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KTELCERFGIEYPIFVFTPSEKVAAAVSKAGGLGVLGCVRFNDADDLEDVLQWMDANTDGKPYGVDVVMP AKVPTEGTAVDINKLIPQGHRDFVAKTLADLGVPPLPEDGERNEGVLGWLHSVARSHVEVALKHPIKLIA NALGSPPKDVIDQAHAAGVPVAALAGSAKHALRHVENGVDIVVAQGHEAGGHTGEIGSMVLWPEIVDALD GKAPVLAAGGIGTGRQVAAALALGASGVWMGSAFLTSAEYDLGHRKPSGVSTIQEALLRAGTADTVRRKI YTGKPARLLKTKWTDAWDAPEAPEPLPMPLQNILVSEAHQRMNESDNPDTVAMPVGQIVGRMNQIRPVAD IIAELVEGFEKATNRLDTVRDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5913 | - | - | 100% (373) | dioxygenase |
| M. smegmatis MC2 155 | MSMEG_3519 | - | 1e-86 | 45.34% (386) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_0992 | - | 5e-79 | 42.63% (380) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1927c | - | 4e-87 | 45.19% (385) | hypothetical protein Mb1927c |
| M. gilvum PYR-GCK | Mflv_1544 | - | 0.0 | 88.44% (372) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv1894c | - | 4e-87 | 45.19% (385) | hypothetical protein Rv1894c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4162c | - | 1e-172 | 78.71% (371) | putative 2-nitropropane dioxygenase |
| M. marinum M | MMAR_2346 | - | 2e-86 | 45.34% (386) | dioxygenase |
| M. avium 104 | MAV_2807 | - | 3e-93 | 47.78% (383) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. thermoresistible (build 8) | TH_1822 | - | 0.0 | 85.22% (372) | dioxygenase |
| M. ulcerans Agy99 | MUL_1143 | - | 3e-86 | 45.43% (383) | hypothetical protein MUL_1143 |
| M. vanbaalenii PYR-1 | Mvan_5214 | - | 0.0 | 88.17% (372) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1927c|M.bovis_AF2122/97 MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFT-PEQLEI
Rv1894c|M.tuberculosis_H37Rv MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFT-PEQLEI
MUL_1143|M.ulcerans_Agy99 MHTAICDELGIEFPIFAFTHCRDVVLAVSKAGGFGVLGAVGFT-PEQLEI
MAV_2807|M.avium_104 MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFT-PEQLEI
Mflv_1544|M.gilvum_PYR-GCK MRTELCDRFGIEYPIFVFTPSEKVAAAVTKAGGLGVLGCVRFNDADDLEN
Mvan_5214|M.vanbaalenii_PYR-1 MKTELCDRFGIEYPLFVFTPSEKVAAAVSKAGGLGVLGCVRFNDADDLEN
MSMEG_5913|M.smegmatis_MC2_155 MKTELCERFGIEYPIFVFTPSEKVAAAVSKAGGLGVLGCVRFNDADDLED
TH_1822|M.thermoresistible__bu MRTELCERFGIRYPIFVFTPSEKVAAAVSRAGGLGVLGCVRFNDPDDLEN
MAB_4162c|M.abscessus_ATCC_199 MRTDLCERFGIRYPIFGFTPSEKVAAAISRAGGMGVLGCVRFNDPDELDA
MMAR_2346|M.marinum_M MRTRVAEMLGVEFPICAFSHCRDVVAAVTNAGGFGILGATAHS-PKRLES
*:* :.: :*:.:*: *: ...*. *::.***:*:**.. .. .. *:
Mb1927c|M.bovis_AF2122/97 ELNWIDEHIGDHPYGVDIVIPNKYEGMDSQLSADELAKT---LRSMVPQE
Rv1894c|M.tuberculosis_H37Rv ELNWIDEHIGDHPYGVDIVIPNKYEGMDSQLSADELAKT---LRSMVPQE
MUL_1143|M.ulcerans_Agy99 ELNWIDEHIGDHPYGVDIVIPNKYEGMDSHLSAEELANT---LRSMVPQQ
MAV_2807|M.avium_104 ELKWIDENIGDHPYGVDIVIPNKYEGMDSHLSAEELAET---LRKMVPQE
Mflv_1544|M.gilvum_PYR-GCK VLQWMDANTDGKPYGVDIVMP-------AKVPTEGTSVD---INKLIPAE
Mvan_5214|M.vanbaalenii_PYR-1 VLQWMDANTDGKPYGVDIVMP-------AKVPTEGTSVD---INKLIPAE
MSMEG_5913|M.smegmatis_MC2_155 VLQWMDANTDGKPYGVDVVMP-------AKVPTEGTAVD---INKLIPQG
TH_1822|M.thermoresistible__bu VLCWMDDNTDGLPYGVDVVMP-------AKVPTEGSAVD---IDKLIPQG
MAB_4162c|M.abscessus_ATCC_199 VLNWMDENTDGKPYGVDIVMP-------AKVPAEGTAVD---IDKLIPQG
MMAR_2346|M.marinum_M ELTWIEEQTRGKPYGVDLLLP------PKYVGAEQGGIDPVQARELVPEA
* *:: : . *****:::* : :: . .::*
Mb1927c|M.bovis_AF2122/97 HLDFARKILADHGVP-VEDADEDSLQLLGWTEATAT----PQVDAALKHP
Rv1894c|M.tuberculosis_H37Rv HLDFARKILADHGVP-VEDADEDSLQLLGWTEATAT----PQVDAALKHP
MUL_1143|M.ulcerans_Agy99 HLDFARKILADHGVP-IEDADEDSLQLLGWTEATAT----PQVEVALKHS
MAV_2807|M.avium_104 HLDFGKKILADHGVP-IEDSDSDSLQLLGWTEATAT----PQVEVALKHP
Mflv_1544|M.gilvum_PYR-GCK HREFVDKTLADLGVPPLPEDEERSEGVLGWLHSVAR----SHVEVALKHP
Mvan_5214|M.vanbaalenii_PYR-1 HREFVDKTLADLGVPPLPADEERSEGVLGWLHSVAR----SHVEVALKHP
MSMEG_5913|M.smegmatis_MC2_155 HRDFVAKTLADLGVPPLPEDGERNEGVLGWLHSVAR----SHVEVALKHP
TH_1822|M.thermoresistible__bu HRDFVNKTLTELGVPPLSEDQQRNEGVLGWLHSVAR----SHVDVALKHP
MAB_4162c|M.abscessus_ATCC_199 HKDFVEKTLADLGVPPLPGERE-SAGVLGWLHSVAR----SHVEVALKHP
MMAR_2346|M.marinum_M HRAFVEELLARYGIAPSPEAGAERISRSGGGLNISPKGYEPLLDVAFSHD
* * : *: *:. * : . ::.*:.*
Mb1927c|M.bovis_AF2122/97 KMTMVANALGTPPADMIKHIHDSGRKVAALCGSPSQARKHADAGVDIIIA
Rv1894c|M.tuberculosis_H37Rv KMTMVANALGTPPADMIKHIHDSGRKVAALCGSPSQARKHADAGVDIIIA
MUL_1143|M.ulcerans_Agy99 KVTMIANALGTPPAEMIAHIHERGRKVAALCGSPSQARKHANAGVDIIIA
MAV_2807|M.avium_104 KVKMIANALGTPPADMIKHIHDAGLKVAALCGSPSQARKHADAGVDIIIA
Mflv_1544|M.gilvum_PYR-GCK -IKLIANALGSPPKDVIDQVHEAGVPVAALAGSPKHALRHVENGVDIVVA
Mvan_5214|M.vanbaalenii_PYR-1 -IKLIANALGSPPKDVIDQAHQAGVPVAALAGSAKHALRHVDNGVDIVVA
MSMEG_5913|M.smegmatis_MC2_155 -IKLIANALGSPPKDVIDQAHAAGVPVAALAGSAKHALRHVENGVDIVVA
TH_1822|M.thermoresistible__bu -IKLIANALGSPPTDVIERVHKAGVPVAALAGSAKHAQRHVDNGVDIVVA
MAB_4162c|M.abscessus_ATCC_199 -IKLIANALGSPPKDVIDQAHEHGVPVAALAGKAEHARRHVENGVDIVVA
MMAR_2346|M.marinum_M -IRLIASALGPPPSDLVERAHKKEVLVAALAGTTQHARRHAAAGVDLIVA
: ::*.***.** ::: : * ****.*...:* :*. ***:::*
Mb1927c|M.bovis_AF2122/97 QGGEAGGHCGEVGSIVLWPQVVKEVAP-VPVLAAGGIGSGQQIAAALALG
Rv1894c|M.tuberculosis_H37Rv QGGEAGGHCGEVGSIVLWPQVVKEVAP-VPVLAAGGIGSGQQIAAALALG
MUL_1143|M.ulcerans_Agy99 QGGEAGGHCGEVGSIVLWPQVVKEVAP-VPVLAAGGIGSGQQIAAALALG
MAV_2807|M.avium_104 QGGEAGGHCGEVGSIVLWPQVVKEVAP-LPVLAAGGIGSGQQIAAALALG
Mflv_1544|M.gilvum_PYR-GCK QGHEAGGHTGEIGSMVLWPEIVDALDGRAPVLAAGGIGTGRQVAAALALG
Mvan_5214|M.vanbaalenii_PYR-1 QGHEAGGHTGEIGSMVLWPEIVDAIEGRAPVLAAGGIGTGRQVAAALALG
MSMEG_5913|M.smegmatis_MC2_155 QGHEAGGHTGEIGSMVLWPEIVDALDGKAPVLAAGGIGTGRQVAAALALG
TH_1822|M.thermoresistible__bu QGHEAGGHTGEIGSVVLWPEIVDAVGDQVPVLAAGGIGTGRQVAAALALG
MAB_4162c|M.abscessus_ATCC_199 QGYEAGGHTGDVASMVLWPEIVDALDGSAPVLAAGGIGSGRQAAAALALG
MMAR_2346|M.marinum_M QGTEAGGHTGEVATMVLVPEVVDAVAP-TPVLAAGGIARGRQIAAALALG
** ***** *::.::** *::*. : ********. *:* *******
Mb1927c|M.bovis_AF2122/97 TQGAWTGSQWLMVEE-------AANTAVQQAAYVKATSRDTVRSRSFTGK
Rv1894c|M.tuberculosis_H37Rv TQGAWTGSQWLMVEE-------AANTAVQQAAYVKATSRDTVRSRSFTGK
MUL_1143|M.ulcerans_Agy99 CQGAWTGSQWLMVEE-------ASNTPVQQAAYAKASSRDTVRSRSFTGK
MAV_2807|M.avium_104 AQGAWTGSQWLMVEE-------SSNTPVQQAAYAKAGSRDTVRSRSFTGK
Mflv_1544|M.gilvum_PYR-GCK AQGVWMGSAFLTSAEYDLGVRLESGRSVIQEAMLKATSADTVRRRIYTGK
Mvan_5214|M.vanbaalenii_PYR-1 AQGVWMGSAFLTSAEYDLGVRLPSGRSVVQEAMLNATSADTVRRRIYTGK
MSMEG_5913|M.smegmatis_MC2_155 ASGVWMGSAFLTSAEYDLGHRKPSGVSTIQEALLRAGTADTVRRKIYTGK
TH_1822|M.thermoresistible__bu AQGVWMGSAFLTSAEYDLGVRRESGISTIQQALLDATSADTVRRRIYTGK
MAB_4162c|M.abscessus_ATCC_199 ASGVWTGSIWLTAAEYDLGTVTAGGDSVVQQALLKATSGDTVRTRIYTGK
MMAR_2346|M.marinum_M AEGVWCGSVWLTTEE-------AETVPAVKDKFLAATSSDTVRSRSMTGK
.*.* ** :* * .. : * : **** : ***
Mb1927c|M.bovis_AF2122/97 PARMLRNDWTEAWEQPESPKPLGMPLQYMVSGMAVKATHKYPNETVD---
Rv1894c|M.tuberculosis_H37Rv PARMLRNDWTEAWEQPESPKPLGMPLQYMVSGMAVKATHKYPNETVD---
MUL_1143|M.ulcerans_Agy99 PARMLRNDWTEAWEQADNPKPLGMPLQYMVSGMAVRATNKYPNETVD---
MAV_2807|M.avium_104 PARMLRNDWTEAWEAPGNPKPLGMPLQYMVSGMAVRATNKYPNESVD---
Mflv_1544|M.gilvum_PYR-GCK PARLLKSRWTDAWDAEGAPEPLPMPLQNILVSEAHQRMSES-SDPTT---
Mvan_5214|M.vanbaalenii_PYR-1 PARLLKSRWTDAWDADGAPEPLPMPLQNILVSEAHQRMSEN-SDPTA---
MSMEG_5913|M.smegmatis_MC2_155 PARLLKTKWTDAWDAPEAPEPLPMPLQNILVSEAHQRMNES-DNPDT---
TH_1822|M.thermoresistible__bu PARLLKSRWTDAWDAPDAPEPLPMPLQNILVSEAHQRMNYS-TDPTT---
MAB_4162c|M.abscessus_ATCC_199 PARLLKTKWTQAWDAEDAPTPLPMPLQNILVSEAHERMNRA-HDPET---
MMAR_2346|M.marinum_M PARMLRTAWTDEWARPDTPEPLGMPLQTTLITDSQIRINQAAVQPGAKAR
***:*:. **: * * ** **** : : :.
Mb1927c|M.bovis_AF2122/97 -VAFNPVGQVVGQFTKVEKTATVIERWVQEYLEATARLDALNAAASV
Rv1894c|M.tuberculosis_H37Rv -VAFNPVGQVVGQFTKVEKTATVIERWVQEYLEATARLDALNAAASV
MUL_1143|M.ulcerans_Agy99 -VAFNPVGQVVGQFTKVEKAATVIERWVQEYLEATNRLDELNAAAV-
MAV_2807|M.avium_104 -VAFNPVGQVVGQFTKVEKTATVIERWVQEYLEATNRLDELNEAASV
Mflv_1544|M.gilvum_PYR-GCK -VAM-PVGQIVGRMNEIRPVADIIAELVSGFDEASKRLDAIRDN---
Mvan_5214|M.vanbaalenii_PYR-1 -VAM-PVGQIVGRMNEIRPVADIIAELVSGFEEATRRLDAIRDN---
MSMEG_5913|M.smegmatis_MC2_155 -VAM-PVGQIVGRMNQIRPVADIIAELVEGFEKATNRLDTVRDA---
TH_1822|M.thermoresistible__bu -VAM-PVGQIVGRMNEIRPVGDIIADLVAEFEEATRRLDTIRDG---
MAB_4162c|M.abscessus_ATCC_199 -VCF-PAGQIVGRMNEIRPTAEIVADLVSGFEAAVDRLDEIRG----
MMAR_2346|M.marinum_M ELATYFVGQVVGSLDRVRPTRSVVLEMVEEFIDTIGRLERLAD----
:. .**:** : .:. . :: * : : **: :