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TFETILLDLDHEVRVATVTLNRPDALNSFNRAMCEEMKDVWRIIKADEGINAVVLRAAGERAFSAGLDVR ASYGQPEIVWNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGALYFVNEADIVICSRGATFFDSHVSAGLV CALEPVGLMRRIGLGDTLRMALMGNDERVGAETALRIGLVTEVVDENDLWARAHEIATTIAAKPPTATQG TVKAIWESLDKPYRAAMDQGLIYTRLGNPIAKAELAERPVPKTPPRIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1983 | - | - | 100% (259) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_1984 | - | 2e-36 | 39.39% (231) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_2320 | - | 1e-23 | 34.55% (220) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2855 | echA16 | 1e-24 | 33.77% (228) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4361 | - | 1e-137 | 88.80% (259) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv2831 | echA16 | 1e-24 | 33.77% (228) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 3e-17 | 28.51% (228) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3124 | - | 8e-24 | 35.68% (199) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4024 | echA16_1 | 1e-115 | 77.82% (248) | enoyl-CoA hydratase EchA16_1 |
| M. avium 104 | MAV_1581 | - | 1e-116 | 80.00% (245) | enoyl-CoA hydratase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_2218 | - | 1e-132 | 86.38% (257) | enoyl-CoA hydratase/isomerase family protein |
| M. thermoresistible (build 8) | TH_3648 | - | 1e-116 | 75.68% (259) | PUTATIVE Enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_3889 | echA16_1 | 1e-115 | 77.82% (248) | enoyl-CoA hydratase EchA16_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1983|M.vanbaalenii_PYR-1 ---------------MTFETILLDLDHEVRVATVTLNRPDALNSFNRAMC
Mflv_4361|M.gilvum_PYR-GCK -------------MPMTFETIDLDLDHDVRVATITLNRPEALNSFNRAMC
MSMEG_2218|M.smegmatis_MC2_155 --------------MTEYETVLLDLDHEVRVATVTLNRPESLNSFNRTMC
MMAR_4024|M.marinum_M -------MTPQRSEKPDFTTILVDVNTTDHVATITLHRPDQLNAFNRTMC
MUL_3889|M.ulcerans_Agy99 -----MPVTPQRSEKPDFTTILVDVNTTDHVATITLHRPDQLNAFNRTMC
MAV_1581|M.avium_104 -----MPMSAQ------FDTILLEVDATDHVATITLNRPEQLNAFNRAMC
TH_3648|M.thermoresistible__bu -------MSGP-----SFETIRLDVEPGDRVATITLNRPERLNAFNRTMC
Mb2855|M.bovis_AF2122/97 -----------------MTDDILLIDTDERVRTLTLNRPQSRNALSAALR
Rv2831|M.tuberculosis_H37Rv -----------------MTDDILLIDTDERVRTLTLNRPQSRNALSAALR
MAB_3124|M.abscessus_ATCC_1997 -----------------MTEPILLTHTEDRICTITLNRPQARNALSTALG
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
: .: :**:** *:: :
Mvan_1983|M.vanbaalenii_PYR-1 EEMKDVWRIIKADEGINAVVLRAAG-------ERAFSAGLDVRASYGQPE
Mflv_4361|M.gilvum_PYR-GCK REMRDAWHLVKSDESINAVVLRAAG-------DRAFSAGLDVKSSYGQPD
MSMEG_2218|M.smegmatis_MC2_155 EEMRQIWHVIKGDEQINAVVLRAAG-------DRAFSAGLDVKSRYGQPE
MMAR_4024|M.marinum_M EEMAAAWHLIKHDESVHAVVLRAAG-------SRAFSAGLDIKTPYGQPK
MUL_3889|M.ulcerans_Agy99 EEMAAAWHLIKHDESVHAVVLRAAG-------SRAFSAGLDIKTPYGQPK
MAV_1581|M.avium_104 AEMAQAWRLVKLDDAVHAVVLRAAG-------DRAFSAGLDIKTPYGQPE
TH_3648|M.thermoresistible__bu EEMAQAWRAVKFDDRVHAVVLRAAG-------DRAFSAGLDIKSSYGQPD
Mb2855|M.bovis_AF2122/97 DRFFAALADAEADDDIDVVILTGA--------DPVFCAGLDLKELAGQ--
Rv2831|M.tuberculosis_H37Rv DRFFAALADAEADDDIDVVILTGA--------DPVFCAGLDLKELAGQ--
MAB_3124|M.abscessus_ATCC_1997 EEIVKAVTAADADENVDVMILTAA--------DPVFCAGVDLKELGSG--
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQPV
: *. : .::* .* . * * :
Mvan_1983|M.vanbaalenii_PYR-1 IVWNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGALYFVNEADIVICSRG
Mflv_4361|M.gilvum_PYR-GCK IVWNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGALYFVNEADVVICSDG
MSMEG_2218|M.smegmatis_MC2_155 IVWNHEDPGELLSPKWQKMWKPVVCAVHGMCTAGALYFVNESDVVICSSD
MMAR_4024|M.marinum_M NIWNHEDPGEFLSPKWRKMWKPVVCAVQGMCTAGAFYFINESDVVICSTG
MUL_3889|M.ulcerans_Agy99 NIWNHEDPGEFLSPKWQKIWKPVVCAVQGMCTAGAFYFINESDVVICSTG
MAV_1581|M.avium_104 NIWNHEDPGEALSPKWQKMWKPVVCAVQGMCTAGAFYFVNESDVVICSQD
TH_3648|M.thermoresistible__bu NVWNHEDPGELLSPKWQQMWKPVVCAVHGICTAGAFYFVNEADVVICSPD
Mb2855|M.bovis_AF2122/97 ------TALPDISPRWPAMTKPVIGAINGAAVTGGLELALYCDILIASEH
Rv2831|M.tuberculosis_H37Rv ------TALPDISPRWPAMTKPVIGAINGAAVTGGLELALYCDILIASEH
MAB_3124|M.abscessus_ATCC_1997 ------DRAESLDPWWPELSKPVIGAINGAAVTGGLELALACDILIASEK
MLBr_01241|M.leprae_Br4923 RALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVASTR
: : :**: *::* . *.: : .*: :.*
Mvan_1983|M.vanbaalenii_PYR-1 ATFFDSHVSAGLVC-ALEP-VGLMRRIGLGDTLRMALMGNDERVGAETAL
Mflv_4361|M.gilvum_PYR-GCK ATFFDSHVSAGLVS-ALEP-IGLMRRVGLGDTLRMALMGNDERVGAQTAL
MSMEG_2218|M.smegmatis_MC2_155 ATFFDSHVSAGLVS-ALEP-VGLMRRVGLGDTLRMALMGNDERVSADTAL
MMAR_4024|M.marinum_M ATFFDSHVSAGLVC-ALEP-IGLMRRIGLGETLRIALMGNDERVGAETAL
MUL_3889|M.ulcerans_Agy99 ATFFDSHVSAGLVC-ALEP-IGLMRRIGLGETLRIALMGNDERVGAETAL
MAV_1581|M.avium_104 ATFFDSHVSAGLVC-ALEP-VGLMRRIGLGETLRIALMGNDERVGADTAL
TH_3648|M.thermoresistible__bu ATFFDSHVSAGLVC-ALEP-IGLMRKVGLAETLRIALMGNDERIGAETAL
Mb2855|M.bovis_AF2122/97 ARFADTHARVGLLP-TWGLSVRLPQKVGIGLARRMSLTG--DYLSATDAL
Rv2831|M.tuberculosis_H37Rv ARFADTHARVGLLP-TWGLSVRLPQKVGIGLARRMSLTG--DYLSATDAL
MAB_3124|M.abscessus_ATCC_1997 ARFADTHARVGILP-TWGLTTLLPLSVGRGLARRMSLTG--DYLSAEDAL
MLBr_01241|M.leprae_Br4923 AYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSG--RDVGAEEAE
* * : *: * :* . : .: * * :.* *
Mvan_1983|M.vanbaalenii_PYR-1 RIGLVTEVVDENDLWARAHEIATTIAAKPPTATQGTVKAIWESLDKP--Y
Mflv_4361|M.gilvum_PYR-GCK RIGLVTEVVPEDELWSRAHEIATAIAAKPPTATQGTVKAIWESLDKP--Y
MSMEG_2218|M.smegmatis_MC2_155 RIGLVTEVVPREQLWARAHQIASTIATKPPTATQGTVRAIWESLDRP--Y
MMAR_4024|M.marinum_M RIGLVSEVVAPQRLWERAHEIAATIAAKPPSATQGTVKAIWESLDKP--Y
MUL_3889|M.ulcerans_Agy99 RIGLVSEVVAPQRLWGRAHEIAATIAAKPPSATQGTVKAIWESLDKP--Y
MAV_1581|M.avium_104 RIGLVTEVVPAERLWDRAHEIAATIAAKPPTATAGTVKAIWESLDKP--Y
TH_3648|M.thermoresistible__bu RISLVTEIVPREQLWDRAHEIAATIAAKPPSATQGTVKAIWESLDRP--Y
Mb2855|M.bovis_AF2122/97 RAGLVTEVVAHDQLLPTARRVAASIVGN----NQNAVRALLASYHRI--D
Rv2831|M.tuberculosis_H37Rv RAGLVTEVVAHDQLLPTARRVAASIVGN----NQNAVRALLASYHRI--D
MAB_3124|M.abscessus_ATCC_1997 RAGLVTEVVAHNELLPAAKRLAATIAGN----NQPAVRELLASYRRI--E
MLBr_01241|M.leprae_Br4923 QIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASLD
: .**: * : * . :*: :. . : : : .
Mvan_1983|M.vanbaalenii_PYR-1 RAAMDQGLIYTRLGNPIAKAELA----ERPVPKTP-PRIR------
Mflv_4361|M.gilvum_PYR-GCK RAAMDQGLIYTRLGNPIAKAELA----ERPIPKTA-PRIR------
MSMEG_2218|M.smegmatis_MC2_155 RAAMDQGLIYTRLGNPIAKAELA----DRPVPKTP-PRIR------
MMAR_4024|M.marinum_M RAAVEQGLIYTRLGNPLGRAELA---DLPPRPDGSEPKTR------
MUL_3889|M.ulcerans_Agy99 RAAVEQGLIYTRLGNPLGRAELA---DLPPRPDGSEPKTR------
MAV_1581|M.avium_104 RAAMEQGLIYTRLGNPLGTAELAAGRDAGARGAARTPKIR------
TH_3648|M.thermoresistible__bu RAAMEQGLIYTRLGNPLGQAELA---EAAP-THVPAPRIR------
Mb2855|M.bovis_AF2122/97 ESQTAAGLWLEACAAKQFCTSG---DTIAANREAVLQRGRAQVR--
Rv2831|M.tuberculosis_H37Rv ESQTAAGLWLEACAAKQFRTSG---DTIAANREAVLQRGRAQVR--
MAB_3124|M.abscessus_ATCC_1997 SELVGNGLQVALDDAHRWIDQNSIAEGVEARRTAIMERGRSQNA--
MLBr_01241|M.leprae_Br4923 KHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG
.* .