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TVAAQVSYPKTRRISFRFGESESEDRYFANNDIAFSHTVAFLSAVFPPGEDIFVRSVRRYRDKIADPDLK KRVAGFIGQEMTHGLHHRDLNKQLAEMGYPTAWFEYILNSTERMEKFLDEQYPDPDRCRRFRHLLLAFTV GAEHFTAVLAENVLSRPELQHMMTDPEIKNLLNWHAIEELEHKSVAFDVYRAIGGSETLRINMMRVLANI VIPVGVLSSWVSILTTDPVGRKQPWRVLRETVGVVRGPLLRGFYREMKPFMRRGFHPDDIDTNALLNEWQ DKLFGVNGELVDHLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4451c | - | - | 100% (296) | hypothetical protein MAB_4451c |
| M. abscessus ATCC 19977 | MAB_1116 | - | 3e-94 | 56.90% (297) | hypothetical protein MAB_1116 |
| M. abscessus ATCC 19977 | MAB_2967c | - | 1e-77 | 53.22% (295) | hypothetical protein MAB_2967c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2799c | - | 1e-21 | 29.53% (254) | hypothetical protein Mb2799c |
| M. gilvum PYR-GCK | Mflv_4629 | - | 7e-49 | 39.36% (282) | metal-dependent hydrolase |
| M. tuberculosis H37Rv | Rv2777c | - | 1e-21 | 29.53% (254) | hypothetical protein Rv2777c |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_3143 | - | 3e-47 | 37.81% (283) | hypothetical protein MMAR_3143 |
| M. avium 104 | MAV_3671 | - | 8e-20 | 29.62% (260) | FF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3675 | - | 1e-14 | 28.86% (246) | metal-dependent hydrolase |
| M. thermoresistible (build 8) | TH_2221 | - | 7e-15 | 28.86% (246) | metal-dependent hydrolase |
| M. ulcerans Agy99 | MUL_2157 | - | 6e-22 | 31.01% (258) | hypothetical protein MUL_2157 |
| M. vanbaalenii PYR-1 | Mvan_0314 | - | 6e-49 | 40.07% (282) | metal-dependent hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2799c|M.bovis_AF2122/97 MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
Rv2777c|M.tuberculosis_H37Rv MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
MUL_2157|M.ulcerans_Agy99 --------------------------------------------------
MAV_3671|M.avium_104 --------------------------------------------------
MSMEG_3675|M.smegmatis_MC2_155 --------------------------------------------------
TH_2221|M.thermoresistible__bu --------------------------------------------------
Mflv_4629|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3143|M.marinum_M --------------------------------------------------
MAB_4451c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2799c|M.bovis_AF2122/97 AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWT---NLPFHYVPNE
Rv2777c|M.tuberculosis_H37Rv AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWT---NLPFHYVPNE
MUL_2157|M.ulcerans_Agy99 -MFTVDNRAVGPHSGESGAADHERLVLEARDVEFDWA---NLPFHYVPNE
MAV_3671|M.avium_104 -MVIIDNQAAGPHDAS---VDHERLVLEARDVDFDWA---QLPFHYAPGE
MSMEG_3675|M.smegmatis_MC2_155 -MLRPLRFDH--------EIDPGPVQIQARKVHFDLS---DIPLHWIPGH
TH_2221|M.thermoresistible__bu -MLRPRRFAT--------EVDPGPVQIQARQVHFDVS---GIPLHWIPGH
Mflv_4629|M.gilvum_PYR-GCK ------------MSDDSSTRPTTRVVPKPRRVRFDMP-AETSRQHFVDGD
Mvan_0314|M.vanbaalenii_PYR-1 ------------MSDDSSTRPTTRVVPKPRRVRFDMP-AGTSRQHFVDGD
MMAR_3143|M.marinum_M ------------MPEDRAS-TKSRVLPKPRRVRFPMP-TSTKRRHFVDGD
MAB_4451c|M.abscessus_ATCC_199 -----------------MTVAAQVSYPKTRRISFRFGESESEDRYFANND
:.* : * :: ..
Mb2799c|M.bovis_AF2122/97 PMATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAM
Rv2777c|M.tuberculosis_H37Rv PMATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAM
MUL_2157|M.ulcerans_Agy99 PLPTHVLNVLHLLLPAGEEFFVEVFKKTLPLIKDDQLRLDVQGFIGQEAM
MAV_3671|M.avium_104 PFATHVLNVLHLLLPAGEQFFVEVFKQALPLIRDDQLRLDVQGFIGQEGV
MSMEG_3675|M.smegmatis_MC2_155 PVASTMVNLFNVVLPVAEHWFVDTFNEALPYVRDPKLADDMRGFIGQEAT
TH_2221|M.thermoresistible__bu PVASNLISLLNVVLPDAERWFVATFNEALPYVKDPKLADDMRGFIGQEAT
Mflv_4629|M.gilvum_PYR-GCK LVMSHFVSTLSATFPEGEDFFIRSVREYRDHISDADLKEAVKGFIAQEAT
Mvan_0314|M.vanbaalenii_PYR-1 LVMSHFVSTLSATFPEGEDFFIRSVREYRDHISDADLKEAVKGFIAQEAT
MMAR_3143|M.marinum_M LVMSHFISVLSATFPEGEDFFIRSVKYFQSSIDDPQLLTAVKGFIGQEAT
MAB_4451c|M.abscessus_ATCC_199 IAFSHTVAFLSAVFPPGEDIFVRSVRRYRDKIADPDLKKRVAGFIGQEMT
: : : :* .* *: .. : * .* : ***.**
Mb2799c|M.bovis_AF2122/97 HSQAHSGVVDHFD-AQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYS-W
Rv2777c|M.tuberculosis_H37Rv HSQAHSGVVDHFD-AQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYS-W
MUL_2157|M.ulcerans_Agy99 HSQAHSGVLAHFE-AQGVDVTPYTDQIRWLFGKLLAEKPGRNPRQRHR-W
MAV_3671|M.avium_104 HSRAHANVLAHFA-ARGIDLRPYTGQIEWLFGTLLGPRPNWSPRRRQS-W
MSMEG_3675|M.smegmatis_MC2_155 HAETHDKVLEEFLTAHDVHYQPILELVDHVFNTMLAPKPATDPRRRLN-D
TH_2221|M.thermoresistible__bu HADVHEQVMYDFMVEHGVNPEPILAQIEYMFTKVLTPSTSSDPKRRFN-N
Mflv_4629|M.gilvum_PYR-GCK HRHQHRLLNDRLQ-AMGYPTEGID---RHIKKLVGRLEKRFSP-------
Mvan_0314|M.vanbaalenii_PYR-1 HRHQHRLLNDRLQ-AMGYPTEGID---RHIKKLVGRLEKRFSP-------
MMAR_3143|M.marinum_M HRHQHRLLNERLQ-AMGYPTARID---RHVARLIKRLERRFSP-------
MAB_4451c|M.abscessus_ATCC_199 HGLHHRDLNKQLA-EMGYPTAWFEYILNSTERMEKFLDEQYPDPDRCRRF
* * : : .
Mb2799c|M.bovis_AF2122/97 LLEQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVE
Rv2777c|M.tuberculosis_H37Rv LLEQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVE
MUL_2157|M.ulcerans_Agy99 LLEQVSFIAAIEHYTAVLGEWILNSPQLDVVGTDPVMLDMLRWHGAEEVE
MAV_3671|M.avium_104 LLEQISLVSAIEHYTAILGEWILDSPAHDRIGTDPVMLDMLRWHGAEEVE
MSMEG_3675|M.smegmatis_MC2_155 LCDRLWLIAAIEHYTAVLGDFVLN-CAWDDHHADPTLTDLFRWHGAEEVE
TH_2221|M.thermoresistible__bu LCERLWLIAALEHYTAVLGDFALN-CRWDDHGAHPTMVDLYRWHGAEEVE
Mflv_4629|M.gilvum_PYR-GCK -KMRLAVTAALEHYTATFAEIILTSDEAQELIGYTEVRPILLWHALEECE
Mvan_0314|M.vanbaalenii_PYR-1 -RMRLAVTAALEHYTATFAEIILTSDEAQELIGDTEVRPILLWHALEECE
MMAR_3143|M.marinum_M -EMRLSMTSALEHYTATLAEIILTSDDAQKLIGQTEVRPILLWHAFEESE
MAB_4451c|M.abscessus_ATCC_199 RHLLLAFTVGAEHFTAVLAENVLSRPELQHMMTDPEIKNLLNWHAIEELE
: . . **:** :.: * : . : : **. ** *
Mb2799c|M.bovis_AF2122/97 HKAVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPP
Rv2777c|M.tuberculosis_H37Rv HKAVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPP
MUL_2157|M.ulcerans_Agy99 HKAVAFDTMKHLRAGYWRQVRAQLAVTPVMLLLWIRGVRFMYTVDPLLAP
MAV_3671|M.avium_104 HKAVAFDTMKHLRAGYWRQVRTQLVVTPAMLLLWIRGVRFMYSRDPYLPP
MSMEG_3675|M.smegmatis_MC2_155 HRSVAHDVAVYFQDSYLARVRAMTIAATAVYMFFQRGTWAMIRKDPTVDI
TH_2221|M.thermoresistible__bu HRNVAHDVAVYFRDSYVDRIRAMCIAMPLMWAFFERGMWYLVKTDPSVEL
Mflv_4629|M.gilvum_PYR-GCK HKAVAFDVYETVGGSERTRVWGMRIASLLLFTELVIQTTRSLAG---DRA
Mvan_0314|M.vanbaalenii_PYR-1 HKAVAFDVYETVGGSERTRVWGMRIASLLLFSELVIQTTRSLAG---DRA
MMAR_3143|M.marinum_M HKAVAFDAYRLIGGTERTRVRGMRIASAILFGELILQTALSMAS---DKA
MAB_4451c|M.abscessus_ATCC_199 HKSVAFDVYRAIGGSETLRINMMRVLANIVIPVGVLSSWVSILTT--DPV
*: **.*. . :: :
Mb2799c|M.bovis_AF2122/97 GTKPRWRDYFKAARRGLVPGLPRLLRV-VGHYYKPGFHPSQLGGLGAAVD
Rv2777c|M.tuberculosis_H37Rv GTKPRWRDYFKAARRGLVPGLPRLLRV-VGHYYKPGFHPSQLGGLGAAVD
MUL_2157|M.ulcerans_Agy99 GTKPRWRDYVRSARRGLTPGPWRLIRV-VGDYYKPGFHPSQLGGLERAVD
MAV_3671|M.avium_104 HTKPRWRDYFRAAWRGLVPGPLRFVRA-VANYYRPGFHPSQLGGLQRAVD
MSMEG_3675|M.smegmatis_MC2_155 GWWKMHRLRMRDSKLGLLPKFSTLFGTNTLAYCRPSFTPDQMGSTAQAVA
TH_2221|M.thermoresistible__bu SWWQTQRQRCRDSGLGLLPKWRTLFFTNTLDYFRPGFTPEQMGSTAQAVA
Mflv_4629|M.gilvum_PYR-GCK AYN-PVRLLRSLRAFRHNPLFSRAAIERFRSYTHAGFHPDDWDSAEILER
Mvan_0314|M.vanbaalenii_PYR-1 AYN-PVRLLRSLRAFRHNPLFSSAAIERFRSYSRGGFHPDDWDSAEILEC
MMAR_3143|M.marinum_M SYN-PVTLVRSLRRFSRTPMFTADALQRFRSYNRPGFHPDDWDSTAVLER
MAB_4451c|M.abscessus_ATCC_199 GRKQPWRVLRETVGVVRGPLLR-GFYREMKPFMRRGFHPDDIDTNALLNE
* : : .* *.: .
Mb2799c|M.bovis_AF2122/97 YLAVSPAARASH-------
Rv2777c|M.tuberculosis_H37Rv YLAVSPAARASH-------
MUL_2157|M.ulcerans_Agy99 YLAVSPAARASH-------
MAV_3671|M.avium_104 YLAVSPAARASH-------
MSMEG_3675|M.smegmatis_MC2_155 YLASSPAARAAHL------
TH_2221|M.thermoresistible__bu YLASSPAARSARL------
Mflv_4629|M.gilvum_PYR-GCK WTKELFDADGGQQLRSNV-
Mvan_0314|M.vanbaalenii_PYR-1 WTKELFDADGRQQARSSV-
MMAR_3143|M.marinum_M WSKELFDQDGSQKVIAQPG
MAB_4451c|M.abscessus_ATCC_199 WQDKLFGVNG--ELVDHLR
: .