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TVDTPTDNPTQLRFSDKETAGRVVYLDSNATTPVDPRVADEVLTYMAREFGNAGSRTHGYGQVAKERVAR AREQVAEVVRAQPDDVIFTSGATESNNLAILGLAPSGEKANRRHIVSTQIEHKAVLEPLAILTDRGFEVT LVPPTRGGRIEPSAIADAVRPDTLLVSTMAVNNETGVIQPIPEIAEVLAPHDAYLHVDAAQAFGKIIEPL RNSRIDMLSVSGHKVFAPKGIGALVARRRGYRRVPLQPLMFGGGQERGLRPGTLPVALIAGLGLAAELAL KENDARARHALALKHQALNALSELGIQANGDEEHTVPHTLNFSVPGVDAEAAIVALKEVVAISNGSACTS QKYEPSHVLVAADLPKKQIDGALRFSWSHLTGEVPWDVVAQRLAQLVT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1093c | - | - | 100% (399) | putative L-cysteine desulfurase |
| M. abscessus ATCC 19977 | MAB_3357c | - | 8e-53 | 35.90% (376) | putative aminotransferase/cysteine desulfurase |
| M. abscessus ATCC 19977 | MAB_4673c | - | 1e-49 | 37.57% (370) | putative aminotransferase/cysteine desulfhydrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3051c | iscS | 6e-55 | 37.70% (382) | cysteine desulfurase IscS |
| M. gilvum PYR-GCK | Mflv_4255 | - | 1e-52 | 35.71% (392) | aminotransferase, class V |
| M. tuberculosis H37Rv | Rv3025c | iscS | 6e-55 | 37.70% (382) | cysteine desulfurase IscS |
| M. leprae Br4923 | MLBr_01708 | - | 4e-52 | 35.00% (380) | putative aminotransferase |
| M. marinum M | MMAR_1689 | iscS | 2e-54 | 36.98% (384) | cysteine desulfurase IscS |
| M. avium 104 | MAV_3872 | - | 8e-54 | 36.88% (385) | cysteine desulfurase |
| M. smegmatis MC2 155 | MSMEG_2357 | - | 7e-57 | 38.07% (394) | cysteine desulfurase |
| M. thermoresistible (build 8) | TH_1185 | - | 7e-53 | 36.17% (376) | PROBABLE CYSTEINE DESULFURASE ISCS (NIFS PROTEIN HOMOLOG) |
| M. ulcerans Agy99 | MUL_1927 | iscS | 4e-55 | 37.76% (384) | cysteine desulfurase IscS |
| M. vanbaalenii PYR-1 | Mvan_2105 | - | 7e-51 | 34.73% (383) | aminotransferase, class V |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3051c|M.bovis_AF2122/97 ------------------------------MAYLDHAATTPMHP-AAIEA
Rv3025c|M.tuberculosis_H37Rv ------------------------------MAYLDHAATTPMHP-AAIEA
MLBr_01708|M.leprae_Br4923 ----------------MIRQAPIAGILKCVMAYLDHAATTPMHP-AAIEA
MAV_3872|M.avium_104 ------------------------------MVYLDHAATTPMHP-AAVEA
MMAR_1689|M.marinum_M ------------------------------MVYLDHAATTPMHP-TAIEA
MUL_1927|M.ulcerans_Agy99 ------------------------------MVYLDHAATTPMHP-TAIEA
Mflv_4255|M.gilvum_PYR-GCK MRWSRERDRGARPRGRYPGTAMSASAAAPRPVYLDHAATTPMRP-AAIEA
Mvan_2105|M.vanbaalenii_PYR-1 ----------------MPG---------PAPVYLDHAATTPMRP-GAIEA
MSMEG_2357|M.smegmatis_MC2_155 -----------------------MTSTAGRQVYLDHAATTPMHP-AAIEA
TH_1185|M.thermoresistible__bu -------------------------MNTPQTVYLDHAATTPMYP-AAITA
MAB_1093c|M.abscessus_ATCC_199 -------MTVDTPTDNPTQLRFSDKETAGRVVYLDSNATTPVDPRVADEV
.*** ****: * * .
Mb3051c|M.bovis_AF2122/97 MAAVQRTIGNASS-LHTSGRSARRRIEEARELIADKLGARPSEVIFTAGG
Rv3025c|M.tuberculosis_H37Rv MAAVQRTIGNASS-LHTSGRSARRRIEEARELIADKLGARPSEVIFTAGG
MLBr_01708|M.leprae_Br4923 MTTALGTVGNASS-LHTSGRVARRRIEESRELIADKLAARPSEVIFTAGG
MAV_3872|M.avium_104 MTAVLGTVGNASS-LHTSGRAARRRIEESRELVADKLGARPSEVIFTAGG
MMAR_1689|M.marinum_M MMAVLATVGNASS-LHTTGRAARRRLEESRELIAAKLGARPSEVIFTAGG
MUL_1927|M.ulcerans_Agy99 MTAVLATVGNASS-LHTTGRAARRRLEESRELIAAKLGARPSEVIFTAGG
Mflv_4255|M.gilvum_PYR-GCK MTAALATVGNASS-LHGSGRTARRRLEESRETLAQLLGARPSEVIFTAGG
Mvan_2105|M.vanbaalenii_PYR-1 MTAALATVGNAAS-LHGSGRLARRRLEESRETLARLLGARPSEVIFTAGG
MSMEG_2357|M.smegmatis_MC2_155 MTAVLAGVGNASS-LHGSGRAARRRMEEAREALARLLGARPSEIIFTTGG
TH_1185|M.thermoresistible__bu MTDVMSTVGNASS-LHSSGRVARRRMEEARETLARLLGARPSEVVFTAGG
MAB_1093c|M.abscessus_ATCC_199 LTYMAREFGNAGSRTHGYGQVAKERVARAREQVAEVVRAQPDDVIFTSGA
: .***.* * *: *:.*: .:** :* : *:*.:::**:*.
Mb3051c|M.bovis_AF2122/97 TESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHV
Rv3025c|M.tuberculosis_H37Rv TESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHV
MLBr_01708|M.leprae_Br4923 TESDNLAVKGIYWARRDAQPCHRRIVTTEVEHHAVLDSVNWLVEHEGAEV
MAV_3872|M.avium_104 TESDNLAVKGIYWARRDAEPRQRRIVTSEVEHHAVLDSVNWLVEHEGAEV
MMAR_1689|M.marinum_M TESDNLAVKGMYWARRDAQPARRRIVTTRVEHHAVLDTVDWLVEHEGAEV
MUL_1927|M.ulcerans_Agy99 TESDNLAVKGMYWARRDAQPARRRIVTTRVEHHAVLDTVDWLVEHEGAEV
Mflv_4255|M.gilvum_PYR-GCK TESDNLAVKGIYWARRDAEPQRRRIVTTPVEHHAVLDAVQWLADHEGAEV
Mvan_2105|M.vanbaalenii_PYR-1 TESDNLVVKGIYWARRASSPKRRRIITTPVEHHAVLDAVEWLVEHEDAEV
MSMEG_2357|M.smegmatis_MC2_155 TESDNLAVKGIYWARHDADPARRRIITTAVEHHAVLDAVEWLVAHEGAEV
TH_1185|M.thermoresistible__bu TESDNLAVKGLYWARRAASPGLRRIITTRVEHHAVLDAVDWLVQHEGAEV
MAB_1093c|M.abscessus_ATCC_199 TESNNLAILGLAPSGEKAN--RRHIVSTQIEHKAVLEPLAILTDRG-FEV
***:**.: *: : . :. *:*::: :**:***:.: *. : .*
Mb3051c|M.bovis_AF2122/97 TWLPTAADGSVSATALREALQS-HDDVALVSVMWANNEVGTILPIAEMSV
Rv3025c|M.tuberculosis_H37Rv TWLPTAADGSVSATALREALQS-HDDVALVSVMWANNEVGTILPIAEMSV
MLBr_01708|M.leprae_Br4923 TWLPTAADGSVSAFGLREALQQ-HNDVALVSVMWANNEVGTVMPVVELAA
MAV_3872|M.avium_104 TWLPTAADGSVSPAALREVLTR-HDDVALVSVMWANNEVGTVQPVAELAA
MMAR_1689|M.marinum_M TWLPTDADGSVSASALRDALES-HDDVALVSVMWANNEVGTIMPIAELAG
MUL_1927|M.ulcerans_Agy99 TWLPTDADGSVSASALRDALES-HDDVALVSVMWANNEVGTIMPIAELAG
Mflv_4255|M.gilvum_PYR-GCK TWLPVDQYGAVNPADLRVALSE-TADVALVSVMWANNEVGTIQPIAELAA
Mvan_2105|M.vanbaalenii_PYR-1 TWLPVDEFGAVGAADLRTALAD-PDDVALISVMWANNEVGTIMPIHELAS
MSMEG_2357|M.smegmatis_MC2_155 TWLPVDRDGAVSPAALREALQAGAHDVALVSVMWANNEVGTIMPIAELAA
TH_1185|M.thermoresistible__bu TWLPVEPDGSVTPATLREALRA-HDDVALVTLMWANNEVGTVSPIAELAA
MAB_1093c|M.abscessus_ATCC_199 TLVPPTRGGRIEPSAIADAVRP---DTLLVSTMAVNNETGVIQPIPEIAE
* :* * : . : .: *. *:: * .***.*.: *: *::
Mb3051c|M.bovis_AF2122/97 VAMEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLL
Rv3025c|M.tuberculosis_H37Rv VAMEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLL
MLBr_01708|M.leprae_Br4923 VAAEFGVPMHSDAIQAVGQLPVKFGVSGLSAMSVAAHKFGGPPGVGALLL
MAV_3872|M.avium_104 VAAEFGVPMHSDAVQAVGQLPVDFTASGLSAMSVTAHKFGGPPAVGALLL
MMAR_1689|M.marinum_M VAAEFGVPMHSDAVQAVGQVPVDFGACGLAAMSVTAHKFGGPPGAGALLM
MUL_1927|M.ulcerans_Agy99 VAAEFGVPMHSDAVQAVGQIPVDFGACGLAAMSVTAHKFGGPPGAGALLM
Mflv_4255|M.gilvum_PYR-GCK IATEFGVPMHSDAIQAIGQLPVDFGASGLSAMSVAAHKFGGPAGVGALLL
Mvan_2105|M.vanbaalenii_PYR-1 VAAEFEIPMHSDAIQVVGQLPVDFAASGLSAMSVTAHKFGGPIGVGALLL
MSMEG_2357|M.smegmatis_MC2_155 VAAEFGVPMHSDAVQAVGQIPVNFGASGLAAMSVTAHKFGGPTGVGALLL
TH_1185|M.thermoresistible__bu VAAEFSVPMHSDAVQAVGHLPVDFSASGLSAMSISAHKFGGPTGVGALLI
MAB_1093c|M.abscessus_ATCC_199 VLAPHDAYLHVDAAQAFGKIIEPLRNSRIDMLSVSGHKVFAPKGIGALVA
: . :* ** *..*:: : . : :*::.**. .* . ***:
Mb3051c|M.bovis_AF2122/97 RR----DVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEEN
Rv3025c|M.tuberculosis_H37Rv RR----DVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEEN
MLBr_01708|M.leprae_Br4923 RR----DISCVPLLHGGGQERDIRSGTPGVASVVGMAAAAQIAVDGLEIN
MAV_3872|M.avium_104 RR----DVACVPLAHGGGQERDIRSGTADVAGAVGMAAAARISVDGLETN
MMAR_1689|M.marinum_M RR----DVSCVPLLHGGGQERDIRSGTPDVASAVGMAAAARIAVDGLEAN
MUL_1927|M.ulcerans_Agy99 RR----DVSCVPLLHGGGQERDIRSGTPDVASAVGIAAAARIAVDGLEAN
Mflv_4255|M.gilvum_PYR-GCK RR----DTACVPQLHGGGQERDVRSGTQDVAGVIGMAVAARDAADTMEPV
Mvan_2105|M.vanbaalenii_PYR-1 RR----ETACVPLLHGGGQERDVRSGTQDVPGAVGMAAAAQIAADTMDSA
MSMEG_2357|M.smegmatis_MC2_155 RR----DTACVPLLHGGGQERDVRSGTPDVAGVVAMATAAGVAIENLADN
TH_1185|M.thermoresistible__bu RR----DAECVPLLHGGGQERDIRSGTPHVAGVVAMAVAAEAAIENLPAV
MAB_1093c|M.abscessus_ATCC_199 RRRGYRRVPLQPLMFGGGQERGLRPGTLPVALIAGLGLAAELALKENDAR
** * .******.:*.** *. .:. ** : .
Mb3051c|M.bovis_AF2122/97 SARLRLLRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALL
Rv3025c|M.tuberculosis_H37Rv SARLRLLRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALL
MLBr_01708|M.leprae_Br4923 SIRLQVLRDRLIEGVLATIDDVALNGARDRMRLPGNAHFIFRGCEGDVLL
MAV_3872|M.avium_104 SARLRALRDRLVDGVLGGIEDVTLNGARDPLRLPGNAHFTFRGCEGDALL
MMAR_1689|M.marinum_M SARLQTLRDRLVAGVLAEIDDVRLNGARDPLRLPGNAHFTFRGCEGDALL
MUL_1927|M.ulcerans_Agy99 SARLQTLRDRLVAGVLAEIDDVRLNGARDPLRLPGNAHFTFRGCEGDALL
Mflv_4255|M.gilvum_PYR-GCK IARVRDLRDRLVAGVLESIDDVDVNGAPGPGRLPGNAHFTFRGCEGDSLL
Mvan_2105|M.vanbaalenii_PYR-1 AEKVRALRDRLIDGVLDAVDDVDVNGAPGAGRLPGNAHFTFRGCEGDSLL
MSMEG_2357|M.smegmatis_MC2_155 SARVRALRDRLIDGVLSAIEDAQLNGARGDARLPGNAHFTFHGCEGDSLL
TH_1185|M.thermoresistible__bu SARIAALRDRLIDGVLTGIDDAYLNGARGADRLPGNAHFTFRGCEGDSLL
MAB_1093c|M.abscessus_ATCC_199 ARHALALKHQALN-ALSELG-IQANGDEE-HTVPHTLNFSVPGVDAEAAI
: *:.: : .* : ** :. . :* . * :.: :
Mb3051c|M.bovis_AF2122/97 MLLDANGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSV
Rv3025c|M.tuberculosis_H37Rv MLLDANGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSV
MLBr_01708|M.leprae_Br4923 MLLDANGIECSTGSACTSGVPQPSHVLIAMGADPASARGSLRLSLGHNSV
MAV_3872|M.avium_104 MLLDANGIECSTGSACTAGVAQPSHVLVAMGVDPASARGSLRLSLGHTSI
MMAR_1689|M.marinum_M MLLDANGIECSTGSACTAGVAQPSHVLIAMGADPASARGSLRLSLGHTTV
MUL_1927|M.ulcerans_Agy99 MLLDANGIECSTGSACTAGVAQPSHVLIAMGADPASARGSLRLSLGHTTV
Mflv_4255|M.gilvum_PYR-GCK MLLDAKGIECSTGSACTAGVAQPSHVLTAMGVDPASARGSLRLSLGHTST
Mvan_2105|M.vanbaalenii_PYR-1 MLLDAKGIECSTGSACTAGVAQPSHVLTAMGADPVSARGSLRLSLGHTST
MSMEG_2357|M.smegmatis_MC2_155 MLLDAKGVECSTGSACTAGVAQASHVLIAMGADAVKARGSLRLSLGHTST
TH_1185|M.thermoresistible__bu MLLDANGIECSTGSACTAGVAQPSHVLIAMGADSASARGSLRLSLGHTST
MAB_1093c|M.abscessus_ATCC_199 VALKEV-VAISNGSACTSQKYEPSHVLVAADLPKKQIDGALRFSWSHLTG
: *. : *.*****: :.**** * . . *:**:* .* :
Mb3051c|M.bovis_AF2122/97 EADVDAALEVLPGAVARARRAALAAAGASR---
Rv3025c|M.tuberculosis_H37Rv EADVDAALEVLPGAVARARRAALAAAGASR---
MLBr_01708|M.leprae_Br4923 EVDVEEVLRVLPGAVDRARRASLAAAGAGGVGV
MAV_3872|M.avium_104 DADVDAVLRVLPGAVERARRAALAAAGAS----
MMAR_1689|M.marinum_M EADVDAALQVLPAAVARARSAAVAAAGAAW---
MUL_1927|M.ulcerans_Agy99 EADVDAALQVLPAAVARARSAAVAAAGAAW---
Mflv_4255|M.gilvum_PYR-GCK EADIEAVLEVLPAAVDRARQAALASSGRH----
Mvan_2105|M.vanbaalenii_PYR-1 DADIDAVLDVLPAAVERARQAALASSGRR----
MSMEG_2357|M.smegmatis_MC2_155 EADVDTALEVLPAAVERARQAALASAGTVSR--
TH_1185|M.thermoresistible__bu EADVDAALAVLPAAVERARQAALASAG-VDK--
MAB_1093c|M.abscessus_ATCC_199 EVPWDVVAQRLAQLVT-----------------
:. : . *. *