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MPDIHDPLALANGQVLRNRLMKSALSEALGNAEQGPDHRLVQLFSRWGAGGYGLIVTGNVMVDHNHLGEP GNVVIEDDRHLEGLSRWAKATKDGGGLIWMQVNHPGRQANPLATKHQPVAPSAVRMSVPGWQAPRELTDV EIEDIIDRYARTAVVADTAGFDGVQIHGAHGYLVAQFLSPNTNRRTDRWGGDAQRRMRFVLEIVRRTKAA VSPGFAVAIKLNSADFQRGGFTEEESRGVIAALAAEGIDLIEISGGTYESPAMEGRPVVVSTSTQAREAY FLEYATTARAVAGDVPLAVTGGFRTTAAMNEAIESGACDVIGLGRPTTVNPEAAIELLSTRRDRLTVPDA ALPLPARLAATARAKAFLSAHELQWHGTQMHRLGAGSDPDPSIGPWITTLRLLKNNGVEAFRKRRSS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4635 | - | - | 100% (417) | NADH:flavin oxidoreductase/NADH oxidase |
| M. abscessus ATCC 19977 | MAB_3694 | - | 2e-26 | 29.16% (367) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2740c | - | 3e-26 | 30.46% (325) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 1e-32 | 29.28% (345) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_4553 | - | 6e-28 | 28.69% (373) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 1e-32 | 29.28% (345) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4276 | fadH | 7e-36 | 30.43% (345) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 8e-27 | 30.28% (360) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2969 | - | 8e-33 | 29.97% (337) | NADH:flavin oxidoreductase/NADH oxidase |
| M. thermoresistible (build 8) | TH_4117 | - | 7e-70 | 64.29% (196) | PUTATIVE putative NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 3e-35 | 30.43% (345) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_2887 | - | 9e-28 | 34.48% (261) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4635|M.abscessus_ATCC_1997 ----MPDIHDPLALANGQVLRNRLMKSALSEALGNAEQGPDHRLVQLFSR
TH_4117|M.thermoresistible__bu -VTTTDTLHDPVTLPCGLVLPNRIMKAALSEVLADREHAPDARLERLYSA
MMAR_4276|M.marinum_M MTSPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRPKDTDR-LAEYFAE
MUL_1023|M.ulcerans_Agy99 MTSPYPNLLFPLDLG-FTTLRNRVVMGSMHTGLEDRPKDTDR-LAEYFAE
Mb1208c|M.bovis_AF2122/97 MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRARHIDR-LADYFAE
Rv1175c|M.tuberculosis_H37Rv MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRARHIDR-LADYFAE
Mflv_4553|M.gilvum_PYR-GCK MSPNPPEPFSPVSLG-PVTLRNRVIKAATSEGRSPHGLVTDD-LIAFHRA
Mvan_2887|M.vanbaalenii_PYR-1 MADVTPDPFAPVQLG-PVRLRNRIIKAATSEGRSPDGRVTDD-LIAFHRS
MAV_4324|M.avium_104 -MPTPPDVFSPAKLG-PITLRNRIIKSATFEARTPDALVTDD-LIEYHRL
MSMEG_2969|M.smegmatis_MC2_155 -MTNTHPALTSVRLG-GLKLDNRFAVAPMTRVSATADGAPTDAMAGYYAE
. * * **. .. : .
MAB_4635|M.abscessus_ATCC_1997 WGAGGYGLIVTGNVMVDHNHLG-EPGNVVIEDDRHLEGLSRWAKATKDGG
TH_4117|M.thermoresistible__bu WARGGYGLIVTGNVMVDGSQLA-EPGNIVIEDTRHLDALTRWARTTKDGN
MMAR_4276|M.marinum_M RARGGVGMLITGGYAPNRTGWL-YPFASELVTPAEARRHRRITGAVHDAD
MUL_1023|M.ulcerans_Agy99 RARGGVGMLITGGYAPNRTGWL-YPFASELVTPAEARRHRRITGAVHDAD
Mb1208c|M.bovis_AF2122/97 RARGGVGLIITGGYAPNRTGWL-LPFASELVTSAQARRHRRINRAVHDSG
Rv1175c|M.tuberculosis_H37Rv RARGGVGLIITGGYAPNRTGWL-LPFASELVTSAQARRHRRITRAVHDSG
Mflv_4553|M.gilvum_PYR-GCK FADGGVGMTTVAYCCVSPQGAS-APGQIVMN-EAALPGLRRLTESVHEGG
Mvan_2887|M.vanbaalenii_PYR-1 FAEGGVGMTTVAYCCVSPQGAS-APGQIVMD-TEALPGLRRLTDAVHSAG
MAV_4324|M.avium_104 PAAGGVGMTTVAYCAVSPGGRT-EGNGIWMR-PEAVPGFRRLTDAIHAEG
MSMEG_2969|M.smegmatis_MC2_155 FARGGFGLVITEGTYTDTTHSQGYLNQPGLATDAHAAGWRPVTDAVHAAG
. ** *: . . : : : .
MAB_4635|M.abscessus_ATCC_1997 G---LIWMQVNHPGRQANPLATKHQPVAPSAVRM---------SVPGWQA
TH_4117|M.thermoresistible__bu GGGVPILAQLNHPGRQANPLAFGHVPVAPSPVPL---------NFPGAAT
MMAR_4276|M.marinum_M AK---ILLQVLHAGR----YAYHPLSVSASSIKA---------PIN-PFR
MUL_1023|M.ulcerans_Agy99 AK---ILLQVLHAGR----YAYHPLSVSASSIKA---------PIN-PFR
Mb1208c|M.bovis_AF2122/97 AK---ILLQILHAGR----YAYHPLAVSASPIKA---------PIT-PFR
Rv1175c|M.tuberculosis_H37Rv AK---ILLQILHAGR----YAYHPLAVSASPIKA---------PIT-PFR
Mflv_4553|M.gilvum_PYR-GCK AA---ISAQLGHAGVVAPKKLTGVTAVAPSRFVN---------PTS-FAY
Mvan_2887|M.vanbaalenii_PYR-1 AG---ISAQLGHAGVVAPKKLTGVTAVAPSRFVN---------PTS-FAY
MAV_4324|M.avium_104 AA---VSAQIGHAGPVANARSNKAHALAPVRFFN---------PIG-MRF
MSMEG_2969|M.smegmatis_MC2_155 VP---IVAQLMHAGALSQGNSHGVETIAPSAVAPRGTMLEEYGGAGTWPT
: *: *.* .::. .
MAB_4635|M.abscessus_ATCC_1997 PRELTDVEIEDIIDRYARTAVVADTAGFDGVQIHGAHGYLVAQFLSPNTN
TH_4117|M.thermoresistible__bu PRELTSAEIEDIIDRFATTAAICEAAGFDGVQIHGAHGYLITQFLSPLSN
MMAR_4276|M.marinum_M PRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAPRTN
MUL_1023|M.ulcerans_Agy99 SRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAPRTN
Mb1208c|M.bovis_AF2122/97 PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAPRTN
Rv1175c|M.tuberculosis_H37Rv PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAPRTN
Mflv_4553|M.gilvum_PYR-GCK CRQITRDEIRSVTAQFAAAAQIAVDAGFDAVELHFGHLYLPSSFLSPLIN
Mvan_2887|M.vanbaalenii_PYR-1 CREIRRDEIATVIDQFGQAAQVAVDAGFDAVELHFGHLYLPSSFLSPLIN
MAV_4324|M.avium_104 AKKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYLASSFLSPLIN
MSMEG_2969|M.smegmatis_MC2_155 PREMSAADIDAAIAGFVDAAVRARAAGFDGVEIHAANGYLLDQFLTTYTN
: : . * . **:*.*:: .. ** .**:. *
MAB_4635|M.abscessus_ATCC_1997 RRTDRWGGDAQRRMRFVLEIVRRTK---AAVSPGFAVAIKLNSADFQRGG
TH_4117|M.thermoresistible__bu RRTDEWGGXXX--SRGCSGWPRRSR-------------------------
MMAR_4276|M.marinum_M KRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYRMSMADYVEGG
MUL_1023|M.ulcerans_Agy99 QRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYRMSMADYVEGG
Mb1208c|M.bovis_AF2122/97 KRTDSWGGTPANRRRFPVEIIRRSR---AAVGSDFIICYRLSMADYVAEG
Rv1175c|M.tuberculosis_H37Rv KRTDSWGGTPANRRRFPVEIIRRSR---AAVGCDFIICYRLSMADYVAEG
Mflv_4553|M.gilvum_PYR-GCK RRKDDYGGSIDNRSRFVREIAARVR---DTVGGRIAVIAKLDMDDGLPGS
Mvan_2887|M.vanbaalenii_PYR-1 RRRDEYGGDIDNRSRLVREIAHRVR---DVVGDRIAVIAKLDMDDGLPGS
MAV_4324|M.avium_104 RRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAVTAKLNMADGVRGG
MSMEG_2969|M.smegmatis_MC2_155 HRTDEYGGTVAHRIRLAAQISAAVR---TAVGADFLVGVRLSQTKVNDFE
:* * :** : :
MAB_4635|M.abscessus_ATCC_1997 FTEEESRGVIAALAAEGIDLIEISGGTYES--------------------
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M QSWDEIVALASELETAGATIINSGFGWHEARIPTIVTSVPSGAFVDISNA
MUL_1023|M.ulcerans_Agy99 QSWDEIVALATELESAGATIINSGFGWHEARIPTIVTSVPSGAFVEISNA
Mb1208c|M.bovis_AF2122/97 QSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDISSA
Rv1175c|M.tuberculosis_H37Rv QSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDISSA
Mflv_4553|M.gilvum_PYR-GCK IWIDEALRTAALLDADGA--------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 IWIDEALRTVALLDADAT--------------------------------
MAV_4324|M.avium_104 ISTEESLTTAKWLESDGG--------------------------------
MSMEG_2969|M.smegmatis_MC2_155 YRWPGG--------------------------------------------
MAB_4635|M.abscessus_ATCC_1997 --------PAMEGRPVVVSTSTQAREAYFLEYATTARAVAGDVPLAVTGG
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M VAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLKAQ
MUL_1023|M.ulcerans_Agy99 VAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLKAQ
Mb1208c|M.bovis_AF2122/97 VAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLKAQ
Rv1175c|M.tuberculosis_H37Rv VAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLKAQ
Mflv_4553|M.gilvum_PYR-GCK -----------LDALELTQGSSVYKPMYLFRGDVPVREFATVMPPAMRPA
Mvan_2887|M.vanbaalenii_PYR-1 -----------LDAIELTQGSSVYRPMYLFRGDVPVREFTKVMPPLLRPG
MAV_4324|M.avium_104 -----------LDAIELTAGSSLVNPMYLFRGDAPLKEFAGAFKPPLRWG
MSMEG_2969|M.smegmatis_MC2_155 -----------AQDAEVIFTALAATGIDYLHIASEGRDFIDG--------
MAB_4635|M.abscessus_ATCC_1997 FRTTAAMNEAIES--------GACDVIGLGRPTTVNPEAAIELLSTRRDR
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M SGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTLSPTQRAR
MUL_1023|M.ulcerans_Agy99 SGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTMSPTQRAR
Mb1208c|M.bovis_AF2122/97 SNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRRAR
Rv1175c|M.tuberculosis_H37Rv SNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRRAR
Mflv_4553|M.gilvum_PYR-GCK VRLVGKQ-------------TMGVYPYQDLYMLDAARQFVPVMRNTKLVL
Mvan_2887|M.vanbaalenii_PYR-1 VRILGKG-------------VMGSYPYEDLYMLPAARQFVPIMRNTELIL
MAV_4324|M.avium_104 MRMTGKK-------------FLREYPYREAYLLRDAKLFRAELK-MPLIL
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------ARLDDGRTITALARQVTG
MAB_4635|M.abscessus_ATCC_1997 LTVPDAALPLPARLAATARAK----AFLSAHELQWHGTQMHRLGAGSDPD
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M TVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKEEF
MUL_1023|M.ulcerans_Agy99 TVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKEEF
Mb1208c|M.bovis_AF2122/97 SVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKEEF
Rv1175c|M.tuberculosis_H37Rv SVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKEEF
Mflv_4553|M.gilvum_PYR-GCK LGGITERSHIETGLREGFDFVAMGRALLREPDLVNRIRSDPSTR---SRC
Mvan_2887|M.vanbaalenii_PYR-1 LGGITNRDHVETGMREGFAFVAMGRALLREPDLVDKMIADGGVR---SRC
MAV_4324|M.avium_104 LGGITNRETMDLAMAEGFEFVAMARALLAEPDLINRIAADGAAHRVHSAC
MSMEG_2969|M.smegmatis_MC2_155 LPVIANGGMHDTTQAAGVLDGGHADVLSIGRGALANPDLPQRVSSGAPLE
MAB_4635|M.abscessus_ATCC_1997 PSIGPWITTLRLLKNNGVEAFRKRRSS-----------------------
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M NETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPAIPG
MUL_1023|M.ulcerans_Agy99 NETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPAIPG
Mb1208c|M.bovis_AF2122/97 SETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPAIPG
Rv1175c|M.tuberculosis_H37Rv SETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPAIPG
Mflv_4553|M.gilvum_PYR-GCK THNNKCMVTVFGRTHCVLD--PDQRYGGVSPVQQRGELLA----------
Mvan_2887|M.vanbaalenii_PYR-1 NHNNKCMVTVFARTHCVLD--PDQRYGAAVPIAEPGRPAVSS--------
MAV_4324|M.avium_104 THCNQCMPTIYSRTHCVVTGAPDRHTSAAT--------------------
MSMEG_2969|M.smegmatis_MC2_155 RFDHGMLSPMATIVNAAAWTAARHRERVPR--------------------
MAB_4635|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M IAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTLNLK
MUL_1023|M.ulcerans_Agy99 IAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTLNLK
Mb1208c|M.bovis_AF2122/97 IDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTLNLK
Rv1175c|M.tuberculosis_H37Rv IDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTLNLK
Mflv_4553|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4635|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M EWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKTSGW
MUL_1023|M.ulcerans_Agy99 EWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKTSGW
Mb1208c|M.bovis_AF2122/97 EWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKTTGW
Rv1175c|M.tuberculosis_H37Rv EWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKTTGW
Mflv_4553|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4635|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4117|M.thermoresistible__bu --------------------------------------------------
MMAR_4276|M.marinum_M VHRASVKAKGVHQLSGVNYERISDDGLHISFGPERQRPQLLAVDSVVICA
MUL_1023|M.ulcerans_Agy99 VHRASVKAKGVHQLSGVNYERISDDGLHISFGPDRQRPQLLAVDSVVICA
Mb1208c|M.bovis_AF2122/97 VHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVVVCA
Rv1175c|M.tuberculosis_H37Rv VHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVVVCA
Mflv_4553|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4635|M.abscessus_ATCC_1997 -----------------------------------------------
TH_4117|M.thermoresistible__bu -----------------------------------------------
MMAR_4276|M.marinum_M GQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL
MUL_1023|M.ulcerans_Agy99 GQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL
Mb1208c|M.bovis_AF2122/97 GQEPVRDLESELRRHGINPHISGGAAVAAELDAKRAIKQGTELAARL
Rv1175c|M.tuberculosis_H37Rv GQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGTELAARL
Mflv_4553|M.gilvum_PYR-GCK -----------------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 -----------------------------------------------
MAV_4324|M.avium_104 -----------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 -----------------------------------------------