WNHEDPGE---LLSPKWQQMWKPVVCAVHGICTAGAFYFVNEADVVICSP
MAV_1898|M.avium_104 FNQEDPGQ---LLGPKAHKVWKPVIAALHSIVAGGAMYFVNECDFAICGE
Mb3545|M.bovis_AF2122/97 FKDGSYDPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGE
Rv3516|M.tuberculosis_H37Rv FKDGSYGPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGE
MAB_2058|M.abscessus_ATCC_1997 PKD--FAP----QFGRNIDVAKPTIAAVNGVAFAGGFLLAQQCDLVVAAE
MLBr_01241|M.leprae_Br4923 VRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVAST
. : :* :.*:.. .*. : *. :..
Mflv_4361|M.gilvum_PYR-GCK GATFFDSHVSAGL-VSALEPIGLMRR-VGLGDTLRMALMGNDERVGAQTA
Mvan_1983|M.vanbaalenii_PYR-1 GATFFDSHVSAGL-VCALEPVGLMRR-IGLGDTLRMALMGNDERVGAETA
MSMEG_2218|M.smegmatis_MC2_155 DATFFDSHVSAGL-VSALEPVGLMRR-VGLGDTLRMALMGNDERVSADTA
MMAR_4024|M.marinum_M GATFFDSHVSAGL-VCALEPIGLMRR-IGLGETLRIALMGNDERVGAETA
MUL_3889|M.ulcerans_Agy99 GATFFDSHVSAGL-VCALEPIGLMRR-IGLGETLRIALMGNDERVGAETA
TH_3648|M.thermoresistible__bu DATFFDSHVSAGL-VCALEPIGLMRK-VGLAETLRIALMGNDERIGAETA
MAV_1898|M.avium_104 TATFFDPHANAGI-VSALEPMGMLALGVPYGEVMRWALLGSEERMTAQTA
Mb3545|M.bovis_AF2122/97 SAKFGISEAKWSL-YPMGGSAVRLVRQIPYTLACDLLLTG--RHITAAEA
Rv3516|M.tuberculosis_H37Rv SAKFGISEAKWSL-YPMGGSAVRLVRQIPYTLACDLLLTG--RHITAAEA
MAB_2058|M.abscessus_ATCC_1997 HATFAVSEVKVGR-GSP--WATPLSWLVPPRVAMQILLTG--DPITAARA
MLBr_01241|M.leprae_Br4923 RAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSG--RDVGAEEA
* * . . . : : . * * : * *
Mflv_4361|M.gilvum_PYR-GCK LRIGLVTEVVPEDELWSRAHEIATAIAAKPPTATQGTVKAIWESLDKPYR
Mvan_1983|M.vanbaalenii_PYR-1 LRIGLVTEVVDENDLWARAHEIATTIAAKPPTATQGTVKAIWESLDKPYR
MSMEG_2218|M.smegmatis_MC2_155 LRIGLVTEVVPREQLWARAHQIASTIATKPPTATQGTVRAIWESLDRPYR
MMAR_4024|M.marinum_M LRIGLVSEVVAPQRLWERAHEIAATIAAKPPSATQGTVKAIWESLDKPYR
MUL_3889|M.ulcerans_Agy99 LRIGLVSEVVAPQRLWGRAHEIAATIAAKPPSATQGTVKAIWESLDKPYR
TH_3648|M.thermoresistible__bu LRISLVTEIVPREQLWDRAHEIAATIAAKPPSATQGTVKAIWESLDRPYR
MAV_1898|M.avium_104 LRIGIVTEVVPDDQLRSRAIELAREIAARRPLGVQGTVRAMWEARDLPPT
Mb3545|M.bovis_AF2122/97 KEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPEN
Rv3516|M.tuberculosis_H37Rv KEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPEN
MAB_2058|M.abscessus_ATCC_1997 HQVGLVNEVVPADQLRERTQQLALSIAANAPLSVLASKRTVYLSAQHHLA
MLBr_01241|M.leprae_Br4923 EQIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASL
.:.:: * .:* ::: .. :::
Mflv_4361|M.gilvum_PYR-GCK AAMDQGLIYTRLGNPIAKAELAERPI--PKTAPRIR-----------
Mvan_1983|M.vanbaalenii_PYR-1 AAMDQGLIYTRLGNPIAKAELAERPV--PKTPPRIR-----------
MSMEG_2218|M.smegmatis_MC2_155 AAMDQGLIYTRLGNPIAKAELADRPV--PKTPPRIR-----------
MMAR_4024|M.marinum_M AAVEQGLIYTRLGNPLGRAELADLPPRPDGSEPKTR-----------
MUL_3889|M.ulcerans_Agy99 AAVEQGLIYTRLGNPLGRAELADLPPRPDGSEPKTR-----------
TH_3648|M.thermoresistible__bu AAMEQGLIYTRLGNPLGQAELAEAAP-THVPAPRIR-----------
MAV_1898|M.avium_104 IAARHGKFYTDLGNAGATPDSLNNKK-----RPRTR-----------
Mb3545|M.bovis_AF2122/97 EAFKIDTQIGIKVFLSDDAKEGPRAFA-EKRAPNFQNR---------
Rv3516|M.tuberculosis_H37Rv EAFKIDTQIGIKVFLSDDAKEGPRAFA-EKRAPNFQNR---------
MAB_2058|M.abscessus_ATCC_1997 AAYDLADEIWEPVYLSDDAQEGPAAFR-EKRAPQWKGH---------
MLBr_01241|M.leprae_Br4923 DKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG
.. *