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SAPSQVLNPPTQVAPTEIYLDYAATAPLHPRAAQAVLNGHQLVGNPSSRHGAGRDAADALAAARKTVARL LGADAEEVVLTSGGSEANTLALWGTFAAVGFRGHLVTSSIEHPAVLANAHALRDLGVQVTLVDPAPSGHI CSADVAQALRPDTTLVSVMHANNETGAIQPVWEIADIARQSGVAFHTDAVHTAGKLDLTVVGATMMSVSA HKFGGPRGIGALLVRSGHRLLPVTRGGPQENRLRAGTENVPGALGMAAAADVCLRTVEREYRLGMRKRRE QLIDGLRAVGGVHLNVTEPVLEETVSVRFDGVRADTLADHLDMHGIYVSTGSACHAGEDTVSHVLRAMCL TEDQARGTVRFSLGPGVSPADVDTVVAVTVQAVHRLRATAGGMIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4673c | - | - | 100% (396) | putative aminotransferase/cysteine desulfhydrase |
| M. abscessus ATCC 19977 | MAB_3357c | - | 4e-58 | 37.82% (386) | putative aminotransferase/cysteine desulfurase |
| M. abscessus ATCC 19977 | MAB_1093c | - | 1e-49 | 37.57% (370) | putative L-cysteine desulfurase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3051c | iscS | 2e-64 | 40.62% (384) | cysteine desulfurase IscS |
| M. gilvum PYR-GCK | Mflv_4255 | - | 1e-66 | 42.16% (389) | aminotransferase, class V |
| M. tuberculosis H37Rv | Rv3025c | iscS | 2e-64 | 40.62% (384) | cysteine desulfurase IscS |
| M. leprae Br4923 | MLBr_01708 | - | 1e-61 | 39.44% (393) | putative aminotransferase |
| M. marinum M | MMAR_1689 | iscS | 4e-63 | 40.78% (385) | cysteine desulfurase IscS |
| M. avium 104 | MAV_3872 | - | 6e-67 | 42.60% (385) | cysteine desulfurase |
| M. smegmatis MC2 155 | MSMEG_2357 | - | 8e-67 | 40.71% (393) | cysteine desulfurase |
| M. thermoresistible (build 8) | TH_1185 | - | 2e-67 | 40.87% (389) | PROBABLE CYSTEINE DESULFURASE ISCS (NIFS PROTEIN HOMOLOG) |
| M. ulcerans Agy99 | MUL_1927 | iscS | 1e-62 | 40.52% (385) | cysteine desulfurase IscS |
| M. vanbaalenii PYR-1 | Mvan_2105 | - | 1e-67 | 41.49% (388) | aminotransferase, class V |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3051c|M.bovis_AF2122/97 ------------------------------MAYLDHAATTPMHPAAIEAM
Rv3025c|M.tuberculosis_H37Rv ------------------------------MAYLDHAATTPMHPAAIEAM
MLBr_01708|M.leprae_Br4923 ----------------MIRQAPIAGILKCVMAYLDHAATTPMHPAAIEAM
MAV_3872|M.avium_104 ------------------------------MVYLDHAATTPMHPAAVEAM
MMAR_1689|M.marinum_M ------------------------------MVYLDHAATTPMHPTAIEAM
MUL_1927|M.ulcerans_Agy99 ------------------------------MVYLDHAATTPMHPTAIEAM
MSMEG_2357|M.smegmatis_MC2_155 -----------------------MTSTAGRQVYLDHAATTPMHPAAIEAM
TH_1185|M.thermoresistible__bu -------------------------MNTPQTVYLDHAATTPMYPAAITAM
Mflv_4255|M.gilvum_PYR-GCK MRWSRERDRGARPRGRYPGTAMSASAAAPRPVYLDHAATTPMRPAAIEAM
Mvan_2105|M.vanbaalenii_PYR-1 ----------------MPG---------PAPVYLDHAATTPMRPGAIEAM
MAB_4673c|M.abscessus_ATCC_199 -------------MSAPSQVLNPPTQVAPTEIYLDYAATAPLHPRAAQAV
***:***:*: * * *:
Mb3051c|M.bovis_AF2122/97 AAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTE
Rv3025c|M.tuberculosis_H37Rv AAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTE
MLBr_01708|M.leprae_Br4923 TTALGTVGNASSLHTSGRVARRRIEESRELIADKLAARPSEVIFTAGGTE
MAV_3872|M.avium_104 TAVLGTVGNASSLHTSGRAARRRIEESRELVADKLGARPSEVIFTAGGTE
MMAR_1689|M.marinum_M MAVLATVGNASSLHTTGRAARRRLEESRELIAAKLGARPSEVIFTAGGTE
MUL_1927|M.ulcerans_Agy99 TAVLATVGNASSLHTTGRAARRRLEESRELIAAKLGARPSEVIFTAGGTE
MSMEG_2357|M.smegmatis_MC2_155 TAVLAGVGNASSLHGSGRAARRRMEEAREALARLLGARPSEIIFTTGGTE
TH_1185|M.thermoresistible__bu TDVMSTVGNASSLHSSGRVARRRMEEARETLARLLGARPSEVVFTAGGTE
Mflv_4255|M.gilvum_PYR-GCK TAALATVGNASSLHGSGRTARRRLEESRETLAQLLGARPSEVIFTAGGTE
Mvan_2105|M.vanbaalenii_PYR-1 TAALATVGNAASLHGSGRLARRRLEESRETLARLLGARPSEVIFTAGGTE
MAB_4673c|M.abscessus_ATCC_199 LNGHQLVGNPSSRHGAGRDAADALAAARKTVARLLGADAEEVVLTSGGSE
:**.:* * :** * : :*: :* *.* ..*:::*:**:*
Mb3051c|M.bovis_AF2122/97 SDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTW
Rv3025c|M.tuberculosis_H37Rv SDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTW
MLBr_01708|M.leprae_Br4923 SDNLAVKGIYWARRDAQPCHRRIVTTEVEHHAVLDSVNWLVEHEGAEVTW
MAV_3872|M.avium_104 SDNLAVKGIYWARRDAEPRQRRIVTSEVEHHAVLDSVNWLVEHEGAEVTW
MMAR_1689|M.marinum_M SDNLAVKGMYWARRDAQPARRRIVTTRVEHHAVLDTVDWLVEHEGAEVTW
MUL_1927|M.ulcerans_Agy99 SDNLAVKGMYWARRDAQPARRRIVTTRVEHHAVLDTVDWLVEHEGAEVTW
MSMEG_2357|M.smegmatis_MC2_155 SDNLAVKGIYWARHDADPARRRIITTAVEHHAVLDAVEWLVAHEGAEVTW
TH_1185|M.thermoresistible__bu SDNLAVKGLYWARRAASPGLRRIITTRVEHHAVLDAVDWLVQHEGAEVTW
Mflv_4255|M.gilvum_PYR-GCK SDNLAVKGIYWARRDAEPQRRRIVTTPVEHHAVLDAVQWLADHEGAEVTW
Mvan_2105|M.vanbaalenii_PYR-1 SDNLVVKGIYWARRASSPKRRRIITTPVEHHAVLDAVEWLVEHEDAEVTW
MAB_4673c|M.abscessus_ATCC_199 ANTLAL----WGTFAAVGFRGHLVTSSIEHPAVLANAHALRDLG-VQVTL
::.*.: *. : :::*: :** *** .. * ..**
Mb3051c|M.bovis_AF2122/97 LPTAADGSVSATALREALQS-HDDVALVSVMWANNEVGTILPIAEMSVVA
Rv3025c|M.tuberculosis_H37Rv LPTAADGSVSATALREALQS-HDDVALVSVMWANNEVGTILPIAEMSVVA
MLBr_01708|M.leprae_Br4923 LPTAADGSVSAFGLREALQQ-HNDVALVSVMWANNEVGTVMPVVELAAVA
MAV_3872|M.avium_104 LPTAADGSVSPAALREVLTR-HDDVALVSVMWANNEVGTVQPVAELAAVA
MMAR_1689|M.marinum_M LPTDADGSVSASALRDALES-HDDVALVSVMWANNEVGTIMPIAELAGVA
MUL_1927|M.ulcerans_Agy99 LPTDADGSVSASALRDALES-HDDVALVSVMWANNEVGTIMPIAELAGVA
MSMEG_2357|M.smegmatis_MC2_155 LPVDRDGAVSPAALREALQAGAHDVALVSVMWANNEVGTIMPIAELAAVA
TH_1185|M.thermoresistible__bu LPVEPDGSVTPATLREALRA-HDDVALVTLMWANNEVGTVSPIAELAAVA
Mflv_4255|M.gilvum_PYR-GCK LPVDQYGAVNPADLRVALSE-TADVALVSVMWANNEVGTIQPIAELAAIA
Mvan_2105|M.vanbaalenii_PYR-1 LPVDEFGAVGAADLRTALAD-PDDVALISVMWANNEVGTIMPIHELASVA
MAB_4673c|M.abscessus_ATCC_199 VDPAPSGHICSADVAQALRP---DTTLVSVMHANNETGAIQPVWEIADIA
: * : . : .* *.:*:::* ****.*:: *: *:: :*
Mb3051c|M.bovis_AF2122/97 MEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRR
Rv3025c|M.tuberculosis_H37Rv MEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRR
MLBr_01708|M.leprae_Br4923 AEFGVPMHSDAIQAVGQLPVKFGVSGLSAMSVAAHKFGGPPGVGALLLRR
MAV_3872|M.avium_104 AEFGVPMHSDAVQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLLRR
MMAR_1689|M.marinum_M AEFGVPMHSDAVQAVGQVPVDFGACGLAAMSVTAHKFGGPPGAGALLMRR
MUL_1927|M.ulcerans_Agy99 AEFGVPMHSDAVQAVGQIPVDFGACGLAAMSVTAHKFGGPPGAGALLMRR
MSMEG_2357|M.smegmatis_MC2_155 AEFGVPMHSDAVQAVGQIPVNFGASGLAAMSVTAHKFGGPTGVGALLLRR
TH_1185|M.thermoresistible__bu AEFSVPMHSDAVQAVGHLPVDFSASGLSAMSISAHKFGGPTGVGALLIRR
Mflv_4255|M.gilvum_PYR-GCK TEFGVPMHSDAIQAIGQLPVDFGASGLSAMSVAAHKFGGPAGVGALLLRR
Mvan_2105|M.vanbaalenii_PYR-1 AEFEIPMHSDAIQVVGQLPVDFAASGLSAMSVTAHKFGGPIGVGALLLRR
MAB_4673c|M.abscessus_ATCC_199 RQSGVAFHTDAVHTAGKL--DLTVVGATMMSVSAHKFGGPRGIGALLVRS
: :.:*:**::. *:: .: . * : **::.****** . ****:*
Mb3051c|M.bovis_AF2122/97 DVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLE-ENSARLR
Rv3025c|M.tuberculosis_H37Rv DVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLE-ENSARLR
MLBr_01708|M.leprae_Br4923 DISCVPLLHGGGQERDIRSGTPGVASVVGMAAAAQIAVDGLE-INSIRLQ
MAV_3872|M.avium_104 DVACVPLAHGGGQERDIRSGTADVAGAVGMAAAARISVDGLE-TNSARLR
MMAR_1689|M.marinum_M DVSCVPLLHGGGQERDIRSGTPDVASAVGMAAAARIAVDGLE-ANSARLQ
MUL_1927|M.ulcerans_Agy99 DVSCVPLLHGGGQERDIRSGTPDVASAVGIAAAARIAVDGLE-ANSARLQ
MSMEG_2357|M.smegmatis_MC2_155 DTACVPLLHGGGQERDVRSGTPDVAGVVAMATAAGVAIENLA-DNSARVR
TH_1185|M.thermoresistible__bu DAECVPLLHGGGQERDIRSGTPHVAGVVAMAVAAEAAIENLP-AVSARIA
Mflv_4255|M.gilvum_PYR-GCK DTACVPQLHGGGQERDVRSGTQDVAGVIGMAVAARDAADTME-PVIARVR
Mvan_2105|M.vanbaalenii_PYR-1 ETACVPLLHGGGQERDVRSGTQDVPGAVGMAAAAQIAADTMD-SAAEKVR
MAB_4673c|M.abscessus_ATCC_199 GHRLLPVTRGGPQENRLRAGTENVPGALGMAAAADVCLRTVEREYRLGMR
:* :** **. :*:** *...:.:*.** . : :
Mb3051c|M.bovis_AF2122/97 LLRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDA
Rv3025c|M.tuberculosis_H37Rv LLRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDA
MLBr_01708|M.leprae_Br4923 VLRDRLIEGVLATIDDVALNGARDRMRLPGNAHFIFRGCEGDVLLMLLDA
MAV_3872|M.avium_104 ALRDRLVDGVLGGIEDVTLNGARDPLRLPGNAHFTFRGCEGDALLMLLDA
MMAR_1689|M.marinum_M TLRDRLVAGVLAEIDDVRLNGARDPLRLPGNAHFTFRGCEGDALLMLLDA
MUL_1927|M.ulcerans_Agy99 TLRDRLVAGVLAEIDDVRLNGARDPLRLPGNAHFTFRGCEGDALLMLLDA
MSMEG_2357|M.smegmatis_MC2_155 ALRDRLIDGVLSAIEDAQLNGARGDARLPGNAHFTFHGCEGDSLLMLLDA
TH_1185|M.thermoresistible__bu ALRDRLIDGVLTGIDDAYLNGARGADRLPGNAHFTFRGCEGDSLLMLLDA
Mflv_4255|M.gilvum_PYR-GCK DLRDRLVAGVLESIDDVDVNGAPGPGRLPGNAHFTFRGCEGDSLLMLLDA
Mvan_2105|M.vanbaalenii_PYR-1 ALRDRLIDGVLDAVDDVDVNGAPGAGRLPGNAHFTFRGCEGDSLLMLLDA
MAB_4673c|M.abscessus_ATCC_199 KRREQLIDG-LRAVGGVHLN-VTEP-VLEETVSVRFDGVRADTLADHLDM
*::*: * * : .. :* . * .. . * * ..* * **
Mb3051c|M.bovis_AF2122/97 NGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVD
Rv3025c|M.tuberculosis_H37Rv NGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVD
MLBr_01708|M.leprae_Br4923 NGIECSTGSACTSGVPQPSHVLIAMGADPASARGSLRLSLGHNSVEVDVE
MAV_3872|M.avium_104 NGIECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGHTSIDADVD
MMAR_1689|M.marinum_M NGIECSTGSACTAGVAQPSHVLIAMGADPASARGSLRLSLGHTTVEADVD
MUL_1927|M.ulcerans_Agy99 NGIECSTGSACTAGVAQPSHVLIAMGADPASARGSLRLSLGHTTVEADVD
MSMEG_2357|M.smegmatis_MC2_155 KGVECSTGSACTAGVAQASHVLIAMGADAVKARGSLRLSLGHTSTEADVD
TH_1185|M.thermoresistible__bu NGIECSTGSACTAGVAQPSHVLIAMGADSASARGSLRLSLGHTSTEADVD
Mflv_4255|M.gilvum_PYR-GCK KGIECSTGSACTAGVAQPSHVLTAMGVDPASARGSLRLSLGHTSTEADIE
Mvan_2105|M.vanbaalenii_PYR-1 KGIECSTGSACTAGVAQPSHVLTAMGADPVSARGSLRLSLGHTSTDADID
MAB_4673c|M.abscessus_ATCC_199 HGIYVSTGSACHAGEDTVSHVLRAMCLTEDQARGTVRFSLGPGVSPADVD
:*: ****** :* **** ** .***::*:*** .*::
Mb3051c|M.bovis_AF2122/97 AALEVLPGAVARARRAALAAAGASR---
Rv3025c|M.tuberculosis_H37Rv AALEVLPGAVARARRAALAAAGASR---
MLBr_01708|M.leprae_Br4923 EVLRVLPGAVDRARRASLAAAGAGGVGV
MAV_3872|M.avium_104 AVLRVLPGAVERARRAALAAAGAS----
MMAR_1689|M.marinum_M AALQVLPAAVARARSAAVAAAGAAW---
MUL_1927|M.ulcerans_Agy99 AALQVLPAAVARARSAAVAAAGAAW---
MSMEG_2357|M.smegmatis_MC2_155 TALEVLPAAVERARQAALASAGTVSR--
TH_1185|M.thermoresistible__bu AALAVLPAAVERARQAALASAG-VDK--
Mflv_4255|M.gilvum_PYR-GCK AVLEVLPAAVDRARQAALASSGRH----
Mvan_2105|M.vanbaalenii_PYR-1 AVLDVLPAAVERARQAALASSGRR----
MAB_4673c|M.abscessus_ATCC_199 TVVAVTVQAVHRLRATAGGMIR------
.: * ** * * :: .