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MMSQAPAPADAVDVSRVDTENYRSIWMYLKELEFRQGFIDIPVNGVLVRTRYAEAGGPDKPHAILLHGTG GHWETFAPNLAALSQHFHCVAIDMVGNGFSGKPDYDYEIAVYVEHVLGVMDHFGMASANFIAMSLGAFVA SAVCVGHADRVEKVILMSPAGREASASNMARIRTERTKAVNEPTWESLHAVFAHLIADEANRLPDLIGLR QAVYRREDTRNTIDRLLILQDEKVRHRNLIPDDKWRGIEAPVMIVASGKDHGVYQDTARTIADLIPNSEV FEMPSVRHWPHFEDPEAFNAAAIEFLTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2616 | - | - | 100% (308) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. avium 104 | MAV_1905 | - | e-161 | 87.66% (308) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. avium 104 | MAV_0877 | - | 4e-51 | 36.14% (285) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 5e-19 | 26.43% (280) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_2400 | - | 3e-52 | 35.44% (285) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 5e-19 | 26.43% (280) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02269 | - | 2e-12 | 22.34% (273) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3810 | - | 1e-15 | 26.28% (274) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4778 | bphD_1 | 2e-52 | 36.71% (286) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1 |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 4e-59 | 38.95% (285) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 1e-52 | 36.52% (282) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4140 | bphD | 4e-18 | 25.96% (285) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_4246 | - | 4e-54 | 37.54% (285) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 ---------------------MTATEELTFESTSRFAEVDVDGP---LKL
Rv3569c|M.tuberculosis_H37Rv ---------------------MTATEELTFESTSRFAEVDVDGP---LKL
MUL_4140|M.ulcerans_Agy99 -----------------MTVTQSKTAEHTFESTSRYAEVDVDGP---LKL
MAB_3810|M.abscessus_ATCC_1997 -------------------------MDVTYEGTKRELATDEG------TL
Mflv_2400|M.gilvum_PYR-GCK ------------------MAEFESVWSDLQGVAFSQGYLDAGG----VRT
Mvan_4246|M.vanbaalenii_PYR-1 ------------------MTEFESVWSDLQGVPFSQGYLDAGG----VRT
TH_4528|M.thermoresistible__bu ------------------------VWSDLQGVAFTQGYLDAGG----VRT
MSMEG_4867|M.smegmatis_MC2_155 -------MTSTAAAGTASAVEFESIWSDLQGVAFSQGYLDVPVGDRKIRT
MMAR_4778|M.marinum_M ------------------MTDFESVWSDLQGVMFEQGYLTTAQG---VRT
MAV_2616|M.avium_104 MMSQAPAPADAVDVSRVDTENYRSIWMYLKELEFRQGFIDIPVNGVLVRT
MLBr_02269|M.leprae_Br4923 ----------------------------------------------MINL
Mb3600c|M.bovis_AF2122/97 HYHEAG-VGNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPG
Rv3569c|M.tuberculosis_H37Rv HYHEAG-VGNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPG
MUL_4140|M.ulcerans_Agy99 HYHEAG-VGNDQTVVLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPG
MAB_3810|M.abscessus_ATCC_1997 RYHEAGTAGEGEPLILLHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPG
Mflv_2400|M.gilvum_PYR-GCK RYLHAG-DPADPALVFLHGSG---GHAEAYVRNLEAHAEHFSTWSIDMLG
Mvan_4246|M.vanbaalenii_PYR-1 RYLHAG-DPGKPALVFLHGSG---GHAEAYVRNLEAHAEHFSTWSIDMLG
TH_4528|M.thermoresistible__bu RYLHAG-EADKPVLIFLHGSG---GHAEAYVRNLEAHAEHFSTWSIDMLG
MSMEG_4867|M.smegmatis_MC2_155 RYLHAG-NPQAPALLFLHGSG---GHAEAYVRNLAAHAEHFSTWSIDMLG
MMAR_4778|M.marinum_M RYLRAG-EPDRPLLMLLHGSG---GHAEAYVRNLAAHAEHFWTWAIDMLG
MAV_2616|M.avium_104 RYAEAG-GPDKPHAILLHGTG---GHWETFAPNLAALSQHFHCVAIDMVG
MLBr_02269|M.leprae_Br4923 AYEDRG---TGEPVVFIAGRGGAGRTWQPHQ-VPAFLAAGYRVITFDNRG
* * ::: * * . : : .: *
Mb3600c|M.bovis_AF2122/97 YGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFAL
Rv3569c|M.tuberculosis_H37Rv YGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFAL
MUL_4140|M.ulcerans_Agy99 YGHSDKRAEHGQFNHYAARALKELFDQLGLGRVLLVGNSLGGGTAVRFAL
MAB_3810|M.abscessus_ATCC_1997 FGVSDAVPGHPVLT--AGASVIRFMDGLGISSAAVVGNSMGGVVGINLAI
Mflv_2400|M.gilvum_PYR-GCK HGYTDK-PGHPLEIPHYVDHLAAFLDAIGARRAHISGESLGGWVAARIAA
Mvan_4246|M.vanbaalenii_PYR-1 HGYTDK-PGHPLEIAHYVEHLAGFLDAIGASRAHISGESLGGWVAARFAA
TH_4528|M.thermoresistible__bu HGYTDK-PGHPLEVRHYVEHLAAVLDAIGADRAHISGESLGGWVASRFAI
MSMEG_4867|M.smegmatis_MC2_155 HGYTDK-PGHPLEVAHYVDHVIAFLDTIGAQRAHISGESLGGWVAARVAV
MMAR_4778|M.marinum_M HGYTDK-PGHPLEIRHYVEHLMAVLRAIGAQRASISGESLGGWVAARAAV
MAV_2616|M.avium_104 NGFSGK-PDYDYEIAVYVEHVLGVMDHFGMASANFIAMSLGAFVASAVCV
MLBr_02269|M.leprae_Br4923 IGATEN--TEGFTTQTMVADTAVLIESLGAVPARIVGVSMGSFIAQELMV
* : .: :* . . . *:*. .
Mb3600c|M.bovis_AF2122/97 DYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLR
Rv3569c|M.tuberculosis_H37Rv DYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLR
MUL_4140|M.ulcerans_Agy99 DYPDRAGRLVLMGPGGLSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLR
MAB_3810|M.abscessus_ATCC_1997 KHPDRITKLVTIG--GVGPNIFSPSPSEGLRLLQEFTDNPDRDKLIRWLN
Mflv_2400|M.gilvum_PYR-GCK DRPERVDRLVLNTAGGSQADPEVMKRIITLS--MAAAENPTWDTVQARIK
Mvan_4246|M.vanbaalenii_PYR-1 DRPERVERLVLNTAGGSQADPEVMKRIVTLS--MAAAENPTWETVQARIK
TH_4528|M.thermoresistible__bu DRPDRLDRLVLNTAGGSQADPEVMKRIITLS--MAAAENPSWDTVQARIT
MSMEG_4867|M.smegmatis_MC2_155 DHPDRVEKLVLNTAGGSQADPEVMKRIITLS--MAAAENPTWDTVQARIK
MMAR_4778|M.marinum_M DHPEAVERLVLNTAGGSQADPEVMARIVTLS--MAAAENPTWETVQARIK
MAV_2616|M.avium_104 GHADRVEKVILMSPAGREASASNMARIRTER--TKAVNEPTWESLHAVFA
MLBr_02269|M.leprae_Br4923 ARPELVRAAVLMATRGRLDRTRQFFHAAEAEFHDSGIQLPSGYNAKVRLL
. : * * . :
Mb3600c|M.bovis_AF2122/97 VMVYDKNLITPELVDQRFALASTPESLTATRAMG--KSFAG-----ADFE
Rv3569c|M.tuberculosis_H37Rv VMVYDKNLITPELVDQRFALASTPESLTATRAMG--KSFAG-----ADFE
MUL_4140|M.ulcerans_Agy99 VMVYDQKLITPELVDQRFELARTPESLAATRAMG--KSFAA-----ADFE
MAB_3810|M.abscessus_ATCC_1997 SMVWDPAVVTDELIEERWEAAINPDAHKTAQLMYGSKAFAMQQQFLANAD
Mflv_2400|M.gilvum_PYR-GCK WLMADKSKDYDDIVASRQRVYRQPGFANAMRDIMALQDPEIR------QR
Mvan_4246|M.vanbaalenii_PYR-1 WLMADKTKDYDDIVASRQRVYRQPGFVNAMRDIMALQDPEIR------AR
TH_4528|M.thermoresistible__bu WLMADKSKGYDDIVASRQKIYRQPGFVDAMRNIMALQDPEIR------AR
MSMEG_4867|M.smegmatis_MC2_155 WLMADKSKDYDDIVASRQRVYRQPGFVAAMSDIMALQDPQIR------AR
MMAR_4778|M.marinum_M WLMADKSKDYDDLVASRQRIYRQPGFVAAMRDIMALQDPQIR------AR
MAV_2616|M.avium_104 HLIADEANRLPDLIGLRQAVYRREDTRNTIDRLLILQDEKVR------HR
MLBr_02269|M.leprae_Br4923 ENLSRKTLNDDVAVADWIAMFN-MWPIKSTPGLRCQTDVAPQ--------
: : : :
Mb3600c|M.bovis_AF2122/97 AGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCG
Rv3569c|M.tuberculosis_H37Rv AGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCG
MUL_4140|M.ulcerans_Agy99 LGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCG
MAB_3810|M.abscessus_ATCC_1997 IPPYWAMMHKIKCPTLLTWGRDDRVSPPDMAIVPMRLIPNAELHIFPNSG
Mflv_2400|M.gilvum_PYR-GCK NLLGPNEYGAITAPTLVVWTSDDPTADVEEGRRIASMIPGARFEVMPGCG
Mvan_4246|M.vanbaalenii_PYR-1 NLLGTNEYGAITAPTLVVWTSDDPTADVKEGRRIASMIPGARFEVMPGCG
TH_4528|M.thermoresistible__bu NLLGPEEYGAITAPTLVVWTSDDPTADVDEGKRIASMIPGARFEVMPGCG
MSMEG_4867|M.smegmatis_MC2_155 NLLGQAEYGSITAPTLVVWTSDDPTADVAEGRRIASMIPGARFEVMPGCG
MMAR_4778|M.marinum_M NLLGPAEYGAIKAPTLVLWTSHDPTADVTEGRRIASMIPGARFEVMSGCG
MAV_2616|M.avium_104 NLIPDDKWRGIEAPVMIVASGKDHGVYQDTARTIADLIPNSEVFEMPSVR
MLBr_02269|M.leprae_Br4923 -NNRLPAYRSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQIPDAG
: *.:: .* . :* .. :
Mb3600c|M.bovis_AF2122/97 HWVQVEKFDEFNKLTIEFLGGGR----
Rv3569c|M.tuberculosis_H37Rv HWVQVEKFDEFNKLTIEFLGGGR----
MUL_4140|M.ulcerans_Agy99 HWAQVEKFDEFNRLTIDFLGGAR----
MAB_3810|M.abscessus_ATCC_1997 HWVMIEAKQAFEQTVVDFLRR------
Mflv_2400|M.gilvum_PYR-GCK HWPQYEDPKTFDRLHLDFLLGRA----
Mvan_4246|M.vanbaalenii_PYR-1 HWPQYEDPKTFDRLHLDFLLGRA----
TH_4528|M.thermoresistible__bu HWPQYEDPATFNRLHIDFLLGRS----
MSMEG_4867|M.smegmatis_MC2_155 HWPQYEDPATFNALHLDFLLGR-----
MMAR_4778|M.marinum_M HWPQYEDAKSFNRRHLDFLMGH-----
MAV_2616|M.avium_104 HWPHFEDPEAFNAAAIEFLTR------
MLBr_02269|M.leprae_Br4923 HLGFFERPEAVNAAALQFFAGVKGEWP
* * .: ::*: