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SPNPPEPFSPVSLGPVTLRNRVIKAATSEGRSPHGLVTDDLIAFHRAFADGGVGMTTVAYCCVSPQGASA PGQIVMNEAALPGLRRLTESVHEGGAAISAQLGHAGVVAPKKLTGVTAVAPSRFVNPTSFAYCRQITRDE IRSVTAQFAAAAQIAVDAGFDAVELHFGHLYLPSSFLSPLINRRKDDYGGSIDNRSRFVREIAARVRDTV GGRIAVIAKLDMDDGLPGSIWIDEALRTAALLDADGALDALELTQGSSVYKPMYLFRGDVPVREFATVMP PAMRPAVRLVGKQTMGVYPYQDLYMLDAARQFVPVMRNTKLVLLGGITERSHIETGLREGFDFVAMGRAL LREPDLVNRIRSDPSTRSRCTHNNKCMVTVFGRTHCVLDPDQRYGGVSPVQQRGELLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4553 | - | - | 100% (409) | NADH:flavin oxidoreductase/NADH oxidase |
| M. gilvum PYR-GCK | Mflv_4880 | - | e-118 | 54.16% (397) | NADH:flavin oxidoreductase/NADH oxidase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 8e-20 | 29.72% (212) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3394 | - | 1e-118 | 56.10% (385) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3359 | - | 1e-118 | 56.10% (385) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3694 | - | 1e-118 | 54.95% (384) | oxidoreductase |
| M. marinum M | MMAR_1175 | - | 1e-116 | 54.76% (389) | oxidoreductase |
| M. avium 104 | MAV_4324 | - | 1e-115 | 53.18% (393) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2889 | - | 0.0 | 82.18% (404) | NADH:flavin oxidoreductase/NADH oxidase |
| M. thermoresistible (build 8) | TH_2463 | - | 0.0 | 81.31% (396) | PUTATIVE NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 1e-24 | 32.79% (244) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_2887 | - | 0.0 | 81.25% (400) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3394|M.bovis_AF2122/97 MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVTDDLIEYHR
Rv3359|M.tuberculosis_H37Rv MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVTDDLIEYHR
MMAR_1175|M.marinum_M MSP----TPDVLSPAQLGPLTLRNRVIKAATFEARTPNALVTDDLIEYHR
MAV_4324|M.avium_104 MPT----PPDVFSPAKLGPITLRNRIIKSATFEARTPDALVTDDLIEYHR
MAB_3694|M.abscessus_ATCC_1997 MGSDAAGIPDVLAPARLGPITLRNRTIKAATFEAASPDAFVTDDLIEYHR
MSMEG_2889|M.smegmatis_MC2_155 MTD---LSPDPFAPVQLGPVRLRNRVIKAATSEGRSPDGVVTDDLIDFHR
TH_2463|M.thermoresistible__bu VTH---TSLDPFAPAQLGPVRLRNRVIKAATSEGRSPDGLVTDDLVEFHR
Mvan_2887|M.vanbaalenii_PYR-1 MAD---VTPDPFAPVQLGPVRLRNRIIKAATSEGRSPDGRVTDDLIAFHR
Mflv_4553|M.gilvum_PYR-GCK MSP---NPPEPFSPVSLGPVTLRNRVIKAATSEGRSPHGLVTDDLIAFHR
MUL_1023|M.ulcerans_Agy99 MTS---PYPNLLFPLDLGFTTLRNRVVMGSMHTGLEDRPKDTDRLAEYFA
: : : * ** **** : .: . ** * :.
Mb3394|M.bovis_AF2122/97 LPAAGGVAMTTVA-YCAVSPGGRTGGNQIWMRPHAVPGLRRLTEAIHAEG
Rv3359|M.tuberculosis_H37Rv LPAAGGVAMTTVA-YCAVSPGGRTGGNQIWMRPHAVPGLRRLTEAIHAEG
MMAR_1175|M.marinum_M QPAAGGIAMTTVA-YCAVSPGGRTSGEQIWMRREAVPGLRRLTEAIHAEG
MAV_4324|M.avium_104 LPAAGGVGMTTVA-YCAVSPGGRTEGNGIWMRPEAVPGFRRLTDAIHAEG
MAB_3694|M.abscessus_ATCC_1997 RPALGGVGMTTVA-YCAVAPEGRTEYGQVWMREEAIPGLRRLTDAIHDTG
MSMEG_2889|M.smegmatis_MC2_155 GFAEGGVGMTTVA-YCCVSPQAASAPGQIVMNAKALPGLRKLTDAVHGAG
TH_2463|M.thermoresistible__bu RFARGGVAMTTVA-YCCVSPEAASAPGQIVMADRALPGLRRLTDAVHEAG
Mvan_2887|M.vanbaalenii_PYR-1 SFAEGGVGMTTVA-YCCVSPQGASAPGQIVMDTEALPGLRRLTDAVHSAG
Mflv_4553|M.gilvum_PYR-GCK AFADGGVGMTTVA-YCCVSPQGASAPGQIVMNEAALPGLRRLTESVHEGG
MUL_1023|M.ulcerans_Agy99 ERARGGVGMLITGGYAPNRTGWLYPFASELVTPAEARRHRRITGAVHDAD
* **:.* .. *. . : *::* ::* .
Mb3394|M.bovis_AF2122/97 AAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKATREDIDDVL
Rv3359|M.tuberculosis_H37Rv AAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKATREDIDDVL
MMAR_1175|M.marinum_M AAVSAQIGHAGPVADARSNKATALAPVRFFNPIAMRFAKRATRDDIDDVL
MAV_4324|M.avium_104 AAVSAQIGHAGPVANARSNKAHALAPVRFFNPIGMRFAKKATREDIDEVI
MAB_3694|M.abscessus_ATCC_1997 AAVSAQIGHAGPVANARSNGSPALSPIRFFNPLGMKFARRASASDIDGVI
MSMEG_2889|M.smegmatis_MC2_155 AAISAQLGHAGVVAQKKLTGVTAVAPSRFVNPTSFAYCRAITRSEIAMVI
TH_2463|M.thermoresistible__bu AAVSAQLGHAGVVAPKKLTGVTAVAPSRFINPTSLAYCREITRDEIEAVI
Mvan_2887|M.vanbaalenii_PYR-1 AGISAQLGHAGVVAPKKLTGVTAVAPSRFVNPTSFAYCREIRRDEIATVI
Mflv_4553|M.gilvum_PYR-GCK AAISAQLGHAGVVAPKKLTGVTAVAPSRFVNPTSFAYCRQITRDEIRSVT
MUL_1023|M.ulcerans_Agy99 AKILLQVLHAGRYAYHPLS----VSASSIKAPINPFRSRKLTSRGVEATI
* : *: *** * . ::. : * .: : .
Mb3394|M.bovis_AF2122/97 AAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDEFGGSLQNR
Rv3359|M.tuberculosis_H37Rv AAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDEFGGSLQNR
MMAR_1175|M.marinum_M AAHANAARLAVEAGFDAVEIHLGHNYLASSFLSPLINRRADEFGGSLENR
MAV_4324|M.avium_104 AAHANAARLAIEAGFDAVEIHLGHNYLASSFLSPLINRRNDEFGGSLQNR
MAB_3694|M.abscessus_ATCC_1997 AAHANAARLAIEAGFDAVEIHLGHGYFVSSFLSPLFNRRGDEYGGSLANR
MSMEG_2889|M.smegmatis_MC2_155 DQFGDAAQVAVDAGFDAVELHFGHLYLPSSFLSPLINRRKDEYGGDIDNR
TH_2463|M.thermoresistible__bu DQFGEAARIAAEAGFDAVELHFGHLYLPSSFLSPLINRRTDEYGGDIDNR
Mvan_2887|M.vanbaalenii_PYR-1 DQFGQAAQVAVDAGFDAVELHFGHLYLPSSFLSPLINRRRDEYGGDIDNR
Mflv_4553|M.gilvum_PYR-GCK AQFAAAAQIAVDAGFDAVELHFGHLYLPSSFLSPLINRRKDDYGGSIDNR
MUL_1023|M.ulcerans_Agy99 ADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAPRTNQRTDSWGGTPAKR
.. .*::* :**:*.**: .. *: . **:* *:* *.:** :*
Mb3394|M.bovis_AF2122/97 AKVARGLVMAVRRAVR----QQVAVTAKLNMTDGIRGGITVDEALTTARW
Rv3359|M.tuberculosis_H37Rv AKVARGLVMAVRRAVR----QQVAVTAKLNMTDGIRGGITVDEALTTARW
MMAR_1175|M.marinum_M AKVARGLVRAVRGALDKDGISHVAVTAKLNMADGVRGGISTEESLRTAKW
MAV_4324|M.avium_104 AKVARGMVMAVRRAVEKEGTP-IAVTAKLNMADGVRGGISTEESLTTAKW
MAB_3694|M.abscessus_ATCC_1997 AKVARAVVQAVRKVAG----SRLAVTAKLTMTDGIRGGIPIEESLQTATW
MSMEG_2889|M.smegmatis_MC2_155 SRFVREIAGRVREVVG----DRVAVIAKLNMDDGLPGSIWIDEALRTASL
TH_2463|M.thermoresistible__bu SRFVRRIARRVREVVG----DRIAVIAKLNMDDGLPGGIWIDEALRTAQL
Mvan_2887|M.vanbaalenii_PYR-1 SRLVREIAHRVRDVVG----DRIAVIAKLDMDDGLPGSIWIDEALRTVAL
Mflv_4553|M.gilvum_PYR-GCK SRFVREIAARVRDTVG----GRIAVIAKLDMDDGLPGSIWIDEALRTAAL
MUL_1023|M.ulcerans_Agy99 RRFPVEIVRRTRAAVG----PDFIICYRMSMADYVEGGQSWDEIVALATE
:. :. .* . . : :: * * : *. :* : .
Mb3394|M.bovis_AF2122/97 LQDDGG---------LDAIELTAGSSLVNPMYLFRGDAPVKEFAAAFKPP
Rv3359|M.tuberculosis_H37Rv LQDDGG---------LDAIELTAGSSLVNPMYLFRGDAPVKEFAAAFKPP
MMAR_1175|M.marinum_M LEEDGG---------LDAIELTAGSSLVNPMYLFRGDAPVKEFAAAFKPP
MAV_4324|M.avium_104 LESDGG---------LDAIELTAGSSLVNPMYLFRGDAPLKEFAGAFKPP
MAB_3694|M.abscessus_ATCC_1997 LQEDGG---------LDALELTAGSSLVNPMYLFRGDVPIRELAKGFPKP
MSMEG_2889|M.smegmatis_MC2_155 LDADQT---------LDAIELTQGSSVFKPMYLFRGDVPVREFAQVMPPA
TH_2463|M.thermoresistible__bu LDADAT---------LDALELTQGSSVFKPMYLFRGDVPVREFAEVMPAM
Mvan_2887|M.vanbaalenii_PYR-1 LDADAT---------LDAIELTQGSSVYRPMYLFRGDVPVREFTKVMPPL
Mflv_4553|M.gilvum_PYR-GCK LDADGA---------LDALELTQGSSVYKPMYLFRGDVPVREFATVMPPA
MUL_1023|M.ulcerans_Agy99 LESAGATIINSGFGWHEARIPTIVTSVPSGAFVEISNAVAEQVSIPVMTS
*: :* * :*: :: .:. .:.: .
Mb3394|M.bovis_AF2122/97 LRWGIRMTGHRFFR------------------------------------
Rv3359|M.tuberculosis_H37Rv LRWGIRMTGHRFFR------------------------------------
MMAR_1175|M.marinum_M MRWGVRMMGKKFLR------------------------------------
MAV_4324|M.avium_104 LRWGMRMTGKKFLR------------------------------------
MAB_3694|M.abscessus_ATCC_1997 MGWGVRLTGKKFFR------------------------------------
MSMEG_2889|M.smegmatis_MC2_155 MRPAVRVVGKKAMG------------------------------------
TH_2463|M.thermoresistible__bu MRPGVRLMGKRFMG------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 LRPGVRILGKGVMG------------------------------------
Mflv_4553|M.gilvum_PYR-GCK MRPAVRLVGKQTMG------------------------------------
MUL_1023|M.ulcerans_Agy99 NRINMPQAAEQILADTDVALISMARPMLSDPEWVLKAQSGRVDEINTCIA
: .. :
Mb3394|M.bovis_AF2122/97 --EYPYRDAYLLREARLFRAELT-IPLILLGGITNRTTMDLAMAEGFEFV
Rv3359|M.tuberculosis_H37Rv --EYPYRDAYLLREARLFRAELT-IPLILLGGITNRTTMDLAMAEGFEFV
MMAR_1175|M.marinum_M --EYPYRDAYLLRDARLFRSELS-MPLILLGGITNRETMDLAMAEGFEFV
MAV_4324|M.avium_104 --EYPYREAYLLRDAKLFRAELK-MPLILLGGITNRETMDLAMAEGFEFV
MAB_3694|M.abscessus_ATCC_1997 --SYPYHDAFLLEDARRFRAELD-IPLILLGGITGGESMDLAMAEGFEFV
MSMEG_2889|M.smegmatis_MC2_155 --SYPYEDLYMLPAARQFVPVVRNTKLILLGGITNRDHLETGLREGFELM
TH_2463|M.thermoresistible__bu --SYPYEDLYMLPAARQFVPVMRHTKLILLGGITNRDHLETGLREGFDFL
Mvan_2887|M.vanbaalenii_PYR-1 --SYPYEDLYMLPAARQFVPIMRNTELILLGGITNRDHVETGMREGFAFV
Mflv_4553|M.gilvum_PYR-GCK --VYPYQDLYMLDAARQFVPVMRNTKLVLLGGITERSHIETGLREGFDFV
MUL_1023|M.ulcerans_Agy99 CNQACLDHVFVKKKVSCLLNPRAGHETLLTMSPTQRARTVAVVGAGPAGL
. :: . : :* . * : * :
Mb3394|M.bovis_AF2122/97 AMARALLAEPDLVNRIAAEG-----------SQVRSACTHCNQCMATIYR
Rv3359|M.tuberculosis_H37Rv AMARALLAEPDLVNRIAAEG-----------SQVRSACTHCNQCMATIYR
MMAR_1175|M.marinum_M AMARALLAEPDLINRIAAEG-----------NRVHSACTHCNQCMPTIYS
MAV_4324|M.avium_104 AMARALLAEPDLINRIAADGAA---------HRVHSACTHCNQCMPTIYS
MAB_3694|M.abscessus_ATCC_1997 AMGRALLADPDLVNRVAADR------------ASHSRCTHCNQCMATIFS
MSMEG_2889|M.smegmatis_MC2_155 AMGRALLREPDLVNRMMTDA------------GTRSRCNHNNKCMVTVFG
TH_2463|M.thermoresistible__bu AMGRALLREPDLVNKMIADG------------SVRSRCNHNNKCMVTVFG
Mvan_2887|M.vanbaalenii_PYR-1 AMGRALLREPDLVDKMIADG------------GVRSRCNHNNKCMVTVFA
Mflv_4553|M.gilvum_PYR-GCK AMGRALLREPDLVNRIRSDP------------STRSRCTHNNKCMVTVFG
MUL_1023|M.ulcerans_Agy99 AAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKEEFNETIRYFSTMLA
* . * . : . :: :. .. : : *:
Mb3394|M.bovis_AF2122/97 RTHCVVTGAP----------------------------------------
Rv3359|M.tuberculosis_H37Rv RTHCVVTGAP----------------------------------------
MMAR_1175|M.marinum_M RTRCVVTGAPD---------------------------------------
MAV_4324|M.avium_104 RTHCVVTGAPDRHTSAAT--------------------------------
MAB_3694|M.abscessus_ATCC_1997 KTHCVLT-------------------------------------------
MSMEG_2889|M.smegmatis_MC2_155 RTHCVLDPDQRYGAAIPMD-STRALMSEQA--------------------
TH_2463|M.thermoresistible__bu RTHCVLDPDQRYGAATPMR-PTRSATSAQT--------------------
Mvan_2887|M.vanbaalenii_PYR-1 RTHCVLDPDQRYGAAVPIAEPGRPAVSS----------------------
Mflv_4553|M.gilvum_PYR-GCK RTHCVLDPDQRYGGVSPVQ--QRGELLA----------------------
MUL_1023|M.ulcerans_Agy99 KHGVDVRLATRATADELTGYDEVVLATGVAPRIPAIPGIAHAKVLTYTEA
: :
Mb3394|M.bovis_AF2122/97 --------------------------------------------------
Rv3359|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1175|M.marinum_M --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2889|M.smegmatis_MC2_155 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4553|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1023|M.ulcerans_Agy99 ITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTLNLKEWKAEWGVVDPQ
Mb3394|M.bovis_AF2122/97 --------------------------------------------------
Rv3359|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1175|M.marinum_M --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2889|M.smegmatis_MC2_155 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4553|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1023|M.ulcerans_Agy99 EARGALTTALPTPAAREVYLLQRTKGPQGKRLGKTSGWVHRASVKAKGVH
Mb3394|M.bovis_AF2122/97 --------------------------------------------------
Rv3359|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1175|M.marinum_M --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2889|M.smegmatis_MC2_155 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4553|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1023|M.ulcerans_Agy99 QLSGVNYERISDDGLHISFGPDRQRPQLLAVDSVVICAGQEPVRDLETDL
Mb3394|M.bovis_AF2122/97 -----------------------------------
Rv3359|M.tuberculosis_H37Rv -----------------------------------
MMAR_1175|M.marinum_M -----------------------------------
MAV_4324|M.avium_104 -----------------------------------
MAB_3694|M.abscessus_ATCC_1997 -----------------------------------
MSMEG_2889|M.smegmatis_MC2_155 -----------------------------------
TH_2463|M.thermoresistible__bu -----------------------------------
Mvan_2887|M.vanbaalenii_PYR-1 -----------------------------------
Mflv_4553|M.gilvum_PYR-GCK -----------------------------------
MUL_1023|M.ulcerans_Agy99 RSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL