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RTDLCERFGIRYPIFGFTPSEKVAAAISRAGGMGVLGCVRFNDPDELDAVLNWMDENTDGKPYGVDIVMP AKVPAEGTAVDIDKLIPQGHKDFVEKTLADLGVPPLPGERESAGVLGWLHSVARSHVEVALKHPIKLIAN ALGSPPKDVIDQAHEHGVPVAALAGKAEHARRHVENGVDIVVAQGYEAGGHTGDVASMVLWPEIVDALDG SAPVLAAGGIGSGRQAAAALALGASGVWTGSIWLTAAEYDLGTVTAGGDSVVQQALLKATSGDTVRTRIY TGKPARLLKTKWTQAWDAEDAPTPLPMPLQNILVSEAHERMNRAHDPETVCFPAGQIVGRMNEIRPTAEI VADLVSGFEAAVDRLDEIRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4162c | - | - | 100% (371) | putative 2-nitropropane dioxygenase |
| M. abscessus ATCC 19977 | MAB_0354c | - | 2e-88 | 45.65% (379) | 2-nitropropane dioxygenase family oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0603c | - | 8e-26 | 30.64% (297) | 2-nitropropane dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1560 | - | 9e-92 | 47.40% (384) | hypothetical protein Mb1560 |
| M. gilvum PYR-GCK | Mflv_1544 | - | 1e-171 | 78.71% (371) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv1533 | - | 9e-92 | 47.40% (384) | hypothetical protein Rv1533 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2787 | - | 1e-89 | 47.11% (380) | hypothetical protein MMAR_2787 |
| M. avium 104 | MAV_2807 | - | 3e-93 | 48.28% (379) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_5913 | - | 1e-172 | 78.71% (371) | dioxygenase |
| M. thermoresistible (build 8) | TH_1822 | - | 1e-167 | 76.55% (371) | dioxygenase |
| M. ulcerans Agy99 | MUL_1143 | - | 1e-90 | 47.63% (380) | hypothetical protein MUL_1143 |
| M. vanbaalenii PYR-1 | Mvan_5214 | - | 1e-169 | 77.63% (371) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1544|M.gilvum_PYR-GCK MRTELCDRFGIEYPIFVFTPSEKVAAAVTKAGGLGVLGCVRFNDADDLEN
Mvan_5214|M.vanbaalenii_PYR-1 MKTELCDRFGIEYPLFVFTPSEKVAAAVSKAGGLGVLGCVRFNDADDLEN
MSMEG_5913|M.smegmatis_MC2_155 MKTELCERFGIEYPIFVFTPSEKVAAAVSKAGGLGVLGCVRFNDADDLED
TH_1822|M.thermoresistible__bu MRTELCERFGIRYPIFVFTPSEKVAAAVSRAGGLGVLGCVRFNDPDDLEN
MAB_4162c|M.abscessus_ATCC_199 MRTDLCERFGIRYPIFGFTPSEKVAAAISRAGGMGVLGCVRFNDPDELDA
MMAR_2787|M.marinum_M MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFT-PEQLEI
MUL_1143|M.ulcerans_Agy99 MHTAICDELGIEFPIFAFTHCRDVVLAVSKAGGFGVLGAVGFT-PEQLEI
MAV_2807|M.avium_104 MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFT-PEQLEI
Mb1560|M.bovis_AF2122/97 MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHS-PKRLES
Rv1533|M.tuberculosis_H37Rv MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHS-PKRLES
*:* :.: :* .:*: *: ...*. *::.***:*:**.* .. .. *:
Mflv_1544|M.gilvum_PYR-GCK VLQWMDANTDGKPYGVDIVMP-------AKVPTEG---TSVDINKLIPAE
Mvan_5214|M.vanbaalenii_PYR-1 VLQWMDANTDGKPYGVDIVMP-------AKVPTEG---TSVDINKLIPAE
MSMEG_5913|M.smegmatis_MC2_155 VLQWMDANTDGKPYGVDVVMP-------AKVPTEG---TAVDINKLIPQG
TH_1822|M.thermoresistible__bu VLCWMDDNTDGLPYGVDVVMP-------AKVPTEG---SAVDIDKLIPQG
MAB_4162c|M.abscessus_ATCC_199 VLNWMDENTDGKPYGVDIVMP-------AKVPAEG---TAVDIDKLIPQG
MMAR_2787|M.marinum_M ELTWIDEHIGDHPYGVDIVIPNKYEGMDSHLSAEE---LANTLRSMVPQQ
MUL_1143|M.ulcerans_Agy99 ELNWIDEHIGDHPYGVDIVIPNKYEGMDSHLSAEE---LANTLRSMVPQQ
MAV_2807|M.avium_104 ELKWIDENIGDHPYGVDIVIPNKYEGMDSHLSAEE---LAETLRKMVPQE
Mb1560|M.bovis_AF2122/97 ELTWIEEHTGGKPYGVDVLLP------PKYIGAEQGGIDAQQARELIPEG
Rv1533|M.tuberculosis_H37Rv ELTWIEEHTGGKPYGVDVLLP------PKYIGAEQGGIDAQQARELIPEG
* *:: : .. *****:::* : :* : .::*
Mflv_1544|M.gilvum_PYR-GCK HREFVDKTLADLGVPPLPEDEER-SEGVLGWLHSVARSHVEVALKHP-IK
Mvan_5214|M.vanbaalenii_PYR-1 HREFVDKTLADLGVPPLPADEER-SEGVLGWLHSVARSHVEVALKHP-IK
MSMEG_5913|M.smegmatis_MC2_155 HRDFVAKTLADLGVPPLPEDGER-NEGVLGWLHSVARSHVEVALKHP-IK
TH_1822|M.thermoresistible__bu HRDFVNKTLTELGVPPLSEDQQR-NEGVLGWLHSVARSHVDVALKHP-IK
MAB_4162c|M.abscessus_ATCC_199 HKDFVEKTLADLGVPPLPGERE--SAGVLGWLHSVARSHVEVALKHP-IK
MMAR_2787|M.marinum_M HLDFARKILADHGVP-IEDADED-SLQLLGWTEATATPQVEVALEHSKVT
MUL_1143|M.ulcerans_Agy99 HLDFARKILADHGVP-IEDADED-SLQLLGWTEATATPQVEVALKHSKVT
MAV_2807|M.avium_104 HLDFGKKILADHGVP-IEDSDSD-SLQLLGWTEATATPQVEVALKHPKVK
Mb1560|M.bovis_AF2122/97 HRTFVDDLLVRYGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHD-IR
Rv1533|M.tuberculosis_H37Rv HRTFVDDLLVRYGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHD-IR
* * . *. *:* : . * . ::**: * :
Mflv_1544|M.gilvum_PYR-GCK LIANALGSPPKDVIDQVHEAGVPVAALAGSPKHALRHVENGVDIVVAQGH
Mvan_5214|M.vanbaalenii_PYR-1 LIANALGSPPKDVIDQAHQAGVPVAALAGSAKHALRHVDNGVDIVVAQGH
MSMEG_5913|M.smegmatis_MC2_155 LIANALGSPPKDVIDQAHAAGVPVAALAGSAKHALRHVENGVDIVVAQGH
TH_1822|M.thermoresistible__bu LIANALGSPPTDVIERVHKAGVPVAALAGSAKHAQRHVDNGVDIVVAQGH
MAB_4162c|M.abscessus_ATCC_199 LIANALGSPPKDVIDQAHEHGVPVAALAGKAEHARRHVENGVDIVVAQGY
MMAR_2787|M.marinum_M MIANALGTPPAEMIAHIHEQGRKVAALCGSPSQARKHANAGVDIIIAQGG
MUL_1143|M.ulcerans_Agy99 MIANALGTPPAEMIAHIHERGRKVAALCGSPSQARKHANAGVDIIIAQGG
MAV_2807|M.avium_104 MIANALGTPPADMIKHIHDAGLKVAALCGSPSQARKHADAGVDIIIAQGG
Mb1560|M.bovis_AF2122/97 LIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVAQGT
Rv1533|M.tuberculosis_H37Rv LIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVAQGT
:**.***.** ::: : * . ****.*...:* :*. ***:::***
Mflv_1544|M.gilvum_PYR-GCK EAGGHTGEIGSMVLWPEIVDALDGRAPVLAAGGIGTGRQVAAALALGAQG
Mvan_5214|M.vanbaalenii_PYR-1 EAGGHTGEIGSMVLWPEIVDAIEGRAPVLAAGGIGTGRQVAAALALGAQG
MSMEG_5913|M.smegmatis_MC2_155 EAGGHTGEIGSMVLWPEIVDALDGKAPVLAAGGIGTGRQVAAALALGASG
TH_1822|M.thermoresistible__bu EAGGHTGEIGSVVLWPEIVDAVGDQVPVLAAGGIGTGRQVAAALALGAQG
MAB_4162c|M.abscessus_ATCC_199 EAGGHTGDVASMVLWPEIVDALDGSAPVLAAGGIGSGRQAAAALALGASG
MMAR_2787|M.marinum_M EAGGHCGEVGSIVLWPQVVKEVAP-VPVLAAGGIGSGQQIAAALVLGCQG
MUL_1143|M.ulcerans_Agy99 EAGGHCGEVGSIVLWPQVVKEVAP-VPVLAAGGIGSGQQIAAALALGCQG
MAV_2807|M.avium_104 EAGGHCGEVGSIVLWPQVVKEVAP-LPVLAAGGIGSGQQIAAALALGAQG
Mb1560|M.bovis_AF2122/97 EAGGHTGEVATMVLVPEVVDAVSP-TPVLAAGGIARGRQIAAALALGAEG
Rv1533|M.tuberculosis_H37Rv EAGGHTGEVATMVLVPEVVDAVSP-TPVLAAGGIARGRQIAAALALGAEG
***** *::.::** *::*. : ********. *:* ****.**..*
Mflv_1544|M.gilvum_PYR-GCK VWMGSAFLTSAEYDLGVRLESGRSVIQEAMLKATSADTVRRRIYTGKPAR
Mvan_5214|M.vanbaalenii_PYR-1 VWMGSAFLTSAEYDLGVRLPSGRSVVQEAMLNATSADTVRRRIYTGKPAR
MSMEG_5913|M.smegmatis_MC2_155 VWMGSAFLTSAEYDLGHRKPSGVSTIQEALLRAGTADTVRRKIYTGKPAR
TH_1822|M.thermoresistible__bu VWMGSAFLTSAEYDLGVRRESGISTIQQALLDATSADTVRRRIYTGKPAR
MAB_4162c|M.abscessus_ATCC_199 VWTGSIWLTAAEYDLGTVTAGGDSVVQQALLKATSGDTVRTRIYTGKPAR
MMAR_2787|M.marinum_M AWTGSQWLMVEE-------ASNTPVQQAAYAKASSRDTVRSRSFTGKPAR
MUL_1143|M.ulcerans_Agy99 AWTGSQWLMVEE-------ASNTPVQQAAYAKASSRDTVRSRSFTGKPAR
MAV_2807|M.avium_104 AWTGSQWLMVEE-------SSNTPVQQAAYAKAGSRDTVRSRSFTGKPAR
Mb1560|M.bovis_AF2122/97 VWCGSVWLTTEE-------AETPPVVKDKFLAATSSDTVRSRSLTGKPAR
Rv1533|M.tuberculosis_H37Rv VWCGSVWLTTEE-------AETPPVVKDKFLAATSSDTVRSRSLTGKPAR
.* ** :* * .. : * : **** : ******
Mflv_1544|M.gilvum_PYR-GCK LLKSRWTDAWDAEGAPEPLPMPLQNILVSEAHQRMSES-----SDPTTVA
Mvan_5214|M.vanbaalenii_PYR-1 LLKSRWTDAWDADGAPEPLPMPLQNILVSEAHQRMSEN-----SDPTAVA
MSMEG_5913|M.smegmatis_MC2_155 LLKTKWTDAWDAPEAPEPLPMPLQNILVSEAHQRMNES-----DNPDTVA
TH_1822|M.thermoresistible__bu LLKSRWTDAWDAPDAPEPLPMPLQNILVSEAHQRMNYS-----TDPTTVA
MAB_4162c|M.abscessus_ATCC_199 LLKTKWTQAWDAEDAPTPLPMPLQNILVSEAHERMNRA-----HDPETVC
MMAR_2787|M.marinum_M MLRNDWTEAWEQADNPKPLGMPLQYMVSGMAVRATNKHP----NETVDVA
MUL_1143|M.ulcerans_Agy99 MLRNDWTEAWEQADNPKPLGMPLQYMVSGMAVRATNKYP----NETVDVA
MAV_2807|M.avium_104 MLRNDWTEAWEAPGNPKPLGMPLQYMVSGMAVRATNKYP----NESVDVA
Mb1560|M.bovis_AF2122/97 MLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELA
Rv1533|M.tuberculosis_H37Rv MLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELA
:*:. **: *: * ** **** : . . . .. :.
Mflv_1544|M.gilvum_PYR-GCK M-PVGQIVGRMNEIRPVADIIAELVSGFDEASKRLDAIRDN---
Mvan_5214|M.vanbaalenii_PYR-1 M-PVGQIVGRMNEIRPVADIIAELVSGFEEATRRLDAIRDN---
MSMEG_5913|M.smegmatis_MC2_155 M-PVGQIVGRMNQIRPVADIIAELVEGFEKATNRLDTVRDA---
TH_1822|M.thermoresistible__bu M-PVGQIVGRMNEIRPVGDIIADLVAEFEEATRRLDTIRDG---
MAB_4162c|M.abscessus_ATCC_199 F-PAGQIVGRMNEIRPTAEIVADLVSGFEAAVDRLDEIRG----
MMAR_2787|M.marinum_M FNPVGQVVGQFTKVEKAATVIERWVQEYLEATNRLDELNAAAV-
MUL_1143|M.ulcerans_Agy99 FNPVGQVVGQFTKVEKAATVIERWVQEYLEATNRLDELNAAAV-
MAV_2807|M.avium_104 FNPVGQVVGQFTKVEKTATVIERWVQEYLEATNRLDELNEAASV
Mb1560|M.bovis_AF2122/97 TYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR---
Rv1533|M.tuberculosis_H37Rv TYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR---
.**:** : .:. . :: * : : :*: :