For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MNEQLVRRPVIAVQHSPDSVPERLAPVTAAAEVRLVESDRLATALPGAEVLFVYDFRSSALRETWSAADS LRWVQIASTGVDPVLFDEFVASDVVLTNSRGIFERPIAEYVLAQILAFAKDIRRSTRAQAALSWRHFESE SIEGTPVGVLGTGPIGQAISTLLGAVGMRVTVLGRAESADLSSHVGEFEYLVLAAPLTPQTRGIVNARVL SAMRPTARLINVGRGELVGTWDLVSALNRGGIAGAALDVTDPEPLPVGHPLWRTPNTHITPHNSGDVRGW SDRLQDQFVVNFERYLRGEELLNIVDKNRMHRHA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4414 | - | - | 100% (314) | putative NAD-binding protein (D-isomer specific 2-hydroxyacid dehydrogenase) |
| M. abscessus ATCC 19977 | MAB_3304c | - | 2e-22 | 28.24% (301) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4334 | - | 3e-19 | 29.75% (279) | 2-hydroxyacid dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 3e-23 | 28.90% (301) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4234 | - | 2e-22 | 28.24% (301) | D-3-phosphoglycerate dehydrogenase |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 3e-23 | 28.90% (301) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 2e-23 | 29.24% (301) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_1715 | serA1 | 1e-22 | 27.57% (301) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. avium 104 | MAV_3847 | serA | 3e-23 | 28.81% (302) | D-3-phosphoglycerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2496 | - | 2e-71 | 45.86% (314) | NAD-binding protein |
| M. thermoresistible (build 8) | TH_2037 | serA | 3e-22 | 28.15% (302) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_1952 | serA1 | 1e-22 | 27.57% (301) | D-3-phosphoglycerate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 3e-24 | 28.90% (301) | D-3-phosphoglycerate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3020c|M.bovis_AF2122/97 --------------------------MSLPVVLIADKLAPSTVAALGDQV
Rv2996c|M.tuberculosis_H37Rv --------------------------MSLPVVLIADKLAPSTVAALGDQV
MLBr_01692|M.leprae_Br4923 --------------------------MDLPVVLIADKLAQSTVAALGDQV
MMAR_1715|M.marinum_M --------------------------MNLPVVLIADKLAQSTVAALGDQV
MUL_1952|M.ulcerans_Agy99 --------------------------MNLPVVLIADKLAQSTVAALGDQV
MAV_3847|M.avium_104 --------------------------MNLPVVLIADKLAESTVAALGDQV
Mflv_4234|M.gilvum_PYR-GCK --------------------------MSLPVVLIADKLAQSTVEALGDQV
Mvan_2128|M.vanbaalenii_PYR-1 --------------------------MSLPVVLIADKLAQSTVEALGDQV
TH_2037|M.thermoresistible__bu --------------------------VSLPVVLIADKLAESTVAALGDQV
MAB_4414|M.abscessus_ATCC_1997 ----------------MNEQLVR--RPVIAVQHSPDS-VPERLAPVTAAA
MSMEG_2496|M.smegmatis_MC2_155 MVPTLDRVPTPNQSGAAGGRAVRDRRPAVAVLCAQESDRPPGLEALD--V
:.* :. : .: .
Mb3020c|M.bovis_AF2122/97 EVRWVDGPDRDKLLAAVPEADALLVR-SATTVDAEVLAAAPKLKIVARAG
Rv2996c|M.tuberculosis_H37Rv EVRWVDGPDRDKLLAAVPEADALLVR-SATTVDAEVLAAAPKLKIVARAG
MLBr_01692|M.leprae_Br4923 EVRWVDGPDRTKLLAAVPEADALLVR-SATTVDAEVLAAAPKLKIVARAG
MMAR_1715|M.marinum_M EVRWVDGPDREKLLAAVPEADALLVR-SATTVDAEVLAAATKLKIVARAG
MUL_1952|M.ulcerans_Agy99 EVRWVDGPDREKLLAAVPEADALLVR-SATTVDAEVLAAATKLKIVARAG
MAV_3847|M.avium_104 EVRWVDGPDREKLLAAVPEADALLVR-SATTVDAEVLAAAPKLKIVARAG
Mflv_4234|M.gilvum_PYR-GCK EVRWVDGPDREKLLAAVADADALLVR-SATTVDAEVLAAAPKLKIVARAG
Mvan_2128|M.vanbaalenii_PYR-1 EVRWVDGPDREKLLAAVADADALLVR-SATTVDAEVLAAAPKLKIVARAG
TH_2037|M.thermoresistible__bu EVRWVDGPDREKLLAAVADADALLVR-SATTVDAEVLAAAPKLKIVARAG
MAB_4414|M.abscessus_ATCC_1997 EVRLVES---DRLATALPGAEVLFVYDFRSSALRETWSAADSLRWVQIAS
MSMEG_2496|M.smegmatis_MC2_155 EFRYCTA---DTLAEAVRGARAMLLWDFFSKAVRDVWSAAGSVEWIHVTA
*.* . * *: * .::: :.. :. :** .:. : :.
Mb3020c|M.bovis_AF2122/97 VGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADAS
Rv2996c|M.tuberculosis_H37Rv VGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADAS
MLBr_01692|M.leprae_Br4923 VGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADAS
MMAR_1715|M.marinum_M VGLDNVDVDAATTRGVLVVNAPTSNIHSAAEHAMALLLAAARQIPAADAS
MUL_1952|M.ulcerans_Agy99 VGLDNVDVDAATTRGVLVVNAPTSNIHSAAEHAMALLLAAARQIPAADAS
MAV_3847|M.avium_104 VGLDNVDVDAATERGVLVVNAPTSNIHSAAEHALALLLAAAREIPAADAS
Mflv_4234|M.gilvum_PYR-GCK VGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLSTARQIPAADAT
Mvan_2128|M.vanbaalenii_PYR-1 VGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAAARQIPAADAT
TH_2037|M.thermoresistible__bu VGLDNVDVEAATARGVLVVNAPTSNIHSAAEHAIALLLAAARQIPAADAT
MAB_4414|M.abscessus_ATCC_1997 TGVDPVLFDEFVASDVVLTNSRGIFERPIAEYVLAQILAFAKDIRRSTRA
MSMEG_2496|M.smegmatis_MC2_155 AGVDTLLFDELRDSDVVVTNAHGVFDRPIAEYVLGAVIAHAKDTRRSLDL
.*:* : .: .*::.*: :. **:.:. ::: ::: :
Mb3020c|M.bovis_AF2122/97 LREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPY
Rv2996c|M.tuberculosis_H37Rv LREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPY
MLBr_01692|M.leprae_Br4923 LRAHIWKRSSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPY
MMAR_1715|M.marinum_M LREHTWKRSSFSGAEIFGKTVGVVGLGRIGQLVAQRVEAFGAHVVAYDPY
MUL_1952|M.ulcerans_Agy99 LREHTWKRSSFSGAEIFGKTVGVVGLGRIGQLVAQRVEAFGAHVVAYDPY
MAV_3847|M.avium_104 LREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRLSAFGTHLIAYDPY
Mflv_4234|M.gilvum_PYR-GCK LREHTWKRSAFSGTEIFGKTVGVVGLGRIGQLVAQRLAAFGAHITAYDPY
Mvan_2128|M.vanbaalenii_PYR-1 LREHSWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRLAAFGAHITAYDPY
TH_2037|M.thermoresistible__bu LRQRTWKRSEFSGVEIYDKTVGVVGLGRIGQLVAQRLAAFGTHLIAYDPY
MAB_4414|M.abscessus_ATCC_1997 QAALSWRHFESE--SIEGTPVGVLGTGPIGQAISTLLGAVGMRVTVLGR-
MSMEG_2496|M.smegmatis_MC2_155 QRQHRWQHRETR--RVTGSRALVVGTGGIGRETARLLRAAGLEVRGAGRT
*:: : .. . *:* * **: : : * * : .
Mb3020c|M.bovis_AF2122/97 VSPARAAQLG-IELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTK
Rv2996c|M.tuberculosis_H37Rv VSPARAAQLG-IELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTK
MLBr_01692|M.leprae_Br4923 VAPARAAQLG-IELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTK
MMAR_1715|M.marinum_M VSPARAAQLG-IELLPLDDLLARADFISVHLPKTPETAGLLGKEALAKTK
MUL_1952|M.ulcerans_Agy99 VSPARAAQLG-IELLPLDDLLARADFISVHLPKTPETAGLLGKEALAKTK
MAV_3847|M.avium_104 VSPARAAQLG-IELLSLDELLARADFISVHLPKTPETAGLIDKDALAKTK
Mflv_4234|M.gilvum_PYR-GCK VSHARAAQLG-IELLTLDELLSRADFISVHLPKTKETAGLIGTEALAKTK
Mvan_2128|M.vanbaalenii_PYR-1 VSHARAAQLG-IELLTLDELLGRADFISVHLPKTKETAGLIGKEALAKTK
TH_2037|M.thermoresistible__bu VSPARAAQLG-IELVDLDELLGRADIISVHLPKTPETAGLIGADALAKVK
MAB_4414|M.abscessus_ATCC_1997 -----------AESADLSSHVGEFEYLVLAAPLTPQTRGIVNARVLSAMR
MSMEG_2496|M.smegmatis_MC2_155 ARDDDPDFGRVVASSDLSAEVGWCDHLILAVPLTDATRGLVDAAVLGAMK
:. :. : : : * * * *::. .*. :
Mb3020c|M.bovis_AF2122/97 PGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPC-TDSPLFEL
Rv2996c|M.tuberculosis_H37Rv PGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPC-TDSPLFEL
MLBr_01692|M.leprae_Br4923 PGVIIVNAARGGLVDEVALADAVRSGHVRAAGLDVFATEPC-TDSPLFEL
MMAR_1715|M.marinum_M PGVIIVNAARGGLIDESALAEAITSGHVRGAGLDVFATEPC-TDSPLFEL
MUL_1952|M.ulcerans_Agy99 PGVIIVNAARGGLIDESALAEAITSGYVRGAGLDVFATEPC-TDSPLFEL
MAV_3847|M.avium_104 PGVIIVNAARGGLVDEAALADAVRSGHVRAAGLDVFSKEPC-TDSPLFEL
Mflv_4234|M.gilvum_PYR-GCK PGVIIVNAARGGLIDEQALADAITSGHVRGAGLDVFSTEPC-TDSPLFEL
Mvan_2128|M.vanbaalenii_PYR-1 PGVIIVNAARGGLIDEAALADAINSGHVRGAGLDVFSTEPC-TDSPLFEL
TH_2037|M.thermoresistible__bu PGVIIVNAARGGLIDEQALADAIISGRVRAAGIDVFAKEPC-TDSPLFDL
MAB_4414|M.abscessus_ATCC_1997 PTARLINVGRGELVGTWDLVSALNRGGIAGAALDVTDPEPLPVGHPLWRT
MSMEG_2496|M.smegmatis_MC2_155 PDAHLVNIARGPVVDEAALIAALTEHRIGGATLDAFDVEPLPADHPLWDV
* . ::* .** ::. * *: : .* :*. ** .. **:
Mb3020c|M.bovis_AF2122/97 AQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNE
Rv2996c|M.tuberculosis_H37Rv AQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNE
MLBr_01692|M.leprae_Br4923 SQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGVVNE
MMAR_1715|M.marinum_M PQVVVTPHLGASTAEAQDRAGTDVAASVKLALAGEFVPDAVNIAGGAVNE
MUL_1952|M.ulcerans_Agy99 PQVVVTPHLGASTAEAQDRAGTDVAASVKLALAGEFVPDAVNIAGGAVNE
MAV_3847|M.avium_104 PQVVVTPHLGASTTEAQDRAGTDVAASVKLALAGEFVPDAVNVAGGTVNE
Mflv_4234|M.gilvum_PYR-GCK PQVVVTPHLGASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGGGAVGE
Mvan_2128|M.vanbaalenii_PYR-1 PQVVVTPHLGASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGGGAVGE
TH_2037|M.thermoresistible__bu PQVVVTPHLGASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGAGEVSE
MAB_4414|M.abscessus_ATCC_1997 PNTHITPHNSGDVRGWSDRLQDQFVVNFERYLRGEELLNIVDKNRMHRHA
MSMEG_2496|M.smegmatis_MC2_155 PNVTITAHMSGDVVGWRDTLAEQYAENVRRWLAGEPLHNVVDKKLGYISQ
.:. :*.* .... * : . ... * ** : : *:
Mb3020c|M.bovis_AF2122/97 EVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRG
Rv2996c|M.tuberculosis_H37Rv EVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRG
MLBr_01692|M.leprae_Br4923 EVAPWLDLVCKLGVLVAALSDELPASLSVHVRGELASEDVEILRLSALRG
MMAR_1715|M.marinum_M EVAPWLDLACKLGVLAAALSDEPPVSLSVQARGELASEDVEVLKLSALRG
MUL_1952|M.ulcerans_Agy99 EVAPWLDLACKLGVLAAALSDEPPVSLSVQAGGELASEDVEVLKLSALRG
MAV_3847|M.avium_104 EVAPWLDLVRKLGLLAATLSDGPPVSLSVQVRGELASEDVEVLKLSALRG
Mflv_4234|M.gilvum_PYR-GCK EVAPWLDLVRKLGLLVGALSAELPTNLCVQVRGELASEEVEVLRLSALRG
Mvan_2128|M.vanbaalenii_PYR-1 EVAPWLDLVRKLGLLVGVLSSEPPVSLQVQVQGELASEEVEVLKLSALRG
TH_2037|M.thermoresistible__bu EVAPWVDLARKLGLLVGTLSGEPTATLQVRVAGELASEDVEVLRLSALRG
MAB_4414|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2496|M.smegmatis_MC2_155 AGRGVR--------------------------------------------
Mb3020c|M.bovis_AF2122/97 LFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADG
Rv2996c|M.tuberculosis_H37Rv LFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADG
MLBr_01692|M.leprae_Br4923 LFSTVIEDAVTFVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVASDG
MMAR_1715|M.marinum_M LFSAVVEGPVTFVNAPALAAERGVSVEISKASESPNHRSVVDVRVVGADG
MUL_1952|M.ulcerans_Agy99 LFSAVVEGPVTFVNAPALAAERGVSVEISKASESPNHRSVVDVRVVGADG
MAV_3847|M.avium_104 LFSAVVEGPVTFVNAPALAEERGVTAEISTASESPNHRSVVDVRAVSHDG
Mflv_4234|M.gilvum_PYR-GCK LFSAVIEDQVTFVNAPALATERGVEASIDTESESPNHRSVVDVRAVAADG
Mvan_2128|M.vanbaalenii_PYR-1 LFSAVIEHPVTFVNAPALASERGVEASITTATESANHRSVVDVRAVAADG
TH_2037|M.thermoresistible__bu LFSTLTDQQVTYVNAPTLAAERGMQAELEKVSESPNYRSVVDVRAVSTDG
MAB_4414|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2496|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 SVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIG
Rv2996c|M.tuberculosis_H37Rv SVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIG
MLBr_01692|M.leprae_Br4923 SVVNIAGTLSGPQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALGKIG
MMAR_1715|M.marinum_M SVVSVSGTLYGAQLTHKIVQINGRHFDLRAEGTNLIVNYVDQPGALGKIG
MUL_1952|M.ulcerans_Agy99 SVVSVSGTLYGAQLTHKIVQINGRHFDLRAEGTNLIVNYVDQPGALGKIG
MAV_3847|M.avium_104 TVVNVAGTLSGPQLVEKIVQINGRNFDLRARGINLVINYVDQPGALGKIG
Mflv_4234|M.gilvum_PYR-GCK STVNVSGTLTGPQLVEKIVQINGRNLDLRAEGVNVIINYHDQPGALGKIG
Mvan_2128|M.vanbaalenii_PYR-1 STVNVAGTLTGPQLVEKIVQINGRNLELRAEGVNLIINYDDQPGALGKIG
TH_2037|M.thermoresistible__bu TVTNVAGTLSGPQQVEKIVQINGRNFDLRAEGVNLVMHYVDRPGALGKIG
MAB_4414|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2496|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 TLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYK
Rv2996c|M.tuberculosis_H37Rv TLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYK
MLBr_01692|M.leprae_Br4923 TLLGAAGVNIQAAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVSANK
MMAR_1715|M.marinum_M TLLGAAGVNIHAAQLSEDVEGPGATVLLRLDQDVPEDVRSAIAAAVGANR
MUL_1952|M.ulcerans_Agy99 TLLGAAGVNIHAAQLSEDVEGPGATVLLRLDQDVPEDVRSAIAAAVGANR
MAV_3847|M.avium_104 TLLGSAGVNIQAAQLSEDAEGPGATILLRLDQDVPADVRSAIGAAVGANK
Mflv_4234|M.gilvum_PYR-GCK TLLGGANVNILAAQLSQDADGEGATIMLRVDREVPADVLAGIGRDVNALT
Mvan_2128|M.vanbaalenii_PYR-1 TLLGGAAVNILAAQLSQDADGIGATVMLRLDREVPGEVLAAIGRDVNAVT
TH_2037|M.thermoresistible__bu TLLGAADVNILAAQLSQDISGDGATLMLRVNRDVPADVRDAIGAAVGAST
MAB_4414|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2496|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 LEVVDLS
Rv2996c|M.tuberculosis_H37Rv LEVVDLS
MLBr_01692|M.leprae_Br4923 LEVVNLS
MMAR_1715|M.marinum_M LEVVDLS
MUL_1952|M.ulcerans_Agy99 LEVVDLS
MAV_3847|M.avium_104 LEVVDLS
Mflv_4234|M.gilvum_PYR-GCK LEVVDLT
Mvan_2128|M.vanbaalenii_PYR-1 LEVVDLT
TH_2037|M.thermoresistible__bu LEVVDLS
MAB_4414|M.abscessus_ATCC_1997 -------
MSMEG_2496|M.smegmatis_MC2_155 -------