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SDDSSTRPTTRVVPKPRRVRFDMPAETSRQHFVDGDLVMSHFVSTLSATFPEGEDFFIRSVREYRDHISD ADLKEAVKGFIAQEATHRHQHRLLNDRLQAMGYPTEGIDRHIKKLVGRLEKRFSPKMRLAVTAALEHYTA TFAEIILTSDEAQELIGYTEVRPILLWHALEECEHKAVAFDVYETVGGSERTRVWGMRIASLLLFTELVI QTTRSLAGDRAAYNPVRLLRSLRAFRHNPLFSRAAIERFRSYTHAGFHPDDWDSAEILERWTKELFDADG GQQLRSNV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4629 | - | - | 100% (289) | metal-dependent hydrolase |
| M. gilvum PYR-GCK | Mflv_3425 | - | 8e-18 | 28.57% (266) | hypothetical protein Mflv_3425 |
| M. gilvum PYR-GCK | Mflv_4095 | - | 8e-10 | 28.57% (175) | hypothetical protein Mflv_4095 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2799c | - | 1e-21 | 33.85% (192) | hypothetical protein Mb2799c |
| M. tuberculosis H37Rv | Rv2777c | - | 1e-21 | 33.85% (192) | hypothetical protein Rv2777c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2069 | - | 1e-118 | 70.98% (286) | hypothetical protein MAB_2069 |
| M. marinum M | MMAR_3143 | - | 1e-116 | 69.96% (283) | hypothetical protein MMAR_3143 |
| M. avium 104 | MAV_4121 | - | 7e-21 | 33.67% (196) | FF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3675 | - | 3e-14 | 28.50% (200) | metal-dependent hydrolase |
| M. thermoresistible (build 8) | TH_2221 | - | 1e-15 | 29.77% (215) | metal-dependent hydrolase |
| M. ulcerans Agy99 | MUL_2157 | - | 5e-20 | 28.57% (294) | hypothetical protein MUL_2157 |
| M. vanbaalenii PYR-1 | Mvan_0314 | - | 1e-159 | 95.85% (289) | metal-dependent hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2799c|M.bovis_AF2122/97 MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
Rv2777c|M.tuberculosis_H37Rv MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGA
MUL_2157|M.ulcerans_Agy99 --------------------------------------------------
MAV_4121|M.avium_104 --------------------------------------------------
MSMEG_3675|M.smegmatis_MC2_155 --------------------------------------------------
TH_2221|M.thermoresistible__bu --------------------------------------------------
Mflv_4629|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0314|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2069|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3143|M.marinum_M --------------------------------------------------
Mb2799c|M.bovis_AF2122/97 AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTNLP--FHYVPNEP
Rv2777c|M.tuberculosis_H37Rv AMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTNLP--FHYVPNEP
MUL_2157|M.ulcerans_Agy99 -MFTVDNRAVGPHSGESGAADHERLVLEARDVEFDWANLP--FHYVPNEP
MAV_4121|M.avium_104 -MFTVDDKATGPHDA---ALDHERIVLQARDVDFDWSALP--FYYVPGEP
MSMEG_3675|M.smegmatis_MC2_155 -MLRPLRFDH--------EIDPGPVQIQARKVHFDLSDIP--LHWIPGHP
TH_2221|M.thermoresistible__bu -MLRPRRFAT--------EVDPGPVQIQARQVHFDVSGIP--LHWIPGHP
Mflv_4629|M.gilvum_PYR-GCK ---MSDDSSTR---------PTTRVVPKPRRVRFDMPAETSRQHFVDGDL
Mvan_0314|M.vanbaalenii_PYR-1 ---MSDDSSTR---------PTTRVVPKPRRVRFDMPAGTSRQHFVDGDL
MAB_2069|M.abscessus_ATCC_1997 ---MSDDQAP----------TRTRVLPKPRRVRFPMPTSTKRQHFVDGDL
MMAR_3143|M.marinum_M ---MPEDRAS----------TKSRVLPKPRRVRFPMPTSTKRRHFVDGDL
: :.* * * . . ::: ..
Mb2799c|M.bovis_AF2122/97 MATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMH
Rv2777c|M.tuberculosis_H37Rv MATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMH
MUL_2157|M.ulcerans_Agy99 LPTHVLNVLHLLLPAGEEFFVEVFKKTLPLIKDDQLRLDVQGFIGQEAMH
MAV_4121|M.avium_104 FTTHFCNVLHLLLPAGEEFIVEAFKDTLPLIKDDQLRRDVQGFISQEAMH
MSMEG_3675|M.smegmatis_MC2_155 VASTMVNLFNVVLPVAEHWFVDTFNEALPYVRDPKLADDMRGFIGQEATH
TH_2221|M.thermoresistible__bu VASNLISLLNVVLPDAERWFVATFNEALPYVKDPKLADDMRGFIGQEATH
Mflv_4629|M.gilvum_PYR-GCK VMSHFVSTLSATFPEGEDFFIRSVREYRDHISDADLKEAVKGFIAQEATH
Mvan_0314|M.vanbaalenii_PYR-1 VMSHFVSTLSATFPEGEDFFIRSVREYRDHISDADLKEAVKGFIAQEATH
MAB_2069|M.abscessus_ATCC_1997 VMSHFIAVLSATFPEGEDFFIRSVRNFQSSIDDPQLETAVKGFIGQEATH
MMAR_3143|M.marinum_M VMSHFISVLSATFPEGEDFFIRSVKYFQSSIDDPQLLTAVKGFIGQEATH
. : . : :* .* ::: .. : * .* ::***.*** *
Mb2799c|M.bovis_AF2122/97 SQAHSGVVDHFD-AQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYSWLL
Rv2777c|M.tuberculosis_H37Rv SQAHSGVVDHFD-AQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYSWLL
MUL_2157|M.ulcerans_Agy99 SQAHSGVLAHFE-AQGVDVTPYTDQIRWLFGKLLAEKPGRNPRQRHRWLL
MAV_4121|M.avium_104 SQAHAGVLGHFA-AKGIDVTPFTDQMRWLFGQLIGDRPRWSPRRRQSWLL
MSMEG_3675|M.smegmatis_MC2_155 AETHDKVLEEFLTAHDVHYQPILELVDHVFNTMLAPKPATDPRRRLNDLC
TH_2221|M.thermoresistible__bu ADVHEQVMYDFMVEHGVNPEPILAQIEYMFTKVLTPSTSSDPKRRFNNLC
Mflv_4629|M.gilvum_PYR-GCK RHQHR-LLNDRLQAMGYPTEGIDRHIKKLVGRLEK---RFSPKMR-----
Mvan_0314|M.vanbaalenii_PYR-1 RHQHR-LLNDRLQAMGYPTEGIDRHIKKLVGRLEK---RFSPRMR-----
MAB_2069|M.abscessus_ATCC_1997 RHQHR-LLNERLQVMGYPTARIDRHVARLIKRLER---RFSPEMR-----
MMAR_3143|M.marinum_M RHQHR-LLNERLQAMGYPTARIDRHVARLIKRLER---RFSPEMR-----
. * :: . . : :. : .*. :
Mb2799c|M.bovis_AF2122/97 EQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHK
Rv2777c|M.tuberculosis_H37Rv EQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHK
MUL_2157|M.ulcerans_Agy99 EQVSFIAAIEHYTAVLGEWILNSPQLDVVGTDPVMLDMLRWHGAEEVEHK
MAV_4121|M.avium_104 ERVSMVAALEHYTAILGEWILDTPQHDALGTDPVMLDLLRWHGAEEVEHK
MSMEG_3675|M.smegmatis_MC2_155 DRLWLIAAIEHYTAVLGDFVLN-CAWDDHHADPTLTDLFRWHGAEEVEHR
TH_2221|M.thermoresistible__bu ERLWLIAALEHYTAVLGDFALN-CRWDDHGAHPTMVDLYRWHGAEEVEHR
Mflv_4629|M.gilvum_PYR-GCK --LAVTAALEHYTATFAEIILTSDEAQELIGYTEVRPILLWHALEECEHK
Mvan_0314|M.vanbaalenii_PYR-1 --LAVTAALEHYTATFAEIILTSDEAQELIGDTEVRPILLWHALEECEHK
MAB_2069|M.abscessus_ATCC_1997 --LSMTSALEHYTATLAEIILTSEDAQKLIGQTEVRPILLWHAFEESEHK
MMAR_3143|M.marinum_M --LSMTSALEHYTATLAEIILTSDDAQKLIGQTEVRPILLWHAFEESEHK
: . :*:***** :.: * : . : : **. ** **:
Mb2799c|M.bovis_AF2122/97 AVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPPGT
Rv2777c|M.tuberculosis_H37Rv AVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPPGT
MUL_2157|M.ulcerans_Agy99 AVAFDTMKHLRAGYWRQVRAQLAVTPVMLLLWIRGVRFMYTVDPLLAPGT
MAV_4121|M.avium_104 AVAFDTMKHLRAGYWRQVRTQLLVTPALLWLFIRGVRFMYSVDPHLPPGS
MSMEG_3675|M.smegmatis_MC2_155 SVAHDVAVYFQDSYLARVRAMTIAATAVYMFFQRGTWAMIRKDPTVDIGW
TH_2221|M.thermoresistible__bu NVAHDVAVYFRDSYVDRIRAMCIAMPLMWAFFERGMWYLVKTDPSVELSW
Mflv_4629|M.gilvum_PYR-GCK AVAFDVYETVGGSERTRVWGMRIASLLLFTELVIQTTRSLAGDRAAYNPV
Mvan_0314|M.vanbaalenii_PYR-1 AVAFDVYETVGGSERTRVWGMRIASLLLFSELVIQTTRSLAGDRAAYNPV
MAB_2069|M.abscessus_ATCC_1997 AVAFDVYQLIGGTERTRVRGMRIASVILFGELILQTALSMAADRASYNPV
MMAR_3143|M.marinum_M AVAFDAYRLIGGTERTRVRGMRIASAILFGELILQTALSMASDKASYNPV
**.*. . :: . : *
Mb2799c|M.bovis_AF2122/97 KPRWRDYFKAARRGLVPGLPRLLRVVG-HYYKPGFHPSQLGGLGAAVDYL
Rv2777c|M.tuberculosis_H37Rv KPRWRDYFKAARRGLVPGLPRLLRVVG-HYYKPGFHPSQLGGLGAAVDYL
MUL_2157|M.ulcerans_Agy99 KPRWRDYVRSARRGLTPGPWRLIRVVG-DYYKPGFHPSQLGGLERAVDYL
MAV_4121|M.avium_104 KPRWRDYFSAARRGLVPGPFEFLRVIG-AYYTPGFHPSQLGGVGRAVDYL
MSMEG_3675|M.smegmatis_MC2_155 WKMHRLRMRDSKLGLLPKFSTLFGTNTLAYCRPSFTPDQMGSTAQAVAYL
TH_2221|M.thermoresistible__bu WQTQRQRCRDSGLGLLPKWRTLFFTNTLDYFRPGFTPEQMGSTAQAVAYL
Mflv_4629|M.gilvum_PYR-GCK RLLRSLRAFRHNPLFSRAAIERFRSYT----HAGFHPDDWDSAEILERWT
Mvan_0314|M.vanbaalenii_PYR-1 RLLRSLRAFRHNPLFSSAAIERFRSYS----RGGFHPDDWDSAEILECWT
MAB_2069|M.abscessus_ATCC_1997 TLVRSLYRFSRTPMFTADALRRFRSYN----RPGFHPDDWDSAAVLERWS
MMAR_3143|M.marinum_M TLVRSLRRFSRTPMFTADALQRFRSYN----RPGFHPDDWDSTAVLERWS
: : .* *.: .. :
Mb2799c|M.bovis_AF2122/97 AVSPAARASH-------
Rv2777c|M.tuberculosis_H37Rv AVSPAARASH-------
MUL_2157|M.ulcerans_Agy99 AVSPAARASH-------
MAV_4121|M.avium_104 ARSPAARAAH-------
MSMEG_3675|M.smegmatis_MC2_155 ASSPAARAAHL------
TH_2221|M.thermoresistible__bu ASSPAARSARL------
Mflv_4629|M.gilvum_PYR-GCK KELFDADGGQQLRSNV-
Mvan_0314|M.vanbaalenii_PYR-1 KELFDADGRQQARSSV-
MAB_2069|M.abscessus_ATCC_1997 KELFDQDGSQRVIAQSG
MMAR_3143|M.marinum_M KELFDQDGSQKVIAQPG
. :